Abstract：
:Inositol polyphosphate 4-phosphatase type II (INPP4B) is a phosphoinositide phosphatase that plays complex roles in the pathogenesis of different tumors. We aimed to explore the expression, clinicopathological significance, and prognostic value of INPP4B in oral squamous cell carcinoma (OSCC). Tissue microarrays that included samples from 176 primary OSCCs, 42 normal mucosae, and 69 dysplastic tissues were used for immunostaining analyses of INPP4B protein. Aperio ScanScope CS scanner and aperio quantification software were used to scan the microarrays and score the staining, respectively. We also evaluated the correlation between INPP4B expression and clinical parameters, pathological grades, node-positive status, and immune-related markers. Expression of INPP4B was statistically significantly upregulated in human primary OSCC tissues compared with dysplastic and normal tissues. Additionally, we found that patients with strong expression of INPP4B had a statistically significantly poorer overall survival than patients with weak expression of INPP4B. Furthermore, our study indicated that expression of INPP4B in OSCC was positively associated with expression of p-S6Ser235/236 , p-CADSer1859 , and certain immune checkpoints (B7-H4, Galectin-9). Therefore, INPP4B may be an independent prognostic indicator for patients with OSCC, in which it might function as an oncoprotein.
journal_name
Eur J Oral Scijournal_title
European journal of oral sciencesauthors
Yang QC,Li H,Xiao Y,Wu CC,Yang SC,Sun ZJdoi
10.1111/eos.12673subject
Has Abstractpub_date
2020-02-01 00:00:00pages
37-45issue
1eissn
0909-8836issn
1600-0722journal_volume
128pub_type
杂志文章abstract：:The objective of this study was twofold, namely to evaluate the effectiveness of a dental clinical practice guideline on the management of asymptomatic impacted lower third molars (i) on referral rates and (ii) on dentists' change in knowledge. A two-arm cluster randomized controlled trial, with pre- and post-test ass...
journal_title：European journal of oral sciences
pub_type： 杂志文章,随机对照试验
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abstract：:Fluid and ion secretion from the submandibular gland (SMG) is mainly regulated by parasympathetic nerves. This study evaluated the effect of parasympathectomy on salivary secretion from normal and irradiated rat SMGs from 1 to 24 wk after denervation. Although stimulated salivary secretion was significantly lower in d...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12330
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abstract：:Relaxin (Rln) is an ovarian hormone that stimulates osteoclastic and osteoblastic activities and connective tissue turnover. To investigate the expression of Rln during orthodontic tooth movement, rats were implanted with orthodontic appliances that connected a spring from the upper incisors to the first molar with a ...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2011.00814.x
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journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1034/j.1600-0722.2003.00016.x
更新日期：2003-04-01 00:00:00
abstract：:The aim of this study was to compare the oral health-related behaviors of unemployed people with those of employed people and to assess whether they differ according to the length of unemployment. This study is part of the Health 2000 Survey in Finland. The cross-sectional data were based on interviews and questionnai...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12276
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journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2011.00870.x
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abstract：:Temporomandibular joint (TMJ) histology was investigated in 8 female Scandinavian moose. 5 were 1-year-old with a carcass weight (cw) of 125-140 kg, and 3 were 2-years-old (160-175 kg cw). The condylar articular surface consisted of a connective tissue lining with parallel collagen fibres. Numerous blood vessels were ...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.1996.tb00146.x
更新日期：1996-10-01 00:00:00
abstract：:Periodontitis progresses due to increased levels of active metalloproteinases (MMPs) and the imbalance between MMPs and their tissue inhibitors (TIMPs). Natural curcumin limits the lytic activity of MMPs but has low cellular uptake. Use of synthetic curcumin analogs could be a means of overcoming this limitation of tr...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12625
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journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.1998.tb02180.x
更新日期：1998-01-01 00:00:00
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journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2012.00942.x
更新日期：2012-04-01 00:00:00
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journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2007.00445.x
更新日期：2007-06-01 00:00:00
abstract：:RhoA plays a fundamental role in regulation of the actin cytoskeleton, intercellular attachment, and cell proliferation. During amelogenesis, ameloblasts (which produce the enamel proteins) undergo dramatic cytoskeletal changes and the RhoA protein level is up-regulated. Transgenic mice were generated that express a d...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12059
更新日期：2013-08-01 00:00:00
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journal_title：European journal of oral sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-0722.1995.tb01867.x
更新日期：1995-12-01 00:00:00
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journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1034/j.1600-0722.2003.00064.x
更新日期：2003-10-01 00:00:00
abstract：:Viridans streptococci possess a family of immunologically and structurally related cell-surface proteins, termed antigen I/II, which may function as adhesins and enable oral streptococci to adhere to saliva-coated surfaces and matrix proteins. Here we used atomic force microscopy in the molecular force mode to measure...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2010.00785.x
更新日期：2010-12-01 00:00:00
abstract：:Subsurface demineralization in enamel caries is known to entail diffusion of reagents and products both within the lesion and within the plaque biofilm external to the lesion. However, development of a predictive mathematical model for subsurface demineralization is hindered by limited quantitative understanding of th...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2005.00188.x
更新日期：2005-02-01 00:00:00
abstract：:The Enamel Defects Index (EDI) was created based on three innovative principles: (i) a basic level of the three major categories of defects; (ii) more detailed subcategories of each major category; and (iii) each category scored independently as present [1] or absent [0], simplifying decision making. The aim of this i...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2006.00294.x
更新日期：2006-05-01 00:00:00
abstract：:Native and recombinant human bone morphogenetic/osteogenic proteins (BMPs/ OPs) singly initiate bone induction in vivo. The finding of synchronous but spatially different BMPs/OPs expression during periodontal tissue morphogenesis suggests novel therapeutic approaches using morphogen combinations based on recapitulati...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1034/j.1600-0722.2001.00041.x
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journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1034/j.1600-0722.2001.00092.x
更新日期：2001-10-01 00:00:00
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journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2008.00556.x
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journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2011.00888.x
更新日期：2011-12-01 00:00:00
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journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1046/j.0909-8836.1998.eos106406.x
更新日期：1998-08-01 00:00:00
abstract：:This method was designed to quantify root resorption on human premolar root surfaces induced by orthodontic forces by volume. Light (25 g) or heavy (225 g) orthodontic forces were applied to 20 first maxillary premolars in 10 human subjects. The contralateral teeth of the subjects served as controls. All teeth were ex...
journal_title：European journal of oral sciences
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-04-01 00:00:00
abstract：:In this study, the clinical and radiographic material of two groups of 17- and 20-yr-old adolescents, born either in 1970 or in 1976, was compared to study changes in the prevalence of occlusal dentine caries and to determine the additional value of the bitewing radiographs. The first and second molars of 478 particip...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1034/j.1600-0722.2000.00791.x
更新日期：2000-04-01 00:00:00
abstract：:Resin infiltration of non-cavitated proximal caries lesions has been shown to inhibit further demineralization. However, the effect of resin infiltration in cavitated lesions is unknown. Therefore, the aim of this in vitro study was to evaluate infiltration patterns of proximal caries lesions differing in Internationa...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2011.00807.x
更新日期：2011-04-01 00:00:00
abstract：:The authors investigated the effects of felypressin (Fely), a non-adrenergic vasoconstrictor, used together with prilocaine on myocardial oxygen balance. Six open-chest dogs were studied under urethane and alpha-chloralose anesthesia. Systolic arterial pressure, diastolic arterial pressure, mean pulmonary arterial pre...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1034/j.1600-0722.2003.00050.x
更新日期：2003-08-01 00:00:00
abstract：:The aim of this investigation was to study the intraoral pH response on tooth surfaces in relation to dental erosion during and after drinking a sugar-free cola-type soft drink. Six different methods of drinking were tested in a randomized order: holding; short-sipping; long-sipping; gulping; nipping; and sucking. Two...
journal_title：European journal of oral sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-0722.2004.00172.x
更新日期：2004-12-01 00:00:00
abstract：:The aim of this study was to determine the effect of interleukin-10 (IL-10) on the gene expression of osteoclastogenic regulatory molecules in rat dental follicle cells. Interleukin-10 is an anti-inflammatory cytokine that inhibits alveolar bone resorption, but the molecular basis for this is unknown. Alveolar bone re...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2006.00283.x
更新日期：2006-02-01 00:00:00
abstract：:Aesthetic alternatives to stainless-steel crowns for restoring primary molars attain growing interest. We studied the mechanical properties of prefabricated zirconia crowns and conventional crowns. Three brands of prefabricated zirconia crowns were compared with computer-aided design/computer-aided manufacturing (CAD/...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/eos.12645
更新日期：2019-08-01 00:00:00
abstract：:The aims of this study were to evaluate the flexural strength of two different types of glass fibre-reinforced posts bonded to dual-cure composite resin cements. Forty glass methacrylate-based fibre posts (GC Fiber Post) and 20 glass fibre inter-polymerizing network posts (everStick POST) were divided into three group...
journal_title：European journal of oral sciences
pub_type： 杂志文章
doi：10.1111/j.1600-0722.2010.00721.x
更新日期：2010-04-01 00:00:00
