Skeletal morbidity among survivors of critical illness.


OBJECTIVES:To describe the incident fracture rate in survivors of critical illness and to compare fracture risk with population-matched control subjects. DESIGN:Retrospective longitudinal case-cohort study. SETTING:A tertiary adult intensive care unit in Australia. PATIENTS:All patients ventilated admitted to intensive care and requiring mechanical ventilation for ≥48 hrs between January 1998 and December 2005. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:New fractures were identified in the study population for the postintensive care unit period (intensive care unit discharge to January 2008). The incident fracture rate and age-adjusted fracture risk of the female intensive care unit population were compared with the general population adult females derived from the Geelong Osteoporosis Study. Over the 8-yr period, a total of 739 patients (258 women, 481 men) were identified. After a median follow-up of 3.7 yrs (interquartile range, 2.0-5.9 yrs) for women and 4.0 yrs (interquartile range, 2.1-6.1 yrs) for men, incident fracture rates (95% confidence interval) per 100 patient years were 3.84 (2.58-5.09) for females 2.41 (1.73-3.09) for males. Compared with an age-matched random population-based sample of women, elderly women were at increased risk for sustaining an osteoporosis-related fracture after critical illness (hazard ratio, 1.65; 95% confidence interval, 1.08-2.52; p = .02). CONCLUSIONS:The increase in fracture risk observed in postintensive care unit older females suggests an association between critical illness and subsequent skeletal morbidity. The explanation for this association is not explored in this study and includes the effects of pre-existing patient factors and/or direct effects of critical illness. Prospective research evaluating risk factors, the relationship between critical illness and bone turnover, the extent and duration of bone loss, and the associated morbidity in this population is warranted.


Crit Care Med


Critical care medicine


Orford NR,Saunders K,Merriman E,Henry M,Pasco J,Stow P,Kotowicz M




Has Abstract


2011-06-01 00:00:00












  • Reliability of point-of-care testing for glucose measurement in critically ill adults.

    abstract:BACKGROUND:Glycemic control is increasingly being recognized as a priority in the treatment of critically ill patients. Titration and monitoring of insulin infusions involve frequent blood glucose measurement to achieve target glucose ranges and prevent adverse events related to hypoglycemia. Therefore, it is imperativ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Kanji S,Buffie J,Hutton B,Bunting PS,Singh A,McDonald K,Fergusson D,McIntyre LA,Hebert PC

    更新日期:2005-12-01 00:00:00

  • Pathophysiology of the upper gastrointestinal tract in the critically ill patient: rationale for the therapeutic benefits of acid suppression.

    abstract::Gastric mucosal damage occurs in critically ill patients in intensive care units and develops in the setting of severe physiologic stress. Within 24 hrs of admission to the intensive care unit, 75% to 100% of critically ill patients demonstrate evidence of stress-related mucosal disease. Stress ulcers present a risk o...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Fennerty MB

    更新日期:2002-06-01 00:00:00

  • Automated selection of high-risk patients with acute pancreatitis.

    abstract::One hundred six early features were retrospectively collected on 44 patients with acute pancreatitis and stored in a database programmed on a microcomputer. Intraoperative/autopsy findings or clinical course categorized patients as having severe (n = 16) or mild (n = 28) pancreatitis. The frequency of 88 early availab...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: de Bernardinis M,Violi V,Roncoroni L,Montanari M,Peracchia A

    更新日期:1989-04-01 00:00:00

  • Measurement properties of the Clinical Risk Index for Babies--reliabilty, validity beyond the first 12 hours, and responsiveness over 7 days.

    abstract:OBJECTIVES:Clinical Risk Index for Babies (CRIB) is a simple instrument used to measure clinical risk and illness severity in very low birth-weight infants. We assessed its reliability, validity beyond the first 12 hrs after birth, and responsiveness to individual change in condition after 7 days. DESIGN:Cohort study....

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Fowlie PW,Gould CR,Tarnow-Mordi WO,Strang D

    更新日期:1998-01-01 00:00:00

  • Plasma L-arginine concentration, oxygenation index, and systemic blood pressure in premature infants.

    abstract:OBJECTIVE:To determine the relationships between plasma L-arginine concentrations and the severity of respiratory distress syndrome (RDS) or systemic blood pressure in premature infants. DESIGN:Prospective, observational study. SETTING:Neonatal intensive care, tertiary referral hospital. SUBJECTS:Fifty-three prematu...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Zamora SA,Amin HJ,McMillan DD,Fick GH,Butzner JD,Parsons HG,Scott RB

    更新日期:1998-07-01 00:00:00

  • Functional residual capacity measurement by heptafluoropropane in ventilated newborn lungs: in vitro and in vivo validation.

    abstract:OBJECTIVE:Heptafluoropropane is an inert gas commercially used as propellant for inhalers. Since heptafluoropropane can be detected in low concentrations, it could also be used as a tracer gas to measure functional residual capacity and ventilation homogeneity. The aim of the present study was to validate functional re...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Proquitté H,Kusztrich A,Auwärter V,Pragst F,Wauer RR,Schmalisch G

    更新日期:2006-06-01 00:00:00

  • Influence of political power, medical provincialism, and economic incentives on the rationing of surgical intensive care unit beds.

    abstract:OBJECTIVE:To determine factors influencing rationing decisions in a surgical ICU during a temporary nursing shortage when two to six of the unit's 16 beds were closed. DESIGN:Blinded, concurrent data collection, retrospective chart review. SETTING:Surgical ICU. PATIENTS:All patients (n = 308) for whom a surgical ICU...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Marshall MF,Schwenzer KJ,Orsina M,Fletcher JC,Durbin CG Jr

    更新日期:1992-03-01 00:00:00

  • Reduction of colonization and infection rate during pediatric intensive care by selective decontamination of the digestive tract.

    abstract:OBJECTIVE:To compare the effects of two different antibiotic regimes on the colonization and infection rates of critically ill pediatric patients. DESIGN:A prospective randomized trial. SETTING:A pediatric ICU in a university hospital. PATIENTS:Fifty critically ill pediatric patients who required intensive care for ...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Zobel G,Kuttnig M,Grubbauer HM,Semmelrock HJ,Thiel W

    更新日期:1991-10-01 00:00:00

  • Interdisciplinary consultation on the care of the critically ill and dying: the role of one hospital ethics committee.

    abstract::Little is known about the structure and objectives of various hospital ethics committees due to their need to preserve confidentiality, their reluctance to reveal internal hospital problems, and their concern about becoming involved in the developing debate about the appropriate role and value of such committees. The ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Cohen CB

    更新日期:1982-11-01 00:00:00

  • Trajectory of Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock.

    abstract:OBJECTIVES:In-hospital pediatric sepsis mortality has decreased substantially, but long-term mortality and morbidity among children initially surviving sepsis, is unknown. Accordingly, the Life After Pediatric Sepsis Evaluation investigation was conducted to describe the trajectory of mortality and health-related quali...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Zimmerman JJ,Banks R,Berg RA,Zuppa A,Newth CJ,Wessel D,Pollack MM,Meert KL,Hall MW,Quasney M,Sapru A,Carcillo JA,McQuillen PS,Mourani PM,Wong H,Chima RS,Holubkov R,Coleman W,Sorenson S,Varni JW,McGalliard J,Haal

    更新日期:2020-03-01 00:00:00

  • Diaspirin cross-linked hemoglobin improves mucosal perfusion in the ileum of septic rats.

    abstract:OBJECTIVE:To determine the effect of a bolus infusion of diaspirin cross-linked hemoglobin (DCLHb or hemoglobin crosfumaril) on the ileal mucosal microcirculation in septic rats. DESIGN:Prospective, randomized, single-blinded study. SETTING:University-affiliated animal research laboratory. SUBJECTS:Twenty-four male ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Sielenkämper AW,Eichelbrönner O,Martin CM,Madorin SW,Chin-Yee IH,Sibbald WJ

    更新日期:2000-03-01 00:00:00

  • Federal and nationwide intensive care units and healthcare costs: 1986-1992.

    abstract:OBJECTIVES:To establish Department of Veterans Affairs' intensive care unit (ICU) costs from a database and to use this information to validate the Russell equation, the most commonly used method of calculating ICU costs. To compare and trend Department of Veterans Affairs' and nationwide (USA) ICU and healthcare costs...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Halpern NA,Bettes L,Greenstein R

    更新日期:1994-12-01 00:00:00

  • Ethical decision-making in critical care in Hong Kong.

    abstract:OBJECTIVES:Biomedical ethics has assumed an increasingly important role in medicine over the past 30 yrs, and its development has served the important goal of protecting patients' rights and interests. However, medical ethics has evolved within a Western tradition, and conflict often arises when trying to apply Western...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Ip M,Gilligan T,Koenig B,Raffin TA

    更新日期:1998-03-01 00:00:00

  • Influence of renal dysfunction on the accuracy of procalcitonin for the diagnosis of postoperative infection after vascular surgery.

    abstract:OBJECTIVE:Procalcitonin has been advocated as a specific biomarker for bacterial infection. We performed this study to determine whether accuracy of procalcitonin for diagnosis of postoperative bacterial infection is affected by renal function after aortic surgery. DESIGN:Single-center prospective study. SETTING:Univ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Amour J,Birenbaum A,Langeron O,Le Manach Y,Bertrand M,Coriat P,Riou B,Bernard M,Hausfater P

    更新日期:2008-04-01 00:00:00

  • Risk factors predicting laryngeal injury in intubated neonates.

    abstract::We evaluated 95 extubated neonates to determine if certain risk factors could predict the development of laryngeal injury. Risk factors were recorded prospectively during the intubation period and correlated with laryngeal injury determined by laryngoscopy after extubation. Duration of intubation greater than or equal...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Fan LL,Flynn JW,Pathak DR

    更新日期:1983-06-01 00:00:00

  • Plasma catecholamine and free fatty acid levels during infusion of lipid emulsion in critically ill patients.

    abstract::The fractional elimination rate of exogenous fat, and fat-mobilizing lipolysis in relation to plasma catecholamine (CA) levels were studied in seven ventilator-treated ICU patients. Blood levels of CA, triglycerides, cholesterol and free fatty acids (FFA) were also analyzed before and during constant infusion of a soy...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Lindholm M,Eklund JO,Hamberger B,Järnberg PO

    更新日期:1984-11-01 00:00:00

  • Transforming growth factor-beta: a mediator of cell regulation in acute respiratory distress syndrome.

    abstract:OBJECTIVE:To review recent advances in the use of transforming growth factor (TGF)-beta in acute lung injury and to apply this knowledge to understanding the pathophysiology of this syndrome. DATA SOURCES AND STUDY SELECTION:Published research and review articles in the English language related to the role of TGF-beta...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Dhainaut JF,Charpentier J,Chiche JD

    更新日期:2003-04-01 00:00:00

  • A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis.

    abstract:OBJECTIVE:To define a biomarker panel to predict organ dysfunction, shock, and in-hospital mortality in emergency department (ED) patients with suspected sepsis. DESIGN:Prospective observational study. SETTING:EDs of ten academic medical centers. PATIENTS:There were 971 patients enrolled. INCLUSION CRITERIA:1) ED p...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究


    authors: Shapiro NI,Trzeciak S,Hollander JE,Birkhahn R,Otero R,Osborn TM,Moretti E,Nguyen HB,Gunnerson KJ,Milzman D,Gaieski DF,Goyal M,Cairns CB,Ngo L,Rivers EP

    更新日期:2009-01-01 00:00:00

  • The Fragility and Reliability of Conclusions of Anesthesia and Critical Care Randomized Trials With Statistically Significant Findings: A Systematic Review.

    abstract:OBJECTIVES:The Fragility Index, which represents the number of patients responsible for a statistically significant finding, has been suggested as an aid for interpreting the robustness of results from clinical trials. A small Fragility Index indicates that the statistical significance of a trial depends on only a few ...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Grolleau F,Collins GS,Smarandache A,Pirracchio R,Gakuba C,Boutron I,Busse JW,Devereaux PJ,Le Manach Y

    更新日期:2019-03-01 00:00:00

  • Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse.

    abstract:OBJECTIVES:Mild decrease in core temperature (therapeutic hypothermia) provides lasting neuroprotection following cardiac arrest or cerebral ischemia. However, current methods for producing therapeutic hypothermia trigger a cold-defense response that must be countered by sedatives, muscle paralytics, and mechanical ven...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Feketa VV,Zhang Y,Cao Z,Balasubramanian A,Flores CM,Player MR,Marrelli SP

    更新日期:2014-05-01 00:00:00

  • The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation.

    abstract:OBJECTIVE:Acute renal failure remains a major challenge in critical care medicine. Both neutrophils and chemokines have been proposed as key components in the development of acute renal failure. Although the Duffy antigen receptor for chemokines (DARC) is present in several tissues and a highly specific ligand for vari...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Zarbock A,Schmolke M,Bockhorn SG,Scharte M,Buschmann K,Ley K,Singbartl K

    更新日期:2007-09-01 00:00:00

  • Prolonged mechanical ventilation alters diaphragmatic structure and function.

    abstract:OBJECTIVE:To review current knowledge about the impact of prolonged mechanical ventilation on diaphragmatic function and biology. MEASUREMENTS:Systematic literature review. CONCLUSIONS:Prolonged mechanical ventilation can promote diaphragmatic atrophy and contractile dysfunction. As few as 18 hrs of mechanical ventil...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审


    authors: Powers SK,Kavazis AN,Levine S

    更新日期:2009-10-01 00:00:00

  • Open lung ventilation preserves the response to delayed surfactant treatment in surfactant-deficient newborn piglets.

    abstract:OBJECTIVE:Delayed surfactant treatment (>2 hrs after birth) is less effective than early treatment in conventionally ventilated preterm infants with respiratory distress syndrome. The objective of this study was to evaluate if this time-dependent efficacy of surfactant treatment is also present during open lung ventila...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: van Veenendaal MB,van Kaam AH,Haitsma JJ,Lutter R,Lachmann B

    更新日期:2006-11-01 00:00:00

  • High-frequency jet ventilation for differential lung ventilation.

    abstract::High-frequency jet ventilation using a jet injector located at the right mainstem bronchus was superimposed on standard mechanical ventilation to ventilate the injured lung of a patient with unilateral massive atelectasis secondary to pulmonary hemorrhage. This technique of differential ventilation markedly improved a...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Nishimura M,Takezawa J,Nishijima MK,Taenaka N,Shimada Y,Yoshiya I,Fujimoto Y

    更新日期:1984-09-01 00:00:00

  • Assessing and improving safety climate in a large cohort of intensive care units.

    abstract:OBJECTIVES:To evaluate the impact of a comprehensive unit-based safety program on safety climate in a large cohort of intensive care units participating in the Keystone intensive care unit project. DESIGN/SETTING:A prospective cohort collaborative study to improve quality of care and safety culture by implementing and...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究


    authors: Sexton JB,Berenholtz SM,Goeschel CA,Watson SR,Holzmueller CG,Thompson DA,Hyzy RC,Marsteller JA,Schumacher K,Pronovost PJ

    更新日期:2011-05-01 00:00:00

  • Temperature monitored on the cuff surface of an endotracheal tube reflects body temperature.

    abstract:OBJECTIVE:When treating patients with cardiac arrest with mild therapeutic hypothermia, a reliable and easy-to-use temperature probe is desirable. This study was conducted to investigate the accuracy and safety of tracheal temperature as a measurement of body temperature. DESIGN:Observational cohort study. SETTING:Em...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Haugk M,Stratil P,Sterz F,Krizanac D,Testori C,Uray T,Koller J,Behringer W,Holzer M,Herkner H

    更新日期:2010-07-01 00:00:00

  • Tracheal breath sounds for detection of apnea in infants and children.

    abstract::Impedance respiratory monitoring is the standard technique for detecting apnea in infants. A miniature microphone/amplifier system has been used to sense breath sounds over the trachea in order to detect both central and obstructive apnea episodes in infants and children. The tracheal microphone has several advantages...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Beckerman RC,Wegmann MJ,Waring WW

    更新日期:1982-06-01 00:00:00

  • A Multicenter Observational Study of Family Participation in ICU Rounds.

    abstract:OBJECTIVES:Guidelines recommend offering family members of critically ill patients the option to attend interdisciplinary team rounds as a way to improve communication and satisfaction. Uncertainty remains around the benefits and risks. DESIGN:We conducted an observational study to describe family participation in ICU...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究


    authors: Au SS,Roze des Ordons AL,Parsons Leigh J,Soo A,Guienguere S,Bagshaw SM,Stelfox HT

    更新日期:2018-08-01 00:00:00

  • Vecuronium by continuous infusion for neuromuscular blockade in infants and children.

    abstract::Vecuronium's short half-life and minimal cardiopulmonary side-effects make it a suitable drug for continuous infusion. Vecuronium is used frequently in critically ill patients to increase their total compliance and to minimize the adverse effects of mechanical ventilation. This crossover, prospective study evaluates t...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Eldadah MK,Newth CJ

    更新日期:1989-10-01 00:00:00

  • Living and dying with medical technology.

    abstract::Medical technology is a two-edged sword, capable of saving and improving life but also of ending and harming life. Finding the right stance toward technology requires great balance and sensitivity. It has seductive powers because of its expected benefits, the social and professional pressures to use it, and a frequent...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Callahan D

    更新日期:2003-05-01 00:00:00