PhenX: Agent measures for tobacco regulatory research.

Abstract:

:The current paper describes the PhenX (Phenotypes and eXposures) Toolkit Tobacco Regulatory Research Agent specialty area and the Agent Working Group's (WG's) 6-month consensus process to identify high-priority, scientifically supported measures for cross-study comparison and analysis. Eleven measures were selected for inclusion in the Toolkit. Eight of these are interviewer-administered or self-administered protocols: history of switching to lower tar and nicotine cigarettes, passive exposures to tobacco products, tobacco brand and variety (covering cigars, cigarettes and smokeless tobacco separately), tobacco product adulteration (vent-blocking or filter-blocking) and tobacco warning label exposure and recall. The remaining three protocols are either laboratory-based or visual inspection-based: measurement of nicotine content in smoked or smokeless tobacco products and the physical properties of these two classes of products. Supplemental protocols include a biomarker of exposure and smoking topography. The WG identified the lack of standard measurement protocols to assess subjective ratings of tobacco product flavours and their appeal to consumers as a major gap. As the characteristics of tobacco products that influence perception and use are tobacco regulatory research priorities, the reliable assessment of flavours remains an area requiring further development.

journal_name

Tob Control

journal_title

Tobacco control

authors

O'Connor R,Watson CH,Swan GE,Nettles DS,Geisler RC,Hendershot TP,PhenX TRR Agent Working Group.

doi

10.1136/tobaccocontrol-2019-054976

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

s20-s26

issue

Suppl 1

eissn

0964-4563

issn

1468-3318

pii

tobaccocontrol-2019-054976

journal_volume

29

pub_type

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