Hepatocellular carcinoma: diagnostic performance of multidetector CT and MR imaging-a systematic review and meta-analysis.

Abstract:

PURPOSE:To perform a systematic review and meta-analysis of the diagnostic performance of computed tomography (CT) and magnetic resonance (MR) imaging as noninvasive modalities for evaluating hepatocellular carcinoma (HCC) in patients with chronic liver disease. MATERIALS AND METHODS:A search of the MEDLINE, EMBASE, and Cochrane Library databases was performed to identify studies providing per-patient or per-lesion diagnostic accuracies of multidetector CT and MR imaging for HCCs in patients with chronic liver disease. Studies published from January 2000 to December 2012 that used a reference standard based on histopathologic findings and/or findings at follow-up were included. Summary estimates of diagnostic accuracy were obtained by using a random-effects model with further exploration with meta-regression and subgroup analyses. RESULTS:Forty studies (six on multidetector CT, 22 on MR imaging, and 12 on both CT and MR imaging) were included. The studies evaluated a total of 1135 patients with multidetector CT and 2489 patients with MR imaging. The overall per-patient sensitivity of MR imaging was 88% (95% confidence interval [CI]: 83%, 92%), with a specificity of 94% (95% CI: 85%, 98%). The overall per-lesion sensitivity of MR imaging was higher than that of multidetector CT when the paired data of the 11 available studies were pooled (80% vs 68%, P = .0023). Gadoxetic acid-enhanced MR imaging showed significantly higher per-lesion sensitivity than MR imaging performed with other contrast agents (87% vs 74%, P = .03). Per-lesion sensitivity was significantly lower for HCCs smaller than 1 cm than that for HCCs 1 cm or larger (P < .001 for CT, P = .02 for MR imaging) and for those in explanted livers (P = .04 for CT, P < .001 for MR imaging). CONCLUSION:MR imaging showed higher per-lesion sensitivity than multidetector CT and should be the preferred imaging modality for the diagnosis of HCCs in patients with chronic liver disease.

journal_name

Radiology

journal_title

Radiology

authors

Lee YJ,Lee JM,Lee JS,Lee HY,Park BH,Kim YH,Han JK,Choi BI

doi

10.1148/radiol.14140690

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

97-109

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

275

pub_type

杂志文章,meta分析,评审
  • Persistent low back pain in patients suspected of having herniated nucleus pulposus: radiologic predictors of functional outcome--implications for treatment selection.

    abstract:PURPOSE:To assess the relationship between imaging findings, therapy, and functional outcome in patients with persistent low back pain who are suspected of having herniated nucleus pulposus. MATERIALS AND METHODS:Data collected during a multicenter, longitudinal study were retrospectively analyzed (n = 1,084). Multiva...

    journal_title:Radiology

    pub_type: 杂志文章,多中心研究

    doi:10.1148/radiology.203.3.9169710

    authors: Ackerman SJ,Steinberg EP,Bryan RN,BenDebba M,Long DM

    更新日期:1997-06-01 00:00:00

  • Renal cell carcinoma: radiofrequency ablation with a multiple-electrode switching system--a phase II clinical study.

    abstract:PURPOSE:To prospectively evaluate the safety and effectiveness of radiofrequency ablation with a multiple-electrode switching system for the treatment of renal cell carcinoma (RCC). MATERIALS AND METHODS:From November 2009 to December 2010, 33 patients (mean age, 70.7 years; range, 44-86 years) with histologically pro...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.12121070

    authors: Takaki H,Nakatsuka A,Uraki J,Yamanaka T,Fujimori M,Hasegawa T,Arima K,Sugimura Y,Yamakado K

    更新日期:2013-04-01 00:00:00

  • Computed tomography in congenital anomalies of the aortic arch and great vessels.

    abstract::Computed tomography can help in the evaluation of congenitally anomalous aortic arches and subclavian arteries. The authors discuss the role of computed tomography in the evaluation of such anomalies in seven patients. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.138.2.7455120

    authors: McLoughlin MJ,Weisbrod G,Wise DJ,Yeung HP

    更新日期:1981-02-01 00:00:00

  • Label-free Detection of Lymph Node Metastases with US-guided Functional Photoacoustic Imaging.

    abstract:PURPOSE:To determine the ability of ultrasonography (US)-guided spectroscopic photoacoustic (sPA) imaging to depict changes in blood oxygen saturation (SO2) in metastatic lymph nodes of a mouse model of oral cancer. MATERIALS AND METHODS:All studies were performed by following protocols approved by the institutional a...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2015141909

    authors: Luke GP,Emelianov SY

    更新日期:2015-11-01 00:00:00

  • Intravenous contrast material exposure is not an independent risk factor for dialysis or mortality.

    abstract:PURPOSE:To determine the risk of emergent dialysis and short-term mortality following intravenous iodinated contrast material exposure. MATERIALS AND METHODS:This single-center retrospective study was HIPAA compliant and institutional review board approved. All contrast material-enhanced (contrast group) and unenhance...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.14132418

    authors: McDonald RJ,McDonald JS,Carter RE,Hartman RP,Katzberg RW,Kallmes DF,Williamson EE

    更新日期:2014-12-01 00:00:00

  • The Haglund syndrome: initial and differential diagnosis.

    abstract::Haglund syndrome is a common cause of posterior heel pain, characterized clinically by a painful soft-tissue swelling at the level of the achilles tendon insertion. On the lateral heel radiograph the syndrome is characterized by a prominent calcaneal bursal projection, retrocalcaneal bursitis, thickening of the Achill...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.144.1.7089270

    authors: Pavlov H,Heneghan MA,Hersh A,Goldman AB,Vigorita V

    更新日期:1982-07-01 00:00:00

  • Effect of cross-sectional imaging on negative appendectomy and perforation rates in children.

    abstract:PURPOSE:To compare negative appendectomy and perforation rates in children who underwent ultrasonography (US), computed tomography (CT), or no imaging before urgent appendectomy. MATERIALS AND METHODS:All children who underwent urgent appendectomy during a 4(1/2)-year period were identified in a surgical billing datab...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.220.1.r01jl17103

    authors: Applegate KE,Sivit CJ,Salvator AE,Borisa VJ,Dudgeon DL,Stallion AE,Grisoni ER

    更新日期:2001-07-01 00:00:00

  • Liver size evaluated by ultrasound: ROC curves for hepatitis and alcoholism.

    abstract::A previous study determined the normal values and upper limits of liver size, as measured by the longitudinal and sagittal diameters in the midclavicular line and the midline. The present study was performed to determine which of the four sonographic diameters best differentiates between patients who have liver diseas...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.153.2.6385110

    authors: Niederau C,Sonnenberg A

    更新日期:1984-11-01 00:00:00

  • Imaging characteristics of an amorphous silicon flat-panel detector for digital chest radiography.

    abstract:PURPOSE:To evaluate the imaging characteristics of an amorphous silicon flat-panel detector (FPD) for digital chest radiography. MATERIALS AND METHODS:The 41 x 41-cm digital FPD is constructed on a single monolithic glass substrate with a structured cesium iodide scintillator layer and an amorphous silicon thin-film t...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.218.3.r01fe45683

    authors: Floyd CE Jr,Warp RJ,Dobbins JT 3rd,Chotas HG,Baydush AH,Vargas-Voracek R,Ravin CE

    更新日期:2001-03-01 00:00:00

  • Acute massive gastrointestinal bleeding: detection and localization with arterial phase multi-detector row helical CT.

    abstract:PURPOSE:To prospectively evaluate accuracy of arterial phase multi-detector row helical computed tomography (CT) for detection and localization of acute massive gastrointestinal (GI) bleeding, with angiography as reference standard. MATERIALS AND METHODS:Institutional review board approved this study; written informed...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2383050175

    authors: Yoon W,Jeong YY,Shin SS,Lim HS,Song SG,Jang NG,Kim JK,Kang HK

    更新日期:2006-04-01 00:00:00

  • Hemochromatosis of the pituitary gland: MR imaging.

    abstract::Magnetic resonance imaging of the pituitary gland in a patient with secondary hemochromatosis is described. On T1-weighted images, the anterior lobe had almost no signal intensity, and only the high-signal posterior lobe was seen. These findings are compatible with the distribution of iron deposition and clinical symp...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.168.1.3380960

    authors: Fujisawa I,Morikawa M,Nakano Y,Konishi J

    更新日期:1988-07-01 00:00:00

  • Peripheral T-cell lymphoma of the colon: double-contrast barium enema examination findings in six patients.

    abstract:PURPOSE:To evaluate radiologic findings of peripheral T-cell lymphoma (PTCL) of the colon at double-contrast barium enema examination. MATERIALS AND METHODS:Double-contrast barium enema findings in six patients with pathologically proved PTCL of the colon were retrospectively evaluated and compared with colonoscopic a...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.218.3.r01mr23751

    authors: Lee HJ,Han JK,Kim TK,Kim YH,Kim KW,Choi BI

    更新日期:2001-03-01 00:00:00

  • Myocardial positron tomography with manganese-52m.

    abstract::The biodistribution of radiomanganese (54Mn) was studied in mice, rats, and dogs. Disappearance of radioactivity from the blood was extremely rapid, with a half-time of approximately 0.8 minutes. This resulted in very favorable myocardium-to-blood ratios, even at early times after administration. The myocardial uptake...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/133.3.769

    authors: Atkins HL,Som P,Fairchild RG,Hui J,Schachner E,Goldman A,Ku T

    更新日期:1979-12-01 00:00:00

  • Pneumatosis coli secondary to acute appendicitis. Case report.

    abstract::An unusual case of pneumatosis coli is presented. The patient had acute inflammatory disease with gangrene of the appendix associated with air within the wall of the contiguous right colon. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/120.1.90

    authors: DiDonato LR

    更新日期:1976-07-01 00:00:00

  • Complications of cesarean section: role of transperineal US.

    abstract::The pelvic area was prospectively examined with transabdominal and transperineal ultrasonography (US) in 22 patients referred for US evaluation for possible complications of cesarean section. The region of the uterine wound was seen with transabdominal US in all patients and with transperineal US in 20. The two in who...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.188.2.8327710

    authors: Hertzberg BS,Bowie JD,Kliewer MA

    更新日期:1993-08-01 00:00:00

  • Three-dimensional, navigator-echo MR coronary angiography in detecting stenoses of the major epicardial vessels, with conventional coronary angiography as the standard of reference.

    abstract:PURPOSE:To test three-dimensional (3D), navigator-echo magnetic resonance (MR) coronary angiography in detecting stenoses of the coronary arteries. MATERIALS AND METHODS:Forty-two patients (age range, 50-79 years) underwent MR coronary angiography (1.5 T). A navigator-echo sequence was used. Two or three 15% overlappe...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.214.3.r00mr01808

    authors: Sardanelli F,Molinari G,Zandrino F,Balbi M

    更新日期:2000-03-01 00:00:00

  • Evaluation of White Matter Injury Patterns Underlying Neuropsychiatric Symptoms after Mild Traumatic Brain Injury.

    abstract:PURPOSE:To determine if a central axonal injury underlies neuropsychiatric symptoms after mild traumatic brain injury (mTBI) by using tract-based spatial statistics analysis of diffusion-tensor images. MATERIALS AND METHODS:The institutional review board approved this study, with waiver of informed consent. Diffusion-...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2015142974

    authors: Alhilali LM,Delic JA,Gumus S,Fakhran S

    更新日期:2015-12-01 00:00:00

  • Xeroradiography of axillary lymph node disease.

    abstract::Xeroradiographic evaluation of the axillary lymph nodes permits differentiation of characteristic patterns, including normal nodes and those enlarged as the result of fatty infiltration, inflammation, metastases from a breast primary, or primary nodal disease such as lymphoma or hyperplasia. The author describes his e...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/115.1.67

    authors: Kalisher L

    更新日期:1975-04-01 00:00:00

  • Thalamic resting-state functional networks: disruption in patients with mild traumatic brain injury.

    abstract:PURPOSE:To explore the neural correlates of the thalamus by using resting-state functional magnetic resonance (MR) imaging and to investigate whether thalamic resting-state networks (RSNs) are disrupted in patients with mild traumatic brain injury (MTBI). MATERIALS AND METHODS:This HIPAA-compliant study was approved b...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.11110014

    authors: Tang L,Ge Y,Sodickson DK,Miles L,Zhou Y,Reaume J,Grossman RI

    更新日期:2011-09-01 00:00:00

  • Atrial and ventricular functional and structural adaptations of the heart in elite triathletes assessed with cardiac MR imaging.

    abstract:PURPOSE:To assess cardiac morphologic and functional adaptations in elite triathletes with magnetic resonance (MR) imaging and to compare findings to those in recreationally active control subjects. MATERIALS AND METHODS:The institutional review board approved the study, and written informed consent was obtained from ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.10092377

    authors: Scharf M,Brem MH,Wilhelm M,Schoepf UJ,Uder M,Lell MM

    更新日期:2010-10-01 00:00:00

  • Radiofrequency ablation as a substitute for surgery in elderly patients with nonresected breast cancer: pilot study with long-term outcomes.

    abstract:PURPOSE:To determine the efficacy and tolerance of ultrasonography (US)-guided percutaneous radiofrequency (RF) ablation with endocrine therapy in elderly patients with breast cancer who decline or are not candidates for surgery. MATERIALS AND METHODS:Internal ethics committee approval was obtained, and patients gave ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.12111303

    authors: Palussière J,Henriques C,Mauriac L,Asad-Syed M,Valentin F,Brouste V,Mathoulin-Pélissier S,Tunon de Lara C,Debled M

    更新日期:2012-08-01 00:00:00

  • Conspicuity of renal calculi at unenhanced CT: effects of calculus composition and size and CT technique.

    abstract:PURPOSE:To determine the effects of calculus size, composition, and technique (kilovolt and milliampere settings) on the conspicuity of renal calculi at unenhanced helical computed tomography (CT). MATERIALS AND METHODS:The authors performed unenhanced CT of a phantom containing 188 renal calculi of varying size and c...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2251010242

    authors: Tublin ME,Murphy ME,Delong DM,Tessler FN,Kliewer MA

    更新日期:2002-10-01 00:00:00

  • Abdominal MR imaging with a volumetric interpolated breath-hold examination.

    abstract:PURPOSE:To compare a T1-weighted, three-dimensional (3D), gradient-echo (GRE) sequence for magnetic resonance (MR) imaging of the body (volumetric interpolated breath-hold examination, or VIBE) with a two-dimensional (2D) GRE breath-hold equivalent. MATERIALS AND METHODS:Twenty consecutive patients underwent 1.5-T MR ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.212.3.r99se34876

    authors: Rofsky NM,Lee VS,Laub G,Pollack MA,Krinsky GA,Thomasson D,Ambrosino MM,Weinreb JC

    更新日期:1999-09-01 00:00:00

  • Quantification of articular cartilage in the knee with pulsed saturation transfer subtraction and fat-suppressed MR imaging: optimization and validation.

    abstract:PURPOSE:To assess the reproducibility and accuracy of volumetric quantifications of articular cartilage in the knee determined with three-dimensional (3D) magnetic resonance (MR) imaging combined with pulsed saturation transfer subtraction (STS) or T1-weighted fat suppression (FS) imaging. MATERIALS AND METHODS:Eight ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.192.2.8029420

    authors: Peterfy CG,van Dijke CF,Janzen DL,Glüer CC,Namba R,Majumdar S,Lang P,Genant HK

    更新日期:1994-08-01 00:00:00

  • The opossum as an animal model for studying radiation esophagitis.

    abstract::Six opossums were evaluated as a possible animal model of radiation esophagitis. In a single exposure to the esophagus, four animals received 60Co radiation of various doses; two served as controls. Pre- and postirradiation evaluations using fiberoptic endoscopy, mucosal biopsy, barium esophagography, and manometry we...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/131.3.731

    authors: Northway MG,Libshitz HI,West JJ,Withers HR,Mukhopadhyay AK,Osborne BM,Szwarc IA,Dodd GD

    更新日期:1979-06-01 00:00:00

  • Self-expanding endovascular stent in experimental atherosclerosis. Work in progress.

    abstract::To investigate the physiologic and histologic responses induced by the self-expanding endovascular prosthesis, rabbits subjected to a combination of high-cholesterol diet and intravascular trauma underwent stent implantation. The results were compared with those obtained with the placement of stents in the healthy aor...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.170.3.2916030

    authors: Rousseau H,Joffre F,Raillat C,Julian M,Pierragi MT,Chalabi F,Bouissou H

    更新日期:1989-03-01 00:00:00

  • Anovaginal fistulas: evaluation with endoanal MR imaging.

    abstract:PURPOSE:To evaluate endoanal magnetic resonance (MR) imaging in the assessment of anovaginal fistulas and associated findings. MATERIALS AND METHODS:In a retrospective descriptive study, two radiologists systematically reviewed MR findings in 20 patients with a clinically proved anovaginal fistula and looked for the m...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2311021190

    authors: Dwarkasing S,Hussain SM,Hop WC,Krestin GP

    更新日期:2004-04-01 00:00:00

  • CT-pathologic correlations in Hodgkin's disease and non-Hodgkin's lymphoma.

    abstract::In order to assess its potential uses in the staging and treatment planning of lymphoma, CT was performed in 27 newly diagnosed, previously untreated patients with Hodgkin's disease or non-Hodgkin's lymphoma; 18 staging laparotomies provided pathologic correlations. CT detected and defined disease in areas not well ev...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/126.1.159

    authors: Breiman RS,Castellino RA,Harell GS,Marshall WH,Glatstein E,Kaplan HS

    更新日期:1978-01-01 00:00:00

  • Effect of Change in Portal Venous Blood Flow Rates on the Performance of a 2.45-GHz Microwave Ablation Device.

    abstract:PURPOSE:To investigate the effect of change in portal venous blood flow rates on the size and shape of ablations created by a 2.45-GHz microwave ablation device. MATERIALS AND METHODS:This study was exempt from review by the institutional animal care and use committee. An in vitro bovine liver model perfused with auto...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2015150102

    authors: Dodd GD 3rd,Kreidler SM,Lanctot AC,Glueck DH

    更新日期:2015-12-01 00:00:00

  • Use of CT in stapedial otosclerosis.

    abstract::Otosclerosis (otospongiosis) is a primary focal disease of the labyrinthine capsule. The stapes footplate is fixed when the spongiotic focus expands and invades the oval window. Persons with stapedial otosclerosis experience a progressive conductive hearing loss. In many cases, cochlear degeneration is observed, in wh...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.156.3.4023230

    authors: Mafee MF,Henrikson GC,Deitch RL,Norouzi P,Kumar A,Kriz R,Valvassori GE

    更新日期:1985-09-01 00:00:00