Antibiotic dosing during sustained low-efficiency dialysis: special considerations in adult critically ill patients.

abstract：OBJECTIVE:To compare the effectiveness and safety of the hemoglobin-based nitric oxide scavenger, pyridoxalated hemoglobin polyoxyethylene, against placebo in patients with vasopressor-dependent distributive shock. DESIGN:Multicenter, randomized, placebo-controlled, open-label study. SETTING:Sixty-one participating I...

journal_title：Critical care medicine

authors： Vincent JL,Privalle CT,Singer M,Lorente JA,Boehm E,Meier-Hellmann A,Darius H,Ferrer R,Sirvent JM,Marx G,DeAngelo J

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Citrate anticoagulation is an excellent alternative to heparin anticoagulation for critically ill patients requiring continuous renal replacement therapy. In this article, we provide a safe and an easy-to-handle citrate anticoagulation protocol with variable treatment doses and excellent control of the acid-b...

journal_title：Critical care medicine

authors： Morgera S,Schneider M,Slowinski T,Vargas-Hein O,Zuckermann-Becker H,Peters H,Kindgen-Milles D,Neumayer HH

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of treatment with murine recombinant interleukin-1 beta on inflammatory infiltrate and tissue damage after experimental endotoxic challenge. DESIGN:Randomized, controlled study. SETTING:Experimental Unit, Virgen de las Nieves University Hospital. SUBJECTS:Seventy-two female CBA/H mic...

journal_title：Critical care medicine

authors： Téllez-Gil L,Mansilla-Roselló A,Collado-Torres A,Villar-del-Moral J,Garrote-Lara D,Villegas-Herrera T,Alvarez-Martín MJ,Ferrón-Orihuela JA

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:To determine a meta-analytical definition of the discriminant power of Ranson's signs in the prediction of acute pancreatitis severity and outcome, and of their information content, also compared with clinical judgment. DATA SOURCES:Two hundred eleven studies since 1974, reporting any predictive system for a...

journal_title：Critical care medicine

authors： De Bernardinis M,Violi V,Roncoroni L,Boselli AS,Giunta A,Peracchia A

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVES:Neurologic damage following cardiac arrest remains a major burden for modern resuscitation medicine. Cardiopulmonary resuscitation with extracorporeal circulatory support holds the potential to reduce morbidity and mortality. Furthermore, the endogenous gasotransmitter carbon monoxide attracts attention in r...

journal_title：Critical care medicine

authors： Wollborn J,Steiger C,Doostkam S,Schallner N,Schroeter N,Kari FA,Meinel L,Buerkle H,Schick MA,Goebel U

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:To describe the philosophy and approach to patient care called evidence based medicine, and to highlight how it can enhance the practice of intensive care. DATA SOURCES:We searched MEDLINE, reference lists, and our personal files to identify relevant literature. STUDY SELECTION:Articles on intensive care pr...

journal_title：Critical care medicine

authors： Cook DJ,Sibbald WJ,Vincent JL,Cerra FB

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVES:With the exception of a few single-center descriptive reports, data on critical care organizations are relatively sparse. The objectives of our study were to determine the structure, governance, and experience to date of established critical care organizations in North American academic medical centers. DES...

journal_title：Critical care medicine

authors： Pastores SM,Halpern NA,Oropello JM,Kostelecky N,Kvetan V

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To study the pulmonary effects of aspirating a mixture of sucralfate in water and sucralfate in hydrochloric acid in an animal model of aspiration pneumonia. DESIGN:Prospective, randomized, controlled study with repeated measures. SETTING:University research laboratory. SUBJECTS:Thirty-two in situ, isolate...

journal_title：Critical care medicine

authors： Toung TJ,Rosenfeld BA,Yoshiki A,Grayson RF,Traystman RJ

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVE:The physicochemical approach, described by Stewart to investigate the acid-base balance, includes the strong ion gap (SIG), a quantitative measure of "unmeasured" anions, which strongly correlates to the corrected anion gap. The chemical nature of these anions is for the most part unknown. We hypothesized tha...

journal_title：Critical care medicine

authors： Moviat M,Terpstra AM,Ruitenbeek W,Kluijtmans LA,Pickkers P,van der Hoeven JG

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND METHODS:Calcium-channel blockers may attenuate vasospasm after transient ischemia and improve organ blood flow after resuscitation. Our aim was to assess the effect of diltiazem on systemic oxygen delivery and consumption, hemodynamics, electroencephalogram (EEG), and organ blood flow after restoration o...

journal_title：Critical care medicine

authors： Lindner KH,Prengel AW,Ahnefeld FW,Ensinger H,Schürmann W

更新日期：1992-05-01 00:00:00

abstract：:Seven dogs with electromagnetic flow probes implanted on their main (QT) and left (QL) pulmonary arteries, had catheters placed in their left atria and pulmonary artery, and were ventilated via Carlen's double-lumen endotracheal tubes. The effect of high-frequency oscillation (HFO) on the redistribution of pulmonary b...

journal_title：Critical care medicine

authors： Hall SM,Strawn WB,Levitzky MG

更新日期：1984-05-01 00:00:00

abstract：:Position of the CVP port on a flow-directed balloon-tip pulmonary arterial catheter affects the accuracy of both thermodilution cardiac output determinations and CVP measurements. Systemic allometry (the study of the growth of a part in relation to the total organism) has been used to determine an easily measured inde...

journal_title：Critical care medicine

authors： Borland LM

更新日期：1986-11-01 00:00:00

abstract：:Several variables may account for the response of electrochemical skin surface PO2 sensors to anesthetic gases: cathode material and size, pH of the electrolyte and membrane material. These variables cannot be chosen arbitrarily and their influence has been tested with two types of sensors. In one type (LSC), a large ...

journal_title：Critical care medicine

authors： Eberhard P,Mindt W

更新日期：1981-10-01 00:00:00

abstract：:A survey of acute care/blood gas laboratories was conducted through the memberships of the Society of Critical Care Medicine ( SCCM ) and the National Association of Medical Directors of Respiratory Care ( NAMDRC ). Data were obtained from 227 laboratories and analyzed for operational characteristics, personnel, analy...

journal_title：Critical care medicine

authors： Hall JR,Shapiro BA

更新日期：1984-06-01 00:00:00

abstract：OBJECTIVES:To evaluate the frequency of unsuspected posterior vessel wall penetration of the internal jugular vein during ultrasound-guided needle cannulation. DESIGN:Prospective, single-blinded observational study. SETTING:Urban level I emergency department with an annual census of 80,000. PATIENTS:Residents who ha...

journal_title：Critical care medicine

authors： Blaivas M,Adhikari S

更新日期：2009-08-01 00:00:00

abstract：:The acute effects of controlled O2 therapy on hemodynamics and blood gases were investigated in 22 patients with decompensated chronic obstructive pulmonary disease (COPD). An inspired O2 fraction (FIO2) of 0.24 and 0.28 given to the first 12 patients markedly improved arterial and mixed-venous blood oxygenation with ...

journal_title：Critical care medicine

authors： Lejeune P,Mols P,Naeije R,Hallemans R,Melot C

更新日期：1984-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the effects of continuous infusion of methylene blue (MB), an inhibitor of the nitric oxide pathway, on hemodynamics and organ functions in human septic shock. DESIGN:Prospective, randomized, controlled, open-label, pilot study. SETTING:Multidisciplinary intensive care unit of a university hospi...

journal_title：Critical care medicine

authors： Kirov MY,Evgenov OV,Evgenov NV,Egorina EM,Sovershaev MA,Sveinbjørnsson B,Nedashkovsky EV,Bjertnaes LJ

更新日期：2001-10-01 00:00:00

abstract：:Nine previously untrained health professionals learned to measure cardiac output (Qt) by suprasternal continuous-wave Doppler ultrasound (QtDopp) and by thoracic bioimpedance (Qtbi). Each received standardized written, videotaped, and individual instruction. First the novice, then the reference examiner, measured QtDo...

journal_title：Critical care medicine

authors： Wong DH,Onishi R,Tremper KK,Reeves C,Zaccari J,Wong AB,Miller JB,Cordero V,Davidson J

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between behavioral alterations and changes in monoaminergic systems provoked by ischemia-reperfusion liver injury in rats. DESIGN:Prospective, randomized, controlled animal study. SETTING:University animal laboratory. SUBJECTS:Male Wistar rats. INTERVENTIONS:Acute liver fai...

journal_title：Critical care medicine

authors： Adachi N,Inoue H,Arai T

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:In patients undergoing surgical repair of aortic dissection, false lumen perfusion during cardiopulmonary bypass may produce central nervous system damage, myocardial ischemia, aortic rupture, and death. We describe a method to detect false lumen perfusion at the beginning of retrograde aortic perfusion that ...

journal_title：Critical care medicine

authors： Voci P,Testa G,Tritapepe L,Menichetti A,Caretta Q

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVES:Lung contusion is a major risk factor for the development of acute respiratory distress syndrome. We set to determine the role of toll-like receptor 3 and the binding of double-stranded RNA in the pathogenesis of sterile injury following lung contusion. DESIGN:Toll-like receptor 3 expression was analyzed in...

journal_title：Critical care medicine

authors： Suresh MV,Thomas B,Machado-Aranda D,Dolgachev VA,Kumar Ramakrishnan S,Talarico N,Cavassani K,Sherman MA,Hemmila MR,Kunkel SL,Walter NG,Hogaboam CM,Raghavendran K

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:To determine whether continuous gas flow in the breathing circuit or an airleak around the tracheal tube cuff will introduce errors into the measurement of oxygen consumption (VO2) with indirect calorimetry. DESIGN:Nonrandomized, controlled trial. SETTING:Experimental laboratory. SUBJECTS:Ten healthy, anes...

journal_title：Critical care medicine

authors： Räsänen J

更新日期：1992-09-01 00:00:00

abstract：:A patient with neurogenic pulmonary edema was successfully treated with the alpha-blocking agent, chlorpromazine. A pathophysiologic basis for this drug's efficacy is discussed. ...

journal_title：Critical care medicine

authors： Wohns RN,Tamas L,Pierce KR,Howe JF

更新日期：1985-03-01 00:00:00

abstract：OBJECTIVE:The value of different algorithms that estimate cardiac output (CO) by analysis of a peripheral arterial blood pressure (ABP) waveform has not been definitively identified. In this investigation, we developed a testing data set containing a large number of radial ABP waveform segments and contemporaneous refe...

journal_title：Critical care medicine

authors： Sun JX,Reisner AT,Saeed M,Heldt T,Mark RG

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To determine the number of adult or pediatric intensive care unit patients without documented invasive fungal infection who receive systemic antifungal therapy. DESIGN:A 1-day cross-sectional cohort study. SETTING:One hundred sixty-nine intensive care units in France and Belgium. PATIENTS:All patients stay...

journal_title：Critical care medicine

authors： Azoulay E,Dupont H,Tabah A,Lortholary O,Stahl JP,Francais A,Martin C,Guidet B,Timsit JF

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of the technique of selective decontamination of the digestive tract in preventing the development of secondary infection and its influence on morbidity and mortality rates in multiple trauma patients with chest injuries requiring intermittent positive-pressure ventilation. DESIGN:Pr...

journal_title：Critical care medicine

authors： Hammond JM,Potgieter PD,Saunders GL

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:Although contraindicated, there are situations when a patient who has recently taken a phosphodiesterase 5 inhibitor (e.g., sildenafil) might need intravenous nitroglycerin (NTG) treatment. This study determined if, and at what dose, intravenous NTG could be administered safely to men with coronary artery dis...

journal_title：Critical care medicine

authors： Parker JD,Bart BA,Webb DJ,Koren MJ,Siegel RL,Wang H,Malhotra B,Jen F,Glue P

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and tolerability of intravenous empiric treatment with meropenem compared with ceftazidime-tobramycin in patients with hospital-acquired lower respiratory tract infections. DESIGN:Prospective, nonblind, randomized trial. SETTING:Multicenter trial conducted at 22 centers. PATIENTS:T...

journal_title：Critical care medicine

authors： Sieger B,Berman SJ,Geckler RW,Farkas SA

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:To assess the effect of high-dose N-acetylcysteine on renal function in cardiac surgery patients at higher risk of postoperative renal failure. DESIGN:Multiblind, placebo-controlled, randomized, phase II clinical trial. SETTING:Operating rooms and intensive care units of two tertiary referral hospitals. PA...

journal_title：Critical care medicine

authors： Haase M,Haase-Fielitz A,Bagshaw SM,Reade MC,Morgera S,Seevenayagam S,Matalanis G,Buxton B,Doolan L,Bellomo R

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:To determine the role of toll-like receptor 2 in cardiac dysfunction during polymicrobial sepsis. DESIGN:Controlled animal study. SETTING:University hospital research laboratory. SUBJECTS:Male C57BL/6, wild-type, toll-like receptor 2-/-. INTERVENTION:Polymicrobial peritonitis, a clinically relevant model ...

journal_title：Critical care medicine

authors： Zou L,Feng Y,Chen YJ,Si R,Shen S,Zhou Q,Ichinose F,Scherrer-Crosbie M,Chao W

更新日期：2010-05-01 00:00:00