Care at the edge of viability: medical and ethical issues.

abstract：:Dysphagia and aspiration are commonly encountered problems in the neonatal population. It is often multifactorial in nature and management should be tailored to the individual patient. Multiple causes should be considered, including anatomic abnormalities, neurologic/developmental delay, cardiopulmonary disease/infect...

journal_title：Clinics in perinatology

authors： Raol N,Schrepfer T,Hartnick C

更新日期：2018-12-01 00:00:00

abstract：:Pharmacotherapy for gastroesophageal reflux (GER) in neonates, aimed at interfering with this physiologic process and potentially reducing the negative sequelae that providers often attribute to GER, consists primarily of drugs that increase the viscosity of feeds, reduce stomach acidity, or improve gut motility. Medi...

journal_title：Clinics in perinatology

authors： Malcolm WF,Cotten CM

更新日期：2012-03-01 00:00:00

abstract：:Beta-sympathomimetic agents are used extensively in obstetrics to inhibit premature labor. Knowledge of the pharmacology, mode of action on smooth muscle, and cardiovascular and metabolic side effects of these agents is essential for the obstetrician and perinatologist. This review article draws extensively on recent ...

journal_title：Clinics in perinatology

authors： Nuwayhid B,Rajabi M

更新日期：1987-12-01 00:00:00

abstract：:This article reviews the significance of hypoxic-ischemic encephalopathy and the associated patterns of cerebral injury in the context of the most probable timing of the insult and prognosis. The evolution of the clinical features of significant hypoxic-ischemic encephalopathy, and the diagnostic value of imaging and ...

journal_title：Clinics in perinatology

authors： Hill A,Volpe JJ

更新日期：1989-06-01 00:00:00

abstract：:The development of the flow-directed pulmonary artery catheter in the early 1970s moved invasive monitoring from the laboratory to the patient's bedside. Its current use in obstetrics is directed toward definition of certain pathophysiologic states unique to pregnancy and toward diagnosis and management of critically ...

journal_title：Clinics in perinatology

authors： Hankins GD

更新日期：1986-12-01 00:00:00

abstract：:This article summarizes the commonly used biomarkers currently available for diagnosis of necrotizing enterocolitis. The most exciting advances in diagnostic tests were the use of new nucleic acid sequencing techniques (eg, next-generation sequencing) and molecular screening methods (eg, proteomics and microarray anal...

journal_title：Clinics in perinatology

authors： Ng PC,Chan KY,Poon TC

更新日期：2013-03-01 00:00:00

abstract：:Moderate preterm, late preterm, and early term deliveries represent a major and growing public health concern. These deliveries are associated with significant financial burden and pose serious risks to mothers and newborns. Women who deliver at moderate and late gestational ages in one pregnancy are at increased risk...

journal_title：Clinics in perinatology

authors： Ananth CV,Friedman AM,Gyamfi-Bannerman C

更新日期：2013-12-01 00:00:00

abstract：:Based on the authors' review of the literature on pediatric postoperative pain assessment with special attention to groups of vulnerable infants, this article (1) reports on type of surgery and its relationship to postoperative pain intensity; (2) reviews the characteristics of existing postoperative pain instruments ...

journal_title：Clinics in perinatology

authors： van Dijk M,Peters JW,Bouwmeester NJ,Tibboel D

更新日期：2002-09-01 00:00:00

abstract：:Preterm birth is a major complication of pregnancy and remains a leading cause of neonatal morbidity and mortality worldwide. Improvements in the authors' understanding of the pathophysiology of preterm labor have led to the development of novel diagnostic tools of use to identify women at greatest risk for preterm bi...

journal_title：Clinics in perinatology

authors： Ramsey PS,Andrews WW

更新日期：2003-12-01 00:00:00

abstract：:Using the pregnant woman as a means to medicate her fetus represents a new and exciting therapeutic approach in clinical pharmacology. In years to come, we will see an increase in the use of the currently accepted fetal therapies and an increase in the number of therapies available to the caregiver or clinician aimed ...

journal_title：Clinics in perinatology

authors： Simone C,Derewlany LO,Koren G

更新日期：1994-09-01 00:00:00

abstract：:Although it has been customary to treat neonatal jaundice at lower serum bilirubin levels in low-birth weight infants than in term infants, the threshold bilirubin levels and long-term benefits for early treatment of preterm infants have not been validated. This article summarizes and evaluates existing evidence and s...

journal_title：Clinics in perinatology

authors： Cashore WJ

更新日期：2000-03-01 00:00:00

abstract：:Liquid breathing has been in medical literature for nearly 80 years and has been proposed as a means of improving gas exchange in critically ill infants since the 1970s. Extensive laboratory experience with perfluorochemical liquid ventilation has lead to clinical trials in infants, children, and adults. This article ...

journal_title：Clinics in perinatology

authors： Greenspan JS,Cleary GM,Wolfson MR

更新日期：1998-03-01 00:00:00

abstract：:Rhinitis is extremely common during pregnancy, and asthma is one of the most common potentially serious medical problems to complicate pregnancy. Cutaneous allergy (urticaria/angioedema and eczema) also may occur during pregnancy. All of these entities may worsen with pregnancy in some patients and appear to improve i...

journal_title：Clinics in perinatology

authors： Schatz M,Zeiger RS

更新日期：1997-06-01 00:00:00

abstract：:The percentage of United States cesarean births increased from 20.7% in 1996 to 31.1% in 2006. Cesarean rates increased for women of all ages, race/ethnic groups, and gestational ages and in all states. Both primary and repeat cesareans have increased. Increases in primary cesareans in cases of "no indicated risk" hav...

journal_title：Clinics in perinatology

authors： MacDorman MF,Menacker F,Declercq E

更新日期：2008-06-01 00:00:00

abstract：:The American Academy of Pediatrics supports the feeding of human milk for all infants. Very-low-birth-weight and extremely low-birth-weight infants especially can benefit from the immune and neurodevelopmental effects of human milk. However, human milk alone is nutritionally inadequate for the rapid growth of the very...

journal_title：Clinics in perinatology

authors： Adamkin DH,Radmacher PG

更新日期：2014-06-01 00:00:00

abstract：:A number of ethical considerations arise with regard to screening for, detecting, and managing fetal anomalies. Some of these considerations involve the need to give attention to emotional distress the pregnant woman might be experiencing. The ethical principle of beneficence gives rise to a duty of the obstetrician t...

journal_title：Clinics in perinatology

authors： Strong C

更新日期：2003-03-01 00:00:00

abstract：:Pulmonary hypertension in the perinatal period can present acutely (persistent pulmonary hypertension of the newborn) or chronically. Clinical and echocardiographic diagnosis of acute pulmonary hypertension is well accepted but there are no broadly validated criteria for echocardiographic diagnosis of pulmonary hypert...

journal_title：Clinics in perinatology

authors： Keller RL

更新日期：2016-03-01 00:00:00

abstract：:There is a distinct lack of age-appropriate cardiotonic drugs, and adult derived formulations continue to be administered, without evidence-based knowledge on their dosing, safety, efficacy, and long-term effects. Dopamine remains the most commonly studied and prescribed cardiotonic drug in the neonatal intensive care...

journal_title：Clinics in perinatology

authors： Dempsey E,Rabe H

更新日期：2019-06-01 00:00:00

abstract：:Ultrasonography has increasingly become essential in the practice of obstetrics and gynecology. Its antenatal use is well described in the literature and is a continuing subject of study. However, the use of ultrasonography in the labor and delivery suite has not been the subject of many articles. The purpose of this ...

journal_title：Clinics in perinatology

authors： Benito CW,Guzman ER,Vintzileos AM

更新日期：1996-03-01 00:00:00

abstract：:The neurodevelopmental benefits of breast milk feedings for preterm infants have been controversial. However, the effect on preterm infant neurodevelopment is sustained into childhood. The effects of breast milk feeding during the neonatal period and the duration of breastfeeding display effects on cognition into adol...

journal_title：Clinics in perinatology

authors： Lechner BE,Vohr BR

更新日期：2017-03-01 00:00:00

abstract：:Risk scoring is a quantitative method used to screen populations to identify persons at increased risk of developing a specific adverse health outcome. Risk scoring for preterm birth has taken the form of a simple additive score with risk factors based on clinical experience to sophisticated multivariable risk models ...

journal_title：Clinics in perinatology

authors： Shiono PH,Klebanoff MA

更新日期：1993-03-01 00:00:00

abstract：:The increasing numbers of children born to HIV-infected women poses formidable problems for maternal and child health programs throughout the world. Between 20% and 40% of these children will be infected with HIV and most are expected to die by the age of 5 years as a result. The vast majority of the uninfected childr...

journal_title：Clinics in perinatology

authors： Chin J

更新日期：1994-03-01 00:00:00

abstract：:The management of PPHN entered a new era with the development of inhaled NO therapy for the relief of pulmonary hypertension. The wider application of INO therapy and improved ventilation strategies led to a decrease in the need for invasive life-sustaining therapies such as ECMO. The remarkable advances in the unders...

journal_title：Clinics in perinatology

authors： Konduri GG

更新日期：2004-09-01 00:00:00

abstract：:There is now clear evidence that dietary supplementation of omega-3 fatty acid is essential for normal eye and brain development. Corn oil-based diets induce omega-3 deficiency in preterm infants, affecting retinal responses to light, cortical visual evoked potentials, and behavioral measures of visual acuity. Preterm...

journal_title：Clinics in perinatology

authors： Uauy-Dagach R,Mena P

更新日期：1995-03-01 00:00:00

abstract：:Administrative data research on maternal racial disparities supports 2 broad clinical inferences. First, failure to rescue in terms of both death and severe maternal morbidity likely accounts for a significant proportion of maternal disparities. Second, risk for adverse outcomes by race is generally differential with ...

journal_title：Clinics in perinatology

authors： Friedman A

更新日期：2020-12-01 00:00:00

abstract：:The newborn infant's skin is not a complete barrier to the absorption of externally applied agents, particularly if it is damaged, diseased, or immature. Immaturity is the most important factor that determines percutaneous absorption. Very immature infants in the early neonatal period have a poorly developed epidermis...

journal_title：Clinics in perinatology

authors： Rutter N

更新日期：1987-12-01 00:00:00

abstract：:Staphylococci are common pathogens in the neonatal period. Increased survival of premature infants leads to prolonged hospital stay with associated risk factors for developing invasive staphylococcal disease. Challenges of diagnosing coagulase-negative staphylococcal infections result in conflicting definitions and in...

journal_title：Clinics in perinatology

authors： Blanchard AC,Quach C,Autmizguine J

更新日期：2015-03-01 00:00:00

abstract：:Several limitations and controversies surround the definition of hypotension; however, it remains one of the most common problems faced by neonates. Approximately 15% to 30% of neonates with hypotension fail to respond to volume and/or vasopressor or inotropes. They are considered to have refractory hypotension. Altho...

journal_title：Clinics in perinatology

authors： Kumbhat N,Noori S

更新日期：2020-09-01 00:00:00

abstract：:To understand medical disorders such as obstructive apnea, or pulmonary aspiration, one must understand the many functions performed by the upper airway. These functions include respiration, airway protection at the face, feeding, and regulation of thoracoabdominal pressure. The neuromuscular mechanisms that perform t...

journal_title：Clinics in perinatology

authors： Thach BT

更新日期：1992-12-01 00:00:00

abstract：:Advances in fetal echocardiography are providing highly accurate diagnoses of congenital heart disease prior to delivery, making it possible to plan the delivery-room management of these newborns. Knowledge of the expected transitional circulation occurring with birth and the pathophysiologic implications of congenita...

journal_title：Clinics in perinatology

authors： Johnson BA,Ades A

更新日期：2005-12-01 00:00:00