Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis.


:We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained after autopsy of patients without neurological disorders. The glutamate was decreased in the temporal lobe epilepsy (TLE) -MTS group (p<0.001), suggesting increased release of this neurotransmitter. The IL1β and TNFα were increased in the hippocampus (p<0.05) demonstrating an active inflammatory process. A positive linear correlation between FLAIR signal and NO and IL1β levels and a negative linear correlation between FLAIR signal and glutamate concentration was found. Lymphocytes infiltrates were present in hippocampi of TLE patients. These data showed an association between hippocampal signal alteration and increased inflammatory markers in TLE-MTS.


Arq Neuropsiquiatr


Varella PP,Santiago JF,Carrete H Jr,Higa EM,Yacubian EM,Centeno RS,Caboclo LO,Castro Neto EF,Canzian M,Amado D,Cavalheiro EA,Naffah-Mazzacoratti Mda G




Has Abstract


2011-02-01 00:00:00














  • [Correlation between functional disability, age, and serum enzymes in neuromuscular diseases].

    abstract::We attempt to correlate the patient's disability and serum enzymes (creatinekinase, lactic dehydrogenase, aldolase, glutamic oxalacetic and glutamic piruvic transaminase) in several neuromuscular disorders using the Vignos and Archibald scale (V&A). In 806 cases we studied, serum enzyme levels and the V&A disability u...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Werneck LC

    更新日期:1995-03-01 00:00:00

  • When should MELAS (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes) be the diagnosis?

    abstract::Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) is a rare mitochondrial disorder. Diagnostic criteria for MELAS include typical manifestations of the disease: stroke-like episodes, encephalopathy, evidence of mitochondrial dysfunction (laboratorial or histological) and known m...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,评审


    authors: Lorenzoni PJ,Werneck LC,Kay CS,Silvado CE,Scola RH

    更新日期:2015-11-01 00:00:00

  • Perspective of the frontolateral craniotomies.

    abstract::The pterional craniotomy is one of the most frequently surgical approaches used in neurosurgery and currently it has become a mainsteam. It allows excellent microsurgical exposure of anterior and posterior regions of the arterial circle of Willis, supra and paraselar regions, the superior orbital fissure of sphenoid b...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,评审


    authors: Figueiredo EG,Oliveira AM,Plese JP,Teixeira MJ

    更新日期:2010-06-01 00:00:00

  • Ganglioneuroblastoma of the cerebellum: neuroimaging and pathological features of a case.

    abstract:OBJECTIVE:To report a case of ganglioneuroblastoma of cerebellum, with emphasis to the neuroimaging and pathological findings. CASE REPORT:A one year and eight-month-old girl presented with a two-month history of hypoactivity and tremor in the legs. The MRI showed an enhancing cerebellar mass hypointense on T1 and hyp...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Gasparetto EL,Rosemberg S,Matushita H,Leite Cda C

    更新日期:2007-06-01 00:00:00

  • [Diagnosis and treatment of associated epilepsy and psychogenic pesudoepileptic seizures: case report].

    abstract::We report on a case of a 26 year old patient with seizures since the age of 13, who was sent to our service for differential diagnosis between epilepsy and psychogenic pesudoepileptic seizures. Both diagnoses were confirmed and she was operated for the resection of an occipital cystic tumour, that was considered respo...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Marchetti RL,Kurcgant D

    更新日期:2001-06-01 00:00:00

  • Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study.

    abstract:UNLABELLED:Topical treatments have gained popularity for general use as an adjunct to systemic drugs in neuropathic pain, but their use produces variable clinical results and local adverse events. OBJECTIVE:To evaluate the safety and analgesic effect of a formulation of liposomal capsaicin (LC) (0.025%) in patients wi...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,随机对照试验


    authors: Teixeira MJ,Menezes LM,Silva V,Galhardoni R,Sasson J,Okada M,Duarte KP,Yeng LT,Andrade DC

    更新日期:2015-03-01 00:00:00

  • Demonstration project on epilepsy in Brazil: outcome assessment.

    abstract:PURPOSE:To assess the outcome of patients with epilepsy treated at primary care health units under the framework of the demonstration project on epilepsy in Brazil, part of the WHO/ILAE/IBE Global Campaign Against Epilepsy. METHOD:We assessed the outcome of patients treated at four primary health units. The staff of t...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Li LM,Fernandes PT,Noronha AL,Marques LH,Borges MA,Borges K,Cendes F,Guerreiro CA,Zanetta DM,de Boer HM,Espíndola J,Miranda CT,Prilipko L,Sander JW

    更新日期:2007-06-01 00:00:00

  • Frontal assessment battery in a Brazilian sample of healthy controls: normative data.

    abstract:OBJECTIVE:To show data on the performance of healthy subjects in the Frontal Assessment Battery (FAB), correlating with gender, age, education, and scores in the Mini-Mental State Examination (MMSE). METHODS:Two hundred and seventy-five healthy individuals with mean age of 66.4 ± 10.6 years-old were evaluated. Mean to...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Beato R,Amaral-Carvalho V,Guimarães HC,Tumas V,Souza CP,Oliveira GN,Caramelli P

    更新日期:2012-04-01 00:00:00

  • Cerebrospinal fluid examination may be useful in diagnosing neurosyphilis in asymptomatic HIV+ patients with syphilis.

    abstract::Lumbar puncture in neurologically asymptomatic HIV+ patients is still under debate. There are different criteria for detecting neurosyphilis through cerebrospinal fluid (CSF), especially in cases that are negative through the Venereal Disease Research Laboratory (VDRL), regarding cellularity and protein content. Howev...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Salamano R,Ballesté R,Perna A,Rodriguez N,Lombardo D,García N,López P,Cappuccio P

    更新日期:2016-02-01 00:00:00

  • Magnetic resonance imaging study cannot individually distinguish individuals with mild cognitive impairment, mild Alzheimer's disease, and normal aging.

    abstract:OBJECTIVE:To evaluate the volumetric and spectroscopy aspects of hippocampus in patients with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI). METHODS:A series of patients older than 65 years and with memory deficit were studied. RESULTS:The evocation of words test presented a significant reduction ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Menezes TL,Andrade-Valença LP,Valença MM

    更新日期:2013-04-01 00:00:00

  • [Clinical study of catamenial epilepsy: clinical types of epileptic crises].

    abstract::Four hundred thirty one epileptic patients, aged 10 years or more old, have been studied in the neurology clinic of Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da U.S.P., from February to July, 1981. The authors selected 119 patients aged between 13 to 45 years, that presented periodic menstrual b...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Schelp AO,Speciali JG

    更新日期:1983-06-01 00:00:00

  • [Emotionally-loaded narrative increases dyslogia in schizophrenics].

    abstract::We tested the degree of dyslogia in the narrative of ten schizophrenic non-medicated outpatients while they narrated emotionally-loaded or neutral facts. The "emotional narratives" were much more dyslogic than the "neutral narratives". In order to explain these facts we evoke: 1. A fronto-temporo-limbic connection dys...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Caixeta M,Chaves M,Caixeta L,Reis O

    更新日期:1999-09-01 00:00:00

  • Safety of transcranial direct current stimulation in a patient with deep brain stimulation electrodes.

    abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) has been investigated in movement disorders, making it a therapeutic alternative in clinical settings. However, there is still no consensus on the most appropriate treatment protocols in most cases, and the presence of deep brain stimulation (DBS) electrodes has...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Iannone A,Allam N,Brasil-Neto JP

    更新日期:2019-03-01 00:00:00

  • [Myasthenia gravis: clinical and surgical treatment].

    abstract::The indication for thymectomy in myasthenia gravis still is controversial, and it is uncommon to find in the present days studies comparing conservative treatments, due to the widespread surgical treatment adopted in most centers. We studied 65 cases divided into three groups of patients: (1) 15 thymectomized patients...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Werneck LC,Moreira PR

    更新日期:1991-12-01 00:00:00

  • Clinical, laboratory and neuroimage findings in juvenile systemic lupus erythematosus presenting involvement of the nervous system.

    abstract:OBJECTIVE:To characterize neurological involvement in juvenile systemic lupus erythe-matosus. METHOD:The charts of all patients with the diagnosis of systemic lupus erythematosus before the age of 16 years, followed at the Rheumatology Unit of Pequeno Príncipe Hospital, from January 1992 to January 2006, were retrospe...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Spinosa MJ,Bandeira M,Liberalesso PB,Vieira SC,Janz LL Jr,Sá EG,Löhr A Jr

    更新日期:2007-06-01 00:00:00

  • Neurological examination in the healthy term newborn.

    abstract::We carried out a cross-sectional study with a sample of 106 normal full-term newborns examined within 24 to 72 hours of birth. The following findings were evaluated: head and chest measurements, muscle strength, tone, tendon reflexes, superficial reflexes, primitive reflexes, and cranial nerves. All 106 newborns were ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Pedroso FS,Rotta NT

    更新日期:2003-06-01 00:00:00

  • Prevalence of multiple sclerosis in Goiânia, Goiás, Brazil.

    abstract:OBJECTIVE:Multiple sclerosis (MS) prevalence, in some cities in Brazil, was estimated and was found to range from 0.75 to 30.7/100,000. The reasons for such a large variation in rates of prevalence are not clear, but environment and genetics help to explain this phenomenon. METHODS:A cross-sectional study using three ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Ribeiro TAGJ,Duarte AL,Silva DJD,Borges FE,Costa VMD,Papais-Alvarenga RM,Diniz DS

    更新日期:2019-05-01 00:00:00

  • [Non-Hodgkin lymphoma in adults. Protein profile of CSF and serum in 25 patients].

    abstract::Twenty-five non-Hodgkin's adult patients of a cohort studied for detection of neurologic involvement were evaluated on the cerebrospinal fluid (CSF) protein profile. CSF and serum were collected in the same occasion. Blood-brain barrier and local synthesis of IgG were studied. There was an incidence of neurologic sign...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Mielli SR,Beitler B,Galperin C,Palou VB,Livramento JA,Machado Ldos R,Gomes HR

    更新日期:1998-12-01 00:00:00

  • [West syndrome: clinical and electroencephalographic follow up of 70 patients and response to its treatment with adrenocorticotropic hormone, prednisone, vigabatrin, nitrazepam and valproate].

    abstract::In a retrospective study we assessed the outcome of the criptogenic and symptomatic forms of West syndrome and evaluated the efficacy of adrenocorticotropic hormone, vigabatrin, prednisone, valproate and nitrazepam in the spasms control. Seventy patients were follwed up by 2 years. Twelve (17%) were criptogenics and 5...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 临床试验,杂志文章


    authors: Antoniuk SA,Bruck I,Spessatto A,Halick SM,de Bruyn LR,Meister E,de Paola D

    更新日期:2000-09-01 00:00:00

  • Is there correlation between cognition and functionality in severe dementia? the value of a performance-based ecological assessment for Alzheimer's disease.

    abstract:OBJECTIVE:Besides significant cognitive decline, patients in later stages of Alzheimer's disease (AD) also present global functional impairment, usually reported by their caregivers. This study searched for preserved activities of daily living by investigating correlations among specific instruments for severe dementia...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Wajman JR,Oliveira FF,Marin SM,Schultz RR,Bertolucci PH

    更新日期:2014-11-01 00:00:00

  • [Septic thrombosis of cavernous sinus: report of 6 cases].

    abstract::The cavernous sinus is most frequently involved by septic thrombosis. The common sites of primary infection are the medial face, orbits, tonsils, soft palate, sphenoid and ethmoid sinuses. The usual clinical presentation begins with fever and periorbital edema followed by headache, ptosis and ocular muscles palsy. The...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Dini LI,Sonda I,Saraiva GA,Corso RJ,de Almeida FO,Gallo P

    更新日期:1999-09-01 00:00:00

  • Alzheimer's disease qEEG: spectral analysis versus coherence. Which is the best measurement?

    abstract::There is evidence in electroencephalography that alpha, theta and delta band oscillations reflect cognitive and memory performances and that quantitative techniques can improve the electroencephalogram (EEG) sensitivity. This paper presents the results of comparative analysis of qEEG variables as reliable markers for ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Anghinah R,Kanda PA,Lopes HF,Basile LF,Machado S,Ribeiro P,Velasques B,Sameshima K,Takahashi DY,Pinto LF,Caramelli P,Nitrini R

    更新日期:2011-12-01 00:00:00

  • Interictal dysphoric disorder: a frequent psychiatric comorbidity among patients with epilepsy who were followed in two tertiary centers.

    abstract:UNLABELLED:Psychiatric disorders are frequent among patients with epilepsy. Data in the literature have shown a heterogeneous clinical presentation of psychiatric disorders in patients with epilepsy. Interictal dysphoric disorder could be a specific psychiatric comorbidity associated with epilepsy, primarily in patient...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Nascimento PP,Oliva CH,Franco CM,Mazetto L,Yamashiro AS,Araújo Filho GM,Yacubian EM

    更新日期:2013-11-01 00:00:00

  • Involuntary movements and AIDS: report of seven cases and review of the literature.

    abstract::We studied 1086 AIDS patients in the last six years. Of these 389 (35.82%) had neurological manifestation and 7 (1.8%) male patients had abnormal involuntary movements (parkinsonism in 3, hemichorea-hemiballism in 2, spinal myoclonus in 1 and rubral tremor in another). All patients were men, 5 white and 2 black. Four ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: De Mattos JP,Rosso AL,Corrêa RB,Novis S

    更新日期:1993-12-01 00:00:00

  • [Association of Wilson's disease with non wilsonian extrapyramidal syndrome in the same family].

    abstract::Movement disorders, mostly dystonia, sometimes occur in heterozygotes for Wilson's disease (WD). A patient with metabolic abnormalities suggestive of heterozygote for WD and dystonia is reported. His niece showed the typical neurological and metabolic abnormalities of WD. This rare coincidence and the etiopathogenic m...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Barbosa ER,Kostow UP,Hirsch R,Cançado ER,Scaff M,Canelas HM

    更新日期:1990-12-01 00:00:00

  • Neurodegenerative changes in the brainstem and olfactory bulb in people older than 50 years old: a descriptive study.

    abstract::With the increase in life expectancy in Brazil, concerns have grown about the most prevalent diseases in elderly people. Among these diseases are neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Protein deposits related to the development of these diseases can pre-date the symptomatic phases b...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Oliveira FH,Rodrigues Neto E,Fonseca MK,Costa AS,Rockenbach MA,Padilha Rdos S,Fernandez LL,Hilbig A

    更新日期:2015-07-01 00:00:00

  • Simple and safe heparin regimen for acute ischaemia.

    abstract::The risk/benefit ratio of acute anticoagulation in ischaemic cerebro-vascular disease is not clearly established. A simple and safe intermittent intravenous heparin regimen (20000 IU daily) was used prospectively in 50 patients of 57 +/- 14 (m +/- sd) years of age whose blood pressures ranged from normal to severe hyp...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Bittencourt PR,Padilha S,Mazer S

    更新日期:1986-03-01 00:00:00

  • [Headache incidence in a hospital community].

    abstract::The purpose was to describe the main features of headache incidence in a hospital community, its frequency and the most requested medical investigation. Due to the stressful work environment, hospital is considered to hold a high-risk population. Interviews and questionnaires were utilized. Of a 1006 files, which were...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Zétola VH,Nóvak EM,Luiz A,Branco BO,Sato BK,Nita CS,Bubna MH,Prado Rde A,Werneck LC

    更新日期:1998-09-01 00:00:00

  • [Event-related cerebral potentials. Classification and clinical use].

    abstract::Event-related potentials (ERP) constitute an heterogeneous group of brain electrical signals time-locked to sensory stimulation, motor responses, and associative processes, recorded using computer averaging. Several kinds of brain electric activity are encompassed by the generic term "event related potentials": sensor...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Lolas F

    更新日期:1979-09-01 00:00:00

  • Désiré-Magloire Bourneville and his contributions to pediatric neurology.

    abstract::Désiré-Magloire Bourneville ought to be thought of as the father of Pediatric Neurology for his significant contributions to the field. He worked as a physician, politician, writer, and editor. He was the first to describe the autosomal dominant genetic condition known as "tuberous sclerosis complex", after conducting...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 传,历史文章,杂志文章


    authors: Gómez-López MT,Palacios-Sánchez L,Meerbeke AVV,Botero-Meneses JS

    更新日期:2019-05-13 00:00:00