Single reading with computer-aided detection and double reading of screening mammograms in the United Kingdom National Breast Screening Program.

Abstract:

PURPOSE:To retrospectively determine if the use of a computer-aided detection (CAD) system can improve the performance of single reading of screening mammograms to match that of double reading in the United Kingdom. MATERIALS AND METHODS:Local research ethics committee approval was obtained; informed consent was not required. This study included a sample of 10 267 mammograms obtained in women aged 50 years or older who underwent routine screening at one of two breast screening centers in 1996. Mammograms that were double read in 1996 were randomly allocated to be re-read by eight different radiologists using CAD. The cancer detection and recall rates from double reading and single reading with CAD were compared. Statistical significance and confidence intervals were calculated with the McNemar test to account for the matched nature of the data. RESULTS:Single reading with CAD led to a cancer detection rate that was significantly (P = .02) higher than that achieved with double reading: 6.5% more cancers were detected by means of single reading with CAD than by means of double reading. However, the recall rate was higher for single reading with CAD than for double reading (8.6% vs 6.5%, respectively; P < .001). This was equivalent to relative increases of 15% and 32% in the cancer detection and recall rates, respectively. CONCLUSION:Single reading with CAD leads to an improved cancer detection rate and an increased recall rate.

journal_name

Radiology

journal_title

Radiology

authors

Gilbert FJ,Astley SM,McGee MA,Gillan MG,Boggis CR,Griffiths PM,Duffy SW

doi

10.1148/radiol.2411051092

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

47-53

issue

1

eissn

0033-8419

issn

1527-1315

pii

241/1/47

journal_volume

241

pub_type

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