JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPβ transcription.

abstract：:A water soluble growth inhibitor was isolated from the mammalian ocular iris-ciliary complex. The molecular weight of this protein is 10 kD or lower as determined by ultrafiltration fractionation. The iris-ciliary (IC) complex water soluble protein(s) significantly inhibits synthesis of lower molecular weight proteins...

journal_title：Journal of cellular biochemistry

authors： Banerjee A,Emanuel K,Parafina J,Bagchi M

更新日期：1992-10-01 00:00:00

abstract：:An important aspect of the cellular differentiation in the intestine is the migration of epithelial cells from the crypt to the villus tip. As homeodomaine transcription factor CDX2 has been suggested to influence cell migration, we performed a genome-wide promoter analysis for CDX2 binding in the differentiated human...

journal_title：Journal of cellular biochemistry

authors： Coskun M,Boyd M,Olsen J,Troelsen JT

更新日期：2010-04-15 00:00:00

abstract：:Herbal plants are enriched with compounds with a wide range of biological activities. Furanodiene is a sesquiterpene isolated from Rhizoma Curcumae. Growing evidence shows furanodiene exhibits diversified activities of hepatoprotection, anti-inflammation, anti-angiogenesis, and anti-tumor. However, its biological acti...

journal_title：Journal of cellular biochemistry

authors： Zhong ZF,Li YB,Wang SP,Tan W,Chen XP,Chen MW,Wang YT

更新日期：2012-08-01 00:00:00

abstract：:Pristimerin is a natural product derived from the Celastraceae and Hippocrateaceae families that were used as folk medicines for anti inflammation in ancient times. Although it has been shown that pristimerin induces apoptosis in breast cancer cells, the involved mechanism of action is unknown. The purpose of the curr...

journal_title：Journal of cellular biochemistry

authors： Yang H,Landis-Piwowar KR,Lu D,Yuan P,Li L,Reddy GP,Yuan X,Dou QP

更新日期：2008-01-01 00:00:00

abstract：:The activated c-Ha-rasVal12 oncogene is often involved in the genesis of human malignancies. We show here that in c-Ha-rasVal12 oncogene-transformed mouse NIH 3T3 fibroblasts the copy number and expression level of the mutant ras oncogene correlates with the degree of chromatin decondensation, as assessed by micrococc...

journal_title：Journal of cellular biochemistry

authors： Laitinen J,Sistonen L,Alitalo K,Hölttä E

更新日期：1995-01-01 00:00:00

abstract：:3-Acetyl-11-keto-β-boswellic acid (AKBA), a pentacyclic triterpenic acid present in gum resin of Boswellia serrata, has been found to possess antioxidant and neuroprotective properties. In this study, we aimed to examine protective properties of AKBA against glutamate-induced neuronal injury. To investigate the effect...

journal_title：Journal of cellular biochemistry

authors： Rajabian A,Sadeghnia HR,Hosseini A,Mousavi SH,Boroushaki MT

更新日期：2020-02-01 00:00:00

abstract：:The specific lysis of bloodstream trypanosomes by serum from a nonpermissive mammalian host is the result of interaction between the serum trypanocidal factor (high-density lipoprotein) and the trypanosome surface. The studies described in this paper attempt to define further the mode of action of this cytotoxic lipop...

journal_title：Journal of cellular biochemistry

authors： Rifkin MR

更新日期：1983-01-01 00:00:00

abstract：:Because elevated ubiquitin ligase atrogin-1/MAFbx and MuRF1 mediate skeletal muscle wasting associated with various catabolic conditions, the signaling pathways involved in the upregulation of these genes under pathological conditions are considered therapeutic targets. AKT and NF-kappaB have been previously shown to ...

journal_title：Journal of cellular biochemistry

authors： Jin B,Li YP

更新日期：2007-03-01 00:00:00

abstract：:Wip1 belongs to the protein phosphatase C (PP2C) family, of which expression is up-regulated by a number of external stresses, and serves as a stress modulator in normal physiological conditions. When overexpressed, premature dephosphorylation of stress-mediators by Wip1 results in abrogation of tumor surveillance, th...

journal_title：Journal of cellular biochemistry

authors： Jeong HC,Gil NY,Lee HS,Cho SJ,Kim K,Chun KH,Cho H,Cha HJ

更新日期：2015-08-01 00:00:00

abstract：:Baicalein, a flavonoid present in the root of Scutellaria baicalensis, is well known for its antibacterial, antiviral, anti-inflammatory, antithrombotic, and antioxidant effects. Here we show that baicalein also attenuates cardiac hypertrophy. Aortic banding (AB) was performed to induce cardiac hypertrophy secondary t...

journal_title：Journal of cellular biochemistry

authors： Zong J,Zhang DP,Zhou H,Bian ZY,Deng W,Dai J,Yuan Y,Gan HW,Guo HP,Tang QZ

更新日期：2013-05-01 00:00:00

abstract：:Thrombin is a potent mitogen for human vascular smooth muscle cells (HVSMC) and its enzymatic activity is required for this function. The present study demonstrates that prothrombin is also mitogenic for HVSMC due to the generation of enzymatically active thrombin which occurs upon incubation of prothrombin with the c...

journal_title：Journal of cellular biochemistry

authors： Benzakour O,Kanthou C,Lupu F,Dennehy U,Goodwin C,Scully MF,Kakkar VV,Cooper DN

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Long noncoding RNAs (lncRNAs) regulate gene expression by acting with microRNAs (miRNAs) and indirectly interact with messenger RNA (mRNAs). However, the roles of specific lncRNA and its related competing endogenous RNAs (ceRNA) network in alopecia areata (AA) are not fully understood. METHODS:The blood lnc...

journal_title：Journal of cellular biochemistry

authors： Sheng Y,Ma J,Zhao J,Qi S,Hu R,Yang Q

更新日期：2019-06-01 00:00:00

abstract：:Efficient catabolism of host-derived compounds is essential for bacterial survival and virulence. While these links in intracellular bacteria are well studied, such studies in extracellular bacteria lag behind, mostly for technical reasons. The field has identified important metabolic pathways, but the mechanisms by w...

journal_title：Journal of cellular biochemistry

authors： Meadows JA,Wargo MJ

更新日期：2014-02-01 00:00:00

abstract：:The aim of this study was to determine: (1) whether the Short Chain Fatty Acids (SCFA) Acetate, Propionate, and Butyrate enhance the synthesis and secretion of intestinal apolipoprotein A-IV-containing lipoproteins and (2) if so, whether these particles are able to promote cholesterol efflux in vitro. For this purpose...

journal_title：Journal of cellular biochemistry

authors： Nazih H,Nazih-Sanderson F,Krempf M,Michel Huvelin J,Mercier S,Marie Bard J

更新日期：2001-08-01 00:00:00

abstract：:With a signal trap method, we previously identified stromal interaction molecule (STIM: originally named as SIM) as a protein, which has a signal peptide in 1996. However, recent works have accumulated evidences that STIM1 and STIM2 reside in endoplasmic reticulum (ER) and that both mainly sense ER Ca(2+) depletion, w...

journal_title：Journal of cellular biochemistry

authors： Saitoh N,Oritani K,Saito K,Yokota T,Ichii M,Sudo T,Fujita N,Nakajima K,Okada M,Kanakura Y

更新日期：2011-01-01 00:00:00

abstract：:Madin-Darby canine kidney (MDCK) cells were previously shown to have few or no plasma membrane insulin binding sites (Hofmann et al: J Biol Chem 258:11774, 1983]. Accordingly, neither insulin-stimulated incorporation of [14C]glucose into glycogen, nor insulin-induced uptake of radiolabeled alpha-aminoisobutyrate ([3H]...

journal_title：Journal of cellular biochemistry

authors： Hofmann C,Crettaz M,Bruns P,Hessel P,Hadawi G

更新日期：1985-01-01 00:00:00

abstract：:We explored the feasibility of studying nuclear matrix protein (NMP) expressions of the hepatocytes in normal and cirrhotic rat livers with liver regeneration after partial hepatectomy. Sixteen Wistar healthy rats were studied with experimental liver regeneration and/or liver cirrhosis. Two-dimensional (2-D) gel elect...

journal_title：Journal of cellular biochemistry

authors： Yun JP,Liew CT,Chew EC,Yin XY,Lai PB,Fai YH,Li HK,Jin ML,Ding MX,Li MT,Lin HL,Lau WY

更新日期：2004-04-15 00:00:00

abstract：:Activation of cytokine signaling via the leukemia inhibitory factor receptor (LIFR) plays an integral role in hematopoiesis, osteogenesis, and placental development, along with mediating neurotrophic mechanisms. However, the regulatory control of the LIFR gene has remained largely unexplored. Here, we characterize the...

journal_title：Journal of cellular biochemistry

authors： Qadi AA,Taberlay PC,Phillips JL,Young A,West AC,Brettingham-Moore KH,Dickinson JL,Holloway AF

更新日期：2016-01-01 00:00:00

abstract：:Since claudin-18 (Cldn18) is overexpressed in precursor lesion PanIN and pancreatic duct carcinoma, it serves as a diagnostic marker and a target of immunotherapy. The stomach isoform of Cldn18, Cldn18a2 is regulated via a PKC/MAPK/AP-1-dependent pathway in PKC activator 12-O-tetradecanoylphorbol 13-acetate (TPA)-stim...

journal_title：Journal of cellular biochemistry

authors： Ito T,Kojima T,Yamaguchi H,Kyuno D,Kimura Y,Imamura M,Takasawa A,Murata M,Tanaka S,Hirata K,Sawada N

更新日期：2011-07-01 00:00:00

abstract：:Previous studies demonstrated that, upon attaining confluence, a clone of the renal epithelial cell, LLC-PK1, expressed progressively binding sites for the lectin Dolichos biflorus agglutinin (DBA) at the apical cell surface. Activation of cAMP-dependent protein kinase enhanced surface expression dramatically. The goa...

journal_title：Journal of cellular biochemistry

authors： Amsler K

更新日期：1993-08-01 00:00:00

abstract：:The F1F0 ATP synthase has recently become the focus of anti-cancer research. It was once thought that ATP synthases were located strictly on the inner mitochondrial membrane; however, in 1994, it was found that some ATP synthases localized to the cell surface. The cell surface ATP synthases are involved in angiogenesi...

journal_title：Journal of cellular biochemistry

authors： Wang WJ,Shi XX,Liu YW,He YQ,Wang YZ,Yang CX,Gao F

更新日期：2013-07-01 00:00:00

abstract：:Lack of guidelines for personalized chemotherapy treatment after surgery has caused gastric cancer (GC) patients' unnecessary exposure to toxicity and the financial burden of chemotherapy treatments. In our study, we aimed to identify potential biomarkers to predict GC patients' susceptibility to platinum-based on Gen...

journal_title：Journal of cellular biochemistry

authors： Pan J,Xiang Z,Dai Q,Wang Z,Liu B,Li C

更新日期：2019-08-01 00:00:00

abstract：:Hepatic copper levels differ among patients with Wilson disease (WD) and normal individuals depending on the dietary intake, copper bioavailability, and genetic factors. Copper chloride (CuCl2 ) caused dose-dependent reduction in cell viability of human teratocarcinoma (HepG2) cell line, measured using the 3-(4,5-dime...

journal_title：Journal of cellular biochemistry

authors： Agnihotry S,Dhusia K,Srivastav AK,Upadhyay J,Verma V,Shukla PK,Ramteke PW,Gautam B

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Dysfunction of the peritoneum as a dialysis organ may result from progressive membrane injury on peritoneal dialysis (PD). It has been increasingly recognized that the human peritoneal mesothelial cells (HPMCs) play a key role in peritoneal membrane early injury. Recently, it has been reported that bioincomp...

journal_title：Journal of cellular biochemistry

authors： Zhu N,Gu L,Jia J,Wang X,Wang L,Yang M,Yuan W

更新日期：2019-03-01 00:00:00

abstract：:Pre-eclampsia (PE) is a pregnancy disease that causes maternal death and threatens the health of newborns. Accumulating evidence has revealed the essential roles of long noncoding RNAs (lncRNAs) in the progression of PE. The present investigation determined lncRNA ZEB2 antisense RNA 1 (ZEB2-AS1) expression in PE and l...

journal_title：Journal of cellular biochemistry

authors： Gao Y,Guo X,Li Y,Sha W,She R

更新日期：2019-10-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) action is known to be initiated by its binding to multiple cell surface receptors containing serine/threonine kinase domains that act to stimulate a cascade of signaling events in a variety of cell types. We have previously shown that TGF-beta1 and BMP-2 treatment of primar...

journal_title：Journal of cellular biochemistry

authors： Nesti LJ,Caterson EJ,Li WJ,Chang R,McCann TD,Hoek JB,Tuan RS

更新日期：2007-05-15 00:00:00

abstract：INTRODUCTION:Pancreatic adenocarcinoma (PAAD) is one of the most fatal cancers in the world for early metastasis, extensive invasion, and poor prognosis with a 5-year survival rate less than 5%. However, the underlying mechanisms are poorly understood. Therefore, it is urgent to explore molecular markers for early diag...

journal_title：Journal of cellular biochemistry

authors： Yang Y,Wang Y,Liu S,Zhao X,Jia R,Xiao Y,Zhang M,Li X,Li J,Wang W

更新日期：2018-11-28 00:00:00

abstract：OBJECTIVE:Long intergenic noncoding RNA-p21 (lincRNA-p21) has been proved in the pathogenesis of aortic aneurysms, while its functionality in thoracic aortic aneurysms (TAA) and the mechanism of function remains unclear. Therefore our study aimed to investigate the role of lincRNA-p21 in TAA. METHODS:Aortic media spec...

journal_title：Journal of cellular biochemistry

authors： Hu W,Wang Z,Li Q,Wang J,Li L,Jiang G

更新日期：2019-03-01 00:00:00

abstract：:Irritable bowel syndrome (IBS) is a common disorder of unknown etiology. Studies have found a close relation between IBS and microRNAs (miRNAs), but the study concerning the relationship between IBS and miR-181c-5p in IBS is still blank. Thus, this study aims to explore the role of miR-181c-5p in IBS via interleukin 1...

journal_title：Journal of cellular biochemistry

authors： Ji LJ,Li F,Zhao P,Weng LP,Wei J,Yan J,Liu LN

更新日期：2019-09-01 00:00:00

abstract：:Induction of definitive endoderm (DE) cells is a prerequisite for the whole process of embryonic stem (ES) cells differentiating into hepatic or pancreatic progenitor cells. We have established an efficient method to induce mouse ES cell-derived DE cells in suspension embryonic body (EB) culture. Similar to previous s...

journal_title：Journal of cellular biochemistry

authors： Li F,He Z,Li Y,Liu P,Chen F,Wang M,Zhu H,Ding X,Wangensteen KJ,Hu Y,Wang X

更新日期：2011-04-01 00:00:00