Abstract：
:Synaptic input activity affects the neurogenesis in adult hippocampal dentate gyrus (DG), while the input activity is potentiated by neurosteroid pregnenolone sulfate (PREGS). This study focused on exploring the effects of PREGS on the survival of newborn neurons in the DG of adult male mice. Proliferating cells were labeled with bromodeoxyuridine (BrdU) and injection (i.c.v.) of PREGS (3 nmol for two successive days) was made on various paired days from 0-1 to 20-21 after BrdU-injection. PREGS given on day 11-12 or 15-16, roughly corresponding to the prophase of synaptogenesis, produced an approximately 2-fold increase in the number of 22-day-old BrdU(+) cells. Hippocampal slices, which were prepared 60 min after the in vivo PREGS-injection and followed by 60 min perfusion with artificial cerebrospinal fluid (ACSF), showed a sustained (>60 min) increase in the presynaptic glutamate release at perforant path-granule cell synapses. PREGS-inducted presynaptic potentiation required a co-activation of α7 nicotinic acetylcholine receptor (α7nAChR), NMDA receptor (NMDAr) and sigma-1 receptor (σ1R), while its maintenance after PREGS-washout depended only on NMDAr and neuronal NO synthase (nNOS) activation. PREGS enhanced the NMDAr-mediated nNOS expression to increase presynaptic glutamate release via a retrograde NO signaling. The sustained presynaptic potentiation was critical to keep the PREGS-enhanced survival of newborn neurons in an NMDAr-dependent manner. These results for the first time provide in vivo evidence that PREGS enhances the survival of newborn neurons in adult animals through the potentiation of synaptic input activity.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Yang R,Zhou R,Chen L,Cai W,Tomimoto H,Sokabe M,Chen Ldoi
10.1016/j.neuropharm.2010.11.017subject
Has Abstractpub_date
2011-02-01 00:00:00pages
529-41issue
2-3eissn
0028-3908issn
1873-7064pii
S0028-3908(10)00316-3journal_volume
60pub_type
杂志文章abstract：:The aim of the present study was to evaluate, by means of quantitative and multivariate analyses, the effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test as well as whether such changes are associated with drug-induced effects on anxiety and/or nociception. To this purpo...
journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2017.01.022
更新日期：2017-05-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/0028-3908(86)90036-5
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
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更新日期：2018-10-01 00:00:00
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
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