Sepsis and its complications: the clinical problem.

abstract：:Cardiogenic shock is the most common cause of death in patients hospitalized with acute myocardial infarction and is associated with a poor prognosis. More than 75% of cases are due to extensive left ventricular infarction and ventricular failure. Other causes include right ventricular infarction and papillary muscle ...

journal_title：Critical care medicine

authors： Topalian S,Ginsberg F,Parrillo JE

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Procalcitonin (PCT), a marker of bacterial sepsis, may also act as a mediator of the inflammatory response to infection, and thus influence outcome. OBJECTIVE:To investigate the relationship between PCT, interleukin (IL)-10, tumor necrosis factor (TNF), organ failure, and mortality in pediatric septic shock...

journal_title：Critical care medicine

authors： Hatherill M,Tibby SM,Turner C,Ratnavel N,Murdoch IA

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:To determine the role of serum albumin concentration as a predictor of mechanical ventilation dependency. DESIGN:Prospective, observation trial. SETTING:Multidisciplinary intensive care unit (ICU) in a university hospital. PATIENTS:One hundred forty-five consecutive patients who required mechanical ventila...

journal_title：Critical care medicine

authors： Sapijaszko MJ,Brant R,Sandham D,Berthiaume Y

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:The adrenal gland is the endocrine organ most commonly involved in patients infected with human immunodeficiency virus (HIV). It is important to recognize patients with adrenal insufficiency, because this disorder may be fatal if untreated. The incidence of adrenal insufficiency in critically ill HIV-infected...

journal_title：Critical care medicine

authors： Marik PE,Kiminyo K,Zaloga GP

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVES:Hyperammonemia is a key contributing factor for cerebral edema in acute liver failure. Continuous renal replacement therapy may help reduce ammonia levels. However, the optimal timing, mode, intensity, and duration of continuous renal replacement therapy in this setting are unknown. We aimed to study continu...

journal_title：Critical care medicine

authors： Warrillow S,Fisher C,Bellomo R

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:In patients undergoing surgical repair of aortic dissection, false lumen perfusion during cardiopulmonary bypass may produce central nervous system damage, myocardial ischemia, aortic rupture, and death. We describe a method to detect false lumen perfusion at the beginning of retrograde aortic perfusion that ...

journal_title：Critical care medicine

authors： Voci P,Testa G,Tritapepe L,Menichetti A,Caretta Q

更新日期：2000-06-01 00:00:00

abstract：:The determination of minute oxygen consumption (VO2) for metabolic studies on patients using either the Beckman Metabolic Cart (MMC) or the Respiratory Monitoring System (RMS) requires a stable fractional inspired oxygen concentration (FIO2). Measurement of VO2 on mechanically ventilated patients using the Bourns BEAR...

journal_title：Critical care medicine

authors： Browning JA,Linberg SE,Turney SZ,Chodoff P

更新日期：1982-02-01 00:00:00

abstract：OBJECTIVES:To evaluate the frequency of unsuspected posterior vessel wall penetration of the internal jugular vein during ultrasound-guided needle cannulation. DESIGN:Prospective, single-blinded observational study. SETTING:Urban level I emergency department with an annual census of 80,000. PATIENTS:Residents who ha...

journal_title：Critical care medicine

authors： Blaivas M,Adhikari S

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVES:To compare the frequency and preventability of adverse drug events and potential adverse drug events in intensive care units (ICUs) and non-ICUs. To evaluate systems factors involving the individual caregivers, care unit teams, and patients involved in each adverse drug event by comparing ICUs with non-ICUs ...

journal_title：Critical care medicine

authors： Cullen DJ,Sweitzer BJ,Bates DW,Burdick E,Edmondson A,Leape LL

更新日期：1997-08-01 00:00:00

abstract：:The disciplines of critical care and palliative care may initially seem to be polar opposites, yet they share fundamental features. Both focus on the sickest patients in the healthcare system. Each discipline's primary goal-extending life for critical care and comfort and quality of life for palliative care-represents...

journal_title：Critical care medicine

authors： Byock I

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier of bovine origin. DESIGN:Randomized, single-blind, placebo-controlled, dose-escalation study. SETTING:The Upjohn Research Clinics (Kalamazoo, MI). SUBJECTS:Normal healthy adult men between the ages of 18 and 45 yrs. ...

journal_title：Critical care medicine

authors： Hughes GS Jr,Antal EJ,Locker PK,Francom SF,Adams WJ,Jacobs EE Jr

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVES:Preliminary studies have suggested that low doses of corticosteroids might rapidly improve hemodynamics in late septic shock treated with catecholamines. We examined the effect of hydrocortisone on shock reversal, hemodynamics, and survival in this particular setting. DESIGN:Prospective, randomized, double-...

journal_title：Critical care medicine

authors： Bollaert PE,Charpentier C,Levy B,Debouverie M,Audibert G,Larcan A

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the relationship between the acute inflammatory response after surgical trauma and changes in hepatic cytochrome P450 3A4 activity, compare changes in cytochrome P450 3A4 activity after procedures with varying degrees of surgical stress, and to explore the time course of any potential drug-cytokin...

journal_title：Critical care medicine

authors： Haas CE,Kaufman DC,Jones CE,Burstein AH,Reiss W

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:Severe thermal injury causes immune dysfunctions involving both pro- and anti-inflammatory mechanisms. It subsequently leads to a state of immune deficiency that shares some similarities with sepsis-induced immunosuppression. A hallmark of the latter is established by decreased monocyte human leukocyte antige...

journal_title：Critical care medicine

authors： Venet F,Tissot S,Debard AL,Faudot C,Crampé C,Pachot A,Ayala A,Monneret G

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of death and disability among children worldwide. Identifying sepsis in pediatric patients is difficult and can lead to treatment delay. Our objective was to assess the host proteomic response...

journal_title：Critical care medicine

authors： Shubin NJ,Navalkar K,Sampson D,Yager TD,Cermelli S,Seldon T,Sullivan E,Zimmerman JJ,Permut LC,Piliponsky AM

更新日期：2020-01-01 00:00:00

abstract：:Sequential assessment of renal function in 50 critically ill postoperative patients was done by simultaneous determinants of osmolar, free water, creatinine and sodium clearances, and fractional excretion of sodium. The traumatic and nontraumatic critically ill surgical patients had a characteristic pattern of creatin...

journal_title：Critical care medicine

authors： Brown R,Babcock R,Talbert J,Gruenberg J,Czurak C,Campbell M

更新日期：1980-02-01 00:00:00

abstract：OBJECTIVE:To measure exhaled nitric oxide (NO) and compare it with lung function after cardiopulmonary bypass (CPB) in adult patients. Pulmonary dysfunction is sometimes observed after CPB. Impaired production of NO may account for this dysfunction. DESIGN:Prospective, single-center, observational study. SETTING:Univ...

journal_title：Critical care medicine

authors： Ishibe Y,Liu R,Hirosawa J,Kawamura K,Yamasaki K,Saito N

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVE:To describe the current status and the clinical data related to the effects of tight glucose control by intensive insulin therapy in critically ill patients. DESIGN:Review article. SETTING:University hospital. PATIENTS:Medical and surgical critically ill patients in whom a correlation between blood glucose...

journal_title：Critical care medicine

authors： Preiser JC,Devos P

更新日期：2007-09-01 00:00:00

abstract：:In the last three decades, numerous articles on plasma catecholamine concentrations in various settings have been published in the medical literature. Despite this abundance of information, no summary article has analyzed the species variations in circulating catecholamine concentrations. In this paper, the plasma cat...

journal_title：Critical care medicine

authors： Hart BB,Stanford GG,Ziegler MG,Lake CR,Chernow B

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVES:Capillary refill time is a noninvasive method to assess tissue perfusion to determine shock status. Capillary refill time is defined as the time required to regain skin color after blanching pressure is applied. Although common methods to measure capillary refill time depend on clinicians' visual assessment,...

journal_title：Critical care medicine

authors： Nickel AJ,Jiang S,Napolitano N,Yehya N,Fitzgerald JC,Bruins BB,Lockman JL,Nadkarni VM,Nishisaki A

更新日期：2020-10-01 00:00:00

abstract：:Bacterial translocation and ileal and cecal injury have been shown to occur 24 h after limited periods of hemorrhagic shock. The present studies were performed to determine the temporal sequence of mucosal injury, permeability, and bacterial translocation after hemorrhagic shock. The results indicated that bacterial t...

journal_title：Critical care medicine

authors： Deitch EA,Morrison J,Berg R,Specian RD

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:To investigate the optimal rewarming rate following therapeutic hypothermia in a rate model of cardiopulmonary resuscitation. Both clinical and laboratory studies have demonstrated that mild therapeutic hypothermia following cardiopulmonary resuscitation improves myocardial and neurologic outcomes of cardiac ...

journal_title：Critical care medicine

authors： Lu X,Ma L,Sun S,Xu J,Zhu C,Tang W

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Cytomegalovirus reactivation may complicate critical illness in latent carriers of the virus, even in patients who were previously immunocompetent. Patients with acute respiratory distress syndrome are considered to be prone for reactivation. Prophylactic antiviral therapy in immunocompetent cytomegalovirus s...

journal_title：Critical care medicine

authors： Ong DS,Klein Klouwenberg PM,Verduyn Lunel FM,Spitoni C,Frencken JF,Dekker HA,Schultz MJ,Bonten MJ,Cremer OL

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:Currently 162-325 mg aspirin is recommended for the treatment of acute coronary syndrome. We tested the effect of an additional loading dose of 250 mg aspirin at the onset of acute coronary syndrome in patients who were already on chronic therapy with 100 mg aspirin. DESIGN:This was a prospective trial in pa...

journal_title：Critical care medicine

authors： Fuchs I,Spiel AO,Frossard M,Derhaschnig U,Riedmüller E,Jilma B

更新日期：2010-06-01 00:00:00

abstract：:Critically ill patients who fear impending death may die suddenly. We studied prospectively the incidence of death in critically ill surgical patients who articulated the fear that they were about to die. Physiologic, environmental, and behavioral correlates which might influence perceptions of impending death were ex...

journal_title：Critical care medicine

authors： Poulton TJ,Butdorf MB

更新日期：1986-07-01 00:00:00

abstract：OBJECTIVE:To determine the incidence and risk factors of chronic critical illness after severe blunt trauma. DESIGN:Prospective observational cohort study (NCT01810328). SETTING:Two level-one trauma centers in the United States. PATIENTS:One hundred thirty-five adult blunt trauma patients with hemorrhagic shock who ...

journal_title：Critical care medicine

authors： Mira JC,Cuschieri J,Ozrazgat-Baslanti T,Wang Z,Ghita GL,Loftus TJ,Stortz JA,Raymond SL,Lanz JD,Hennessy LV,Brumback B,Efron PA,Baker HV,Moore FA,Maier RV,Moldawer LL,Brakenridge SC

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To determine the efficacy of supplemental 25% albumin in reducing morbidity and mortality rates in the surgical intensive care unit (ICU). DESIGN:Prospective, randomized, unblinded clinical study. SETTING:Surgical ICU in a community hospital. PATIENTS:Two hundred nineteen patients with admission circulatin...

journal_title：Critical care medicine

authors： Golub R,Sorrento JJ Jr,Cantu R Jr,Nierman DM,Moideen A,Stein HD

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVE:To compare the cardiopulmonary and peripheral circulatory effects of the nonselective nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester (L-NAME) to the more selective inducible NOS inhibitor S-methylisothiourea (SMT) and to phenylephrine (PE) in endotoxic and normal swine. DESIGN:Prospec...

journal_title：Critical care medicine

authors： Cohen RI,Shapir Y,Davis A,Loona R,Scharf SM

更新日期：2000-09-01 00:00:00

abstract：:Cerebral arteriovenous differences in oxygen content [C(a-v)O2] and glucose content [C(a-v)gluc] were used to predict outcome in 20 patients who remained comatose after resuscitation for cardiopulmonary arrest. Cerebral prognosis was good when C(a-v)O2 values were greater than 1.8 mMol/L and the oxygen glucose index (...

journal_title：Critical care medicine

authors： Ducassé JL,Marc-Vergnes JP,Cathala B,Genestal M,Lareng L

更新日期：1984-10-01 00:00:00

abstract：OBJECTIVE:Families and other surrogate decisionmakers for chronically critically ill patients often lack information about patient prognosis or options for care. This study describes an approach to develop and validate a printed information brochure about chronic critical illness aimed at improving comprehension of the...

journal_title：Critical care medicine

authors： Carson SS,Vu M,Danis M,Camhi SL,Scheunemann LP,Cox CE,Hanson LC,Nelson JE

更新日期：2012-01-01 00:00:00