Biomarkers for prediction and diagnosis of necrotizing enterocolitis.

Abstract:

:This article summarizes the commonly used biomarkers currently available for diagnosis of necrotizing enterocolitis. The most exciting advances in diagnostic tests were the use of new nucleic acid sequencing techniques (eg, next-generation sequencing) and molecular screening methods (eg, proteomics and microarray analysis) for the discovery of novel biomarkers. The new technology platform coupled with stringent protocols of biomarker discovery and validation would enable neonatologists to study biologic systems at a level never before possible and discover unique biomarkers for specific organ injury and/or disease entity.

journal_name

Clin Perinatol

journal_title

Clinics in perinatology

authors

Ng PC,Chan KY,Poon TC

doi

10.1016/j.clp.2012.12.005

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

149-59

issue

1

eissn

0095-5108

issn

1557-9840

pii

S0095-5108(12)00138-8

journal_volume

40

pub_type

杂志文章,评审
  • Regionalization of perinatal care for the United States.

    abstract::A scheme of regionalization is proposed in which a regional perinatal system within a defined geographic area permits access of the high risk mother-fetus and infant to the appropriate level of technology for improved perinatal outcome. ...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章

    doi:

    authors: Merkatz IR,Johnson KG

    更新日期:1976-09-01 00:00:00

  • Optical coherence tomography in retinopathy of prematurity: looking beyond the vessels.

    abstract::Retinopathy of Prematurity (ROP) is a leading cause of childhood blindness in the United States. Optical Coherence Tomography (OCT) is a relatively new imaging technology capable of imaging ocular structures in cross section at high resolution. We present an age-customized approach to perform Spectral Domain OCT in ne...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.clp.2013.02.007

    authors: Maldonado RS,Toth CA

    更新日期:2013-06-01 00:00:00

  • Surgical problems and outcome in infants less than 1000 grams at birth.

    abstract::This study was undertaken to identify the pathologic processes in premature infants weighing less than 1000 gm who require surgery, and the outcome of such operations. These neonates required surgery for NEC and PDA. Congenital anomalies were not encountered in our series. No increased mortality due to surgery was obs...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章

    doi:

    authors: Lemon DG,Wesselhoeft CW Jr,DeLuca FG

    更新日期:1986-06-01 00:00:00

  • Tuberculosis in pregnancy.

    abstract::There were approximately 2 million deaths worldwide from tuberculosis in 1997, 98% of them in developing countries. Factors implicated in the resurgence of tuberculosis in the United States in the late 80s and early 90s included increased immigration from countries with high prevalence, HIV infection, emergence of res...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.clp.2005.04.010

    authors: Laibl VR,Sheffield JS

    更新日期:2005-09-01 00:00:00

  • Current surfactant use in premature infants.

    abstract::Exogenous surfactant therapy has been a significant advance in the management of preterm infants with RDS. It has become established as a standard part of the management of such infants. Both natural and synthetic surfactants lead to clinical improvement and decreased mortality, with natural surfactants having additio...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章

    doi:10.1016/s0095-5108(05)70112-3

    authors: Suresh GK,Soll RF

    更新日期:2001-09-01 00:00:00

  • Asthma and allergy in pregnancy.

    abstract::Rhinitis is extremely common during pregnancy, and asthma is one of the most common potentially serious medical problems to complicate pregnancy. Cutaneous allergy (urticaria/angioedema and eczema) also may occur during pregnancy. All of these entities may worsen with pregnancy in some patients and appear to improve i...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Schatz M,Zeiger RS

    更新日期:1997-06-01 00:00:00

  • Gastrointestinal Endoscopy in the Neonate.

    abstract::Gastrointestinal endoscopy permits direct observation of the alimentary tract, acquisition of mucosal tissue for histopathologic examination, and other diagnostic and therapeutic maneuvers. Endoscopes of appropriate size for many neonates and an expanding array of compatible tools and accessories have broadened what i...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.clp.2020.02.012

    authors: Mezoff EA,Williams KC,Erdman SH

    更新日期:2020-06-01 00:00:00

  • Pain management in newborns.

    abstract::As a standard of care for preterm/term newborns effective pain management may improve their clinical and neurodevelopmental outcomes. Neonatal pain is assessed using context-specific, validated, and objective pain methods, despite the limitations of currently available tools. Therapeutic approaches reducing invasive p...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.clp.2014.08.010

    authors: Hall RW,Anand KJ

    更新日期:2014-12-01 00:00:00

  • Boarder babies and placement in foster care.

    abstract::This article describes the early history of the "boarder baby" phenomenon through the late 1980s and early 1990s. The characteristics of the recent "boarder baby" population and of the problem are described with particular emphasis on the role of alcohol and drug abuse and the historical lack of coordination between h...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章

    doi:

    authors: Maza PL

    更新日期:1999-03-01 00:00:00

  • Medical negligence lawsuits relating to labor and delivery.

    abstract::Most allegations in obstetric lawsuits against obstetrician-gynecologists relate in some manner to the management of labor and delivery; few solely involve perceived flaws in prenatal or postpartum care. Although many of these cases accuse the defendant of not having properly monitored the fetus during labor for signs...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.clp.2007.03.011

    authors: Cohen WR,Schifrin BS

    更新日期:2007-06-01 00:00:00

  • The contribution of experimental models to our understanding of the pathogenesis and treatment of bronchopulmonary dysplasia.

    abstract::The extensive data from animal models of BPD and specific aspects of lung injury have helped to expand and refine the concept of pathogenesis introduced by Northway et al. Given the complexity and heterogeneity of the human illness, it is unreasonable to presume that any single model or research group could elucidate ...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: deLemos RA,Coalson JJ

    更新日期:1992-09-01 00:00:00

  • Maternal education during the perinatal period.

    abstract::The nature of perinatal education has been transformed, reflecting the changes in health care and health care consumers. Because of short maternity stays, the venue of most perinatal education, especially postpartum education, has moved from hospitals to other areas, including the home. In light of conflicting finding...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Standing TS,el-Sabagh N,Brooten D

    更新日期:1998-06-01 00:00:00

  • Thoracoscopic Lobectomy for Congenital Lung Lesions.

    abstract::Congenital lung lesions (CLLs) comprise a heterogeneous group of developmental and histologic entities often diagnosed on screening prenatal ultrasound. Most fetuses with CLL are asymptomatic at birth; however, the risk of malignancy and infection drives the decision to prophylactically resect these lesions. The autho...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.clp.2017.08.003

    authors: Moyer J,Lee H,Vu L

    更新日期:2017-12-01 00:00:00

  • Sleep and brain development.

    abstract::Historically, researchers studying the field of sleep have been divided into two main groups. The first group of sleep studies was based on behaviors and behavioral sleep. The second group of researchers based their studies on electroencephalogram EEG patterns and changes. With technologic advancements, a third group ...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章

    doi:10.1016/j.clp.2006.06.009

    authors: Graven S

    更新日期:2006-09-01 00:00:00

  • Cerebral palsy secondary to perinatal ischemic stroke.

    abstract::Congenital hemiplegia is the most common form of cerebral palsy in children born at term, and stroke is the number one cause. Neonatal ischemic stroke includes perinatal arterial ischemic stroke, presumed pre- or perinatal stroke, and cerebral sinovenous thrombosis, all of which have emerged as important contributors ...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.clp.2006.03.008

    authors: Kirton A,deVeber G

    更新日期:2006-06-01 00:00:00

  • The molecular and genetic mechanisms of neocortex development.

    abstract::This article reviews key recent findings in the field of human cortical development. This development is divided into three major time-dependent phases: neural proliferation of inhibitory and excitatory neurons in spatially distinct regions, migration through multiple cellular boundaries, and maturation through morpho...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.clp.2009.06.008

    authors: Diaz AL,Gleeson JG

    更新日期:2009-09-01 00:00:00

  • Multiple gestation: the role of multifetal pregnancy reduction and selective termination.

    abstract::With the increased use of fertility agents and the transfer of multiple embryos, multifetal gestations have increased in number. As the number of fetuses increases, the probability of premature birth and delivery does. The role of multifetal pregnancy reduction and selective termination is reviewed. ...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Evans MI,Littmann L,King M,Fletcher JC

    更新日期:1992-06-01 00:00:00

  • Relationship of intrapartum and delivery room events to long-term neurologic outcome.

    abstract::Our current ability to predict neurologic outcome based on intrapartum information is very limited. Adding information on neurologic state during the first days of life adds powerfully to the ability to predict long-term outcome. Further enhancement of predictive abilities will require putting together into single stu...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Nelson KB

    更新日期:1989-12-01 00:00:00

  • Digitalis, digitalis antibodies, digitalis-like immunoreactive substances, and sodium homeostasis: a review.

    abstract::Most pharmacokinetic and biologic attributes of digitalis are age dependent. They are determined in great measure by the chemical structure of the specific cardiac glycoside being used. These effects differ in the intact normal circulation and in heart failure because of the altered autonomic nervous system and hormon...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Hastreiter AR,John EG,van der Horst RL

    更新日期:1988-09-01 00:00:00

  • Infection in late preterm infants.

    abstract::Late preterm neonates have unique susceptibilities to infection. The closed setting of the neonatal ICU (NICU) and the immunologic immaturity of premature infants set the state for the development of nosocomial infections. This article discusses infections that might be seen in this population and gives options for di...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.clp.2006.09.005

    authors: Benjamin DK Jr,Stoll BJ

    更新日期:2006-12-01 00:00:00

  • Neutropenia in the neonate.

    abstract::Neutropenia, a below normal concentration of neutrophils in the circulating blood, can be the kinetic result of diminished neutrophil production, excessive neutrophil margination, or accelerated neutrophil utilization and destruction. The significance of neutropenia to the well-being of the subject is dependent, in pa...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: al-Mulla ZS,Christensen RD

    更新日期:1995-09-01 00:00:00

  • Posterior nuchal cystic hygroma.

    abstract::When cystic hygroma is detected antenatally, the prognosis is usually poor, and intrauterine or neonatal death are common. This seems especially true for Turner syndrome (the largest etiologic group associated with cystic hygroma) and the lethal multiple pterygium syndromes. However, some fetuses with Turner syndrome,...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Edwards MJ,Graham JM Jr

    更新日期:1990-09-01 00:00:00

  • Short bowel syndrome.

    abstract::This article discusses the management of short bowel syndrome during the neonatal period. It includes information regarding etiology and pathophysiology and parenteral and enteral nutrition therapy. Finally, a discussion of the role of intestinal transplantation in the treatment of short bowel syndrome is included. ...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Vanderhoof JA

    更新日期:1996-06-01 00:00:00

  • Perinatal arrhythmias: diagnosis and management.

    abstract::The final common pathway to death in all of us is an arrhythmia, yet we still know far too little about the contribution of conduction abnormalities and arrhythmias to the compromised states of the human fetus. At no other time in the human life cycle is the human being at more risk of unexplained and unexpected death...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.clp.2007.10.002

    authors: Strasburger JF,Cheulkar B,Wichman HJ

    更新日期:2007-12-01 00:00:00

  • Cesarean birth in the United States: epidemiology, trends, and outcomes.

    abstract::The percentage of United States cesarean births increased from 20.7% in 1996 to 31.1% in 2006. Cesarean rates increased for women of all ages, race/ethnic groups, and gestational ages and in all states. Both primary and repeat cesareans have increased. Increases in primary cesareans in cases of "no indicated risk" hav...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.clp.2008.03.007

    authors: MacDorman MF,Menacker F,Declercq E

    更新日期:2008-06-01 00:00:00

  • Congenital lobar emphysema.

    abstract::Congenital lobar emphysema is an uncommon but potentially life-threatening cause of respiratory distress in the newborn. The clinical picture and radiologic findings are diagnostic. Lobectomy in the distressed neonate is curative. In infants with onset of symptoms between one and four months of age surgery may not be ...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章

    doi:

    authors: Buckner DM

    更新日期:1978-03-01 00:00:00

  • Distributive justice across generations. Epidemiology of ICU care for the very young and the very old.

    abstract::Babies of extremely low birthweight and elderly adults both require expensive and scarce resources, and both have a relatively poor prognosis for survival if they require intensive care. Thus, proposals for rationing often target one or both of these groups. We suspected that although mortality rates might be higher i...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章

    doi:

    authors: Meadow W,Lantos JD,Mokalla M,Reimshisel T

    更新日期:1996-09-01 00:00:00

  • Kidney disease and pregnancy: obstetric outcome and long-term renal prognosis.

    abstract::In patients with chronic renal disease, all advice and decisions must take into account the balance between pregnancy outcome and the long-term impact that pregnancy might have on the disease. To help the clinician address these concerns, the authors focus on the renal changes in normal pregnancy, the problems of chro...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Davison JM,Katz AI,Lindheimer MD

    更新日期:1985-10-01 00:00:00

  • Role of innate host defenses in susceptibility to early-onset neonatal sepsis.

    abstract::Neonatal sepsis continues to take a devastating toll globally. Although adequate to protect against invasive infection in most newborns, the distinct function of neonatal innate host defense coupled with impairments in adaptive immune responses increases the likelihood of acquiring infection early in life, with subseq...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.clp.2010.04.001

    authors: Wynn JL,Levy O

    更新日期:2010-06-01 00:00:00

  • Obstetrics: basic equipment needs.

    abstract::The enunciation of equipment requirements has been attempted as needs appear today. Detailed and technical specifications for some of this equipment must be understood prior to major acquisitions. An awareness of current trends in clinical research can often be obtained from appropriate consultants which should forest...

    journal_title:Clinics in perinatology

    pub_type: 杂志文章

    doi:

    authors: Paul RH

    更新日期:1976-09-01 00:00:00