Abstract:
:The diterpenes andrographolide (I), andrographiside (II) and neoandrographolide (III) isolated from Andrographis paniculata were investigated for their protective effects on hepatotoxicity induced in mice by carbon tetrachloride or tert-butylhydroperoxide (tBHP) intoxication. Pretreatment of mice with the diterpenes (I, II & III; 100 mg/kg, i.p.) for 3 consecutive days produced significant reduction in malondialdehyde formation, reduced glutathione (GSH) depletion and enzymatic leakage of glutamic-pyruvate transaminase (GPT) and alkaline phosphatase (AP) in either group of the toxin-treated animals. A comparison with the known hepatoprotective agent silymarin revealed that I exhibited a lower protective potential than II and III, which were as effective as silymarin with respect to their effects on the formation of the degradation products of lipid peroxidation and release of GPT and AP in the serum. GSH status was returned to normal only by III. The greater protective activity of II and III could be due to their glucoside groups which may act as strong antioxidants.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Kapil A,Koul IB,Banerjee SK,Gupta BDdoi
10.1016/0006-2952(93)90364-3subject
Has Abstractpub_date
1993-07-06 00:00:00pages
182-5issue
1eissn
0006-2952issn
1873-2968pii
0006-2952(93)90364-3journal_volume
46pub_type
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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pub_type: 历史文章,杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2020-12-09 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.bcp.2011.03.024
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pub_type: 杂志文章
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
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更新日期:2006-04-28 00:00:00