Abstract:
:Unitary excitatory (EPSP) and inhibitory (IPSP) postsynaptic potentials (PSPs) were evoked between neurons in Rexed's laminae (L)II-V of spinal slices from young hamsters (7-24 days old) at 27°C using paired whole cell recordings. Laminar differences in synaptic efficacy were observed: excitatory connections were more secure than inhibitory connections in LII and inhibitory linkages in LII were less reliable than those in LIII-V. A majority of connections displayed paired-pulse facilitation or depression. Depression was observed for both EPSPs and IPSPs, but facilitation was seen almost exclusively for IPSPs. There were no frequency-dependent shifts between facilitation and depression. Synaptic depression was associated with an increased failure rate and decreased PSP half-width for a majority of connections. However, there were no consistent changes in failure rate or PSP time course at facilitating connections. IPSPs evoked at high-failure synapses had consistently smaller amplitude and showed greater facilitation than low-failure connections. Facilitation at inhibitory connections was positively correlated with synaptic jitter and associated with a decrease in latency. At many connections, the paired-pulse ratio varied from trial to trial and depended on the amplitude of the first PSP; dependence was greater for inhibitory synapses than excitatory synapses. Paired-pulse ratios for connections onto neurons with rapidly adapting, "phasic" discharge to depolarizing current injection were significantly greater than for connections onto neurons with tonic discharge properties. These results are evidence of diversity in synaptic transmission between dorsal horn neurons, the nature of which may depend on the types of linkage, laminar location, and intrinsic firing properties of postsynaptic cells.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Zhang W,Schneider SPdoi
10.1152/jn.00684.2010subject
Has Abstractpub_date
2011-06-01 00:00:00pages
2920-30issue
6eissn
0022-3077issn
1522-1598pii
jn.00684.2010journal_volume
105pub_type
杂志文章abstract::Retinal degeneration (rd) leads to progressive photoreceptor cell death, resulting in vision loss. Stimulation of the inner-retinal neurons by neuroprosthetic implants is one of the clinically approved vision-restoration strategies, providing basic visual percepts to blind patients. However, little is understood as to...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01095.2015
更新日期:2016-10-01 00:00:00
abstract::Recent evidence implicates the superior colliculus (SC) in cognitive processes, such as target selection and control of spatial attention, in addition to the execution of saccadic eye movements. We report here the presence of a cognitive response in some cells in the SC in a task that requires the long-term associatio...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01071.2005
更新日期:2006-06-01 00:00:00
abstract::We developed a sway-referenced system for sitting to highlight the role of vestibular and visual contributions to trunk control. Motor control was investigated by measuring trunk kinematics in the frontal plane while manipulating visual availability and introducing a concurrent cognitive task. We examined motor learni...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00330.2017
更新日期:2018-07-01 00:00:00
abstract::1. Adult rats and rats with a postnatal age of 3-29 days (PN 3-29) were used for the preparation of in vitro slices of the frontal neocortex. Epileptiform activity was induced by bath application of the gamma-aminobutyric acid-A (GABAA) receptor antagonists bicuculline or picrotoxin. 2. The voltage-sensitive dye RH 41...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.4.1756
更新日期:1994-10-01 00:00:00
abstract::Arrays of closely spaced quartz-insulated, platinum-tungsten microelectrodes are widely used to obtain acute recordings from chronically prepared subjects. These electrodes have excellent recording characteristics and can be fabricated to a wide variety of tip specifications. Typically, in such experiments, electrodes...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01141.2004
更新日期:2005-05-01 00:00:00
abstract::1. Presynaptic activity of identified primary afferents from flexor, extensor, and bifunctional hindlimb muscles was studied with intra-axonal recordings during fictive locomotion. Fictive locomotion appeared spontaneously in decorticate cats (n = 9), with stimulation of the mesencephalic locomotor region (n = 4), and...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1991.65.4.914
更新日期:1991-04-01 00:00:00
abstract::Substance P (SP) hyperpolarizes approximately 80% of ferret vagal sensory neurons (nodose ganglion neurons) via NK-1 receptor-mediated activation of a potassium current (IK). A depolarizing current activated by membrane hyperpolarization could minimize the SP-induced hyperpolarization. Such a current exists in 65% of ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.2.769
更新日期:1998-02-01 00:00:00
abstract::The central axons of peripherally regenerated Abeta primary sensory neurons were impaled in the dorsal columns of alpha-chloralose-anesthetized cats 9-12 mo after axotomy. The adequate peripheral stimulus was determined, and the afferent fibers intracellularly stimulated while simultaneously recording the resulting co...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.4.1636
更新日期:1999-04-01 00:00:00
abstract::The performance of neural codes to represent attributes of sensory signals has been evaluated in the vertebrate peripheral and central nervous system. Here, we determine how information signaled by populations of neurons is modified by plasticity. Suprathreshold neuronal responses from a large number of neurons were r...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01001.2010
更新日期:2011-09-01 00:00:00
abstract::Although previous research with human and nonhuman primates has examined the neural correlates of performance monitoring, discrepancies in methodology have limited our ability to make cross-species generalizations. One major obstacle arises from the use of different behavioral responses and tasks across different prim...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00803.2011
更新日期:2012-05-01 00:00:00
abstract::The visual world presents multiple potential targets that can be brought to the fovea by saccadic eye movements. These targets produce activity at multiple sites on a movement map in the superior colliculus (SC), an area of the brain related to saccade generation. The saccade made must result from competition between ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01151.2002
更新日期:2003-09-01 00:00:00
abstract::1. B31 and B32 are pattern-initiator neurons in the buccal ganglia of Aplysia. Along with the B61/B62 neurons, B31/B32 are also motor neurons that innervate the 12 buccal muscle via the I2 nerve. This research was aimed at determining the physiological functions of the B31/B32 and B61/B62 neurons, and of the I2 muscle...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.75.4.1309
更新日期:1996-04-01 00:00:00
abstract::The structural elements of the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) signaling pathway have been described in the vestibular peripheral system. However, the functions of NO in the vestibular endorgans are still not clear. We evaluated the action of NO on the Ca(2+) currents in hair cells isolated from ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00849.2006
更新日期:2007-02-01 00:00:00
abstract::It was recently shown that repeated heat stimulation, using brief contacts (<1 s) with a preheated thermode at sufficiently short interstimulus intervals (ISIs <5 s) and high temperatures (> or =51 degrees C), will elicit in humans a sensation of rapidly augmenting "second" (burning) pain with only a weak "first" (sha...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00578.2001
更新日期:2002-04-01 00:00:00
abstract::1. The response to an optimally oriented stimulus of both simple and complex cells in the cat's striate visual cortex (area 17) can be suppressed by the superposition of an orthogonally oriented drifting grating. This effect is referred to as cross-orientation suppression. We have examined the spatial organization and...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.1.144
更新日期:1992-07-01 00:00:00
abstract::A pair of antagonistic thermoreceptive cells is associated with each of two peg-in-pit sensilla located on the antennal tip of Aedes aegypti. One, the warm cell, responds to rapid warming with a sudden increase in the rate of discharge. The other, a cold cell, responds to rapid cooling with a sudden increase in the di...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01164.2004
更新日期:2005-07-01 00:00:00
abstract::We developed a physiologically realistic mathematical model of the Golgi tendon organ (GTO) whose elements correspond to anatomical features of the biological receptor. The mechanical interactions of these elements enable it to capture all salient aspects of GTO afferent behavior reported in the literature. The model ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00869.2005
更新日期:2006-10-01 00:00:00
abstract::Rhythmic movements of the gastric mill and pyloric regions of the crustacean foregut are controlled by two stomatogastric neuronal networks that have been intensively studied in vitro. By using electromyographic recordings from the European lobster, Homarus gammarus, we have monitored simultaneously the motor activity...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.3.1396
更新日期:1998-03-01 00:00:00
abstract::1. The purpose of this study is to define the cortical regions that subserve voluntary saccadic eye movements and spatial working memory in humans. 2. Regional cerebral blood flow (rCBF) during performance of oculomotor tasks was measured with [15O]-H2O positron emission tomography (PET). Eleven well-trained, healthy ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.75.1.454
更新日期:1996-01-01 00:00:00
abstract::Dual whole-cell patch clamp recordings from the soma and dendrites of CA1 pyramidal neurons located in hippocampal slices of adult rats were used to examine the potential mechanisms of phase precession. To mimic phasic synaptic input, 5-Hz sine wave current injections were simultaneously delivered both to the soma and...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.1.528
更新日期:2001-07-01 00:00:00
abstract::Acetic acid applied to the hind limb of a frog evokes nocifensive behaviors, including a vigorous wiping of the exposed skin, referred to as the wiping response. The aim of this study was to examine the responses of cutaneous primary afferent fibers in frogs to acetic acid (pH 2.84-1.42) applied topically to the skin....
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00324.2003
更新日期:2003-08-01 00:00:00
abstract::Inner ear hair cell afferent fiber synapses are capable of transferring information at high rates for long periods of time with extraordinary fidelity. As at other sensory synapses, hair cells rely on graded receptor potentials and unique vesicle trafficking and release properties of ribbon synapses to relay intensity...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00121.2013
更新日期:2013-07-01 00:00:00
abstract::There is mounting evidence for the idea that performance in a visuomotor rotation task can be supported by both implicit and explicit forms of learning. The implicit component of learning has been well characterized in previous experiments and is thought to arise from the adaptation of an internal model driven by sens...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00009.2015
更新日期:2015-06-01 00:00:00
abstract::Basal ganglia circuits are organized as parallel loops that have been proposed to compete in a winner-take-all fashion to determine the appropriate behavioral outcome. However, limited experimental support for strong lateral inhibition mechanisms within striatal regions questions this model. Here, stimulation of the p...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.91002.2008
更新日期:2009-04-01 00:00:00
abstract::In the main olfactory bulb, several populations of granule cells (GCs) can be distinguished based on the soma location either superficially, interspersed with mitral cells within the mitral cell layer (MCL), or deeper, within the GC layer (GCL). Little is known about the physiological properties of superficial GCs (sG...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01202.2006
更新日期:2007-04-01 00:00:00
abstract::The computational role of the olfactory bulb remains a mystery after 60 yr of physiological research. Recently, Fantana and colleagues proposed a new model of bulb function based on sparse inhibitory connections between glomeruli, the functional units of the bulb, rather than the existing lateral inhibition model. I p...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.91146.2008
更新日期:2009-01-01 00:00:00
abstract::Beyond being essential for long-term motor-skill development, movement repetition has immediate benefits on performance, increasing speed and accuracy of a second execution. While repetition effects have been reported for single reaching movements, it has yet to be determined whether they also occur for movement seque...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00054.2020
更新日期:2020-05-01 00:00:00
abstract::Mg2+-extrusion from Mg2+-loaded neurons of the leech, Hirudo medicinalis, is mediated mainly by Na+/Mg2+ antiport. However, in a number of leech neurons, Mg2+ is extruded in the nominal absence of extracellular Na+, indicating the existence of an additional, Na+-independent Mg2+ transport mechanism. This mechanism was...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01221.2004
更新日期:2005-07-01 00:00:00
abstract::Rack and Westbury showed that low-frequency asynchronous stimulation of a muscle produces greater force compared with synchronous stimulation. This study tested the hypothesis that the difference results from the dynamic stretch of the common elastic elements. In eight anesthetized cats, the soleus was attached to a s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01304.2005
更新日期:2006-09-01 00:00:00
abstract::Cellular mechanisms underlying learning and memory were investigated in the octopus using a brain slice preparation of the vertical lobe, an area of the octopus brain involved in learning and memory. Field potential recordings revealed long-term potentiation (LTP) of glutamatergic synaptic field potentials similar to ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00645.2003
更新日期:2003-11-01 00:00:00