Collaborative radiologic and histopathologic assessment of fibrotic lung disease.

Abstract:

:The idiopathic interstitial pneumonias (IIPs) are a seemingly disconnected collection of diseases usually associated with the presence of pulmonary fibrosis. Categorization of the IIPs continues to be problematic despite recent attempts to refine the diagnostic criteria and suggests that rather than separate diseases, these pneumonias represent a spectrum of injury and abnormal repair of the alveolar wall. Although the initiating injury or injuries are unknown, the IIPs share a restricted number of final common abnormal pathways that lead to volume loss and lung distortion. The pathways include (a) alveolar collapse, (b) incorporation of fibroblastic material into alveolar walls, and (c) cigarette smoke-related inflammation and fibrosis. A collaborative diagnostic process in which data from radiologic and histologic assessments are combined allows a more reliable identification of the predominant pathways leading to pulmonary fibrosis. This approach has implications for therapy and the future direction of research.

journal_name

Radiology

journal_title

Radiology

authors

Galvin JR,Frazier AA,Franks TJ

doi

10.1148/radiol.10090717

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

692-706

issue

3

eissn

0033-8419

issn

1527-1315

pii

255/3/692

journal_volume

255

pub_type

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