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Reduced cerebrovascular reserve at CO2 BOLD MR imaging is associated with increased risk of periinterventional ischemic lesions during carotid endarterectomy or stent placement: preliminary results.

Abstract：

PURPOSE:To determine whether any initial reductions in cardiovascular reserve (CVR) normalize after carotid revascularization and-because reduced CVR represents a risk factor for ischemic events-whether patients who develop periinterventional infarction have more severely reduced pretreatment CVR than those who do not. MATERIALS AND METHODS:Ethics committee approval and informed consent were obtained. Twenty-four consecutive patients with symptomatic high-grade internal carotid artery stenosis (seven women; mean age, 73.1 years +/- 9.4 [standard deviation]) were recruited from a prospective, randomized trial that compared carotid artery stent placement with endarterectomy. Magnetic resonance (MR) imaging, including CO(2) blood oxygen level-dependent (BOLD) MR, was performed 1-3 days before, 1-3 days after, and 1 month after carotid revascularization (carotid artery stent placement, n = 13; carotid endarterectomy, n = 11). RESULTS:Mean CVR in the ipsilateral middle cerebral artery (MCA) territory was reduced prior to treatment (mean DeltaT2* in ipsilateral territory, 1.92% +/- 1.18; mean DeltaT2* in contralateral territory, 2.28% +/- 1.15 [P < .05]) and normalized after treatment (mean DeltaT2* 1-3 days after treatment in ipsilateral territory, 2.66% +/- 1.01; that in contralateral territory, 2.48% +/- 1.27 [P > .05]; mean DeltaT2* 1 month after treatment in ipsilateral territory, 2.27% +/- 1.05; that in contralateral territory, 2.14% +/- 0.96 [P > .05]). Those patients who developed new periinterventional infarcts (n = 7 with punctate foci of restricted diffusion) had greater reduction of CVR in the ipsilateral MCA territory prior to treatment (relative reduction, 32.5% +/- 46.0; P < .05) than those who did not develop infarction (n = 17; relative reduction, 9.2% +/- 55.9). CONCLUSION:CO(2) BOLD MR imaging could be used successfully to monitor the hemodynamic effects of carotid revascularization; initial reductions in CVR normalized after carotid revascularization. Severely reduced pretreatment CVR was associated with increased occurrence of new periinterventional therapy infarction.

journal_name

Radiology

journal_title

Radiology

authors

Haller S,Bonati LH,Rick J,Klarhöfer M,Speck O,Lyrer PA,Bilecen D,Engelter ST,Wetzel SG

doi

10.1148/radiol.2491071644

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

251-8

issue

eissn

0033-8419

issn

1527-1315

pii

249/1/251

journal_volume

249

pub_type

杂志文章

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Reduced cerebrovascular reserve at CO2 BOLD MR imaging is associated with increased risk of periinterventional ischemic lesions during carotid endarterectomy or stent placement: preliminary results.