Abstract:
BACKGROUND AND AIM:As a newly identified subset of T helper cells, T-helper 17 cells (Th17) are major mediators of inflammation-associated disease. Some reports have revealed significantly increased Th17 cells in hepatitis B virus-infected patients, and a recent study has demonstrated that hepatitis C virus (HCV)-specific Th17 cells can be induced in vitro and regulated by transforming growth factor-β. This study attempted to characterize the role of Th17 cells in the disease progression of chronic hepatitis C (CHC). METHODS:The current study enrolled 53 patients with CHC and 23 healthy controls, in which the circulating and liver-infiltrating Th17 cells were monitored. RESULTS:We found that CHC patients had increased proportions of both circulating and liver-infiltrating Th17 cells compared to healthy individuals, and both measures of Th17 cells were correlated with severity of liver inflammation. We further demonstrated that the HCV-specific Th17 cells were correlated with liver damage but not HCV viral replication. CONCLUSIONS:Such a correlation between the severity of liver damage of CHC and Th17 cells illustrated in this study sheds some light on the understanding of the pathogenesis of CHC.
journal_name
J Gastroenterol Hepatoljournal_title
Journal of gastroenterology and hepatologyauthors
Chang Q,Wang YK,Zhao Q,Wang CZ,Hu YZ,Wu BYdoi
10.1111/j.1440-1746.2011.06782.xsubject
Has Abstractpub_date
2012-02-01 00:00:00pages
273-8issue
2eissn
0815-9319issn
1440-1746journal_volume
27pub_type
杂志文章abstract:BACKGROUND AND AIM:Celiac disease (CD) is emerging in Asia. While a few population-based studies from Asia have reported a prevalence of CD from 0.1% to 1.3%, the exact prevalence of CD in Asia is not known. We conducted a systematic review and meta-analysis to estimate the prevalence of CD in Asia. METHODS:On search ...
journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章,meta分析,评审
doi:10.1111/jgh.13270
更新日期:2016-06-01 00:00:00
abstract::Previous research from this laboratory using a continuous enteral ethanol (EtOH) administration model demonstrated that Kupffer cells are pivotal in the development of EtOH-induced liver injury. When Kupffer cells were destroyed using gadolinium chloride (GdCl3 ) or the gut was sterilized with polymyxin B and neomycin...
journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/jgh.1998.13.s1.39
更新日期:1998-09-01 00:00:00
abstract::Functional dyspepsia (FD) is a common disorder in East and Southeast Asia where subjects experience post prandial fullness/bloating, early satiety, belching, epigastric pain, and/or burning. A subset of patients with FD experience triggers exclusively related to meals, defined as the post prandial distress syndrome in...
journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章,评审
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更新日期:2017-03-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/jgh.13196
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/jgh.15361
更新日期:2020-11-26 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/jgh.15091
更新日期:2020-05-09 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 临床试验,杂志文章
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更新日期:1995-07-01 00:00:00
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doi:10.1111/jgh.13001
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pub_type: 杂志文章
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1046/j.1440-1746.2001.02433.x
更新日期:2001-03-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/j.1440-1746.1993.tb01554.x
更新日期:1993-09-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/j.1440-1746.2004.03545.x
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/j.1440-1746.1990.tb01763.x
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:This study aimed to describe the clinical features, manometric findings, prevalence and incidence of achalasia in Singapore. METHODS:A total of 615 new patients referred for oesophageal manometry between 1989 and 1996 were examined prospectively. Twenty-four men and 25 women fulfilled the manometric and cli...
journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1046/j.1440-1746.1999.01950.x
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) ranks third of all cancer mortalities in Hong Kong. CRC screening can reduce mortality. However, participation in the CRC screening program depends on the knowledge and attitude of the population. The aim of this study is to investigate the knowledge and attitude towards CRC screening...
journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/j.1440-1746.2005.04000.x
更新日期:2006-01-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1111/j.1440-1746.2007.05157.x
更新日期:2008-02-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章,评审
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更新日期:2008-10-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章,meta分析,评审
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更新日期:2009-08-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/j.1440-1746.1995.tb01355.x
更新日期:1995-09-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/jgh.14302
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:By analyzing a tumor growth of hepatocellular carcinoma (HCC) detected in sustained responders (SR) to interferon (IFN) therapy for chronic hepatitis C, we sought to determine the duration of follow up in SR that would be sufficient to detect HCC. In addition, we sought to elucidate the presence of HCC, whic...
journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1046/j.1440-1746.2001.02595.x
更新日期:2001-10-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 临床试验,杂志文章,随机对照试验,评审
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更新日期:1991-09-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1111/j.1440-1746.2009.06147.x
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章,评审
doi:10.1111/jgh.12886
更新日期:2015-05-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1440-1746.2003.03041.x
更新日期:2003-06-01 00:00:00
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journal_title:Journal of gastroenterology and hepatology
pub_type: 杂志文章
doi:10.1046/j.1440-1746.2003.03038.x
更新日期:2003-07-01 00:00:00