Incidence rate of community-acquired sepsis among hospitalized acute medical patients-a population-based survey.

abstract：OBJECTIVE:Despite concern over the appropriateness and quality of care provided in an intensive care unit (ICU) at the end of life, the number of Americans who receive ICU care at the end of life is unknown. We sought to describe the use of ICU care at the end of life in the United States using hospital discharge data ...

journal_title：Critical care medicine

authors： Angus DC,Barnato AE,Linde-Zwirble WT,Weissfeld LA,Watson RS,Rickert T,Rubenfeld GD,Robert Wood Johnson Foundation ICU End-Of-Life Peer Group.

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:To describe blood conservation strategies for critically ill patients. DATA SOURCES:By using a predefined strategy, we searched the electronic databases of Medline, EMBASE, CINAHL, the Cochrane database of systematic reviews, Cochrane central register of controlled trials, ACP Journal Club, Database of abstr...

journal_title：Critical care medicine

authors： Fowler RA,Berenson M

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:To examine the role of platelets, fibrin, and adhesion molecules in mediating neutrophil-endothelial cell interactions in septic shock. DESIGN:Controlled experiments using phase contrast microscopy to examine neutrophil, platelet, and endothelial cell interactions in flowing cell suspensions under simulated ...

journal_title：Critical care medicine

authors： Kirschenbaum LA,McKevitt D,Rullan M,Reisbeck B,Fujii T,Astiz ME

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVES:Low tidal volume (= tidal volume ≤ 6 mL/kg, predicted body weight) ventilation using volume control benefits patients with acute respiratory distress syndrome. Airway pressure release ventilation is an alternative to low tidal volume-volume control ventilation, but the release breaths generated are variable ...

journal_title：Critical care medicine

authors： Hirshberg EL,Lanspa MJ,Peterson J,Carpenter L,Wilson EL,Brown SM,Dean NC,Orme J,Grissom CK

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:Currently 162-325 mg aspirin is recommended for the treatment of acute coronary syndrome. We tested the effect of an additional loading dose of 250 mg aspirin at the onset of acute coronary syndrome in patients who were already on chronic therapy with 100 mg aspirin. DESIGN:This was a prospective trial in pa...

journal_title：Critical care medicine

authors： Fuchs I,Spiel AO,Frossard M,Derhaschnig U,Riedmüller E,Jilma B

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:To compare in the same patient with septic shock, respective effects of epinephrine, norepinephrine, and the combination of norepinephrine and dobutamine (5 microg/kg/min) on systemic hemodynamic parameters and gastric mucosal perfusion using gastric tonometry and laser-Doppler flowmetry techniques. DESIGN:...

journal_title：Critical care medicine

authors： Duranteau J,Sitbon P,Teboul JL,Vicaut E,Anguel N,Richard C,Samii K

更新日期：1999-05-01 00:00:00

abstract：:The relationship between oxygen uptake (Vo2) and delivery (Do2) was examined in 64 patients immediately after cardiopulmonary bypass. In 44 patients with lactate levels below 2.5 mmol/L, Vo2 decreased proportionally when Do2 decreased below 300 ml/min X m2. At a Do2 over this level, Vo2 plateaued at 105 +/- 13 (SD) ml...

journal_title：Critical care medicine

authors： Komatsu T,Shibutani K,Okamoto K,Kumar V,Kubal K,Sanchala V,Lees DE

更新日期：1987-03-01 00:00:00

abstract：:We studied prospectively 40 critically ill neurosurgical patients who required prolonged mechanical ventilation to determine the current incidence of stress-related gastroduodenal erosions and ulcers, and to assess endoscopically the efficacy of acid-reducing prophylactic treatment. Nineteen patients were randomized t...

journal_title：Critical care medicine

authors： Reusser P,Gyr K,Scheidegger D,Buchmann B,Buser M,Zimmerli W

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVES:To investigate pharmacokinetics and metabolism of sodium citrate in critically ill patients. To determine the risk of citrate accumulation in the setting of liver dysfunction (cirrhosis, hepatorenal syndrome). DESIGN:Prospective cohort study. SETTING:Intensive Care Unit, Department of Medicine IV, Universi...

journal_title：Critical care medicine

authors： Kramer L,Bauer E,Joukhadar C,Strobl W,Gendo A,Madl C,Gangl A

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:End-of-life practices vary worldwide. The objective was to demonstrate that there is no clear-cut distinction between treatments administered to relieve pain and suffering and those intended to shorten the dying process. DESIGN:Secondary analysis of a prospective, observational study. SETTING:Thirty-seven i...

journal_title：Critical care medicine

authors： Sprung CL,Ledoux D,Bulow HH,Lippert A,Wennberg E,Baras M,Ricou B,Sjokvist P,Wallis C,Maia P,Thijs LG,Solsona Duran J,ETHICUS Study Group.

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To compare the effectiveness and safety of the hemoglobin-based nitric oxide scavenger, pyridoxalated hemoglobin polyoxyethylene, against placebo in patients with vasopressor-dependent distributive shock. DESIGN:Multicenter, randomized, placebo-controlled, open-label study. SETTING:Sixty-one participating I...

journal_title：Critical care medicine

authors： Vincent JL,Privalle CT,Singer M,Lorente JA,Boehm E,Meier-Hellmann A,Darius H,Ferrer R,Sirvent JM,Marx G,DeAngelo J

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:To define a curriculum that outlines the core knowledge residents should possess upon completion of graduate training in order to be able to formulate and initiate a treatment plan for the critically ill patient. DATA SOURCES:Requirements for training program certification as outlined by the Accreditation C...

journal_title：Critical care medicine

authors：

更新日期：1995-11-01 00:00:00

abstract：:The ability of ACTH-(1-24) to prolong survival and to extend the deadline for effective blood reinfusion has been studied in a model of lethal hypovolemic shock in the rat. Anesthetized rats were bled to a mean arterial pressure of 18 to 25 mm Hg and then subjected to one of the following iv treatments: a) saline; b) ...

journal_title：Critical care medicine

authors： Guarini S,Tagliavini S,Bazzani C,Ferrari W,Bertolini A

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVES:To evaluate the impact of a comprehensive unit-based safety program on safety climate in a large cohort of intensive care units participating in the Keystone intensive care unit project. DESIGN/SETTING:A prospective cohort collaborative study to improve quality of care and safety culture by implementing and...

journal_title：Critical care medicine

authors： Sexton JB,Berenholtz SM,Goeschel CA,Watson SR,Holzmueller CG,Thompson DA,Hyzy RC,Marsteller JA,Schumacher K,Pronovost PJ

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:To determine whether the difference between oxygen consumption (VO2) measured by metabolic gas monitoring systems and by the Fick principle is related to venous admixture, deadspace/tidal volume ratio, or alveolar-arterial oxygen tension gradient in critically ill patients. DESIGN:A prospective study. SETTI...

journal_title：Critical care medicine

authors： Myburgh JA,Webb RK,Worthley LI

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVES:To provide an overview of key elements of the Affordable Care Act. To evaluate ways in which the Affordable Care Act will likely impact the practice of critical care medicine. To describe strategies that may help health systems and providers effectively adapt to changes brought about by the Affordable Care A...

journal_title：Critical care medicine

authors： Dogra AP,Dorman T

更新日期：2016-03-01 00:00:00

abstract：:Thromboembolic disease ranks among the most dangerous and common complication in the postoperative or post-traumatic patient. As previously mentioned, the incidence is increasing and fatalities from this complication have also risen substantially. The pathogenesis of thromboembolic disease and the predictability of it...

journal_title：Critical care medicine

authors： Evarts CM

更新日期：1976-03-01 00:00:00

abstract：OBJECTIVES:Swallowing disorders may be associated with adverse clinical outcomes in patients following invasive mechanical ventilation. We investigated the incidence of dysphagia, its time course, and association with clinically relevant outcomes in extubated critically ill patients. DESIGN:Prospective observational t...

journal_title：Critical care medicine

authors： Schefold JC,Berger D,Zürcher P,Lensch M,Perren A,Jakob SM,Parviainen I,Takala J

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the use of enriched thioglycolate as a transport medium of protected specimen brush samples, in particular its value in direct examination of respiratory specimens and in guiding initial antibiotic prescription. DESIGN:Prospective, randomized, pilot study. SETTING:Medical-surgical teaching inten...

journal_title：Critical care medicine

authors： Rello J,Mariscal D,Gallego M,Valles J

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:Resuscitation of hemorrhagic hypotension after traumatic brain injury is challenging. A hemoglobin-based oxygen carrier may offer advantages. The novel therapeutic hemoglobin-based oxygen carrier, polynitroxylated pegylated hemoglobin (PNPH), may represent a neuroprotective hemoglobin-based oxygen carrier for...

journal_title：Critical care medicine

authors： Shellington DK,Du L,Wu X,Exo J,Vagni V,Ma L,Janesko-Feldman K,Clark RS,Bayir H,Dixon CE,Jenkins LW,Hsia CJ,Kochanek PM

更新日期：2011-03-01 00:00:00

abstract：:Suction applied to a chest-tube drainage system produces subambient pressure within the chest tube and may increase or decrease the flow of gas passing from the airway through a bronchopleural fistula. Such gas may have participated in gas exchange and contain more CO2 and less O2 than inspired gas. Calculated or meas...

journal_title：Critical care medicine

authors： Powner DJ,Cline CD,Rodman GH Jr

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:To test whether spectral indices derived from the electroencephalogram (EEG), and especially the bispectral index (BIS), can be used as measures of neurologic status in unsedated, critically ill patients. DESIGN:Prospective, observational study. SETTING:Medical intensive care unit (ICU) of a university-affi...

journal_title：Critical care medicine

authors： Gilbert TT,Wagner MR,Halukurike V,Paz HL,Garland A

更新日期：2001-10-01 00:00:00

abstract：:Serum ionized calcium (Ca+2), creatinine, magnesium, phosphate, and arterial pH were measured in patients on admission to the medical ICU (MICU). Patients were classified into three groups: a) hypotensive (n = 38), those who received vasopressor support for frank hypotension; b) hypertensive (n = 21), those who requir...

journal_title：Critical care medicine

authors： Desai TK,Carlson RW,Thill-Baharozian M,Geheb MA

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVE:Catheter-associated infections are common, costly, and potentially lethal. The impact of catheter insertion site on infection risk remains controversial. We aimed to establish whether nontunneled central venous catheters inserted in the subclavian vein are associated with lower risk of catheter-associated inf...

journal_title：Critical care medicine

authors： Parienti JJ,du Cheyron D,Timsit JF,Traoré O,Kalfon P,Mimoz O,Mermel LA

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to test the hypothesis that cocaine-induced cerebral vasodilation in newborn sheep is mediated via beta-adrenergic receptor activation. DESIGN:The cerebral effects of a single intravenous injection of cocaine (4 mg/kg) given 30 mins after pretreatment with propranolol (1 mg/kg...

journal_title：Critical care medicine

authors： O'Brien TP,Pane MA,Traystman RJ,Gleason CA

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVES:To identify the prevalence, risk factors, and outcomes of intra-abdominal hypertension in a mixed multicenter ICU population. DESIGN:Prospective observational study. SETTING:Fifteen ICUs worldwide. PATIENTS:Consecutive adult ICU patients with a bladder catheter. INTERVENTIONS:None. MEASUREMENTS AND MAIN...

journal_title：Critical care medicine

authors： Reintam Blaser A,Regli A,De Keulenaer B,Kimball EJ,Starkopf L,Davis WA,Greiffenstein P,Starkopf J,Incidence, Risk Factors, and Outcomes of Intra-Abdominal (IROI) Study Investigators.

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:To compare the effects of two lung-protective ventilation strategies on pulmonary vascular mechanics in early acute respiratory distress syndrome. DESIGN:Experimental study. SETTING:University animal research laboratory. SUBJECTS:Twelve pigs (30.8 ± 2.5 kg). INTERVENTIONS:Acute respiratory distress syndr...

journal_title：Critical care medicine

authors： Santos A,Gomez-Peñalver E,Monge-Garcia MI,Retamal J,Borges JB,Tusman G,Hedenstierna G,Larsson A,Suarez-Sipmann F

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:To evaluate the impact of an emergency department mechanical ventilation protocol on clinical outcomes and adherence to lung-protective ventilation in patients with acute respiratory distress syndrome. DESIGN:Quasi-experimental, before-after trial. SETTING:Emergency department and ICUs of an academic cente...

journal_title：Critical care medicine

authors： Fuller BM,Ferguson IT,Mohr NM,Drewry AM,Palmer C,Wessman BT,Ablordeppey E,Keeperman J,Stephens RJ,Briscoe CC,Kolomiets AA,Hotchkiss RS,Kollef MH

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVES:To determine the proportion of patients with documented bacterial aspiration pneumonia among comatose ICU patients with symptoms suggesting either bacterial aspiration pneumonia or non-bacterial aspiration pneumonitis. DESIGN:Prospective observational study. SETTING:University-affiliated 30-bed ICU. PATIE...

journal_title：Critical care medicine

authors： Lascarrou JB,Lissonde F,Le Thuaut A,Bachoumas K,Colin G,Henry Lagarrigue M,Vinatier I,Fiancette M,Lacherade JC,Yehia A,Joret A,Lebert C,Bourdon S,Martin Lefèvre L,Reignier J

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:To determine the incidence and risk factors of chronic critical illness after severe blunt trauma. DESIGN:Prospective observational cohort study (NCT01810328). SETTING:Two level-one trauma centers in the United States. PATIENTS:One hundred thirty-five adult blunt trauma patients with hemorrhagic shock who ...

journal_title：Critical care medicine

authors： Mira JC,Cuschieri J,Ozrazgat-Baslanti T,Wang Z,Ghita GL,Loftus TJ,Stortz JA,Raymond SL,Lanz JD,Hennessy LV,Brumback B,Efron PA,Baker HV,Moore FA,Maier RV,Moldawer LL,Brakenridge SC

更新日期：2017-12-01 00:00:00