The cardiac output from blood pressure algorithms trial.

Abstract:

OBJECTIVE:The value of different algorithms that estimate cardiac output (CO) by analysis of a peripheral arterial blood pressure (ABP) waveform has not been definitively identified. In this investigation, we developed a testing data set containing a large number of radial ABP waveform segments and contemporaneous reference CO by thermodilution measurements, collected in an intensive care unit (ICU) patient population during routine clinical operations. We employed this data set to evaluate a set of investigational algorithms, and to establish a public resource for the meaningful comparison of alternative CO-from-ABP algorithms. DESIGN:A retrospective comparative analysis of eight investigational CO-from-ABP algorithms using the Multiparameter Intelligent Monitoring in Intensive Care II database. SETTING:Mixed medical/surgical ICU of a university hospital. PATIENTS:A total of 120 cases. INTERVENTIONS:None. MEASUREMENTS:CO estimated by eight investigational CO-from-ABP algorithms, and CO(TD) as a reference. MAIN RESULTS:All investigational methods were significantly better than mean arterial pressure (MAP) at estimating direction changes in CO(TD). Only the formula proposed by Liljestrand and Zander in 1928 was a significantly better quantitative estimator of CO(TD) compared with MAP (95% limits-of-agreement with CO(TD): -1.76/+1.41 L/min versus -2.20/+1.82 L/min, respectively; p < 0.001, per the Kolmogorov-Smirnov test). The Liljestrand method was even more accurate when applied to the cleanest ABP waveforms. Other investigational algorithms were not significantly superior to MAP as quantitative estimators of CO. CONCLUSIONS:Based on ABP data recorded during routine intensive care unit (ICU) operations, the Liljestrand and Zander method is a better estimator of CO(TD) than MAP alone. Our attempts to fully replicate commercially-available methods were unsuccessful, and these methods could not be evaluated. However, the data set is publicly and freely available, and developers and vendors of CO-from-ABP algorithms are invited to test their methods using these data.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Sun JX,Reisner AT,Saeed M,Heldt T,Mark RG

doi

10.1097/CCM.0b013e3181930174

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

72-80

issue

1

eissn

0090-3493

issn

1530-0293

pii

00003246-200901000-00011

journal_volume

37

pub_type

杂志文章
  • Overestimation of pulmonary artery occlusion pressure in pulmonary hypertension due to partial occlusion.

    abstract:OBJECTIVE:To evaluate partial occlusion in patients with pulmonary hypertension with regard to a) the degree to which it leads to overestimation of pulmonary artery occlusion pressure (Ppao) and b) identification of factors that could enhance its recognition. DESIGN:Observational descriptive study. SETTING:Medical in...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200301000-00015

    authors: Leatherman JW,Shapiro RS

    更新日期:2003-01-01 00:00:00

  • The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation.

    abstract:OBJECTIVE:Acute renal failure remains a major challenge in critical care medicine. Both neutrophils and chemokines have been proposed as key components in the development of acute renal failure. Although the Duffy antigen receptor for chemokines (DARC) is present in several tissues and a highly specific ligand for vari...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.ccm.0000280570.82885.32

    authors: Zarbock A,Schmolke M,Bockhorn SG,Scharte M,Buschmann K,Ley K,Singbartl K

    更新日期:2007-09-01 00:00:00

  • Discriminant power and information content of Ranson's prognostic signs in acute pancreatitis: a meta-analytic study.

    abstract:OBJECTIVE:To determine a meta-analytical definition of the discriminant power of Ranson's signs in the prediction of acute pancreatitis severity and outcome, and of their information content, also compared with clinical judgment. DATA SOURCES:Two hundred eleven studies since 1974, reporting any predictive system for a...

    journal_title:Critical care medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/00003246-199910000-00035

    authors: De Bernardinis M,Violi V,Roncoroni L,Boselli AS,Giunta A,Peracchia A

    更新日期:1999-10-01 00:00:00

  • Early treatment with ACTH-(1-24) in a rat model of hemorrhagic shock prolongs survival and extends the time-limit for blood reinfusion to be effective.

    abstract::The ability of ACTH-(1-24) to prolong survival and to extend the deadline for effective blood reinfusion has been studied in a model of lethal hypovolemic shock in the rat. Anesthetized rats were bled to a mean arterial pressure of 18 to 25 mm Hg and then subjected to one of the following iv treatments: a) saline; b) ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199008000-00014

    authors: Guarini S,Tagliavini S,Bazzani C,Ferrari W,Bertolini A

    更新日期:1990-08-01 00:00:00

  • Extracellular Mitochondrial DNA and N-Formyl Peptides in Trauma and Critical Illness: A Systematic Review.

    abstract:OBJECTIVES:Extracellular mitochondrial DNA and N-formyl peptides released following tissue damage may contribute to systemic inflammation through stimulation of the innate immune system. In this review, we evaluate existing in vivo human data regarding a role for mitochondrial DNA and N-formyl peptides in producing sys...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000003381

    authors: Lubkin DT,Bishawi M,Barbas AS,Brennan TV,Kirk AD

    更新日期:2018-12-01 00:00:00

  • Effect of insulin therapy on coagulation and fibrinolysis in medical intensive care patients.

    abstract:OBJECTIVE:Most intensive care deaths beyond the first few days of critical illness are attributable to nonresolving organ failure, either due to or coinciding with sepsis. One of the mechanisms that is thought to contribute to the pathogenesis of organ failure is microvascular thrombosis. Recently, we reported signific...

    journal_title:Critical care medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/CCM.0b013e31816f7bae

    authors: Langouche L,Meersseman W,Vander Perre S,Milants I,Wouters PJ,Hermans G,Gjedsted J,Hansen TK,Arnout J,Wilmer A,Schetz M,Van den Berghe G

    更新日期:2008-05-01 00:00:00

  • Serum Protein Changes in Pediatric Sepsis Patients Identified With an Aptamer-Based Multiplexed Proteomic Approach.

    abstract:OBJECTIVES:Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of death and disability among children worldwide. Identifying sepsis in pediatric patients is difficult and can lead to treatment delay. Our objective was to assess the host proteomic response...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004083

    authors: Shubin NJ,Navalkar K,Sampson D,Yager TD,Cermelli S,Seldon T,Sullivan E,Zimmerman JJ,Permut LC,Piliponsky AM

    更新日期:2020-01-01 00:00:00

  • Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice.

    abstract:OBJECTIVE:Isoflurane, a volatile anesthetic agent, has been recognized for its potential neuroprotective properties and has antiapoptotic effects. We examined whether isoflurane posttreatment is protective against early brain injury after subarachnoid hemorrhage and determined whether this effect needs sphingosine-rela...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3182474bc1

    authors: Altay O,Hasegawa Y,Sherchan P,Suzuki H,Khatibi NH,Tang J,Zhang JH

    更新日期:2012-06-01 00:00:00

  • Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury.

    abstract:OBJECTIVE:To determine whether clinically relevant airspace concentrations of beta2-adrenergic agonists stimulated maximal alveolar fluid clearance rates and to determine whether beta2 agonist therapy decreased pulmonary edema in experimental acute lung injury. DESIGN:Prospective randomized laboratory investigation. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.ccm.0000129489.34416.0e

    authors: McAuley DF,Frank JA,Fang X,Matthay MA

    更新日期:2004-07-01 00:00:00

  • Early recovery after closed traumatic head injury: somatosensory evoked potentials and clinical findings.

    abstract:OBJECTIVE:To determine the ability of somatosensory evoked potentials (SEP) compared with clinical findings to monitor and predict recovery in patients suffering from closed head injury with predominantly diffuse axonal injury (DAI). DESIGN:Prospective cohort study. SETTING:Neurologic intensive care unit (ICU) of a u...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200103000-00005

    authors: Claassen J,Hansen HC

    更新日期:2001-03-01 00:00:00

  • Systemic endothelial activation is greater in septic than in traumatic-hemorrhagic shock but does not correlate with endothelial activation in skin biopsies.

    abstract:OBJECTIVE:Sepsis and severe trauma result in endothelial activation and damage. The activated endothelium expresses adhesion receptors that control leukocyte trafficking. After activation, some adhesion molecules are also released into plasma as soluble forms. The present study was designed to compare the expression of...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200204000-00015

    authors: Leone M,Boutière B,Camoin-Jau L,Albanèse J,Horschowsky N,Mège JL,Martin C,Dignat-George F

    更新日期:2002-04-01 00:00:00

  • Intramyocardial hypercarbic acidosis during cardiac arrest and resuscitation.

    abstract:OBJECTIVE:To define changes in intramyocardial pH and PCO2 during cardiac arrest and resuscitation. DESIGN:Prospective and observational trial. SETTING:Mammalian research laboratory utilizing a porcine model of cardiac arrest. SUBJECTS:Sixteen domestic pigs. INTERVENTIONS:Ventricular fibrillation was induced by an ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199306000-00020

    authors: Kette F,Weil MH,Gazmuri RJ,Bisera J,Rackow EC

    更新日期:1993-06-01 00:00:00

  • Detection of false lumen perfusion at the beginning of cardiopulmonary bypass in patients undergoing repair of aortic dissection.

    abstract:OBJECTIVE:In patients undergoing surgical repair of aortic dissection, false lumen perfusion during cardiopulmonary bypass may produce central nervous system damage, myocardial ischemia, aortic rupture, and death. We describe a method to detect false lumen perfusion at the beginning of retrograde aortic perfusion that ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200006000-00026

    authors: Voci P,Testa G,Tritapepe L,Menichetti A,Caretta Q

    更新日期:2000-06-01 00:00:00

  • History of emergency and critical care ultrasound: the evolution of a new imaging paradigm.

    abstract::The tradition of clinical ultrasound in the hands of physicians who provide critical care to the most acutely ill patients stretches back into the 1980s and is rich with experiences from surgical, emergency medicine, and other practices. Now, as critical care ultrasound explodes around the world, it is important to re...

    journal_title:Critical care medicine

    pub_type: 历史文章,杂志文章

    doi:10.1097/01.CCM.0000260623.38982.83

    authors: Kendall JL,Hoffenberg SR,Smith RS

    更新日期:2007-05-01 00:00:00

  • Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution.

    abstract:OBJECTIVE:To determine how top loads with different doses of carbon monoxide (CO)-saturated saline solutions (CO-saline) affect microvascular and systemic hemodynamics and to delineate the corresponding biochemical mechanisms. DESIGN:Prospective study. SETTING:University research laboratory. SUBJECTS:Male Golden Syr...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000259533.84180.C7

    authors: Hangai-Hoger N,Tsai AG,Cabrales P,Suematsu M,Intaglietta M

    更新日期:2007-04-01 00:00:00

  • Effects of off-pump coronary surgery on the mechanics of the respiratory system, lung, and chest wall: Comparison with extracorporeal circulation.

    abstract:OBJECTIVE:To compare the effects of cardiac surgery with and without extracorporeal circulation on the mechanics of the respiratory system, lung, and chest wall. We also determined the time course of those effects. DESIGN:Prospective, controlled study. SETTING:An eight-bed, cardiac-surgical intensive care unit at a u...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/00003246-200211000-00005

    authors: Roosens C,Heerman J,De Somer F,Caes F,Van Belleghem Y,Poelaert JI

    更新日期:2002-11-01 00:00:00

  • Burden of early-onset candidemia: analysis of culture-positive bloodstream infections from a large U.S. database.

    abstract:OBJECTIVES:: To characterize the epidemiology and burden of early-onset, nonnosocomial candidemia. DESIGN:: Retrospective review of Cardinal Health Outcomes Research Database, which comprises all acute care admissions at participating hospitals. SETTING:: A total of 176 acute care hospitals. PATIENTS:: All patients ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3181a0f95d

    authors: Shorr AF,Gupta V,Sun X,Johannes RS,Spalding J,Tabak YP

    更新日期:2009-09-01 00:00:00

  • 4-Aminopyridine, A Blocker of Voltage-Dependent K+ Channels, Restores Blood Pressure and Improves Survival in the Wistar Rat Model of Anaphylactic Shock.

    abstract:OBJECTIVES:Anaphylactic shock is associated with severe hypotension. Potassium channel blockers, such as 4-aminopyridine, induce vasoconstriction. The objective of this study was to test the ability of 4-aminopyridine to restore blood pressure and increase survival in anaphylactic shock. DESIGN:Experimental study. SE...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000001822

    authors: Bellou A,Al-Hammadi S,Aburawi EH,Dhanasekaran S,Nemmar A,Oulhaj A,Shafiuallah M,Zerrouki M,Yasin J,Bellou L,Alper SL,Bellou S,Kazzam E

    更新日期:2016-11-01 00:00:00

  • Assessing moral distress in respiratory care practitioners.

    abstract:OBJECTIVE:To test the reliability and validity of a modified moral distress tool, originally developed for the nursing profession, on respiratory care practitioners. To describe the relationship between moral distress, career dissatisfaction, and job turnover in respiratory care. DESIGN:A 28-question survey was develo...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000248879.19054.73

    authors: Schwenzer KJ,Wang L

    更新日期:2006-12-01 00:00:00

  • Hyperkalemia during cardiac arrest and resuscitation in the canine model.

    abstract::Although recent clinical reports have noted hypokalemia after resuscitation from cardiac arrest, extensive animal work indicates that potassium is released from cells during ischemia. This study was undertaken to define the changes that occur in serum potassium ion during cardiac arrest and resuscitation in a canine m...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198604000-00012

    authors: Martin GB,Carden DL,Nowak RM,Foreback C,Tomlanovich MC

    更新日期:1986-04-01 00:00:00

  • Prospectively validated prediction of physiologic variables and organ failure in septic patients: The Systemic Mediator Associated Response Test (SMART).

    abstract:OBJECTIVE:Conventional outcomes research provides only percentage risk of such end points as mortality rate, utilization of resources, and/or broad groupings of multiple organ system dysfunction. These prognostications generally are not applicable to individual patients. The purpose of the present study was to determin...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/00003246-200205000-00014

    authors: Slotman GJ

    更新日期:2002-05-01 00:00:00

  • Tumor necrosis factor-alpha and interleukin-10 gene expression in peripheral blood mononuclear cells after cardiac surgery.

    abstract:OBJECTIVE:Cytokine response after cardiac surgery may be genetically influenced. A study was carried out to investigate the relation between cytokine gene expression in peripheral blood mononuclear cells, genotype, and clinical events after cardiac surgery. DESIGN:A case-control study was performed. SETTING:Cardiac i...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000227647.77356.AB

    authors: Duggan E,Caraher E,Gately K,O'Dwyer M,McGovern E,Kelleher D,McManus R,Ryan T

    更新日期:2006-08-01 00:00:00

  • Cellular phone interference with the operation of mechanical ventilators.

    abstract:OBJECTIVE:To determine whether a cellular phone would interfere with the operation of mechanical ventilators. DESIGN:Laboratory study. SETTING:University medical center. SUBJECTS:Fourteen mechanical ventilators. INTERVENTIONS:We evaluated change in operation and malfunction of the mechanical ventilators. MEASUREME...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.ccm.0000120061.01431.db

    authors: Shaw CI,Kacmarek RM,Hampton RL,Riggi V,El Masry A,Cooper JB,Hurford WE

    更新日期:2004-04-01 00:00:00

  • Reactive hemophagocytic syndrome presenting as a component of multiple organ dysfunction syndrome.

    abstract:OBJECTIVE:To report two cases of severe reactive hemophagocytic syndrome (RHS), to discuss their impact, and to present evidence that RHS may be a constitutive part of multiple organ dysfunction syndrome (MODS). DESIGN:Case-report. SETTING:Pediatric intensive care unit (PICU). PATIENTS:Two patients with RHS and MODS...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200009000-00038

    authors: Gauvin F,Toledano B,Champagne J,Lacroix J

    更新日期:2000-09-01 00:00:00

  • Opportunities to Improve Antibiotic Appropriateness in U.S. ICUs: A Multicenter Evaluation.

    abstract:OBJECTIVES:To use a standardized tool for a multicenter assessment of antibiotic appropriateness in ICUs and identify local antibiotic stewardship improvement opportunities. DESIGN:Pilot point prevalence conducted on October 5, 2016; point prevalence survey conducted on March 1, 2017. SETTING:ICUs in 12 U.S. acute ca...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004344

    authors: Trivedi KK,Bartash R,Letourneau AR,Abbo L,Fleisher J,Gagliardo C,Kelley S,Nori P,Rieg GK,Silver P,Srinivasan A,Vargas J,Ostrowsky B,Partnership for Quality Care (PQC) Inpatient Antimicrobial Stewardship Working Group.

    更新日期:2020-07-01 00:00:00

  • Pulmonary microvascular fracture in a patient with acute respiratory distress syndrome.

    abstract:OBJECTIVE:To present electron micrographs of lung tissue obtained from a patient exposed to high ventilatory pressures in the context of pulmonary dysfunction and pulmonary hypertension. DESIGN:Case report. SETTING:Adult intensive care unit of a university-affiliated teaching hospital. PATIENTS:A patient exposed to ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200210000-00030

    authors: Hotchkiss JR,Simonson DA,Marek DJ,Marini JJ,Dries DJ

    更新日期:2002-10-01 00:00:00

  • Hemodynamic and colloid osmotic pressure alterations in the surgical patient.

    abstract::Colloid osmotic pressure (COP) was measured simultaneously with cardiorespiratory measurements in 103 surgical patients suspected of having circulatory problems. In a small subset of 28 patients, measurements were taken before, during, and after surgical operations. Similarly, data sets were taken before, during, and ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198303000-00010

    authors: Shippy CR,Shoemaker WC

    更新日期:1983-03-01 00:00:00

  • At-risk drinkers are at higher risk to acquire a bacterial infection during an intensive care unit stay than abstinent or moderate drinkers.

    abstract:OBJECTIVES:To determine whether excessive alcohol consumption increases the risk for intensive care unit (ICU)-acquired bacterial infection, especially ventilator-associated pneumonia (VAP), in nontrauma patients. DESIGN:Prospective observational cohort study. SETTING:A 21-bed polyvalent ICU in a university hospital....

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e318174dd75

    authors: Gacouin A,Legay F,Camus C,Volatron AC,Barbarot N,Donnio PY,Thomas R,Le Tulzo Y

    更新日期:2008-06-01 00:00:00

  • Pharmacokinetics of continuous infusions of fentanyl in critically ill children.

    abstract:OBJECTIVE:To determine the pharmacokinetics of fentanyl when used as a long-term continuous infusion for sedation/analgesia in mechanically ventilated critically ill infants and children. DESIGN:Prospective, case series. SETTING:A university hospital pediatric intensive care unit (ICU). PATIENTS:Nineteen mechanicall...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199307000-00012

    authors: Katz R,Kelly HW

    更新日期:1993-07-01 00:00:00

  • Comparison of noninvasive measurements of carbon dioxide tension during withdrawal from mechanical ventilation.

    abstract::End tidal CO2 tension (PetCO2) and transcutaneous CO2 tension (PtcCO2) were compared with arterial CO2 (PaCO2) before and after withdrawal of mechanical ventilation in 20 patients predisposed to hypercarbia. With stable PaCO2 during mechanical ventilation, the correlation coefficient (r) between PaCO2 and PetCO2 was ....

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198708000-00011

    authors: Healey CJ,Fedullo AJ,Swinburne AJ,Wahl GW

    更新日期:1987-08-01 00:00:00