Abstract：
:The whole slide histopathology images (WSIs) play a critical role in gastric cancer diagnosis. However, due to the large scale of WSIs and various sizes of the abnormal area, how to select informative regions and analyze them are quite challenging during the automatic diagnosis process. The multi-instance learning based on the most discriminative instances can be of great benefit for whole slide gastric image diagnosis. In this paper, we design a recalibrated multi-instance deep learning method (RMDL) to address this challenging problem. We first select the discriminative instances, and then utilize these instances to diagnose diseases based on the proposed RMDL approach. The designed RMDL network is capable of capturing instance-wise dependencies and recalibrating instance features according to the importance coefficient learned from the fused features. Furthermore, we build a large whole-slide gastric histopathology image dataset with detailed pixel-level annotations. Experimental results on the constructed gastric dataset demonstrate the significant improvement on the accuracy of our proposed framework compared with other state-of-the-art multi-instance learning methods. Moreover, our method is general and can be extended to other diagnosis tasks of different cancer types based on WSIs.
journal_name
Med Image Analjournal_title
Medical image analysisauthors
Wang S,Zhu Y,Yu L,Chen H,Lin H,Wan X,Fan X,Heng PAdoi
10.1016/j.media.2019.101549subject
Has Abstractpub_date
2019-12-01 00:00:00pages
101549eissn
1361-8415issn
1361-8423pii
S1361-8415(19)30084-2journal_volume
58pub_type
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