Celebrating the 70 years of pyridostigmine on therapy of Myasthenia Gravis: historical aspects of the preliminary trials.

Abstract:

:Currently, pyridostigmine bromide is an indispensable anticholinesterase agent used worldwide to treat patients with Myasthenia Gravis (MG). However, pyridostigmine bromide was unsuccessful in its "pioneering trials" to treat a series of MG patients. There are important historical landmarks before pyridostigmine bromide becomes useful, safe and indispensable for MG therapy. After 70 years of these "pioneering trials", this article reviews some historical aspects related to them, as well as other preliminary trials using pyridostigmine bromide as therapy for MG patients.

journal_name

Arq Neuropsiquiatr

authors

Lorenzoni PJ,Kay CSK,Ducci RD,Fustes OJH,Werneck LC,Scola RH

doi

10.1590/0004-282X20190189

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

179-181

issue

3

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2020005006205

journal_volume

78

pub_type

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