Mechanisms of ventilator-induced lung injury.

abstract：OBJECTIVE:To determine whether polymorphisms of the surfactant protein B gene may be associated with increased mortality in patients with the acute respiratory distress syndrome. DESIGN:A prospective cohort study. SETTING:Four adult intensive care units at a tertiary academic medical center. PATIENTS:Two hundred fou...

journal_title：Critical care medicine

authors： Currier PF,Gong MN,Zhai R,Pothier LJ,Boyce PD,Xu L,Yu CL,Thompson BT,Christiani DC

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To assess the intrarater and interrater reliability of electrocardiogram (ECG) interpretation in critically ill patients and to assess the effect of knowledge of cardiac troponin values on these reliability estimates. DESIGN:Prospective cohort study. SETTING:Fifteen-bed medical-surgical intensive care unit....

journal_title：Critical care medicine

authors： Lim W,Qushmaq I,Cook DJ,Devereaux PJ,Heels-Ansdell D,Crowther MA,Tkaczyk A,Meade MO,Cook RJ

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:We previously reported gene expression-based endotypes of pediatric septic shock, endotypes A and B, and that corticosteroid exposure was independently associated with increased mortality among pediatric endotype A patients. The Vasopressin vs Norepinephrine as Initial Therapy in Septic Shock trial tested th...

journal_title：Critical care medicine

authors： Wong HR,Hart KW,Lindsell CJ,Sweeney TE

更新日期：2021-01-01 00:00:00

abstract：:Fluosol-DA 20% (FDA-20) resuscitation has been proposed for prehospital therapy of hemorrhagic shock (HS). Acute HS (mean arterial pressure 60 mm Hg X 90 min, then 40 mm Hg X 30 min) in 24 splenectomized dogs was treated with 50 ml/kg of lactated Ringer's solution (RL) plus a volume equal to 105% of shed blood volume ...

journal_title：Critical care medicine

authors： Elliott LA,Ledgerwood AM,Lucas CE,McCoy LE,McGonigal M,Sullivan MW

更新日期：1989-02-01 00:00:00

abstract：OBJECTIVES:The mortality outcome of mechanical ventilation, a key intervention in the critically ill, has been variously reported to be determined by intensive care patient volume. We determined the volume-(mortality)-outcome relationship of mechanically ventilated patients whose records were contributed to the Austral...

journal_title：Critical care medicine

authors： Moran JL,Solomon PJ,ANZICS Centre for Outcome and Resource Evaluation of the Australian and New Zealand Intensive Care Society.

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:Phenylephrine is often used for management of cerebral perfusion pressure after traumatic brain injury, but can have undesirable actions. Few studies have evaluated alternatives. The hypothesis was that arginine vasopressin was as effective as phenylephrine for maintaining tissue oxygenation during cerebral p...

journal_title：Critical care medicine

authors： Dudkiewicz M,Proctor KG

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To validate performance characteristics of the intensive care unit (ICU) admission mortality probability model, version III (MPM0-III) on Project IMPACT data submitted in 2004 and 2005. This data set was external from the MPM0-III developmental and internal validation data collected between 2001 and 2004. DE...

journal_title：Critical care medicine

authors： Higgins TL,Kramer AA,Nathanson BH,Copes W,Stark M,Teres D

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:Oxygenation measured 24 hours after acute respiratory distress syndrome onset more accurately stratifies risk, relative to oxygenation at onset, in both children and adults. However, waiting 24 hours is problematic, especially for interventions that are more efficacious early in the disease course. We aimed t...

journal_title：Critical care medicine

authors： Yehya N,Thomas NJ,Khemani RG

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:To analyze the effects of an extracorporeal bioartificial liver containing alginate bead-entrapped hepatocytes on pigs with ischemia-induced acute hepatic failure. DESIGN:Prospective animal study. SETTING:University and INSERM laboratory. SUBJECTS:Fifteen Large White/Pietrin female pigs weighing 20-30 kg. ...

journal_title：Critical care medicine

authors： Desille M,Mahler S,Seguin P,Mallédant Y,Frémond B,Sébille V,Bouix A,Desjardins JF,Joly A,Desbois J,Lebreton Y,Campion JP,Clément B

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:To determine whether a continuous intravenous infusion of pentoxifylline, a methylxanthine derivative, alters the serum cytokine concentrations and/or hemodynamic measurements in patients with septic shock. DESIGN:A prospective, randomized, double-blind, placebo-controlled study. SETTING:Medical intensive c...

journal_title：Critical care medicine

authors： Zeni F,Pain P,Vindimian M,Gay JP,Gery P,Bertrand M,Page Y,Page D,Vermesch R,Bertrand JC

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVES:To determine the point prevalence of medication errors at the time of transition of care from an ICU to non-ICU location and assess error types and risk factors for medication errors during transition of care. DESIGN:This was a multicenter, retrospective, 7-day point prevalence study. SETTING:Fifty-eight I...

journal_title：Critical care medicine

authors： Tully AP,Hammond DA,Li C,Jarrell AS,Kruer RM

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:Inhaled nitric oxide is being utilized as a selective pulmonary vasodilator in the treatment of persistent pulmonary hypertension of the newborn. However, the effects of inhaled nitric oxide on cerebral hemodynamics and distribution of left ventricular output in newborn subjects have not been studied. This s...

journal_title：Critical care medicine

authors： Rosenberg AA,Kinsella JP,Abman SH

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVE:To explore the potential value of heart rate variability features for automated monitoring of sedation levels in mechanically ventilated ICU patients. DESIGN:Multicenter, pilot study. SETTING:Several ICUs at Massachusetts General Hospital, Boston, MA. PATIENTS:Electrocardiogram recordings from 40 mechanica...

journal_title：Critical care medicine

authors： Nagaraj SB,McClain LM,Zhou DW,Biswal S,Rosenthal ES,Purdon PL,Westover MB

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:Procalcitonin (PCT) has been described as an early, discriminating marker of bacteria-associated sepsis in patients. However, little is known of its source and actions, in part because no appropriate animal models have been available. We tested the hypothesis that plasma PCT increases during various pathophy...

journal_title：Critical care medicine

authors： Redl H,Schlag G,Tögel E,Assicot M,Bohuon C

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:Hematopoietic stem cell transplant (HSCT) recipients admitted to the intensive care unit (ICU) have high mortality. The prognostic importance of peripheral blood stem cell source in critically ill HSCT recipients and the performance of Acute Physiology and Chronic Health Evaluation (APACHE) III have not been ...

journal_title：Critical care medicine

authors： Afessa B,Tefferi A,Dunn WF,Litzow MR,Peters SG

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:The antimetabolite drug, 5-fluorouracil, inhibits microbial growth. Coating of central venous catheters with 5-fluorouracil may reduce the risk of catheter infection. Our objective was to compare the safety and efficacy of central venous catheters externally coated with 5-fluorouracil with those coated with c...

journal_title：Critical care medicine

authors： Walz JM,Avelar RL,Longtine KJ,Carter KL,Mermel LA,Heard SO,5-FU Catheter Study Group.

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:To review the difficulties associated with defining sepsis and its complications and to characterize the role of the proinflammatory cytokines in the development of human septic shock, adult respiratory distress syndrome, and the systemic inflammatory response syndrome. DATA SOURCES:Information presented at...

journal_title：Critical care medicine

authors： Bone RC

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:The objective of the present study was to determine whether selective inflammatory cytokine concentrations within cerebrospinal fluid are useful markers for the differential diagnosis of aseptic and bacterial meningitis within neurosurgical patients. DESIGN:Prospective, open-label, observational, cohort stud...

journal_title：Critical care medicine

authors： Liu ZH,Tu PH,Chen NY,Yip PK,Bowes AL,Lee CC,Chan SH,Kung CC,Wang AY,Wu CT,Lee ST

更新日期：2015-11-01 00:00:00

abstract：:Sixty-four (48%) of 133 children with hematologic malignancy who were admitted to three pediatric ICUs died. Children who required management because of airway obstruction or after general anesthesia had the best outlook (mortality rate of 7% or less); those children who required major circulatory support or mechanica...

journal_title：Critical care medicine

authors： Butt W,Barker G,Walker C,Gillis J,Kilham H,Stevens M

更新日期：1988-08-01 00:00:00

abstract：:Intravenous dobutamine was used in ten patients requiring aggressive therapy for massive pulmonary embolism with circulatory failure. Except in one patient who rapidly died, a 30-min dobutamine infusion (8.3 +/- 2.7 micrograms/kg . min) increased both cardiac index (from 1.7 +/- 0.4 to 2.3 +/- 0.6 L/min . m2, p less t...

journal_title：Critical care medicine

authors： Jardin F,Genevray B,Brun-Ney D,Margairaz A

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVE:The pathogenesis of acute gastric stress ulceration in the seriously ill is uncertain, and any role of Helicobacter pylori infection is unknown. We aimed to assess the relationship between H. pylori serological status and stress ulceration in seriously ill patients, as well as H. pylori serological status in ...

journal_title：Critical care medicine

authors： Robertson MS,Cade JF,Clancy RL

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:Extracorporeal membrane oxygenation is increasingly used in the management of severe acute respiratory distress syndrome. With extracorporeal membrane oxygenation, select patients with acute respiratory distress syndrome can be managed without mechanical ventilation, sedation, or neuromuscular blockade. Publ...

journal_title：Critical care medicine

authors： Kurihara C,Walter JM,Singer BD,Cajigas H,Shayan S,Al-Qamari A,DeCamp MM,Wunderink R,Budinger GRS,Bharat A

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:Cardiac surgery-associated acute kidney injury occurs in up to 50% of patients and is associated with increased mortality and morbidity. This study aimed to discover if perioperative urinary alkalinization with sodium bicarbonate infusion reduces the prevalence of cardiac surgery-associated acute kidney inju...

journal_title：Critical care medicine

authors： McGuinness SP,Parke RL,Bellomo R,Van Haren FM,Bailey M

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:To compare the plasma volume (PV) expanding effect of a fast infusion rate with that of a slow infusion rate of a fixed volume of 5% albumin, of the synthetic colloids, 6% hydroxyethyl starch 130/0.4 and 4% gelatin, and of 0.9% NaCl in a rat sepsis model and to compare the plasma-expanding effect among these...

journal_title：Critical care medicine

authors： Bark BP,Persson J,Grände PO

更新日期：2013-03-01 00:00:00

abstract：:The image of the physician as a therapist, as well as the general perception of the physician's role in society and in the life of patients and their families, has changed dramatically in past decades. In response, many conferences, editorials, and planning activities for medical and premedical curricula have been dev...

journal_title：Critical care medicine

authors： Detre K

更新日期：1988-10-01 00:00:00

abstract：OBJECTIVE:To describe opioid use after ICU admission, identify factors associated with chronic opioid use after critical care, and determine if chronic opioid use is associated with an increased risk of death. DESIGN:Retrospective cohort study. SETTING:Sweden including all registered ICU admissions between 2010 and 2...

journal_title：Critical care medicine

authors： von Oelreich E,Eriksson M,Sjölund KF,Discacciati A,Larsson E,Oldner A

更新日期：2021-01-28 00:00:00

abstract：:To determine whether end-tidal carbon dioxide tension (PETCO2) accurately reflects PaCO2 during high-frequency jet ventilation (HFJV), 43 studies were performed on eight mongrel dogs with normal lungs. During HFJV, minute volume was modified to obtain a range of PaCO2 values from 15.5 to 74.5 torr. When PETCO2 was mea...

journal_title：Critical care medicine

authors： Algora-Weber A,Rubio JJ,Dominguez de Villota E,Cortes JL,Gomez D,Mosquera JM

更新日期：1986-10-01 00:00:00

abstract：OBJECTIVES:To evaluate the ability of central venous-to-arterial carbon dioxide pressure difference, central venous oxygen saturation, and the combination of these two parameters to detect extubation failure in critically ill patients. DESIGN:Multicentric, prospective, observational study. SETTING:Three ICUs. PATIEN...

journal_title：Critical care medicine

authors： Mallat J,Baghdadi FA,Mohammad U,Lemyze M,Temime J,Tronchon L,Thevenin D,Fischer MO

更新日期：2020-10-01 00:00:00

abstract：:One hundred six early features were retrospectively collected on 44 patients with acute pancreatitis and stored in a database programmed on a microcomputer. Intraoperative/autopsy findings or clinical course categorized patients as having severe (n = 16) or mild (n = 28) pancreatitis. The frequency of 88 early availab...

journal_title：Critical care medicine

authors： de Bernardinis M,Violi V,Roncoroni L,Montanari M,Peracchia A

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVES:To determine whether glucose utilization and metabolic substrate (glucose and fat) oxidation could be manipulated in patients with secondary multiple organ dysfunction syndrome. DESIGN:Prospective study. SETTING:Intensive care units (ICU) of two university hospitals. PATIENTS:Eight adults free of hepatic ...

journal_title：Critical care medicine

authors： Arnold J,Campbell IT,Hipkin LJ,Keegan M,Jenkins S,O'Sullivan E,Chadwick S

更新日期：1995-01-01 00:00:00