Abstract:
PURPOSE:To determine whether measurements of skewness, kurtosis, and mean lung attenuation on thin-section computed tomographic (CT) histograms in patients with idiopathic pulmonary fibrosis (IPF) correlate with pulmonary physiologic abnormality in a nonspirometrically controlled multicenter study. MATERIALS AND METHODS:The authors analyzed baseline digital thin-section CT data from 144 patients with IPF who enrolled in a double-blind placebo-controlled clinical effectiveness trial of interferon beta 1a in the treatment of IPF. All patients underwent thin-section CT in the supine position at full inspiration. The lungs were isolated by using a semiautomated thresholding technique, with an upper threshold of -200 HU. An attenuation correction algorithm was used. Pulmonary function tests (PFTs) included forced vital capacity, total lung capacity, forced expiratory volume in 1 second, and diffusing lung capacity. Univariate and multiple correlation and regression statistical analyses were used to determine relationships between histogram features and results of PFTs. RESULTS:Moderate correlations existed between histogram features and PFT results. Kurtosis showed the greatest degree of correlation with physiologic abnormality (r = 0.53, P <.01). Strength of correlation increased with exclusion of suboptimal scans but did not change significantly after application of an attenuation correction algorithm. Attenuations for lungs, gas, and soft tissue varied considerably between scanner manufacturers. Kurtosis alone provided predictions of pulmonary function that were virtually as good as those from all histogram features combined. CONCLUSION:Thin-section CT histograms of the lungs were found to correlate with results of PFTs in patients with IPF, which supports the claim that histogram features can be used as valid indexes of IPF in a multiinstitutional nonspirometrically controlled study.
journal_name
Radiologyjournal_title
Radiologyauthors
Best AC,Lynch AM,Bozic CM,Miller D,Grunwald GK,Lynch DAdoi
10.1148/radiol.2282020274subject
Has Abstractpub_date
2003-08-01 00:00:00pages
407-14issue
2eissn
0033-8419issn
1527-1315pii
2282020274journal_volume
228pub_type
临床试验,杂志文章,多中心研究相关文献
RADIOLOGY文献大全abstract::The radiopharmaceutical iodine 131 metaiodobenzylguanidine (I-131 MIBG) has been shown to locate pheochromocytomas scintigraphically with a false-negative rate of approximately 13%. To improve image quality and reduce the false-negative rate, I-123 was examined as a radioactive label for MIBG, as it has many advantage...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.155.3.4001380
更新日期:1985-06-01 00:00:00
abstract::Anti-scatter grids reduce the amount of secondary radiation contributing to the image and improve the signal-to-noise ratio. However, they may also lead to the creation of linear artifacts representing the shadows of the radiopaque septa. Grid motion perpendicular to the septa during the exposure can cause blurring of...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.147.1.6828740
更新日期:1983-04-01 00:00:00
abstract::Growth deformities of the distal femur and unusual gait disturbances were observed in four girls who had had neonatal osteomyelitis and septic arthritis. In each case apparent absence or hypoplasia of one of the femoral condyles, as seen on plain radiographs, was associated with marked genu varum or genu valgum. Arthr...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.161.2.3763900
更新日期:1986-11-01 00:00:00
abstract::The radiologic studies of 107 patients with pulsatile tinnitus or a vascular retrotympanic mass were retrospectively reviewed. Of the 100 patients with pulsatile tinnitus, 25 had objective tinnitus. A vascular tympanic membrane was present in 37 cases (35%). Normal vascular variants were present in 23 patients (21%). ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.174.2.2296650
更新日期:1990-02-01 00:00:00
abstract:PURPOSE:To determine whether any initial reductions in cardiovascular reserve (CVR) normalize after carotid revascularization and-because reduced CVR represents a risk factor for ischemic events-whether patients who develop periinterventional infarction have more severely reduced pretreatment CVR than those who do not....
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2491071644
更新日期:2008-10-01 00:00:00
abstract:PURPOSE:To quantitatively determine the delivery of systemic liposomal doxorubicin to tumors treated with pulsed high-intensity focused ultrasound and to study the mechanism underlying this delivery in a murine model. MATERIALS AND METHODS:All animal work was performed in compliance with guidelines and approval of ins...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2342030889
更新日期:2005-02-01 00:00:00
abstract::Thirty patients underwent 16-section multi-detector row computed tomographic (CT) angiography of the thorax with retrospective electrocardiographic gating. Institutional review board approval was obtained for retrospective analysis of CT scan data and records; patient informed consent was not required. Images reconstr...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2333030826
更新日期:2004-12-01 00:00:00
abstract::Operative ligation of portosystemic shunts is effective in controlling chronic portosystemic encephalopathy (CPSE) but is associated with significant mortality. Review of the records of five patients with CPSE treated with radiologic occlusion procedures showed that these are suitable alternatives to surgery. Three pa...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.165.3.3685350
更新日期:1987-12-01 00:00:00
abstract:PURPOSE:To evaluate the usefulness of a new computed tomographic (CT) sign of "draped aorta" in the diagnosis of a contained leak in an aortic aneurysm. MATERIALS AND METHODS:CT scans were retrospectively evaluated in 10 patients in whom an unidentifiable aortic wall and posterior aspect of the aorta that followed the...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.199.1.8633170
更新日期:1996-04-01 00:00:00
abstract::The diagnostic value of computed tomography (CT) and barium enema (BE) studies was evaluated prospectively in hospitalized patients with the presumptive diagnosis of acute sigmoid diverticulitis based on the presence of left-lower-quadrant pain and tenderness, fever, and leukocytosis. Of 56 patients, 11 had sigmoid di...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.176.1.2191360
更新日期:1990-07-01 00:00:00
abstract::The authors describe three pediatric patients with diffuse pulmonary hemangiomatosis. Virtually identical clinical, radiographic, and pathologic findings were observed in each case. The combination of diffuse interstitial pulmonary infiltration and bloody pleural effusion in a child is pathognomonic. Early recognition...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/127.2.445
更新日期:1978-05-01 00:00:00
abstract:PURPOSE:To examine the efficacy of transperineal sonographically guided drainage of deep pelvic abscesses. MATERIALS AND METHODS:Twelve drainage procedures were performed in 11 adults with symptoms of infection and cross-sectional images demonstrating a deep pelvic abscess. Eight patients had recently undergone abdomi...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.208.1.9646800
更新日期:1998-07-01 00:00:00
abstract:PURPOSE:To analyze asymptomatic adnexal masses at positron emission tomography (PET) with fluorodeoxyglucose (FDG) in correlation with histopathologic findings and evaluate FDG PET for assessing malignancy in comparison with transvaginal B-mode and Doppler ultrasonography (US) and magnetic resonance (MR) imaging. MATE...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2233001850
更新日期:2002-06-01 00:00:00
abstract::The clinical and radiologic findings in 30 patients who sustained injuries to the temporomandibular joint (TMJ) were retrospectively analyzed. Imaging consisted of variable combinations of radiography, tomography, two-compartment arthrography, computed tomography, and magnetic resonance imaging and was performed 2 day...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.173.1.2781010
更新日期:1989-10-01 00:00:00
abstract::Calcifications located in the dermis of the breast may appear indistinguishable from intramammary calcifications. The authors present a sign, called the tattoo sign, that can help radiologists identify dermal calcifications. When mammograms are compared, calcifications that maintain a fixed relationship to each other ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.192.1.8208930
更新日期:1994-07-01 00:00:00
abstract:PURPOSE:To determine the feasibility of a statistical classification strategy (SCS) and the identity of metabolites of bacterial and host origins that potentially contributed to the most discriminatory regions of magnetic resonance (MR) spectra from Staphylococcus aureus abscesses of biopsy material from controls, glio...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2361040869
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:To analyze the clinical outcomes of chemoembolization for solitary caudate lobe hepatocellular carcinoma (HCC) found at initial presentation. MATERIALS AND METHODS:This retrospective study was approved by the institutional review board; the requirement for informed patient consent was waived. From July 1998 to...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.10100105
更新日期:2010-10-01 00:00:00
abstract::Modern rapid magnetic resonance (MR) imaging techniques have led to widespread use of the modality in cardiac imaging. Despite this progress, many MR studies suffer from image degradation due to involuntary motion during the acquisition. This review describes the type and extent of the motion of the heart due to the c...
journal_title:Radiology
pub_type: 杂志文章,评审
doi:10.1148/radiol.2502071998
更新日期:2009-02-01 00:00:00
abstract:PURPOSE:Fast-neutron irradiation and boron-neutron capture therapy (BNCT) have been independently investigated as treatments for malignant disease. This study tested the feasibility of enhancing fast-neutron irradiation with concomitant BNCT. MATERIALS AND METHODS:Seventeen male Fisher rats, each weighing 180-200 g an...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.191.3.8184080
更新日期:1994-06-01 00:00:00
abstract::An aluminum step-wedge filter placed far from the film cassette provides the constant variation of subject contrast required for quantitative sensitometry while virtually eliminating scatter radiations. Attenuation curves made with this configuration are almost exponentially linear. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/128.3.820
更新日期:1978-09-01 00:00:00
abstract::Renal allografts are subject to many vascular complications. Over a 2-year period, 334 duplex Doppler ultrasonographic (US) examinations were performed in 88 renal allograft recipients. Vascular occlusion on the basis of severe vascular rejection was documented in ten patients (11.4%) for a sensitivity and specificity...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.162.1.3538150
更新日期:1987-01-01 00:00:00
abstract::Cranial magnetic resonance (MR) imaging was performed in 38 pregnant and postpartum women and 30 nonpregnant age-matched control subjects to establish standards for pituitary gland size and shape during this period. Gland height and infundibulum width were measured on midline T1-weighted sagittal images. Gland convexi...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.181.2.1924800
更新日期:1991-11-01 00:00:00
abstract::Sixteen patients with biliary atresia and 11 patients with neonatal hepatitis were studied preoperatively with either Tc-99m-diethyl-IDA or TC-99m-diisopropyl-IDA. Two parameters were evaluated: hepatocyte clearance and time to appearance of radioactivity in the intestine. Two observers, using a visual grading system ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.146.2.6681570
更新日期:1983-02-01 00:00:00
abstract::The purpose of the study was to prospectively evaluate a whole-body magnetic resonance (MR) imaging protocol to help depict metastases by using unenhanced T2-weighted and contrast material-enhanced T1-weighted real-time sequences during continuous table movement. The study was conducted after approval of the local ins...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2463062017
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:To retrospectively determine if the use of a computer-aided detection (CAD) system can improve the performance of single reading of screening mammograms to match that of double reading in the United Kingdom. MATERIALS AND METHODS:Local research ethics committee approval was obtained; informed consent was not r...
journal_title:Radiology
pub_type: 杂志文章,随机对照试验
doi:10.1148/radiol.2411051092
更新日期:2006-10-01 00:00:00
abstract::To assess the potential of in vivo magnetic resonance (MR) spectroscopy for breast cancer, hydrogen-1 and phosphorus-31 MR spectra of five malignant human breast tumors were compared with those of unaffected breast tissue. The water-to-fat ratio was high in the tumors (average, 2.2) but low in the unaffected tissue (a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.169.3.2847230
更新日期:1988-12-01 00:00:00
abstract::In 25 patients, 12 with acute-subacute and 13 with chronic extensive femoropopliteal artery occlusions (mean length, 8 cm), a prospective study was performed after application of the Kensey catheter and subsequent performance of percutaneous transluminal angioplasty (PTA). Passage through the occlusion with the Kensey...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.182.1.1530760
更新日期:1992-01-01 00:00:00
abstract::Computed tomography (CT) was compared with chest radiography in the assessment of disease severity in 27 patients with sarcoidosis. The CT scans and radiographs were each read twice by two independent observers. Disease extent was assessed on CT scans by visual scoring (0%-100% involvement of the lung parenchyma) and ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.171.3.2717730
更新日期:1989-06-01 00:00:00
abstract:PURPOSE:To determine if computed tomographic (CT) texture and histogram analysis measurements of the primary mass are independently associated with overall survival in patients with locally advanced squamous cell carcinoma of the head and neck who were previously treated with cisplatin, 5-fluorouracil, and docetaxel (T...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.13130110
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:To analyze the contribution of the transverse relaxation parameter (T2), macroscopic field inhomogeneities (B0), and blood volume fraction (BVf) to blood oxygen level-dependent (BOLD)-based magnetic resonance (MR) measurements of blood oxygen saturation (SO2) obtained in a brain tumor model. MATERIALS AND METH...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.11110518
更新日期:2012-02-01 00:00:00