Abstract:
:We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained after autopsy of patients without neurological disorders. The glutamate was decreased in the temporal lobe epilepsy (TLE) -MTS group (p<0.001), suggesting increased release of this neurotransmitter. The IL1β and TNFα were increased in the hippocampus (p<0.05) demonstrating an active inflammatory process. A positive linear correlation between FLAIR signal and NO and IL1β levels and a negative linear correlation between FLAIR signal and glutamate concentration was found. Lymphocytes infiltrates were present in hippocampi of TLE patients. These data showed an association between hippocampal signal alteration and increased inflammatory markers in TLE-MTS.
journal_name
Arq Neuropsiquiatrjournal_title
Arquivos de neuro-psiquiatriaauthors
Varella PP,Santiago JF,Carrete H Jr,Higa EM,Yacubian EM,Centeno RS,Caboclo LO,Castro Neto EF,Canzian M,Amado D,Cavalheiro EA,Naffah-Mazzacoratti Mda Gdoi
10.1590/s0004-282x2011000100018subject
Has Abstractpub_date
2011-02-01 00:00:00pages
91-9issue
1eissn
0004-282Xissn
1678-4227pii
S0004-282X2011000100018journal_volume
69pub_type
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