Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis.

Abstract:

:We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained after autopsy of patients without neurological disorders. The glutamate was decreased in the temporal lobe epilepsy (TLE) -MTS group (p<0.001), suggesting increased release of this neurotransmitter. The IL1β and TNFα were increased in the hippocampus (p<0.05) demonstrating an active inflammatory process. A positive linear correlation between FLAIR signal and NO and IL1β levels and a negative linear correlation between FLAIR signal and glutamate concentration was found. Lymphocytes infiltrates were present in hippocampi of TLE patients. These data showed an association between hippocampal signal alteration and increased inflammatory markers in TLE-MTS.

journal_name

Arq Neuropsiquiatr

authors

Varella PP,Santiago JF,Carrete H Jr,Higa EM,Yacubian EM,Centeno RS,Caboclo LO,Castro Neto EF,Canzian M,Amado D,Cavalheiro EA,Naffah-Mazzacoratti Mda G

doi

10.1590/s0004-282x2011000100018

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

91-9

issue

1

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2011000100018

journal_volume

69

pub_type

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