Abstract:
:Research to date demonstrates a relationship between exposure to ambient air pollutants and cardiovascular disease (CVD). Many studies have shown associations between short-term exposures to elevated levels of air pollutants and CVD events, and several cohort studies suggest effects of long-term exposure on cardiovascular mortality, coronary heart disease events, and stroke. The biologic mechanisms underlying this long-term exposure relationship are not entirely clear but are hypothesized to include systemic inflammation, autonomic nervous system imbalance, changes in vascular compliance, altered cardiac structure, and development of atherosclerosis. The Multi-Ethnic Study of Atherosclerosis provides an especially well-characterized population in which to investigate the relationship between air pollution and CVD and to explore these biologic pathways. This article reviews findings reported to date within this cohort and summarizes the aims and anticipated contributions of a major ancillary study, the Multi-Ethnic Study of Atherosclerosis and Air Pollution.
journal_name
Prog Cardiovasc Disjournal_title
Progress in cardiovascular diseasesauthors
Gill EA,Curl CL,Adar SD,Allen RW,Auchincloss AH,O'Neill MS,Park SK,Van Hee VC,Diez Roux AV,Kaufman JDdoi
10.1016/j.pcad.2011.02.001subject
Has Abstractpub_date
2011-03-01 00:00:00pages
353-60issue
5eissn
0033-0620issn
1873-1740pii
S0033-0620(11)00018-1journal_volume
53pub_type
杂志文章,多中心研究,评审abstract::The application of ultrasound to clinical evaluation of the symptomatic patient requires less precision and accuracy than when it is used as an instrument to study atherogenesis. The clinician's goal is to locate hemodynamically significant lesions; studies of atherogenesis require auxometry (measurement of the growth...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章
doi:10.1016/0033-0620(84)90007-0
更新日期:1984-01-01 00:00:00
abstract::Left ventricular (LV) ejection fraction (EF) and LV end-systolic volumes are important measures of LV global function. However, in many patients with symptoms of heart failure, these measures are within normal limits. This condition is classified as heart failure with normal ejection fraction (HFNEF). Reduced EF and i...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2006.08.008
更新日期:2006-11-01 00:00:00
abstract::Primary percutaneous intervention (PCI) is the treatment of choice for ST-segment elevation myocardial infarction (STEMI). Patients with STEMI frequently have obstructive non-culprit lesions. In addition, STEMI patients with multivessel disease are at increased risk of major adverse cardiac events. However, current gu...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2015.07.006
更新日期:2015-11-01 00:00:00
abstract::The definition of syncope has clinical and pathophysiological parts. The clinical part is that syncope is a form of transient loss of consciousness (TLOC), while the pathophysiological element is that syncope differs from other forms of TLOC by virtue of the basis of true syncope - specifically cerebral hypoperfusion....
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2012.10.016
更新日期:2013-01-01 00:00:00
abstract::This study estimates the percentage of health care expenditures in the non-institutionalized United States (U.S.) adult population associated with levels of physical activity inadequate to meet current guidelines. Leisure-time physical activity data from the National Health Interview Survey (2004-2010) were merged wit...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章
doi:10.1016/j.pcad.2014.08.002
更新日期:2015-01-01 00:00:00
abstract::Echocardiography is a valuable technique for the diagnosis and serial follow-up of patients with impaired cardiac function. It is subject to certain limitations due to the assumptions inherent in deriving ventricular volume from a one-dimensional measurement and must be interpreted with caution in cases of suspected r...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/0033-0620(78)90018-x
更新日期:1978-09-01 00:00:00
abstract::Multimorbidity is the most common chronic health condition in adults and is associated with poor health outcomes. Optimal care for people with multimorbidity requires a person-centred approach that considers goals and preferences, improves quality of life and coordinates care across services. Because care is focused o...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2018.12.010
更新日期:2019-01-01 00:00:00
abstract::Because not all laboratories use the monitoring and stimulation protocols used in the Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM) trial, we reanalyzed the ESVEM patients' data using alternative, commonly used Holter monitor (HM) and programmed stimulation efficacy criteria to determine if d...
journal_title:Progress in cardiovascular diseases
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0033-0620(96)80029-6
更新日期:1996-03-01 00:00:00
abstract::People are at risk from noncommunicable diseases (NCD) and poor health habits, with interventions like medications and surgery carrying further risk of adverse effects. This paper addresses ways people are increasingly moving to healthy living medicine (HLM) to mitigate such health threats. HLM-seekers increasingly le...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2016.12.006
更新日期:2017-01-01 00:00:00
abstract::A large number of drug trials for prevention of restenosis have been conducted with many showing little or conflicting benefit. Antiplatelets such as aspirin, ticlopidine and thromboxane A2 receptor inhibitors have not shown a clear benefit. Similarly, antithrombotics, either acting indirectly such as heparin, or as d...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/s0033-0620(97)80006-0
更新日期:1997-09-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2019.10.001
更新日期:2019-01-01 00:00:00
abstract::Obesity has reached epidemic proportions in most of the Westernized world. Overweightness and obesity adversely impact cardiac structure and function, including on both the right and, especially, left sides of the heart, with adverse affects on systolic and, especially, diastolic ventricular function. Therefore, it is...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2015.12.003
更新日期:2016-01-01 00:00:00
abstract::The success of modern therapies in congenital heart disease has produced a large and growing population of adults with congenital heart disease as a chronic condition. Such success increasingly raises a host of ethical issues, from resource utilization to end of life decision-making. The importance of a multidisciplin...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2012.10.004
更新日期:2012-11-01 00:00:00
abstract::This study systematically analyzed the incidence and variety of adverse reactions to quinidine sulfate in 652 consecutively monitored hospitalized patients. Fourteen percent of the patients sustained adverse reactions of sufficient severity to warrant discontinuation of the drug. These reactions include GI intolerance...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/0033-0620(77)90004-4
更新日期:1977-09-01 00:00:00
abstract::Two central concepts of human hypertensive disease remain poorly understood: (1) elevated blood pressure as merely one component of an underlying systemic condition, characterized by multiple defects in diverse tissues (eg, "Syndrome X"), and (2) the heterogeneity of hypertension, in which different and even opposite ...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/s0033-0620(99)70006-x
更新日期:1999-07-01 00:00:00
abstract::Valvular heart disease is a common cause of increased mean pulmonary artery pressure (PAP). Aortic stenosis and mitral regurgitation are frequently accompanied by pulmonary hypertension (PH), especially when they are severe and symptomatic. In asymptomatic patients, PH is rare, though the exact prevalence is unknown a...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2016.06.004
更新日期:2016-07-01 00:00:00
abstract::The role of metabolic processes in the control of the normal circulation will be discussed with particular emphasis on how metabolic events, particularly those that occur with the performance of exercise, result in production of vasoactive substances and sympathetic activation. Heart failure patients will have altered...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/s0033-0620(05)80013-1
更新日期:1995-07-01 00:00:00
abstract::There is a strong evidence that more marked lowering of low-density lipoprotein cholesterol (LDL-C) leads to progressively lower risk of cardiovascular disease (CVD) events. The evidence on validity of this hypothesis comes from epidemiological, genetic and clinical studies. The hypothesis "the lower the better" has b...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2020.12.008
更新日期:2020-12-28 00:00:00
abstract::Cardiovascular disease is the leading cause of morbidity and mortality with annual costs of care exceeding 300 billion US dollars. Although screening tools are advocated for many cancers, the use of subclinical disease tests for cardiovascular disease are considered controversial. Health care payers and many governmen...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/s0033-0620(03)00085-9
更新日期:2003-09-01 00:00:00
abstract::Stents or endoprostheses have evolved since their introduction. Initially used only in the vascular system, the use of stents has expanded to use in the biliary, urinary, and gastrointestinal tracts and in the tracheo-bronchial tree. Current use of stents includes treatment of both benign and malignant conditions, wit...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
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更新日期:1996-09-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1053/pcad.2000.9028
更新日期:2000-09-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/s0033-0620(98)80053-4
更新日期:1998-01-01 00:00:00
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journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2011.09.006
更新日期:2012-01-01 00:00:00
abstract::Since the early 1900s, coffee has been implicated as having adverse effects on human health. Recent attention has focused on coffee's relation to CHD, but because of conflicting results of epidemiologic studies on coffee and CHD mortality, attention has turned to the effects of coffee and caffeine on individual CHD ri...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/0033-0620(89)90028-5
更新日期:1989-11-01 00:00:00
abstract::There are >1.4 million adult congenital heart disease (CHD; ACHD) patients living in the United States. Coronary artery disease (CAD) is at least as prevalent in ACHD patients as in the general population and has become a leading cause of their mortality. In the majority of cases, CAD in the ACHD population is driven ...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2018.07.018
更新日期:2018-01-01 00:00:00
abstract::In our increasingly cost-conscious health system, patients, clinicians, hospitals, and payers all agree about the urgent need to rein in runaway healthcare costs. High pharmaceutical costs make drugs unaffordable to many patients who may benefit from them, including some insured patients who face prohibitive out-of-po...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2019.10.006
更新日期:2019-01-01 00:00:00
abstract::Low serum high density lipoprotein cholesterol level (HDL-C) <40 mg/dL in men and <50 mg/dL in women is a significant independent risk factor for cardiovascular disease (CVD), and is often observed in patients with hypertriglyceridemia, obesity, insulin resistance, and diabetes. Patients with marked deficiency of HDL-...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2016.08.006
更新日期:2016-01-01 00:00:00
abstract::The chronic disease crisis we currently face must be addressed in rapid fashion. Cardiovascular (CV) and pulmonary diseases, diabetes as well as several forms of cancer are leading causes of morbidity and mortality globally. Collectively, these conditions have a significant impact on the quality of life of individuals...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2017.02.002
更新日期:2017-01-01 00:00:00
abstract::Trastuzumab is the standard of care for the treatment of patients with ERB2-positive breast cancer. In a minority of patients, trastuzumab is associated with an increased incidence of cardiac dysfunction that ranges from asymptomatic decreases in left ventricular ejection fraction to symptomatic heart failure. In tria...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2010.07.001
更新日期:2010-09-01 00:00:00
abstract::The QT Variability Index (QTVI) is a non-invasive measure of repolarization lability that has been applied to a wide variety of subjects with cardiovascular disease. It is a ratio of normalized QT variability to normalized heart rate variability, and therefore includes an assessment of autonomic nervous system tone. T...
journal_title:Progress in cardiovascular diseases
pub_type: 杂志文章,评审
doi:10.1016/j.pcad.2013.07.004
更新日期:2013-09-01 00:00:00