Inhibition of renal ornithine decarboxylase by aminoglycoside antibiotics in vitro.

abstract：:Recent studies in our laboratory have revealed that Mn2+ is capable of promoting cell spreading and neurite outgrowth in PC12 cells, a process which is dependent on Mn2+ stimulation of the interaction between extracellular matrix (ECM) components and their corresponding integrin receptors. Since the major ECM proteins...

journal_title：Biochemical pharmacology

authors： Lin WH,Marcucci K,Roth JA

更新日期：1994-04-29 00:00:00

abstract：:We have previously shown that chronic administration of the 5-hydroxytryptamine (5-HT) receptor antagonist, ritanserin (10 mg/kg/day) or the monoamine oxidase type A inhibitor (MAOI), clorgyline (2 mg/kg/day), results in a reduction in 5-HT2 receptor number in rat cerebral cortex. This study investigates the effects o...

journal_title：Biochemical pharmacology

authors： Twist EC,Brammer MJ,Stephenson JD,Corn TH,Campbell IC

更新日期：1990-11-01 00:00:00

abstract：:Methotrexate (MTX) is a chemotherapy agent linked to cognitive deficits in cancer patients received chemotherapy treatment. MTX decreases cell proliferation in the hippocampus, which is concomitant with cognitive deficits in animal models. The present study aimed to investigate the disadvantages of MTX on cognition as...

journal_title：Biochemical pharmacology

authors： Sirichoat A,Krutsri S,Suwannakot K,Aranarochana A,Chaisawang P,Pannangrong W,Wigmore P,Welbat JU

更新日期：2019-05-01 00:00:00

abstract：:The glutathione-glutathione peroxidase system is an important defense against oxidative stress. The ability of this system to protect against iron-catalyzed microsomal production of hydroxyl radicals [oxidation of 4-methylmercapto-2-oxo-butyrate (KMBA)] and lipid peroxidation was evaluated. When rat liver cytosol was ...

journal_title：Biochemical pharmacology

authors： Beloqui O,Cederbaum AI

更新日期：1986-08-15 00:00:00

abstract：:3,3-Dimethylbutanol (Dimbunol), a competitive inhibitor of choline dehydrogenase (CDH), and ethylcholine mustard aziridinium (ECMA), an effective irreversible inhibitor of both CDH and choline transport, were investigated for their effects upon the uptake and metabolism of [3H]choline in mice. Thirty minutes after Dim...

journal_title：Biochemical pharmacology

authors： Barlow P,Marchbanks RM

更新日期：1985-09-01 00:00:00

abstract：:Cells commonly resist growth inhibition by purine and pyrimidine bases and nucleosides by restricting intracellular formation of the corresponding 5'-mononucleotides. Nucleotide derivatives that can act as effective membrane-transport precursors of the poorly membrane-permeable nucleotides have not been identified so ...

journal_title：Biochemical pharmacology

authors： Freed JJ,Farquhar D,Hampton A

更新日期：1989-10-01 00:00:00

abstract：:There is increasing evidence that human arylamine N-acetyltransferase type 1 (NAT1, EC 2.3.1.5), although first identified as a homologue of a drug-metabolising enzyme, appears to be a marker in human oestrogen receptor positive breast cancer. Mouse Nat2 is the mouse equivalent of human NAT1. The development of mouse ...

journal_title：Biochemical pharmacology

authors： Kawamura A,Westwood I,Wakefield L,Long H,Zhang N,Walters K,Redfield C,Sim E

更新日期：2008-04-01 00:00:00

abstract：:A comparative study of the N-B transition and the drug binding properties of human serum albumin samples from various sources has been carried out with the help of circular dichroism and equilibrium dialysis. It was found that when warfarin was used as a marker the midpoint pH and the cooperative nature of the N-B tra...

journal_title：Biochemical pharmacology

authors： Dröge JH,Wilting J,Janssen LH

更新日期：1982-12-01 00:00:00

abstract：:Polyamines (putrescine, spermidine and spermine) are aliphatic amines that are produced by the action of ornithine decarboxylase (ODC) in a rate-limiting and protein kinase C (PKC)-regulated step. Because high levels of polyamines are found in the synovial fluid of arthritic patients, the aim of the present study was ...

journal_title：Biochemical pharmacology

authors： Silva MA,Klafke JZ,Rossato MF,Gewehr C,Guerra GP,Rubin MA,Ferreira J

更新日期：2011-08-01 00:00:00

abstract：:Inorganic polyphosphate (polyP) is a physiological polymer composed of tens to hundreds of phosphate units linked together via phosphoanhydride bonds. Here we compared the biological activity of polyP (chain length of 40 phosphate units), complexed with Gd(3+) (polyP·Gd), with the one caused by polyP (as calcium salt)...

journal_title：Biochemical pharmacology

authors： Wang X,Huang J,Wang K,Neufurth M,Schröder HC,Wang S,Müller WEG

更新日期：2016-02-15 00:00:00

abstract：:Human flavin-dependent monooxygenase (FMO) isoforms 1 and 3 were expressed by retroviral gene transfer in mouse C3H/10T1/2 cells. FMO function was determined by the sulfoxidation of p-tolylmethylsulfide (TMS). Enzyme activity ranged from 4 to 30 nmol p-tolylmethylsulfoxide (TMSO)/30 min/mg cell protein for FMO 3 clone...

journal_title：Biochemical pharmacology

authors： Smith PB,Crespi C

更新日期：2002-06-01 00:00:00

abstract：:A method is described for the measurement of the polyglutamates of the quinazoline thymidylate synthase inhibitor, N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin- 6-ylmethyl)-N-methylamino]-2-theonyl)-L-glutamic acid (ICI D1694). This involved incubation of cells with [5-3H]ICI D1694, extraction of the polyglutamates a...

journal_title：Biochemical pharmacology

authors： Gibson W,Bisset GM,Marsham PR,Kelland LR,Judson IR,Jackman AL

更新日期：1993-02-24 00:00:00

abstract：:The effects of delta 8-tetrahydrocannabinol (delta 8-THC) and its major and active metabolite, 11-hydroxy-delta 8-tetrahydrocannabinol (11-OH-delta 8-THC), on the hepatic microsomal drug-metabolizing enzyme system were studied in mice. The repeated administration of 11-OH-delta 8-THC (5 mg/kg/day, i.v.) for 3 or 7 day...

journal_title：Biochemical pharmacology

authors： Watanabe K,Arai M,Narimatsu S,Yamamoto I,Yoshimura H

更新日期：1986-06-01 00:00:00

abstract：:The inhibition of rat liver monoamine oxidase by a number of N-propargyl and alpha-methyl amine derivatives has been examined. The results indicate that alpha-methyl-substituted primary and secondary amine derivatives tend to show selectivity as reversible inhibitors towards the A-form of the enzyme. The structural fe...

journal_title：Biochemical pharmacology

authors： Tipton KF,McCrodden JM,Kalir AS,Youdim MB

更新日期：1982-04-01 00:00:00

abstract：:In this study, the differentiation-promoting effects of terbinafine (Lamisil), TB) were investigated in human epithelioid squamous carcinoma (A431) cells. The polyhydroxyethylmethacrylate (poly-HEMA)- and type-I collagen-coated culture plate models were adapted to harvest the TB-induced differentiated cells by agitati...

journal_title：Biochemical pharmacology

authors： Huang CS,Ho WL,Lee WS,Sheu MT,Wang YJ,Tu SH,Chen RJ,Chu JS,Chen LC,Lee CH,Tseng H,Ho YS,Wu CH

更新日期：2008-05-01 00:00:00

abstract：:Metastatic migration of murine L1210 leukemia cells, sensitive and resistant to the antitumor agent L-phenylalanine mustard, from the peritoneal cavity of mice to the liver resulted in a 2-fold elevation in their GSH content. This increase in GSH was accompanied by a corresponding increase in their resistance to the d...

journal_title：Biochemical pharmacology

authors： Ahmad S,Mulberg A,Aljian J,Vistica DT

更新日期：1986-05-15 00:00:00

abstract：:The uptake of iron by the liver and cerebellum was measured in rats using [59Fe]transferrin. An acute ethanol load (50 mmol/kg body wt., i.p.) elicited a significant increase in the hepatic and cerebellar non-heme iron concentration. The uptake of 59Fe by the liver and the cerebellum was significantly greater in the e...

journal_title：Biochemical pharmacology

authors： Rouach H,Houze P,Gentil M,Orfanelli MT,Nordmann R

更新日期：1994-05-18 00:00:00

abstract：:Epilepsy is characterised by spontaneous recurrent seizures that are caused by an imbalance between neuronal excitability and inhibition. Since ion channels play fundamental roles in the generation and propagation of action potentials as well as neurotransmitter release at a subset of excitatory and inhibitory synapse...

journal_title：Biochemical pharmacology

authors： Chow CY,Absalom N,Biggs K,King GF,Ma L

更新日期：2020-11-01 00:00:00

abstract：:The present study investigated the mechanism by which theophylline decreases cis-diamminedichloroplatinum(II) (DDP)-induced DNA crosslinking in L1210 cells. Alkaline elution of DNA from L1210 cells treated with DDP in the presence and absence of 1 mM theophylline showed that theophylline decreased interstrand crosslin...

journal_title：Biochemical pharmacology

authors： Ducore JM

更新日期：1986-02-15 00:00:00

abstract：:N-Trifluoroacetyladriamycin-14-valerate (AD 32), a lipophilic, DNA non-binding analog of Adriamycin (ADR), was found to be a potent inhibitor of the membrane-bound enzyme, protein kinase C (PKC). PKC was isolated and purified from human leukemia ML-1 cells, and the enzyme activity was shown to be activated by the tumo...

journal_title：Biochemical pharmacology

authors： Chuang LF,Kung HF,Israel M,Chuang RY

更新日期：1992-02-18 00:00:00

abstract：:Using a continuous perfusion system, synaptosomes prepared from rat brain released [3H]norepinephrine in a Ca2+-dependent manner when pulse depolarized by briefly elevating external potassium concentrations. Tetrodotoxin (10(-7) M), a sodium channel blocker, inhibited 48% of this pulsed release, and D595 (10(-5) M), a...

journal_title：Biochemical pharmacology

authors： Clark JM,Brooks MW

更新日期：1989-07-15 00:00:00

abstract：:The tetracyclines inhibit specifically mitochondrial (mt) and bacterial protein synthesis when they are present in low concentrations (2-10 micrograms/ml). There is no difference between the various members of this group of antibiotics in this respect. In the present study, however, it is shown that the inhibitory eff...

journal_title：Biochemical pharmacology

authors： van den Bogert C,Holtrop M,Melis TE,Roefsema PR,Kroon AM

更新日期：1987-05-01 00:00:00

abstract：:The role of Ca2+ and protein kinase C (PKC) activity in the release of immunoreactive endothelin-1 (ET-1) from cultured porcine aortic endothelial cells of first or second passage has been studied. ET-1 accumulation within cells and secretion into cell-conditioned medium over 3 and/or 5 hr was measured. Confluent cell...

journal_title：Biochemical pharmacology

authors： Brunner F

更新日期：1995-06-16 00:00:00

abstract：:Hypertension is considered as one of the cancer progressive factors, and often found comorbidity in cancer patients. Renin-angiotensin system (RAS) plays an important role in the regulation of blood pressure, and angiotensin II (Ang II) is well known pressor peptide associated with RAS. Ang II has been reported to acc...

journal_title：Biochemical pharmacology

authors： Ishikane S,Hosoda H,Nojiri T,Tokudome T,Mizutani T,Miura K,Akitake Y,Kimura T,Imamichi Y,Kawabe S,Toyohira Y,Yanagihara N,Takahashi-Yanaga F,Miyazato M,Miyamoto K,Kangawa K

更新日期：2018-08-01 00:00:00

abstract：:The family of natural red pigments, called prodigiosins (PGs), characterised by a common pyrrolylpyrromethene skeleton, are produced by various bacteria. Some members have immunosuppressive properties and apoptotic effects in vitro and they have also displayed antitumour activity in vivo. Understanding the mechanism o...

journal_title：Biochemical pharmacology

authors： Pérez-Tomás R,Montaner B,Llagostera E,Soto-Cerrato V

更新日期：2003-10-15 00:00:00

abstract：:Metabolic and cardiovascular disease patients have increased plasma levels of lipids and, specifically, of palmitate, which can be toxic for several tissues. Trimetazidine (TMZ), a partial inhibitor of lipid oxidation, has been proposed as a metabolic modulator for several cardiovascular pathologies. However, its mech...

journal_title：Biochemical pharmacology

authors： Kuzmicic J,Parra V,Verdejo HE,López-Crisosto C,Chiong M,García L,Jensen MD,Bernlohr DA,Castro PF,Lavandero S

更新日期：2014-10-01 00:00:00

abstract：:Combining site-directed mutagenesis with information obtained from molecular modelling of the bradykinin (BK) human B2 receptor (hB2R) as derived from the bovine rhodopsin crystal structure [Science 289 (2000) 739], we previously defined a putative binding mode for the non-peptide B2 receptor antagonists, FR173657 and...

journal_title：Biochemical pharmacology

authors： Meini S,Cucchi P,Bellucci F,Catalani C,Faiella A,Rotondaro L,Quartara L,Giolitti A,Maggi CA

更新日期：2004-02-15 00:00:00

abstract：:Inhibition of glycogen synthase kinase (GSK)-3 and the consequent activation of the Wnt/β-catenin signaling pathway have been reported to increase bone volume. To develop a novel pharmacotherapy for injured bone, we investigated whether GSK-3 inhibitor was effective in promoting bone formation. In in vitro experiments...

journal_title：Biochemical pharmacology

authors： Arioka M,Takahashi-Yanaga F,Sasaki M,Yoshihara T,Morimoto S,Hirata M,Mori Y,Sasaguri T

更新日期：2014-08-15 00:00:00

abstract：:Rat brain P2Y(1) (rP2Y(1)) receptor-transfected human embryonic kidney cells (HEK 293) were recently shown to have enhanced reactivity to both ATP and ADP (Vöhringer C, Schäfer R, Reiser G. Biochem Pharmacol 2000;59:791-800). Here, we demonstrated the usefulness of this cell line as a system for further studying novel...

journal_title：Biochemical pharmacology

authors： Zündorf G,Schäfer R,Vöhringer C,Halbfinger E,Fischer B,Reiser G

更新日期：2001-05-15 00:00:00

abstract：:The in vitro metabolic ketone reduction of warfarin and its 4'-analogues acenocoumarol (4'-nitrowarfarin) and 4'-chlorowarfarin has been investigated using microsomal and cytosolic fractions of several species. Both subcellular fractions showed ketone reductase activity. The cytosolic fractions, in most species, exhib...

journal_title：Biochemical pharmacology

authors： Hermans JJ,Thijssen HH

更新日期：1989-10-01 00:00:00