Skeletal morbidity among survivors of critical illness.

abstract：OBJECTIVE:In critically ill patients, hepatic dysfunction is regarded as a late organ failure associated with poor prognosis. We investigated the incidence and prognostic implications of early hepatic dysfunction (serum bilirubin >2 mg/dL within 48 hrs of admission). DESIGN:Prospective, multicenter cohort study. SETT...

journal_title：Critical care medicine

authors： Kramer L,Jordan B,Druml W,Bauer P,Metnitz PG,Austrian Epidemiologic Study on Intensive Care, ASDI Study Group.

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:Sepsis is associated with a marked depression of cellular immune function. The steroid hormone dehydroepiandrosterone (DHEA) is proposed to have immunoenhancing activities. We, therefore, investigated the effect of DHEA on the mortality rate and cellular immune functions in an experimental model of sepsis. D...

journal_title：Critical care medicine

authors： Oberbeck R,Dahlweid M,Koch R,van Griensven M,Emmendörfer A,Tscherne H,Pape HC

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVES:Recently, recombinant angiotensin-converting enzyme 2 was shown to protect mice from acute lung injury, an effect attributed to reduced bioavailability of angiotensin II. Since angiotensin-converting enzyme 2 metabolizes angiotensin II to angiotensin-(1-7), we hypothesized that this effect is alternatively m...

journal_title：Critical care medicine

authors： Klein N,Gembardt F,Supé S,Kaestle SM,Nickles H,Erfinanda L,Lei X,Yin J,Wang L,Mertens M,Szaszi K,Walther T,Kuebler WM

更新日期：2013-11-01 00:00:00

abstract：:Hypersensitivity reactions are defined as immunologically based adverse reactions to chemicals or medicinal agents. These reactions are common in the intensive care unit and can present as a simple, mildly symptomatic rash or as life-threatening anaphylactic reactions. Hypersensitivity reactions have traditionally bee...

journal_title：Critical care medicine

authors： Kanji S,Chant C

更新日期：2010-06-01 00:00:00

abstract：:Vecuronium's short half-life and minimal cardiopulmonary side-effects make it a suitable drug for continuous infusion. Vecuronium is used frequently in critically ill patients to increase their total compliance and to minimize the adverse effects of mechanical ventilation. This crossover, prospective study evaluates t...

journal_title：Critical care medicine

authors： Eldadah MK,Newth CJ

更新日期：1989-10-01 00:00:00

abstract：OBJECTIVE:To discuss a potential role for endothelial cell apoptosis in the pathogenesis of sepsis. DATA SOURCES:Studies published in biomedical journals and studies from the authors' laboratory. STUDY SELECTION:In vitro and in vivo studies of endothelial cell apoptosis in endotoxin and sepsis models. DATA EXTRACTIO...

journal_title：Critical care medicine

authors： Hotchkiss RS,Tinsley KW,Swanson PE,Karl IE

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVES:The potential advantages of lowering core temperature during sepsis are to lower energy requirement and to activate various cell-protecting pathways. We experimentally investigated whether postconditioning temperature modifications influence survival duration during experimental sepsis. DESIGN:A prospective...

journal_title：Critical care medicine

authors： L'Her E,Amerand A,Vettier A,Sebert P

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND AND METHODS:Calcium-channel blockers may attenuate vasospasm after transient ischemia and improve organ blood flow after resuscitation. Our aim was to assess the effect of diltiazem on systemic oxygen delivery and consumption, hemodynamics, electroencephalogram (EEG), and organ blood flow after restoration o...

journal_title：Critical care medicine

authors： Lindner KH,Prengel AW,Ahnefeld FW,Ensinger H,Schürmann W

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVES:Studies have shown that endothelium-dependent relaxation (mediated by endothelium-derived nitric oxide) is depressed during the early, hyperdynamic stage of sepsis. Although it is known that ATP-MgCl2 produces beneficial effects following various adverse circulatory conditions, it remains unknown whether thi...

journal_title：Critical care medicine

authors： Wang P,Ba ZF,Cioffi WG,Bland KI,Chaudry IH

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the use of multifrequency bioelectrical impedance analysis to predict creatinine/urea clearance based on 24 hours urine collection. A practical formula was developed, and its performance was compared with that of established formulas such as Cockcroft-Gault, Modification of Diet in Renal Disease,...

journal_title：Critical care medicine

authors： de Jong LAA,Otten-Helmers AG,Spronk PE,van Kan HJM

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:To assess in-hospital neurologic (CNS) complications in adult patients undergoing veno-venous extracorporeal membrane oxygenation for respiratory failure. DESIGN:Retrospective analysis of the Extracorporeal Life Support Organization's data registry. SETTING:Data reported to Extracorporeal Life Support Orga...

journal_title：Critical care medicine

authors： Lorusso R,Gelsomino S,Parise O,Di Mauro M,Barili F,Geskes G,Vizzardi E,Rycus PT,Muellenbach R,Mueller T,Pesenti A,Combes A,Peek G,Frenckner B,Di Nardo M,Swol J,Maessen J,Thiagarajan RR

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:We hypothesized that the extent of injury and release of xanthine oxidase, an oxidant generator, into the circulation would be less in normal-flow hypoxia-reoxygenation than in equal duration no-flow ischemia-reperfusion. DESIGN:Randomized study. SETTING:University-based animal research facility. SUBJECTS:...

journal_title：Critical care medicine

authors： Tan S,Yokoyama Y,Wang Z,Zhou F,Nielsen V,Murdoch AD,Adams C,Parks DA

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVES:Fever is common and associated with increased mortality among patients admitted to adult ICUs, yet recent literature suggests that the incidence of fever may be decreasing. The objective of this study was to determine whether the incidence of fever in adult ICUs changed over time and the factors responsible ...

journal_title：Critical care medicine

authors： Niven DJ,Stelfox HT,Shahpori R,Laupland KB

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to examine whether anandamide, an endogenous cannabinoid receptor ligand, is involved in the pathogenesis of septic encephalopathy. DESIGN:Prospective, controlled study. SUBJECTS:Male Wistar rats (7 wks old) were randomly divided into four groups as follows: group 1, control (...

journal_title：Critical care medicine

authors： Kadoi Y,Hinohara H,Kunimoto F,Saito S,Goto F

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVES:To examine whether niacin attenuates lung inflammation and improves survival during sepsis and to determine whether the beneficial effects of niacin are associated with downregulation of the nuclear factor (NF)-κB pathway. DESIGN:Prospective laboratory study. SETTING:University laboratory. SUBJECTS:Male S...

journal_title：Critical care medicine

authors： Kwon WY,Suh GJ,Kim KS,Kwak YH

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:Prognostic information is important to the family members of incapacitated, critically ill patients, yet little is known about what prognostic information physicians provide. Our objectives were to determine the types of prognostic information provided to families of critically ill patients when making major ...

journal_title：Critical care medicine

authors： White DB,Engelberg RA,Wenrich MD,Lo B,Curtis JR

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:To describe a case of hepatic subcapsular hematoma causing an acute Budd-Chiari-like syndrome, leading to hepatic compartment syndrome, which combines compression of intrahepatic vessels on CT, acute liver failure, and refractory shock. DESIGN:Case report. SETTING:Surgical ICU of a university teaching hospi...

journal_title：Critical care medicine

authors： Marcaire F,Malavieille F,Pichot-Delahaye V,Floccard B,Rimmelé T

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:To determine the incidence and risk factors of chronic critical illness after severe blunt trauma. DESIGN:Prospective observational cohort study (NCT01810328). SETTING:Two level-one trauma centers in the United States. PATIENTS:One hundred thirty-five adult blunt trauma patients with hemorrhagic shock who ...

journal_title：Critical care medicine

authors： Mira JC,Cuschieri J,Ozrazgat-Baslanti T,Wang Z,Ghita GL,Loftus TJ,Stortz JA,Raymond SL,Lanz JD,Hennessy LV,Brumback B,Efron PA,Baker HV,Moore FA,Maier RV,Moldawer LL,Brakenridge SC

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:To evaluate the internal consistency, validity, responsiveness, and minimal important difference of the Functional Status Score for the ICU, a physical function measure designed for the ICU. DESIGN:Clinimetric analysis. SETTINGS:Five international datasets from the United States, Australia, and Brazil. PA...

journal_title：Critical care medicine

authors： Huang M,Chan KS,Zanni JM,Parry SM,Neto SG,Neto JA,da Silva VZ,Kho ME,Needham DM

更新日期：2016-12-01 00:00:00

abstract：:The effects of the Trendelenburg (TREND) position and passive straight leg raising (PLR) on cardiopulmonary performance in 18 anesthetized patients undergoing myocardial revascularization were studied with a two-dimensional transesophageal echocardiography probe and a thermodilution right ventricular ejection fraction...

journal_title：Critical care medicine

authors： Reich DL,Konstadt SN,Raissi S,Hubbard M,Thys DM

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVES:The purposes of this report are to a) describe the University of Michigan experience with venoarterial or venovenous extracorporeal life support for severe pediatric pulmonary rescue therapy, and b) examine survivors and nonsurvivors for differences that might be useful for examination in future, prospective...

journal_title：Critical care medicine

authors： Moler FW,Custer JR,Bartlett RH,Palmisano J,Meliones JN,Delius RE,Braden EI,Snedecor S

更新日期：1992-08-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that the mortality rate of acutely ill patients admitted to a medical ward or medical ICU is higher for those patients who present with hypomagnesemia than for those patients who do not present with hypomagnesemia. DESIGN:Prospective, observational study. SETTING:Emergency Department ...

journal_title：Critical care medicine

authors： Rubeiz GJ,Thill-Baharozian M,Hardie D,Carlson RW

更新日期：1993-02-01 00:00:00

abstract：:Previously, we determined that a colloid concentration of about 3% was optimal for resuscitation of lethal ischemic intestinal shock model in rats. Maximal volumes of lactated Ringer's solution (RL) alone only expanded plasma volume (PV) to 80% of preshock level, while increasing volumes of 3% albumin (ALB) in RL line...

journal_title：Critical care medicine

authors： Dawidson IJ,Willms C,Sandor ZF,Armstrong J,Wilson L

更新日期：1990-01-01 00:00:00

abstract：:Cardiac arrest has a poor prognosis, regardless of age group. Children who fail to respond to two standard doses of epinephrine (0.01 mg/kg) rarely survive to hospital discharge, and most die without the return of spontaneous circulation (ROSC). We treated seven consecutive children in cardiac arrest with high dose ep...

journal_title：Critical care medicine

authors： Goetting MG,Paradis NA

更新日期：1989-12-01 00:00:00

abstract：:We compared the blood culture results obtained either by venipuncture or through an arterial catheter in 51 critically ill patients with 217 clinically suspected episodes of bacteremia. During each episode, three blood culture samples, two arterial and one venous, were drawn within 1 h. One or more cultures were posit...

journal_title：Critical care medicine

authors： Väisänen IT,Michelsen T,Valtonen V,Mäkeläinen A

更新日期：1985-08-01 00:00:00

abstract：OBJECTIVE:Exposure of neutrophils to low doses of bacterial lipopolysaccharides enhances their readiness to respond with inflammatory mediator generation including oxygen radical formation to a subsequently applied inflammatory stimulus ("priming"). In the present study, we investigated the role of lipid mediator synth...

journal_title：Critical care medicine

authors： Sibelius U,Hattar K,Hoffmann S,Mayer K,Grandel U,Schenkel A,Seeger W,Grimminger F

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:To compare the responses of noninvasively measured tissue oxygen saturation (StO2) and calculated muscle oxygen tension (PmO2) to standard hemodynamic variables for early detection of imminent hemodynamic instability during progressive central hypovolemia in humans. DESIGN:Prospective study. SETTING:Researc...

journal_title：Critical care medicine

authors： Soller BR,Ryan KL,Rickards CA,Cooke WH,Yang Y,Soyemi OO,Crookes BA,Heard SO,Convertino VA

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Overdoses of calcium channel blocker agents result in hyperglycemia, primarily due to the blockade of pancreatic L-type calcium channels and insulin resistance on the cellular level. The clinical significance of the hyperglycemia in this setting has not previously been described. METHODS:This study is a ret...

journal_title：Critical care medicine

authors： Levine M,Boyer EW,Pozner CN,Geib AJ,Thomsen T,Mick N,Thomas SH

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety of human albumin administered for therapeutic purposes. DESIGN:Retrospective compilation of spontaneously reported serious adverse events. SETTING:Records of serious adverse event reports received from 1990 through 1997 by nine major suppliers of therapeutic human albumin worldwide. ...

journal_title：Critical care medicine

authors： von Hoegen I,Waller C

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVES:Light chains κ and λ are immunoglobulin constituents but also circulate independently in blood as free light chains. We investigated whether a concomitant abnormality in free light chain and immunoglobulin levels could identify a high risk of death sepsis subpopulation to inform future IV immunoglobulin tria...

journal_title：Critical care medicine

authors： Shankar-Hari M,Singer M,Spencer J

更新日期：2017-11-01 00:00:00