IL-10 gene polymorphism in diabetic retinopathy.

Abstract:

INTRODUCTION:To investigate the relationship between the interleukin-10 (IL-10) gene polymorphism and the pathogenesis of diabetic retinopathy (DR). PATIENTS AND METHODS:According to the fundus examination report, 420 patients with diabetes were divided into the non-DR group (n=200) and the DR group (n=220). The single nucleotide polymorphisms rs1145612 and rs11567245 in the promoter region of the IL-10 gene were classified by the conformational differential gel electrophoresis. RESULTS:No correlation was found between the polymorphism rs1145612 and the clinical information of DR patients. The polymorphism rs11567245 had correlations with multiple clinical indicators of DR patients, including body mass index (BMI), systolic blood pressure (SBP), blood urea nitrogen (BUN), fasting blood glucose (FBG), and 2-h postprandial blood glucose (2hBG) (p<0.05). CONCLUSIONS:The IL-10 gene promoter rs1145612 is not related to the occurrence and development of DR, but a relationship exists between the polymorphism rs11567245 and the occurrence and development of DR.

authors

Shi YL,Shi MY,Yin LZ,Shang JM,Zhuang JY

doi

10.26355/eurrev_201906_18169

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

5059-5064

issue

12

eissn

1128-3602

issn

2284-0729

journal_volume

23

pub_type

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