Efficacy of albumin supplementation in the surgical intensive care unit: a prospective, randomized study.

Abstract:

OBJECTIVE:To determine the efficacy of supplemental 25% albumin in reducing morbidity and mortality rates in the surgical intensive care unit (ICU). DESIGN:Prospective, randomized, unblinded clinical study. SETTING:Surgical ICU in a community hospital. PATIENTS:Two hundred nineteen patients with admission circulating albumin concentrations of < 3.0 g/dL (< 30 g/L). The groups were well matched regarding age, sex, Acute Physiology and Chronic Health Evaluation II scores and initial circulating albumin concentrations. INTERVENTIONS:The treatment group (n = 116) received 37.5 g/day of albumin until the circulating albumin concentration increased to > 3.0 g/dL (> 30 g/L). The control group (n = 103) received no supplemental albumin. Both groups received standard nutritional support. MEASUREMENTS AND MAIN RESULTS:The complication rate was 44% in the albumin group vs. 36.9% in the controls (p = .29). The albumin patients had a mortality rate of 10.3% vs. 5.8% in the control group (p = .22). There were no significant differences between the groups in the number of days spent receiving mechanical ventilation or in the tolerance to tube feedings. CONCLUSIONS:Routine supplemental administration of 25% albumin is expensive and offers no apparent outcome advantage and should be abandoned in the treatment of patients in the surgical ICU.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Golub R,Sorrento JJ Jr,Cantu R Jr,Nierman DM,Moideen A,Stein HD

doi

10.1097/00003246-199404000-00017

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

613-9

issue

4

eissn

0090-3493

issn

1530-0293

journal_volume

22

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章

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