Abstract:
:The current paper describes the PhenX (Phenotypes and eXposures) Toolkit Tobacco Regulatory Research Agent specialty area and the Agent Working Group's (WG's) 6-month consensus process to identify high-priority, scientifically supported measures for cross-study comparison and analysis. Eleven measures were selected for inclusion in the Toolkit. Eight of these are interviewer-administered or self-administered protocols: history of switching to lower tar and nicotine cigarettes, passive exposures to tobacco products, tobacco brand and variety (covering cigars, cigarettes and smokeless tobacco separately), tobacco product adulteration (vent-blocking or filter-blocking) and tobacco warning label exposure and recall. The remaining three protocols are either laboratory-based or visual inspection-based: measurement of nicotine content in smoked or smokeless tobacco products and the physical properties of these two classes of products. Supplemental protocols include a biomarker of exposure and smoking topography. The WG identified the lack of standard measurement protocols to assess subjective ratings of tobacco product flavours and their appeal to consumers as a major gap. As the characteristics of tobacco products that influence perception and use are tobacco regulatory research priorities, the reliable assessment of flavours remains an area requiring further development.
journal_name
Tob Controljournal_title
Tobacco controlauthors
O'Connor R,Watson CH,Swan GE,Nettles DS,Geisler RC,Hendershot TP,PhenX TRR Agent Working Group.doi
10.1136/tobaccocontrol-2019-054976subject
Has Abstractpub_date
2020-01-01 00:00:00pages
s20-s26issue
Suppl 1eissn
0964-4563issn
1468-3318pii
tobaccocontrol-2019-054976journal_volume
29pub_type
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