Abstract：
:A large number of drug trials for prevention of restenosis have been conducted with many showing little or conflicting benefit. Antiplatelets such as aspirin, ticlopidine and thromboxane A2 receptor inhibitors have not shown a clear benefit. Similarly, antithrombotics, either acting indirectly such as heparin, or as direct thrombin inhibitors such as hirudin and hirulog, do not prevent restenosis. Trials with ACE inhibitors, HMG-CoA reductase inhibitors and fish-oil supplements have yielded inconclusive results. The antiproliferatives, angiopeptin, trapidil and tranilast have shown some benefit in small-scale studies. Other drug classes of potential benefit include the glycoprotein IIb/IIIa receptor antagonists, inhibitors of the early coagulation cascade, calcium channel blockers and nitric oxide donors. Drug research into restenosis prevention has been hampered by problems with the definition of restenosis and the applicability in humans of animal models. Although no single drug has conclusively proven effective yet, the promise of a number of agents, together with other nonpharmacological strategies will likely result in further reductions in the incidence of restenosis.
journal_name
Prog Cardiovasc Disjournal_title
Progress in cardiovascular diseasesauthors
Lefkovits J,Topol EJdoi
10.1016/s0033-0620(97)80006-0subject
Has Abstractpub_date
1997-09-01 00:00:00pages
141-58issue
2eissn
0033-0620issn
1873-1740pii
S0033-0620(97)80006-0journal_volume
40pub_type
杂志文章,评审abstract：:We will review the epidemiology, risk factors, and consequences of obstructive sleep apnea (OSA) and short/long sleep duration. Obstructive sleep apnea is a disease characterized by recurrent upper airway obstruction during sleep. Obstructive sleep apnea is common, with moderate to severe disease present in approximat...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2008.08.001
更新日期：2009-01-01 00:00:00
abstract：:The relationship between thyroid disease states and cardiovascular hemodynamics is well recognized. Although the long-term effects of thyroid hormone are thought to result from changes in myocardial gene expression, attention has recently focused on acute, non-nuclear-mediated actions of L-triidothyronine (T3), the bi...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/s0033-0620(96)80017-x
更新日期：1996-01-01 00:00:00
abstract：:Cardiovascular disease is the leading cause of morbidity and mortality with annual costs of care exceeding 300 billion US dollars. Although screening tools are advocated for many cancers, the use of subclinical disease tests for cardiovascular disease are considered controversial. Health care payers and many governmen...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/s0033-0620(03)00085-9
更新日期：2003-09-01 00:00:00
abstract：:The recent advent of an entirely subcutaneous implantable defibrillator (ICD) has provided a relevant contribution to the debate concerning the use of ICD therapy in patients at high risk for death. Although conventional transvenous ICDs have proven very effective during the past 23 years, they still appear to be limi...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2012.03.006
更新日期：2012-05-01 00:00:00
abstract：:The Framingham Heart Study has been a trailblazer in the field of cardiovascular epidemiology. The wealth of novel scientific data that it has generated over 5 decades has made a significant contribution to cardiovascular disease (CVD) prevention in the United States and indirectly influenced global CVD prevention str...
journal_title：Progress in cardiovascular diseases
pub_type： 历史文章,杂志文章
doi：10.1016/j.pcad.2010.01.001
更新日期：2010-07-01 00:00:00
abstract：:Heparin has been the principal anticoagulant in the management of ST-elevation myocardial infarction (STEMI) but has several limitations. Although glycoprotein IIb/IIIa inhibitors have been major adjuncts in previous years, in the era of novel P2Y12 receptor inhibitors they may have a greater role in bailout. Low mole...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2015.08.007
更新日期：2015-11-01 00:00:00
abstract：:Primary percutaneous intervention (PCI) is the treatment of choice for ST-segment elevation myocardial infarction (STEMI). Patients with STEMI frequently have obstructive non-culprit lesions. In addition, STEMI patients with multivessel disease are at increased risk of major adverse cardiac events. However, current gu...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2015.07.006
更新日期：2015-11-01 00:00:00
abstract：:Left ventricular (LV) dysfunction has been shown to be significantly related to ongoing myocardial ischemia, hibernation, and thus, coronary artery disease. Current treatments for patients with LV dysfunction and concomitant coronary artery disease center around the potential benefit of coronary revascularization, in ...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2013.01.003
更新日期：2013-03-01 00:00:00
abstract：:This study estimates the percentage of health care expenditures in the non-institutionalized United States (U.S.) adult population associated with levels of physical activity inadequate to meet current guidelines. Leisure-time physical activity data from the National Health Interview Survey (2004-2010) were merged wit...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章
doi：10.1016/j.pcad.2014.08.002
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:To perform a pilot evaluation of a pharmacist-led, multidisciplinary transitional care clinic for heart failure (HF) patients. BACKGROUND:Transitions of care in HF should include: medication reconciliation, multidisciplinary care, early post-discharge follow-up, and prompt intervention on HF signs and sympto...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章
doi：10.1016/j.pcad.2017.08.005
更新日期：2017-01-01 00:00:00
abstract：:Tachycardia is a strong predictor of both hypertension and excessive cardiovascular risk. This association is robust and prevails after multivariate adjustments for other cardiovascular risk factors. Despite the strong evidence, various guidelines do not list tachycardia as a risk factor because of unwarranted assumpt...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2009.06.002
更新日期：2009-07-01 00:00:00
abstract：:Historically, risk stratification for survivors of acute myocardial infarction (AMI) has centered on 3 principles: assessment of left ventricular function, detection of residual myocardial ischemia, and estimation of the risk for sudden cardiac death. Although these factors still have important prognostic implications...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1053/pcad.2000.0420273
更新日期：2000-01-01 00:00:00
abstract：:The PREDIMED (PREvención con DIeta MEDiterránea) multicenter, randomized, primary prevention trial assessed the long-term effects of the Mediterranean diet (MeDiet) on clinical events of cardiovascular disease (CVD). We randomized 7447 men and women at high CVD risk into three diets: MeDiet supplemented with extra-vir...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2015.04.003
更新日期：2015-07-01 00:00:00
abstract：:Dispersion of ventricular repolarization is a now widely used term describing nonhomogeneous recovery of excitability or heterogeneity of ventricular repolarization. It is usually expressed as the difference or the range of various repolarization measurements obtained from a heart. Experimentally, an increased dispers...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1053/pcad.2000.0420311
更新日期：2000-03-01 00:00:00
abstract：:Bicuspid aortic valve (BAV) patients are at increased risk of valve dysfunction and ascending aorta aneurysm. Imaging techniques are essential to establish diagnosis, identify complications and indicate surgical treatment. Transthoracic echocardiography (TTE) is the imaging technique of choice to diagnose BAV, valve m...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2020.06.003
更新日期：2020-01-01 00:00:00
abstract：:Due to advances in prevention, early detection and treatment, early breast cancer mortality has decreased by nearly 40% during the last four decades. Yet, the risk of cardiovascular disease (CVD) mortality is significantly elevated following a breast cancer diagnosis, and it is a leading cause of death in this populat...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2019.02.002
更新日期：2019-01-01 00:00:00
abstract：:Massive pulmonary embolism carries a high mortality rate as a result of right ventricular failure. In addition to anticoagulation, systemic thrombolysis is the standard first line of therapy for patients with life-threatening massive pulmonary embolism. Surgical embolectomy is often considered in patients with contrai...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2010.01.002
更新日期：2010-03-01 00:00:00
abstract：:Mitral regurgitation (MR) is the most prevalent cause of valvular heart disease (VHD) in western countries. In the Euro Heart Survey on VHD, MR was the second most common heart VHD requiring surgery. It is also the most common form of VHD in community and population-based studies from the United States. The categoriza...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2017.11.008
更新日期：2017-01-01 00:00:00
abstract：:Patients at a low probability of acute cardiac pathology constitute a considerable proportion in many coronary care units (CCUs), such that physicians should consider more effective alternatives than CCU admission "to rule out myocardial infarction." In this article, strategies to increase the efficiency of managing p...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/s0033-0620(05)80021-0
更新日期：1995-05-01 00:00:00
abstract：:Positron-emitting myocardial flow radiotracers such as (15)O-water, (13)N-ammonia and (82)Rubidium in conjunction with positron-emission-tomography (PET) are increasingly applied in clinical routine for coronary artery disease (CAD) detection, yielding high diagnostic accuracy, while providing valuable information on ...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2015.01.001
更新日期：2015-05-01 00:00:00
abstract：:The definition of syncope has clinical and pathophysiological parts. The clinical part is that syncope is a form of transient loss of consciousness (TLOC), while the pathophysiological element is that syncope differs from other forms of TLOC by virtue of the basis of true syncope - specifically cerebral hypoperfusion....
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2012.10.016
更新日期：2013-01-01 00:00:00
abstract：:The QT Variability Index (QTVI) is a non-invasive measure of repolarization lability that has been applied to a wide variety of subjects with cardiovascular disease. It is a ratio of normalized QT variability to normalized heart rate variability, and therefore includes an assessment of autonomic nervous system tone. T...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2013.07.004
更新日期：2013-09-01 00:00:00
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journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1053/pcad.2002.123782
更新日期：2002-05-01 00:00:00
abstract：:With the approval of alteplase (tPA) therapy for stroke, it is likely that combination therapy with tPA to restore blood flow, and agents like glutamate receptor antagonists to halt or reverse the cascade of neuronal damage, will dominate the future of stroke care. The authors describe events and potential targets of ...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/s0033-0620(99)70002-2
更新日期：1999-11-01 00:00:00
abstract：:Multimorbidity is the most common chronic health condition in adults and is associated with poor health outcomes. Optimal care for people with multimorbidity requires a person-centred approach that considers goals and preferences, improves quality of life and coordinates care across services. Because care is focused o...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2018.12.010
更新日期：2019-01-01 00:00:00
abstract：:Nearly 800,000 strokes occur in the United States each year, and stroke is the leading cause of preventable permanent disability. Timely recognition and treatment are imperative to reduce stroke-related morbidity and mortality. Given the evidence supporting intravenous thrombolysis and mechanical thrombectomy for isch...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2017.04.004
更新日期：2017-01-01 00:00:00
abstract：:Physicians who supervise stress-imaging procedures, whether they be stress nuclear or stress echocardiography tests, are increasingly required to incorporate important principles in the interpretation of the test results. Important guiding principles, common to these tests, are reviewed in this article. The principles...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章
doi：10.1053/pcad.2001.20501
更新日期：2001-01-01 00:00:00
abstract：:The underlying causes of hypertensive disease remain unclear. This article has attempted to highlight potential dysfunctions in arterial pressure regulation which could either initiate or sustain the hypertensive process. As has been suggested innumerable times hypertension must certainly be a multifactorial abnormali...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/0033-0620(76)90001-3
更新日期：1976-03-01 00:00:00
abstract：:Barometric pressure falls with increasing altitude and consequently there is a reduction in the partial pressure of oxygen resulting in a hypoxic challenge to any individual ascending to altitude. A spectrum of high altitude illnesses can occur when the hypoxic stress outstrips the subject's ability to acclimatize. Ac...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2010.02.003
更新日期：2010-05-01 00:00:00
abstract：:Infective endocarditis continues to be associated with significant morbidity and mortality despite recent advances in its management and remains a serious and challenging condition requiring a multidisciplinary approach. Surgery is essential in at least 50% of cases. Surgical outcomes have improved with the introducti...
journal_title：Progress in cardiovascular diseases
pub_type： 杂志文章,评审
doi：10.1016/j.pcad.2008.08.007
更新日期：2009-05-01 00:00:00
