Neurosarcoidosis: guidance for the general neurologist.

Abstract:

:Neurosarcoidosis (NS) more commonly occurs in the setting of systemic disease. The diagnosis is based on a clinical history suggestive of NS, presence of noncaseating granulomas, and supportive evidence of sarcoid pathology, laboratory, and imaging studies. NS could involve any part of the nervous system and often demands high doses of steroids for symptom control. It presents low response to isolated steroids administration and frequently requires immunosuppressive agents. In NS, lymphocytes are polarized toward an excessive Th1 response, leading to overproduction of TNF-alpha and INF-gama, as well as lL-2 and IL-15. Infliximab, a chimeric monoclonal antibody that neutralizes the biological activity of TNF-alpha, is a new option in the NS treatment. We revised pathophysiology, clinical manifestations, diagnostic work up, and treatment of NS as guidance for the general neurologist.

journal_name

Arq Neuropsiquiatr

authors

Dutra LA,Braga-Neto P,Oliveira RA,Pedroso JL,Abrahão A,Barsottini OG

doi

10.1590/s0004-282x2012000400014

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

293-9

issue

4

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2012000400014

journal_volume

70

pub_type

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