Abstract：
:Obesity is a chronic disorder that is associated with body mass index (BMI) of greater or equal to 30 kg/m2. The prevalence of obesity in the Kingdom of Saudi Arabia (KSA) is increasing at an alarming rate and is expected to reach 41% in men and up to 78% in women by 2022. Since chemokines are associated with involuntary weight loss, the objective of this study was to elucidate their association with BMI among Saudis. A questionnaire was used to collect information about diet, health conditions, and demographics from 15 men and 16 women who participated in the study. BMI was calculated based on clinical measurements and participants were classified according to their BMI category as: normal, underweight, overweight, or obese. Serum samples were collected for a multiplex assay using the Human Chemokine Magnetic 30-plex panel. The serum concentration of either the monokine induced by gamma interferon (MIG) or the CXC-motif chemokine ligand 9 (CXCL-9) was significantly increased in obese men (P = 0.0194) and women (P = 0.043) as compared to underweight men and women, respectively. However, the serum levels of other chemokines were not significantly different among the groups. We found that MIG levels are differentially regulated in serum, based on individuals' BMI.
journal_name
Saudi J Biol Scijournal_title
Saudi journal of biological sciencesauthors
Harakeh S,Kalamegam G,Pushparaj PN,Al-Hejin A,Alfadul SM,Al Amri T,Barnawi S,Al Sadoun H,Mirza AA,Azhar Edoi
10.1016/j.sjbs.2019.03.006subject
Has Abstractpub_date
2020-01-01 00:00:00pages
6-11issue
1eissn
1319-562Xissn
2213-7106pii
S1319-562X(19)30040-3journal_volume
27pub_type
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