Air pollution and cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis.

Abstract:

:Research to date demonstrates a relationship between exposure to ambient air pollutants and cardiovascular disease (CVD). Many studies have shown associations between short-term exposures to elevated levels of air pollutants and CVD events, and several cohort studies suggest effects of long-term exposure on cardiovascular mortality, coronary heart disease events, and stroke. The biologic mechanisms underlying this long-term exposure relationship are not entirely clear but are hypothesized to include systemic inflammation, autonomic nervous system imbalance, changes in vascular compliance, altered cardiac structure, and development of atherosclerosis. The Multi-Ethnic Study of Atherosclerosis provides an especially well-characterized population in which to investigate the relationship between air pollution and CVD and to explore these biologic pathways. This article reviews findings reported to date within this cohort and summarizes the aims and anticipated contributions of a major ancillary study, the Multi-Ethnic Study of Atherosclerosis and Air Pollution.

journal_name

Prog Cardiovasc Dis

authors

Gill EA,Curl CL,Adar SD,Allen RW,Auchincloss AH,O'Neill MS,Park SK,Van Hee VC,Diez Roux AV,Kaufman JD

doi

10.1016/j.pcad.2011.02.001

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

353-60

issue

5

eissn

0033-0620

issn

1873-1740

pii

S0033-0620(11)00018-1

journal_volume

53

pub_type

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