Pharmacologic advantages of negative-balance isolated pelvic perfusion: achievement of intensive exposure of the pelvis to platinum without systemic leakage.


PURPOSE:To study tissue platinum concentrations and the correlation between tissue and plasma platinum concentrations after negative-balance isolated pelvic perfusion (NIPP) in a porcine model. MATERIALS AND METHODS:All animal experiments were conducted according to the University Guidelines for Animal Care and Experimentation. Cisplatin (5 mg per kilogram of body weight) was administered into balloon catheter-isolated porcine pelvic circulations (n=7) and also systemically to a control group (n=7). Platinum concentrations in pelvic blood, systemic blood, urine, pelvic tissues (uterus, bladder, lymph nodes, and muscles), and kidneys were measured. Maximum platinum concentration (maximum serum drug concentration [C-max]) and area under the blood concentration-time curve (AUC) were compared between the two groups. RESULTS:With NIPP, pelvic C-max (58.4 mg/L) and AUC (1163.6 mg⋅min/L) were 44.9- and 56.2-fold higher than systemic C-max (1.3 mg/L) and AUC (20.7 mg⋅min/L), respectively, whereas the corresponding values in the control group were almost identical. Tissue platinum concentrations in pelvic organs were 2.8-5.6-fold higher than the control values. Platinum concentrations in kidney tissue were markedly lower with NIPP (1.0 mg/L) compared with the controls (8.1 mg/L). High platinum concentrations in pelvic tissues correlated well (P<.01) with high pelvic C-max and AUC. CONCLUSION:The pharmacologic advantages of NIPP were evident, with achievement of high platinum C-max, AUC, and high pelvic tissue concentrations without exposing systemic organs to platinum.






Murata S,Onozawa S,Oda T,Mine T,Ueda T,Kumita S,Nomura K




Has Abstract


2012-02-01 00:00:00














  • Bronchopulmonary sequestration: CT assessment.

    abstract::Computed tomographic (CT) scans of 24 bronchopulmonary sequestrations in 23 patients were reviewed. Seventeen sequestrations were diagnosed at surgery, three at angiography, and four on the basis of radiographic or CT findings combined with appropriate history. Sixteen sequestrations were intralobar, and eight were ex...


    pub_type: 杂志文章


    authors: Ikezoe J,Murayama S,Godwin JD,Done SL,Verschakelen JA

    更新日期:1990-08-01 00:00:00

  • Congenital neuroblastoma: evaluation with multimodality imaging.

    abstract::The authors retrospectively evaluated 12 patients with congenital (neonatal) neuroblastoma to assess the utility of newer imaging modalities. Findings at prenatal ultrasound (US), performed in four patients, were nonspecific (hydramnios and hydrops fetalis) in two and consistent with a suprarenal mass (one solid, one ...


    pub_type: 杂志文章


    authors: Forman HP,Leonidas JC,Berdon WE,Slovis TL,Wood BP,Samudrala R

    更新日期:1990-05-01 00:00:00

  • Posterior interatrial muscular connection between the coronary sinus and left atrium: anatomic and functional study of the coronary sinus with multidetector CT.

    abstract:PURPOSE:To demonstrate coronary sinus-left atrium connections and evaluate coronary sinus function and anatomy in detail by using multidetector computed tomography (CT). MATERIALS AND METHODS:In this institutional review board-approved retrospective study, the authors evaluated coronary CT angiograms obtained in 65 pa...


    pub_type: 杂志文章


    authors: Saremi F,Thonar B,Sarlaty T,Shmayevich I,Malik S,Smith CW,Krishnan S,Sánchez-Quintana D,Narula N

    更新日期:2011-09-01 00:00:00

  • Early renal involvement in diabetes mellitus: comparison of renal Doppler US and radioisotope evaluation of glomerular hyperfiltration.

    abstract:PURPOSE:To evaluate the usefulness of Doppler ultrasonography (US) in the diagnosis of hyperfiltration in patients with insulin-dependent diabetes mellitus (IDDM). MATERIALS AND METHODS:Eighty-one consecutive patients with IDDM were studied. All patients were normotensive and had normal creatinine and blood urea nitro...


    pub_type: 临床试验,杂志文章


    authors: Marzano MA,Pompili M,Rapaccini GL,Covino M,Cotroneo P,Manto A,Todaro L,Ghirlanda G,Gasbarrini G

    更新日期:1998-12-01 00:00:00

  • Chronic pancreatitis: ultrasonic features.

    abstract::A retrospective analysis of 84 ultrasound examinations (in 77 patients) was performed to assess the frequency of sonographic findings in chronic pancreatitis. The findings included: inhomogeneously increased echogenicity in 53% of these examinations, focal or diffuse enlargement in 41%, focal dense echoes in 40%, pseu...


    pub_type: 杂志文章


    authors: Alpern MB,Sandler MA,Kellman GM,Madrazo BL

    更新日期:1985-04-01 00:00:00

  • Demonstration of gastroesophageal reflux in children by radionuclide gastroesophagography.

    abstract::Twenty-five infants and children with proved gastroesophageal reflux were studied by radionuclide gastroesophagography to determine its sensitivity in detecting reflux. Patients swallowed an inert radiotracer (Tc-99m sulfur colloid) and gamma camera images of the stomach and esophagus were made with and without abdomi...


    pub_type: 杂志文章


    authors: Rudd TG,Christie DL

    更新日期:1979-05-01 00:00:00

  • The power button sign: a newly described central sulcal pattern on surface rendering MR images of type 2 focal cortical dysplasia.

    abstract:PURPOSE:To compare the occurrence of several central sulcus variants and to assess the reproducibility of a sulcal pattern named the power button sign (PBS) in patients with type 2 focal cortical dysplasia (FCD2) and healthy control subjects. MATERIALS AND METHODS:The local institutional review board approved the stud...


    pub_type: 杂志文章


    authors: Mellerio C,Roca P,Chassoux F,Danière F,Cachia A,Lion S,Naggara O,Devaux B,Meder JF,Oppenheim C

    更新日期:2015-02-01 00:00:00

  • Cocaine abuse: neurovascular complications.

    abstract::In a review of the records of 3,712 drug abusers, 13 patients were identified with neurologic deficits attributable to the use of cocaine. Ischemic manifestations were the most frequent, occurring in seven (54%) patients, with a mean age of 34.2 years. Three (23%) patients had subarachnoid hemorrhage, and three (23%) ...


    pub_type: 杂志文章


    authors: Jacobs IG,Roszler MH,Kelly JK,Klein MA,Kling GA

    更新日期:1989-01-01 00:00:00

  • Adaptive technique for three-dimensional MR imaging of moving structures.

    abstract::The authors describe an adaptive motion correction method for three-dimensional magnetic resonance (MR) imaging. Three-dimensional imaging offers many advantages over two-dimensional multisection imaging but is susceptible to image corruption due to motion. Thus, it has been of limited use in the imaging of mobile str...


    pub_type: 杂志文章


    authors: Korin HW,Felmlee JP,Ehman RL,Riederer SJ

    更新日期:1990-10-01 00:00:00

  • Transcatheter fiberoptic laser coagulation of blood vessels.

    abstract::In ten rabbit ears the central auricular artery was percutaneously catheterized and subjected to doses of laser energy transmitted through a flexible optical fiber within the artery. Arterial occlusion was not produced in the initial three ears using energy levels less than 600 mW. Higher levels of laser energy, in th...


    pub_type: 杂志文章


    authors: O'Reilly GV,Colucci VM,Astorian DG,Schoene WC,Clarke RH,Hammerschlag SB

    更新日期:1982-03-01 00:00:00

  • Extraperitoneal paravesical spaces: CT delineation with US correlation.

    abstract::The extraperitoneal space around the urinary bladder is lamellate, just like the retroperitoneal space around the kidneys. The bladder, urachus, and obliterated umbilical arteries lie within the perivesical space, surrounded by umbilicovesical fascia, analogous to the perinephric space within the renal fascia. A much ...


    pub_type: 杂志文章


    authors: Auh YH,Rubenstein WA,Schneider M,Reckler JM,Whalen JP,Kazam E

    更新日期:1986-05-01 00:00:00

  • Aortobronchial fistula as a complication of surgery for correction of congenital aortic anomalies.

    abstract::An aortobronchial fistula is a rare condition that is invariably fatal if not diagnosed and surgically treated. Aortic aneurysms, both atherosclerotic and infective, were the main causes in the originally described cases. However, thoracic cardiovascular surgery has recently become the predominant cause. The authors d...


    pub_type: 杂志文章


    authors: Garniek A,Morag B,Schmahmann S,Rubinstein ZJ

    更新日期:1990-05-01 00:00:00

  • Use of ultrasonography in planning intracavitary radiotherapy of endometrial carcinoma.

    abstract::A diagnostic ultrasound examination is a simple and reliable method of obtaining anatomical information for intracavitary irradiation of endometrial carcinoma of the uterus. Scanning before treatment to determine uterine size and shape assists in choosing the most appropriate applicator. Scanning after insertion of an...


    pub_type: 杂志文章


    authors: Brascho DJ,Kim RY,Wilson EE

    更新日期:1978-10-01 00:00:00

  • Work in progress: transcatheter management of primary carcinoma of the liver.

    abstract::Twenty-four patients with hepatocellular carcinoma or cholangiocarcinoma were treated with hepatic artery infusion (HAI) of chemotherapeutic agents (14 patients) or hepatic artery embolization (HAE) (11 patients). One patient had a combination of the two treatments. Ten of the 14 (71%) patients who underwent HAI demon...


    pub_type: 杂志文章


    authors: Charnsangavej C,Chuang VP,Wallace S,Soo CS,Bowers T

    更新日期:1983-04-01 00:00:00

  • Radiologic evaluation of the intravenous oxygenator.

    abstract::This report describes the radiologic appearance of the intravenous oxygenator (IVOX), an intracorporeal CO2-O2 exchanger for use in patients with severe respiratory deficiency, and the extensive radiographic and sonographic support required for its use. Six patients aged 19-39 years who had severe adult respiratory di...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Shukla PR,Snider MT,Hopper KD,Thieme GA,Meilstrup JW

    更新日期:1993-06-01 00:00:00

  • Using computed tomography of the brain to correlate low white-matter attenuation with early gestational age in neonates.

    abstract::Computed tomographic brain scans of the newborn exhibit relatively greater lucency of white matter compared to the mature patient. This study correlated the x-ray attenuation of white matter with gestational age in 23 neonates, both premature and term. The gray-white matter attenuation difference was calculated and pl...


    pub_type: 杂志文章


    authors: Brant-Zawadzki M,Enzmann DR

    更新日期:1981-04-01 00:00:00

  • Early diagnosis of ovarian carcinoma: is a solution in sight?

    abstract:UNLABELLED:Ovarian cancer is the most lethal of the gynecologic malignancies. Because ovarian cancer symptoms are subtle and nonspecific, the diagnosis is often delayed until the disease is well advanced. Overall 5-year survival is a rather dismal 50% but can be improved to greater than 90% if the disease is confined t...


    pub_type: 杂志文章,评审


    authors: Lutz AM,Willmann JK,Drescher CW,Ray P,Cochran FV,Urban N,Gambhir SS

    更新日期:2011-05-01 00:00:00

  • Diagnostic and Prognostic Value of Long-Axis Strain and Myocardial Contraction Fraction Using Standard Cardiovascular MR Imaging in Patients with Nonischemic Dilated Cardiomyopathies.

    abstract::Purpose To assess the utility of established functional markers versus two additional functional markers derived from standard cardiovascular magnetic resonance (MR) images for their incremental diagnostic and prognostic information in patients with nonischemic dilated cardiomyopathy (NIDCM). Materials and Methods App...


    pub_type: 杂志文章


    authors: Arenja N,Riffel JH,Fritz T,André F,Aus dem Siepen F,Mueller-Hennessen M,Giannitsis E,Katus HA,Friedrich MG,Buss SJ

    更新日期:2017-06-01 00:00:00

  • Salivary gland tumors: evaluation with two-phase helical CT.

    abstract:PURPOSE:To evaluate two-phase helical computed tomography (CT) in the characterization of salivary gland tumors. MATERIALS AND METHODS:Sixty-four patients with major salivary gland tumors underwent two-phase helical CT. The histopathologic diagnosis was obtained by means of surgical resection or biopsy in all patients...


    pub_type: 杂志文章


    authors: Choi DS,Na DG,Byun HS,Ko YH,Kim CK,Cho JM,Lee HK

    更新日期:2000-01-01 00:00:00

  • Case 236: Middle Interhemispheric Variant of Holoprosencephaly.

    abstract::History A 13-year-old girl presented for evaluation and further management of spastic diplegia cerebral palsy. Absence of the corpus callosum was noted at screening prenatal head ultrasonography. She was born at full term via spontaneous vaginal delivery. Physical examination revealed decreased axial muscle tone and i...


    pub_type: 杂志文章


    authors: Yahyavi-Firouz-Abadi N,Poretti A,Idowu OR,Hoon AH Jr,Huisman TA,Izbudak I

    更新日期:2016-12-01 00:00:00

  • Extravasation detection accessory: clinical evaluation in 500 patients.

    abstract:PURPOSE:To assess the ability of an extravasation detection accessory (EDA) to detect clinically important (> or = 10 mL) extravascular injection of iodinated contrast material delivered with an automated power injector. MATERIALS AND METHODS:Five hundred patients referred for contrast material-enhanced body computed ...


    pub_type: 杂志文章,多中心研究


    authors: Birnbaum BA,Nelson RC,Chezmar JL,Glick SN

    更新日期:1999-08-01 00:00:00

  • Anatomic features of the carpal scaphoid: validation of biometric measurements and symmetry with three-dimensional MR imaging.

    abstract::The goals of reconstructive surgery for scaphoid fracture nonunions include restoration of normal scaphoid length and shape by use of the contralateral scaphoid bone as a geometric model. A literature search revealed limited documentation of normal biometric measurements and no validation of scaphoid anatomic symmetry...


    pub_type: 杂志文章


    authors: Smith DK

    更新日期:1993-04-01 00:00:00

  • Clinical applications of PET in oncology.

    abstract::Positron emission tomography (PET) provides metabolic information that has been documented to be useful in patient care. The properties of positron decay permit accurate imaging of the distribution of positron-emitting radiopharmaceuticals. The wide array of positron-emitting radiopharmaceuticals has been used to char...


    pub_type: 杂志文章,评审


    authors: Rohren EM,Turkington TG,Coleman RE

    更新日期:2004-05-01 00:00:00

  • The selection, acceptance testing, and quality control of radiotherapy treatment simulators.

    abstract::The critical aspects of selection, acceptance testing, and quality control of a radiotherapy treatment simulator are discussed. The selection of a simulator involves consideration of: (a) motions and readouts, (b) safety features, (c) x-ray and imaging systems, and (d) mechanical tolerances (including guarantees). Whe...


    pub_type: 杂志文章


    authors: McCullough EC,Earle JD

    更新日期:1979-04-01 00:00:00

  • Diagnostic value of spinal US: comparative study with MR imaging in pediatric patients.

    abstract:PURPOSE:To assess the diagnostic value of spinal ultrasonography (US) in pediatric patients. MATERIALS AND METHODS:The findings on 38 spinal US scans in 30 patients (mean age, 5.5 months) were compared with those of corresponding magnetic resonance (MR) images. RESULTS:MR imaging showed a normal spinal canal in 14 of...


    pub_type: 杂志文章


    authors: Rohrschneider WK,Forsting M,Darge K,Tröger J

    更新日期:1996-08-01 00:00:00

  • Effect of downstream cross-sectional area of an arterial bed on the resistive index and the early systolic acceleration.

    abstract:PURPOSE:To evaluate the effect of the increase in total cross-sectional area of arteries as they branch beyond the main trunks on the resistive index (RI) and early systolic acceleration (ESA). MATERIALS AND METHODS:An essentially noncompliant in vitro model that used a pulsatile pump, blood-mimicking fluid, and a bra...


    pub_type: 杂志文章


    authors: Bude RO,Rubin JM

    更新日期:1999-09-01 00:00:00

  • Thoracic tuberculosis, mycobacteriosis, MERosis, and BCGosis in a cancer treatment center.

    abstract::Radiographs and clinical records of 100 patients with tuberculosis or mycobacteriosis and six patients infected with Bacillus Calmette-Guerin (BCG) or methanol extraction residue of BCG (MER) were reviewed. Radiographic presentations were categorized. Tuberculosis or mycobacteriosis simulated pulmonary neoplasm in 64 ...


    pub_type: 杂志文章


    authors: Hill CA

    更新日期:1984-11-01 00:00:00

  • Modification of a serial film changer for frontal magnification angiography.

    abstract::A movable carriage was designed and built for a Franklin film changer to facilitate routine serial 2 times magnification. This simple device permits magnification angiography without major equipment purchases or room alterations. ...


    pub_type: 杂志文章


    authors: Spitzer RM,Olsson HE,Gibson BJ

    更新日期:1975-11-01 00:00:00

  • Nasofrontal duct: CT in frontal sinus trauma.

    abstract::Radiologic evaluation of frontal sinus fractures is instrumental in determining the need for surgery. Computed tomography (CT) is an excellent modality for evaluation of frontal sinus trauma, particularly for anterior and posterior wall fractures. However, fractures of the nasofrontal duct are more difficult to deline...


    pub_type: 杂志文章


    authors: Harris L,Marano GD,McCorkle D

    更新日期:1987-10-01 00:00:00

  • Pulse selection chart for brain MR imaging sequences.

    abstract::A chart for organizing, teaching, and recording the magnetic resonance (MR) pulse sequences used for brain and cervical spine imaging is described. The chart helps document workable sequences and facilitates comparisons between different sequences. It has also been helpful in instructing residents and fellows how to a...


    pub_type: 杂志文章


    authors: Tobias JA,Sheldon JJ,Soila KP,Pomeranz SJ,Garcia L

    更新日期:1985-10-01 00:00:00