Expanding repertoire in the oculomotor periphery: selective compartmental function in rectus extraocular muscles.

abstract：:In recent years, different subphenotypes of obesity have been described, including metabolically healthy obesity (MHO), in which a proportion of obese individuals, despite excess body fat, remain free of metabolic abnormalities and increased cardiometabolic risk. In the absence of a universally accepted set of criteri...

journal_title：Annals of the New York Academy of Sciences

authors： Phillips CM

更新日期：2017-03-01 00:00:00

abstract：:About 1 of 10 women, particularly those older than 60 years of age, shows some degree of thyroid hormone deficiency. Thyroid diseases are generally characterized by perturbations of thyroid signaling homeostasis. The most common examples of thyroid diseases include hypothyroidism, hyperthyroidism, and several types of...

journal_title：Annals of the New York Academy of Sciences

authors： Pistollato F,Masias M,Agudo P,Giampieri F,Battino M

更新日期：2019-05-01 00:00:00

abstract：:The general aim of this experiment was to investigate the processes involved in reading musical notation and to study the relationship between written music and its auditory representation. Our main interest was to determine if musicians can develop expectancies for plausible or implausible auditory events on the sole...

journal_title：Annals of the New York Academy of Sciences

authors： Schön D,Besson M

更新日期：2003-11-01 00:00:00

abstract：:We studied the translational vestibulo-ocular reflex (tVOR) in four healthy human subjects during complex, unpredictable sum-of-sines head motion (combination of 0.73, 1.33, 1.93, and 2.93 Hz), while subjects viewed a target 15 cm away. Ideal eye velocity was calculated from recorded head motion; actual eye velocity w...

journal_title：Annals of the New York Academy of Sciences

authors： Walker M,Liao K

更新日期：2011-09-01 00:00:00

abstract：:Preeclampsia is the disorder of pregnancy with the highest rate of both maternal and neonatal morbidity and mortality. The maternal syndrome is characterized by oxidative stress and activation of the vascular endothelium that may originate from placental release of lipid peroxidation products, cytokines, and micropart...

journal_title：Annals of the New York Academy of Sciences

authors： Poston L,Raijmakers M,Kelly F

更新日期：2004-12-01 00:00:00

abstract：:The molecular archaeology of the mutation spectra of tumor suppressor genes generates hypotheses concerning the etiology and molecular pathogenesis of human cancer. The spectrum of somatic mutations in the p53 gene implicates environmental carcinogens and both endogenous agents and processes in the etiology of human c...

journal_title：Annals of the New York Academy of Sciences

authors： Hussain SP,Hollstein MH,Harris CC

更新日期：2000-01-01 00:00:00

abstract：:GABAA receptor heterogeneity is based on the combinatorial assembly of a large family of subunits into distinct receptor subtypes. A neuron-specific expression pattern of receptor subtypes has been demonstrated in adult rat brain, which can be reproduced in vitro in primary neuron cultures. This suggests that genetic ...

journal_title：Annals of the New York Academy of Sciences

authors： Penschuck S,Paysan J,Giorgetta O,Fritschy JM

更新日期：1999-04-30 00:00:00

abstract：:The formation of metastasis is a dreadful complication of cancer that is associated with a poor prognosis. Several clinical observations and experimental findings indicate that the metastatic process is nonrandom and involves a sequence of multistep events that may all be targeted for therapy. This includes angiogenes...

journal_title：Annals of the New York Academy of Sciences

authors： Laferriere J,Houle F,Huot J

更新日期：2002-11-01 00:00:00

abstract：:Saliva testing for drugs of abuse can provide both qualitative and quantitative information on the drug status of an individual undergoing testing. Self-administration by the oral, intranasal, and smoking routes often produces "shallow depots" of drug that contaminate the oral cavity. This depot produces elevated drug...

journal_title：Annals of the New York Academy of Sciences

authors： Cone EJ

更新日期：1993-09-20 00:00:00

abstract：:Many risk factors have been identified as having either a protective or a negative effect on the development of fibroids, but due to methodological issues and a lack of long-term studies, the exact effect of these factors is ambiguous. In similar dispute is the proper treatment of fibroids. Recent technological advanc...

journal_title：Annals of the New York Academy of Sciences

authors： Moorehead ME,Conard CJ

更新日期：2001-12-01 00:00:00

abstract：:Odorant receptors are thought to be critical determinants of olfactory sensory neuron axon targeting and organization. Nonetheless, a systematic characterization of the onset of odorant receptor expression has not yet been done in the main olfactory epithelium. Here, we briefly review our current understanding regardi...

journal_title：Annals of the New York Academy of Sciences

authors： Rodriguez-Gil DJ,Treloar HB,Miller A,Two A,Iwema C,Greer CA

更新日期：2009-07-01 00:00:00

abstract：:The recent identification of tumor-associated antigens (TAA) and TAA-derived peptides presented by MHC molecules to T cells has provided the tools to design and test clinical vaccines for treating human malignancies, such as melanoma. While the most effective adjuvant for use in vaccine formulation remains unclear, au...

journal_title：Annals of the New York Academy of Sciences

authors： Zitvogel L,Couderc B,Mayordomo JI,Robbins PD,Lotze MT,Storkus WJ

更新日期：1996-10-31 00:00:00

abstract：:Cyclosporin A (CsA) is an immunosuppressive drug commonly given to transplant patients. Its application is accompanied by severe side effects related to calcium, among them hypertension and nephrotoxicity. The Na+/Ca2+ exchanger (NCX) is a major calcium regulator expressed in the surface membrane of all excitable and ...

journal_title：Annals of the New York Academy of Sciences

authors： Rahamimoff H,Elbaz B,Alperovich A,Kimchi-Sarfaty C,Gottesman MM,Lichtenstein Y,Eskin-Shwartz M,Kasir J

更新日期：2007-03-01 00:00:00

abstract：:Both orbital and attitude dynamics employ the method of variation of parameters. In a non-perturbed setting, the coordinates (or the Euler angles) are expressed as functions of the time and six adjustable constants called elements. Under disturbance, each such expression becomes ansatz, the "constants" being endowed w...

journal_title：Annals of the New York Academy of Sciences

authors： Efroimsky M

更新日期：2005-12-01 00:00:00

abstract：:Teaching primary care is an important, but as yet, incompletely fulfilled responsibility of medical schools. The current surge of interest will not provide the needed personnel if primary care is defined too broadly, and if it is made everybody's business, but nobody's in particular. Primary care must not neglect firs...

journal_title：Annals of the New York Academy of Sciences

authors： Pellegrino ED

更新日期：1978-06-21 00:00:00

abstract：:Collagen VI is a large, disulfide-bonded protein complex which is widely distributed in connective tissue. The constituent polypeptide chains (Mr = 110,000-140,000) consist of collagenous and noncollagenous segments, are degraded to chains of about half the size when collagen VI is solubilized by pepsin, and assemble ...

journal_title：Annals of the New York Academy of Sciences

authors： Engel J,Furthmayr H,Odermatt E,von der Mark H,Aumailley M,Fleischmajer R,Timpl R

更新日期：1985-01-01 00:00:00

abstract：:This paper reviews a series of my heat transfer studies of on the so-called "self-rewetting" fluids, in which the Marangoni effect due to concentration gradient and the thermocapillary flow cooperatively result in a strong liquid inflow at the nucleation sites in the course of boiling. First of all, the background of ...

journal_title：Annals of the New York Academy of Sciences

authors： Abe Y

更新日期：2006-09-01 00:00:00

abstract：:Estrogen synthesized in situ plays a more important role in breast cancer cell proliferation than does circulating estrogen. Aromatase is the enzyme that converts androgen to estrogen and is expressed at a higher level in breast cancer tissue than in surrounding noncancer tissue. A promising route of chemoprevention a...

journal_title：Annals of the New York Academy of Sciences

authors： Eng ET,Williams D,Mandava U,Kirma N,Tekmal RR,Chen S

更新日期：2002-06-01 00:00:00

abstract：:Primary hyperparathyroidism (PHPT) results from excessive secretion of parathyroid hormone (PTH), and catabolic and anabolic effects of PTH on bone may lead to overall deleterious effects on skeleton. The aim of this study was to analyze the changes in lumbar spine bone mineral density (BMD) in patients with PHPT who ...

journal_title：Annals of the New York Academy of Sciences

authors： Lumachi F,Camozzi V,Ermani M,Nardi A,Luisetto G

更新日期：2007-11-01 00:00:00

abstract：:The sexual quality of adult song is the result of genetic and epigenetic mechanisms shaping the neural song system throughout life. Genetic brain-intrinsic mechanisms determine the neuron pools that develop into forebrain song control areas independent of gonadal steroid hormones, androgens and estrogens. One fate of ...

journal_title：Annals of the New York Academy of Sciences

authors： Gahr M

更新日期：2004-06-01 00:00:00

abstract：:We investigated Ca2+ clearance mechanisms (CCMs) at the axon terminals of mammalian central neurons: neurohypophysial (NHP) axon terminals and calyces of Held. Ca2+ transients were evoked by applying a short depolarization pulse via a patch pipette containing Ca2+ indicator dye. Quantitative analysis of the Ca2+ decay...

journal_title：Annals of the New York Academy of Sciences

authors： Lee SH,Kim MH,Lee JY,Lee SH,Lee D,Park KH,Ho WK

更新日期：2007-03-01 00:00:00

abstract：:We cloned a kappa 3-related opioid receptor, and although it is still not clear whether this clone corresponds to the kappa 3 receptor itself or is a related gene product, the extensive antisense mapping and the antibody immunoreactivity strongly associate this clone with the kappa 3 receptor. Our approach also indica...

journal_title：Annals of the New York Academy of Sciences

authors： Pasternak GW,Pan YX,Cheng J

更新日期：1995-05-10 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2) are innate immune cells that respond rapidly to their environment through soluble inflammatory mediators and cell-to-cell interactions. As tissue-resident sentinels, ILC2 help orchestrate localized type 2 immune responses. These ILC2-driven type 2 responses are now recognized in di...

journal_title：Annals of the New York Academy of Sciences

authors： Schuijs MJ,Halim TYF

更新日期：2018-04-01 00:00:00

abstract：:Malignancies have developed several strategies to evade immune surveillance. We have investigated pancreatic cancer cell lines and pancreatic cancer surgical specimens to evaluate possibilities of tumor escape in the Fas system, and local immune suppression. Despite Fas expression the majority of cell lines was resist...

journal_title：Annals of the New York Academy of Sciences

authors： Ungefroren H,Voss M,Bernstorff WV,Schmid A,Kremer B,Kalthoff H

更新日期：1999-06-30 00:00:00

abstract：:Recent studies demonstrate major effects of adrenal medullary and catecholaminergic pathways on a wide variety of normal physiologic and regulatory events. Alterations in these pathways, involving changes in catecholamines or in proteins and peptides costored and coreleased with catecholamines, may lead to profound ch...

journal_title：Annals of the New York Academy of Sciences

authors： Parmer RJ,Zinder O

更新日期：2002-10-01 00:00:00

abstract：:Toll-like receptors (TLRs) recognize molecular patterns relating to a variety of microbial infections. Stimulation through TLRs leads to activation of antigen-presenting cells, production of inflammatory cytokines creating inflammation, and production of type 1 interferons (IFNs) that include IFN-alpha and -beta, and ...

journal_title：Annals of the New York Academy of Sciences

authors： Wong FS,Wen L

更新日期：2008-12-01 00:00:00

abstract：:Hybrid liver systems are being developed as temporary extracorporeal liver support therapy. The overview given here emphasizes the development of both hepatocyte culture models for bioreactors and of systems for clinical therapy. In vitro studies demonstrate long term external metabolic function in isolated primary he...

journal_title：Annals of the New York Academy of Sciences

authors： Sauer IM,Obermeyer N,Kardassis D,Theruvath T,Gerlach JC

更新日期：2001-11-01 00:00:00

abstract：:To test a hypothesis about how otoliths resolve roll-tilts from translations, we measured human ocular torsion position [ocular counterrolling (OCR)] to maintained linear acceleration stimuli. All subjects (n = 8) were tested in two conditions where the same magnitude of shear along an interaural axis was generated in...

journal_title：Annals of the New York Academy of Sciences

authors： MacDougall HG,Curthoys IS,Betts GA,Burgess AM,Halmagyi GM

更新日期：1999-05-28 00:00:00

abstract：:The human serum resistance-associated (SRA) gene was identified in 28 (80%) of the 35 T.b. rhodesiense trypanosomes from parasitologically confirmed sleeping sickness cases, using the primers designed by Radwanska and in 27 (77.1%) of the same 35 T.b. rhodesiense trypanosomes using the primers designed by Gibson. Howe...

journal_title：Annals of the New York Academy of Sciences

authors： Enyaru JC,Matovu E,Nerima B,Akol M,Sebikali C

更新日期：2006-10-01 00:00:00

abstract：:Allergic contact dermatitis is a common inflammatory skin disease caused by T cells that recognize environmental and industrial allergens (i.e., haptens). Langerhans' cells (LC), which are skin-specific and "immature" members of the dendritic cell (DC) family of antigen-presenting cells, play crucial roles in the indu...

journal_title：Annals of the New York Academy of Sciences

authors： Takashima A,Mummert M,Kitajima T,Matsue H

更新日期：2000-01-01 00:00:00