Abstract：
:Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN) is the most important mediating mechanism. This mechanism involves direct action of inflammatory mediators such as prostaglandins and sympathetic amines. Pharmacologic control of inflammatory pain is based on two principal strategies: (i) non-steroidal anti-inflammatory drugs targeting inhibition of prostaglandin production by cyclooxygenases and preventing nociceptor sensitization in humans and animals; (ii) opioids and dipyrone that directly block nociceptor sensitization via activation of the NO signaling pathway. This review summarizes basic concepts of inflammatory pain that are necessary to understand the mechanisms of peripheral NO signaling that promote peripheral analgesia; we also discuss therapeutic perspectives based on the modulation of the NO pathway.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Gomes FIF,Cunha FQ,Cunha TMdoi
10.1016/j.bcp.2020.113862subject
Has Abstractpub_date
2020-06-01 00:00:00pages
113862eissn
0006-2952issn
1873-2968pii
S0006-2952(20)30090-3journal_volume
176pub_type
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