Abstract:
:This article summarizes the commonly used biomarkers currently available for diagnosis of necrotizing enterocolitis. The most exciting advances in diagnostic tests were the use of new nucleic acid sequencing techniques (eg, next-generation sequencing) and molecular screening methods (eg, proteomics and microarray analysis) for the discovery of novel biomarkers. The new technology platform coupled with stringent protocols of biomarker discovery and validation would enable neonatologists to study biologic systems at a level never before possible and discover unique biomarkers for specific organ injury and/or disease entity.
journal_name
Clin Perinatoljournal_title
Clinics in perinatologyauthors
Ng PC,Chan KY,Poon TCdoi
10.1016/j.clp.2012.12.005subject
Has Abstractpub_date
2013-03-01 00:00:00pages
149-59issue
1eissn
0095-5108issn
1557-9840pii
S0095-5108(12)00138-8journal_volume
40pub_type
杂志文章,评审abstract::A scheme of regionalization is proposed in which a regional perinatal system within a defined geographic area permits access of the high risk mother-fetus and infant to the appropriate level of technology for improved perinatal outcome. ...
journal_title:Clinics in perinatology
pub_type: 杂志文章
doi:
更新日期:1976-09-01 00:00:00
abstract::Retinopathy of Prematurity (ROP) is a leading cause of childhood blindness in the United States. Optical Coherence Tomography (OCT) is a relatively new imaging technology capable of imaging ocular structures in cross section at high resolution. We present an age-customized approach to perform Spectral Domain OCT in ne...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:10.1016/j.clp.2013.02.007
更新日期:2013-06-01 00:00:00
abstract::This study was undertaken to identify the pathologic processes in premature infants weighing less than 1000 gm who require surgery, and the outcome of such operations. These neonates required surgery for NEC and PDA. Congenital anomalies were not encountered in our series. No increased mortality due to surgery was obs...
journal_title:Clinics in perinatology
pub_type: 杂志文章
doi:
更新日期:1986-06-01 00:00:00
abstract::There were approximately 2 million deaths worldwide from tuberculosis in 1997, 98% of them in developing countries. Factors implicated in the resurgence of tuberculosis in the United States in the late 80s and early 90s included increased immigration from countries with high prevalence, HIV infection, emergence of res...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:10.1016/j.clp.2005.04.010
更新日期:2005-09-01 00:00:00
abstract::Exogenous surfactant therapy has been a significant advance in the management of preterm infants with RDS. It has become established as a standard part of the management of such infants. Both natural and synthetic surfactants lead to clinical improvement and decreased mortality, with natural surfactants having additio...
journal_title:Clinics in perinatology
pub_type: 杂志文章
doi:10.1016/s0095-5108(05)70112-3
更新日期:2001-09-01 00:00:00
abstract::Rhinitis is extremely common during pregnancy, and asthma is one of the most common potentially serious medical problems to complicate pregnancy. Cutaneous allergy (urticaria/angioedema and eczema) also may occur during pregnancy. All of these entities may worsen with pregnancy in some patients and appear to improve i...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:
更新日期:1997-06-01 00:00:00
abstract::Gastrointestinal endoscopy permits direct observation of the alimentary tract, acquisition of mucosal tissue for histopathologic examination, and other diagnostic and therapeutic maneuvers. Endoscopes of appropriate size for many neonates and an expanding array of compatible tools and accessories have broadened what i...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:10.1016/j.clp.2020.02.012
更新日期:2020-06-01 00:00:00
abstract::As a standard of care for preterm/term newborns effective pain management may improve their clinical and neurodevelopmental outcomes. Neonatal pain is assessed using context-specific, validated, and objective pain methods, despite the limitations of currently available tools. Therapeutic approaches reducing invasive p...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:10.1016/j.clp.2014.08.010
更新日期:2014-12-01 00:00:00
abstract::This article describes the early history of the "boarder baby" phenomenon through the late 1980s and early 1990s. The characteristics of the recent "boarder baby" population and of the problem are described with particular emphasis on the role of alcohol and drug abuse and the historical lack of coordination between h...
journal_title:Clinics in perinatology
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract::Most allegations in obstetric lawsuits against obstetrician-gynecologists relate in some manner to the management of labor and delivery; few solely involve perceived flaws in prenatal or postpartum care. Although many of these cases accuse the defendant of not having properly monitored the fetus during labor for signs...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:10.1016/j.clp.2007.03.011
更新日期:2007-06-01 00:00:00
abstract::The extensive data from animal models of BPD and specific aspects of lung injury have helped to expand and refine the concept of pathogenesis introduced by Northway et al. Given the complexity and heterogeneity of the human illness, it is unreasonable to presume that any single model or research group could elucidate ...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:
更新日期:1992-09-01 00:00:00
abstract::The nature of perinatal education has been transformed, reflecting the changes in health care and health care consumers. Because of short maternity stays, the venue of most perinatal education, especially postpartum education, has moved from hospitals to other areas, including the home. In light of conflicting finding...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:
更新日期:1998-06-01 00:00:00
abstract::Congenital lung lesions (CLLs) comprise a heterogeneous group of developmental and histologic entities often diagnosed on screening prenatal ultrasound. Most fetuses with CLL are asymptomatic at birth; however, the risk of malignancy and infection drives the decision to prophylactically resect these lesions. The autho...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:10.1016/j.clp.2017.08.003
更新日期:2017-12-01 00:00:00
abstract::Historically, researchers studying the field of sleep have been divided into two main groups. The first group of sleep studies was based on behaviors and behavioral sleep. The second group of researchers based their studies on electroencephalogram EEG patterns and changes. With technologic advancements, a third group ...
journal_title:Clinics in perinatology
pub_type: 杂志文章
doi:10.1016/j.clp.2006.06.009
更新日期:2006-09-01 00:00:00
abstract::Congenital hemiplegia is the most common form of cerebral palsy in children born at term, and stroke is the number one cause. Neonatal ischemic stroke includes perinatal arterial ischemic stroke, presumed pre- or perinatal stroke, and cerebral sinovenous thrombosis, all of which have emerged as important contributors ...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:10.1016/j.clp.2006.03.008
更新日期:2006-06-01 00:00:00
abstract::This article reviews key recent findings in the field of human cortical development. This development is divided into three major time-dependent phases: neural proliferation of inhibitory and excitatory neurons in spatially distinct regions, migration through multiple cellular boundaries, and maturation through morpho...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:10.1016/j.clp.2009.06.008
更新日期:2009-09-01 00:00:00
abstract::With the increased use of fertility agents and the transfer of multiple embryos, multifetal gestations have increased in number. As the number of fetuses increases, the probability of premature birth and delivery does. The role of multifetal pregnancy reduction and selective termination is reviewed. ...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:
更新日期:1992-06-01 00:00:00
abstract::Our current ability to predict neurologic outcome based on intrapartum information is very limited. Adding information on neurologic state during the first days of life adds powerfully to the ability to predict long-term outcome. Further enhancement of predictive abilities will require putting together into single stu...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:
更新日期:1989-12-01 00:00:00
abstract::Most pharmacokinetic and biologic attributes of digitalis are age dependent. They are determined in great measure by the chemical structure of the specific cardiac glycoside being used. These effects differ in the intact normal circulation and in heart failure because of the altered autonomic nervous system and hormon...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:
更新日期:1988-09-01 00:00:00
abstract::Late preterm neonates have unique susceptibilities to infection. The closed setting of the neonatal ICU (NICU) and the immunologic immaturity of premature infants set the state for the development of nosocomial infections. This article discusses infections that might be seen in this population and gives options for di...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:10.1016/j.clp.2006.09.005
更新日期:2006-12-01 00:00:00
abstract::Neutropenia, a below normal concentration of neutrophils in the circulating blood, can be the kinetic result of diminished neutrophil production, excessive neutrophil margination, or accelerated neutrophil utilization and destruction. The significance of neutropenia to the well-being of the subject is dependent, in pa...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:
更新日期:1995-09-01 00:00:00
abstract::When cystic hygroma is detected antenatally, the prognosis is usually poor, and intrauterine or neonatal death are common. This seems especially true for Turner syndrome (the largest etiologic group associated with cystic hygroma) and the lethal multiple pterygium syndromes. However, some fetuses with Turner syndrome,...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:
更新日期:1990-09-01 00:00:00
abstract::This article discusses the management of short bowel syndrome during the neonatal period. It includes information regarding etiology and pathophysiology and parenteral and enteral nutrition therapy. Finally, a discussion of the role of intestinal transplantation in the treatment of short bowel syndrome is included. ...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:
更新日期:1996-06-01 00:00:00
abstract::The final common pathway to death in all of us is an arrhythmia, yet we still know far too little about the contribution of conduction abnormalities and arrhythmias to the compromised states of the human fetus. At no other time in the human life cycle is the human being at more risk of unexplained and unexpected death...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:10.1016/j.clp.2007.10.002
更新日期:2007-12-01 00:00:00
abstract::The percentage of United States cesarean births increased from 20.7% in 1996 to 31.1% in 2006. Cesarean rates increased for women of all ages, race/ethnic groups, and gestational ages and in all states. Both primary and repeat cesareans have increased. Increases in primary cesareans in cases of "no indicated risk" hav...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:10.1016/j.clp.2008.03.007
更新日期:2008-06-01 00:00:00
abstract::Congenital lobar emphysema is an uncommon but potentially life-threatening cause of respiratory distress in the newborn. The clinical picture and radiologic findings are diagnostic. Lobectomy in the distressed neonate is curative. In infants with onset of symptoms between one and four months of age surgery may not be ...
journal_title:Clinics in perinatology
pub_type: 杂志文章
doi:
更新日期:1978-03-01 00:00:00
abstract::Babies of extremely low birthweight and elderly adults both require expensive and scarce resources, and both have a relatively poor prognosis for survival if they require intensive care. Thus, proposals for rationing often target one or both of these groups. We suspected that although mortality rates might be higher i...
journal_title:Clinics in perinatology
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::In patients with chronic renal disease, all advice and decisions must take into account the balance between pregnancy outcome and the long-term impact that pregnancy might have on the disease. To help the clinician address these concerns, the authors focus on the renal changes in normal pregnancy, the problems of chro...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:
更新日期:1985-10-01 00:00:00
abstract::Neonatal sepsis continues to take a devastating toll globally. Although adequate to protect against invasive infection in most newborns, the distinct function of neonatal innate host defense coupled with impairments in adaptive immune responses increases the likelihood of acquiring infection early in life, with subseq...
journal_title:Clinics in perinatology
pub_type: 杂志文章,评审
doi:10.1016/j.clp.2010.04.001
更新日期:2010-06-01 00:00:00
abstract::The enunciation of equipment requirements has been attempted as needs appear today. Detailed and technical specifications for some of this equipment must be understood prior to major acquisitions. An awareness of current trends in clinical research can often be obtained from appropriate consultants which should forest...
journal_title:Clinics in perinatology
pub_type: 杂志文章
doi:
更新日期:1976-09-01 00:00:00