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Amino acid structures of multiple forms of amyloid-related serum protein SAA from a single individual.

Abstract：

:Multiple forms of the acute-phase serum protein SAA were isolated from the lipoprotein fraction of plasma from a single individual. These protein forms were purified by size-exclusion, ion-exchange, and reverse-phase high-pressure liquid chromatography, and then the tryptic peptides were subjected to amino acid sequence analysis. A total of three distinct 104-residue proteins were identified. Two of these proteins differed only by having either an arginine or a histidine at position 71 while the third protein had seven amino acid differences. Each of these proteins has a 103-residue companion protein where the amino-terminal arginine has been removed. Two of these protein sequences match the two human SAA cDNA structures reported in the literature. The presence of three unique amino acid sequences in one individual is proof that there must be a minimum of two genes for SAA in humans.

journal_name

Biochemistry

journal_title

Biochemistry

authors

Dwulet FE,Wallace DK,Benson MD

doi

10.1021/bi00405a044

subject

Has Abstract

pub_date

1988-03-08 00:00:00

pages

1677-82

issue

5

eissn

0006-2960

issn

1520-4995

journal_volume

27

pub_type

杂志文章

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