Optimal surgical debulking in uterine papillary serous carcinoma affects survival.

abstract：OBJECTIVE:To compare the diagnostic accuracy of dilatation & curettage (D&C) vs. endometrial aspiration biopsy in follow-up evaluation of patients treated with high-dose oral progestin plus levonorgestrel intrauterine system (LNG-IUS) for early-stage endometrial cancer (EC). METHOD:A prospective observational study wa...

journal_title：Gynecologic oncology

authors： Kim MK,Seong SJ,Song T,Kim ML,Yoon BS,Jun HS,Lee GH,Lee YH

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The aim of this study was to assess prognostic factors and implications on further management in a large series of stage-II or III Atypical Proliferative Serous Tumors (APST) with a long-term follow-up. PATIENTS AND METHODS:Patients with APSTs and peritoneal implants treated in, or referred to, our institut...

journal_title：Gynecologic oncology

authors： Maria S,Faron M,Maulard A,Pautier P,Leary A,Chargari C,Genestie C,Gouy S,Morice P

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:This two-arm longitudinal study was performed within a regional organized cervical-cancer-prevention program in which HPV-DNA test is used in primary screening. The aim was to analyze the diagnostic performances of p16INK4a/Ki-67 dual-test and E6/E7-mRNA test in identifying CIN2+ lesion among HPV-DNA positive...

journal_title：Gynecologic oncology

authors： Zappacosta R,Caraceni D,Ciccocioppo L,Rotondo T,Capanna S,Gatta DM,D'Angelo C,Rosini S

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:The consequences of defective homologous recombination and other DNA repair pathways are important in disease outcomes of numerous tumor types. The objective of this study was to explore BRCA1, PARP, FANCD2, PTEN, H2AX, and ATM protein expression in endometrial cancer (EC). METHODS:PARP1, γH2AX, ATM, FANCD2,...

journal_title：Gynecologic oncology

authors： Mhawech-Fauceglia P,Wang D,Kim G,Sharifian M,Chen X,Liu Q,Lin YG,Liu S,Pejovic T

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to examine the clinicopathologic correlates of T-regulatory (T(reg)) cell infiltration in serous ovarian cancers and to define gene signatures associated with high T(reg)s. METHODS:Tumor infiltrating T(reg) and cytotoxic T-cells (CTLs) were quantitated in 232 primary serous ov...

journal_title：Gynecologic oncology

authors： Barnett JC,Bean SM,Whitaker RS,Kondoh E,Baba T,Fujii S,Marks JR,Dressman HK,Murphy SK,Berchuck A

更新日期：2010-03-01 00:00:00

abstract：:Twenty-nine patients with recurrent advanced stage ovarian cancer were treated with 5-fluorouracil (5-FU) and leucovorin by intravenous bolus on 5 consecutive days, repeated every 3 weeks. Twenty-one of these patients had experienced disease progression while receiving a cisplatin- or carboplatin-based regimen. There ...

journal_title：Gynecologic oncology

authors： Reed E,Jacob J,Ozols RF,Young RC,Allegra C

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:To assess the safety and efficacy of pegylated liposomal doxorubicin (PLD), carboplatin, plus bevacizumab in patients with ovarian, fallopian tube, or primary peritoneal cancer. METHODS:Patients with platinum-sensitive, recurrent disease received PLD 30 mg/m(2) and carboplatin area under the curve (AUC) 5 on...

journal_title：Gynecologic oncology

authors： del Carmen MG,Micha J,Small L,Street DG,Londhe A,McGowan T

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:We seek to describe the procedure, complications, and functional outcomes of utilizing the cecum and ascending colon for creation of a neovagina on a gynecologic oncology service. METHODS:A search of all the cases on the gynecologic oncology service over a ten year period yielded fourteen cases of cecal neov...

journal_title：Gynecologic oncology

authors： Khulpateea BR,Silver DF

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:MicroRNA (miRNA) plays an essential role in the progression of a variety of cancers, but its role in cervical cancer progression is not well defined. We aimed to test whether special miRNAs and their target mRNAs contribute to cervical cancer progression. METHODS:The expression profiles of 1145 microRNAs in ...

journal_title：Gynecologic oncology

authors： Li JH,Xiao X,Zhang YN,Wang YM,Feng LM,Wu YM,Zhang YX

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:A constituent of green tea, (-)-epigallocatechin-3-gallate (EGCG), has been known to possess anti-cancer properties. In this study, we investigated the time-course anticancer effects of EGCG on human ovarian cancer cells to provide insights into the molecular-level understanding of growth suppression mechanism ...

journal_title：Gynecologic oncology

authors： Huh SW,Bae SM,Kim YW,Lee JM,Namkoong SE,Lee IP,Kim SH,Kim CK,Ahn WS

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:The primary objective of the study was to prospectively assess quality of life (QOL) among women at increased risk of ovarian cancer who are undergoing risk-reducing salpingo-oophorectomy (RRSO) or serial screening. METHODS:Women at increased risk of ovarian cancer who were undergoing RRSO were recruited int...

journal_title：Gynecologic oncology

authors： Fang CY,Cherry C,Devarajan K,Li T,Malick J,Daly MB

更新日期：2009-03-01 00:00:00

abstract：:From 1970 to 1992, 136 patients with a histologic diagnosis of endometrial hyperplasia underwent total abdominal hysterectomy at the University of Kentucky Medical Center. Slides of the curettage or biopsy specimens were reviewed and classified according to the International Society of Gynecologic Pathologists System ...

journal_title：Gynecologic oncology

authors： Hunter JE,Tritz DE,Howell MG,DePriest PD,Gallion HH,Andrews SJ,Buckley SB,Kryscio RJ,van Nagell JR Jr

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to evaluate the impact of a multidisciplinary approach in patients' selection with advanced ovarian cancer (AOC) for different therapeutic strategies. METHODS:Patients referred at our institution between 2009 and 2012 for AOC were included. Primary multidisciplinary evaluatio...

journal_title：Gynecologic oncology

authors： Aletti GD,Garbi A,Messori P,Achilarre MT,Zanagnolo V,Rizzo S,Alessi S,Bocciolone L,Landoni F,Biffi R,Carinelli S,Colombo N,Maggioni A

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to analyze risk factors for septic complications during adjuvant chemotherapy and their impact on survival in patients with advanced epithelial ovarian cancer treated with neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS). METHODS:We retrospectively revie...

journal_title：Gynecologic oncology

authors： Son JH,Lee JH,Jung JA,Kong TW,Paek J,Chang SJ,Ryu HS

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to examine the relationships between cyclooxygenase-2 (COX-2) expression and prognostic factors in cervical carcinomas. METHODS:We studied COX-2 expression in 53 women with cervical cancers, including 35 squamous cell carcinomas (SCCs), 1 adenosquamous cell carcinoma (ASCC), and...

journal_title：Gynecologic oncology

authors： Chen YJ,Wang LS,Wang PH,Lai CR,Yen MS,Ng HT,Yuan CC

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to evaluate the histological outcome of laser ring biopsies in patients with one or more smears showing cytological mild dyskaryosis where punch biopsies were not performed. The possibilities of predicting histological findings of CIN 2 and CIN 3 were analyzed. METHODS:The study com...

journal_title：Gynecologic oncology

authors： Risberg B,Andersson A,Lie KA,Nordin B,Zetterberg C

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:To determine the effectiveness of chemotherapy alone as postoperative adjuvant therapy for intermediate- and high-risk cervical cancer. METHODS:The study group comprised of 65 consecutive patients with stage IB or IIA squamous cell or adenosquamous cervical cancer who were initially treated with radical hyst...

journal_title：Gynecologic oncology

authors： Takeshima N,Umayahara K,Fujiwara K,Hirai Y,Takizawa K,Hasumi K

更新日期：2006-11-01 00:00:00

abstract：:Fifty consecutive patients with documented advanced or recurrent endometrial carcinoma from 1978 through 1985 were prospectively treated with melphalan, 5-fluorouracil, medroxyprogesterone acetate (MFP) as first-line chemotherapy. From 1987 through 1993, 50 consecutive patients with documented advanced or recurrent en...

journal_title：Gynecologic oncology

authors： Cornelison TL,Baker TR,Piver MS,Driscoll DL

更新日期：1995-11-01 00:00:00

abstract：:A low-molecular-weight glycoprotein containing sequences of the beta subunit of human chorionic gonadotropin (hCG) has been found in the urine of patients with carcinoma of the cervix using an immunoradiometric assay. This fragment has chromatographic and immunological identity with hCG beta core. This molecule was pr...

journal_title：Gynecologic oncology

authors： Norman RJ,Buck RH,Aktar B,Mayet N,Moodley J

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVES:53BP1, a critical mediator of the DNA damage response, functions by regulating the balance between homologous recombination (HR) and the more error-prone non-homologous endjoining (NHEJ). Deletion of 53BP1 in brca1 (but not brca2) null cells partially restores HR and reverses sensitivity to poly-ADP-ribose p...

journal_title：Gynecologic oncology

authors： Pennington KP,Wickramanayake A,Norquist BM,Pennil CC,Garcia RL,Agnew KJ,Taniguchi T,Welcsh P,Swisher EM

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:Although the antiproliferative and differentiating properties of vitamin D have been demonstrated, its effects on cancer cells are variable. Little is known about vitamin D receptor (VDR) levels in patients with ovarian cancer. In this population we sought to determine correlations between VDR expression, cli...

journal_title：Gynecologic oncology

authors： Silvagno F,Poma CB,Realmuto C,Ravarino N,Ramella A,Santoro N,D'Amelio P,Fuso L,Pescarmona G,Zola P

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:The presence of metastases to regional lymph nodes (LN) is the single most important risk factor in endometrial cancer. Advances in molecular biology have provided more sensitive methods for detecting micrometastasis. This was a pilot study to determine whether cytokeratin staining of LN from endometrial canc...

journal_title：Gynecologic oncology

authors： Gonzalez Bosquet J,Keeney GL,Mariani A,Webb MJ,Cliby WA

更新日期：2003-12-01 00:00:00

abstract：:To determine the effects of neoadjuvant chemotherapy (NAC) in the management of cervical carcinoma Stage IB2 (tumor diameter > 4 cm), we reviewed 52 surgically treated patients diagnosed between January 1987 and December 1993. There were 20 patients treated with preoperative neoadjuvant chemotherapy and 32 treated by ...

journal_title：Gynecologic oncology

authors： Serur E,Mathews RP,Gates J,Levine P,Maiman M,Remy JC

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVES:In this study, we analyzed the PTEN expression in a large collection of clear cell adenocarcinomas of the ovary. Furthermore, we analyzed the expression of cyclin D1 and p27, and investigated the correlation among all these variables. METHODS:Totally, 40 clear cell adenocarcinomas were included in this stud...

journal_title：Gynecologic oncology

authors： Hashiguchi Y,Tsuda H,Inoue T,Berkowitz RS,Mok SC

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Diaphragm involvement by ovarian cancer is often considered to be a major obstacle to successful cytoreductive surgery. Lack of evidence of survival benefit, concerns over safety and lack of experience are common justifications for this belief. In this study, we sought to evaluate the therapeutic value of di...

journal_title：Gynecologic oncology

authors： Aletti GD,Dowdy SC,Podratz KC,Cliby WA

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:To evaluate c-erbB2 gene amplification in a series of primary uterine serous carcinoma (USC) cell lines. To assess the efficacy of AZD8055, a novel dual mTORC1/2 inhibitor against primary HER2/neu amplified vs HER2/neu not amplified USC cell lines. METHODS:Twenty-two primary USC cell lines were evaluated for...

journal_title：Gynecologic oncology

authors： English DP,Roque DM,Carrara L,Lopez S,Bellone S,Cocco E,Bortolomai I,Schwartz PE,Rutherford T,Santin AD

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:It has been postulated that gemcitabine inhibits DNA repair, and platinum resistance is due to increased DNA repair activity. The addition of gemcitabine to platinum-based agents may have synergistic tumoricidal activity. METHODS:Retrospective chart review of all patients with recurrent, persistent, or progr...

journal_title：Gynecologic oncology

authors： Villella J,Marchetti D,Odunsi K,Rodabaugh K,Driscoll DL,Lele S

更新日期：2004-12-01 00:00:00

abstract：:Ninety-two patients with early invasive carcinoma of the cervix (5 mm or less) treated between July 1977 and June 1990 are reviewed. Eighty patients had squamous cell carcinomas and 12 had adenocarcinomas. The diagnosis was established by conization in 77 of 92 (83.6%) patients. Thirty-six patients (39%) had a depth o...

journal_title：Gynecologic oncology

authors： Jones WB,Mercer GO,Lewis JL Jr,Rubin SC,Hoskins WJ

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:Overexpression of the tyrosine kinase receptor erbB-2 is important in the pathogenesis of a variety of neoplasms including ovarian cancer. As a strategy to selectively eradicate erbB-2-overexpressing tumor cells, an anti-erbB-2 single-chain immunoglobin (sFv) gene was constructed to direct expression of intra...

journal_title：Gynecologic oncology

authors： Deshane J,Cabrera G,Grim JE,Siegal GP,Pike J,Alvarez RD,Curiel DT

更新日期：1995-10-01 00:00:00

abstract：:Significant vaginal discharge of clear fluid after Wertheim-Taussig hysterectomy with bilateral salpingo-oophorectomy is most often due to urinary fistula. Rarely, the same symptom may be caused by lymphatic fistula, which has not been reported previously. The differentiation between lymph and urine is simple. If this...

journal_title：Gynecologic oncology

authors： Lau TK,Wong WS

更新日期：1994-03-01 00:00:00