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Concentration of phenoxymethylpenicillin in tonsillar tissue.

Abstract：

:Seventeen patients underwent tonsillectomy 55-120 min after receiving oral phenoxymethylpenicillin 12.5 mg/kg bodyweight. The penicillin concentration in serum and tonsillar tissue in each patient was determined by a microbial assay. In 9 patients with tonsillar hyperplasia, but with no prior history of tonsillitis, the mean penicillin concentration in serum and in tonsillar tissue was 5.0 mg.l-1 and 1.32 mg.g-1, respectively, and in 8 patients with manifest tonsillitis the corresponding values were 3.01 mg.l-1 and 0.67 mg.g-1. It appears that the penicillin concentration in tonsillar tissue is about 1/5 to 1/4 of that in serum, regardless of whether the tonsils are inflamed or hypertrophied.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Roos K,Brorson JE

doi

10.1007/BF00315423

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

417-8

issue

4

eissn

0031-6970

issn

1432-1041

journal_volume

39

pub_type

杂志文章

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