Abstract:
PURPOSE:Fast-neutron irradiation and boron-neutron capture therapy (BNCT) have been independently investigated as treatments for malignant disease. This study tested the feasibility of enhancing fast-neutron irradiation with concomitant BNCT. MATERIALS AND METHODS:Seventeen male Fisher rats, each weighing 180-200 g and bearing 36B10 gliomas, were irradiated with graded doses of fast-neutron radiation. Half of the animals received an L-para-boronophenylalanine (BPA) fructose complex prior to treatment. An in vitro colony-forming assay was used to measure surviving fraction. RESULTS:A significantly lower surviving fraction was noted in the tumors from the BPA group compared with those receiving neutrons alone at the three lower neutron doses (P < .005). With use of a linear quadratic curve fit of cell survival, the dose modifying factor was 1.32 at the 0.10 surviving fraction. Mean tumor boron concentration was 68.4 micrograms/g. CONCLUSIONS:BNCT enhancement of fast-neutron irradiation is feasible in an in vivo tumor system.
journal_name
Radiologyjournal_title
Radiologyauthors
Buchholz TA,Rasey JS,Laramore GE,Livesey JC,Chin L,Risler R,Hamlin DK,Spence AM,Griffin TWdoi
10.1148/radiology.191.3.8184080subject
Has Abstractpub_date
1994-06-01 00:00:00pages
863-7issue
3eissn
0033-8419issn
1527-1315journal_volume
191pub_type
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