Concomitant boron-neutron capture therapy during fast-neutron irradiation of a rat glioma.

Abstract:

PURPOSE:Fast-neutron irradiation and boron-neutron capture therapy (BNCT) have been independently investigated as treatments for malignant disease. This study tested the feasibility of enhancing fast-neutron irradiation with concomitant BNCT. MATERIALS AND METHODS:Seventeen male Fisher rats, each weighing 180-200 g and bearing 36B10 gliomas, were irradiated with graded doses of fast-neutron radiation. Half of the animals received an L-para-boronophenylalanine (BPA) fructose complex prior to treatment. An in vitro colony-forming assay was used to measure surviving fraction. RESULTS:A significantly lower surviving fraction was noted in the tumors from the BPA group compared with those receiving neutrons alone at the three lower neutron doses (P < .005). With use of a linear quadratic curve fit of cell survival, the dose modifying factor was 1.32 at the 0.10 surviving fraction. Mean tumor boron concentration was 68.4 micrograms/g. CONCLUSIONS:BNCT enhancement of fast-neutron irradiation is feasible in an in vivo tumor system.

journal_name

Radiology

journal_title

Radiology

authors

Buchholz TA,Rasey JS,Laramore GE,Livesey JC,Chin L,Risler R,Hamlin DK,Spence AM,Griffin TW

doi

10.1148/radiology.191.3.8184080

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

863-7

issue

3

eissn

0033-8419

issn

1527-1315

journal_volume

191

pub_type

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