Abstract：
:Reconstruction of white matter connectivity in the fetal brain from in utero diffusion-weighted magnetic resonance imaging (MRI) faces many challenges, including subject motion, small anatomical scale, and limited image resolution and signal. These issues are compounded by the need to track significant changes in structural connectivity throughout development. We present an automated method for improved reliability and completeness of tract extraction across a wide range of gestational ages, based on the geometry of coherent patterns in streamline tractography, and apply it to the reconstruction of the corpus callosum. This method, focused specifically at addressing the challenges of fetal brain imaging, avoids depending on a tractography atlas, and handles variations in size, shape, and tissue properties of developing brains, both between subjects and across ages. Although tractography from in utero MRI generally suffers from a significant number of misleading and missing pathways, we demonstrate the feasibility of extracting the coherent bundle of the corpus callosum while avoiding inappropriate diversions into other tracts.
journal_name
IEEE Trans Med Imagingjournal_title
IEEE transactions on medical imagingauthors
Hunt D,Dighe M,Gatenby C,Studholme Cdoi
10.1109/TMI.2019.2932681subject
Has Abstractpub_date
2020-03-01 00:00:00pages
601-610issue
3eissn
0278-0062issn
1558-254Xjournal_volume
39pub_type
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