当前位置： SCI文献检索 > European Review for Medical and Pharmacological Sciences期刊下所有文献 > The role of miR-146b-5p in TLR4 pathway of glomerular mesangial cells with lupus nephritis.

The role of miR-146b-5p in TLR4 pathway of glomerular mesangial cells with lupus nephritis.

Abstract：

OBJECTIVE:MicroRNAs (miRNAs) are now recognized as important regulators of gene expression. The aim of the study was to investigate the role of miR-146b-5p in the TLR4 pathway and provide the basis for the treatment of lupus nephritis. MATERIALS AND METHODS:The glomerular mesangial cells were cultured in vitro and divided into 3 groups: control group, a group of miR-146b-5p mimic added, and a group of miR-146b-5p inhibitor added. The levels of IL-6 and IL-8 in the cell culture supernatant of the three groups were detected by ELISA. The cell proliferation was detected by MTT. The expressions of MiR-146b-5p and TLR4 pathway-associated factor TRAF6 were detected by RT- PCR. The expression of TRAF6 and IRAK1 protein was detected by Western blot. RESULTS:The overexpression of miR-146b-5p could reduce the level of IL6 and IL8 in cell culture and inhibit glomerular mesangial cell proliferation in some degree. Also, the overexpression of miR-146b-5p could inhibit the expressions of TLR4 pathway-associated factor TRAF6 and IRAK1mRNA, and the expressions of TRAF6 and IRAK1 protein. CONCLUSIONS:MiR-146b-5p attenuated the inflammatory response of glomerular mesangial cells by inhibiting the expressions levels of TRAF6 and IRAK1 in lupus nephritis.

journal_name

Eur Rev Med Pharmacol Sci

journal_title

European review for medical and pharmacological sciences

authors

Sheng ZX,Yao H,Cai ZY

doi

10.26355/eurrev_201803_14589

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

1737-1743

issue

6

eissn

1128-3602

issn

2284-0729

journal_volume

22

pub_type

杂志文章

相关文献

European Review for Medical and Pharmacological Sciences文献大全
  • LncRNA DANCR accelerates the development of multidrug resistance of gastric cancer.

    abstract：OBJECTIVE:The development of multidrug resistance (MDR) is a key issue for tumor recurrence and metastasis, leading to treatment failure of gastric cancer (GC). Long non-coding RNA (lncRNA) DANCR has been shown to be highly expressed in GC patients, which accelerates growth and metastasis of GC cells. This study aims t...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201904_17554

    authors： Xu YD,Shang J,Li M,Zhang YY

    更新日期：2019-04-01 00:00:00

  • Combination of targeting gene-viro therapy with recombinant Fowl-pox viruses with HN and VP3 genes on mouse osteosarcoma.

    abstract：BACKGROUND:Osteosarcoma is an aggressive cancerous neoplasm arising from primitive transformed cells of mesenchymal origin that exhibit osteoblastic differentiation and produce malignant osteoid. With the rapid development of tumor molecular biology, gene and viral therapy, a highly promising strategy for the treatment...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Zhang ZY,Wang LQ,Fu CF,Li X,Cui ZL,Zhang JY,Xue SH,Sun N,Xu F

    更新日期：2013-03-01 00:00:00

  • Effect of Olmesartan on serum cystatin C levels in the patients with essential hypertension.

    abstract：AIM:We aimed to investigate whether Olmesartan had an effect on cystatin C levels in hypertensive patients, and evaluate its correlation with blood pressure (BP). MATERIALS AND METHODS:Seventy-two patients essential hypertension patients with a known for, at most, the last 3 years were enrolled to the study. Patients ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Koc Y,Mazi E,Sakaci T,Basturk T,Damar AB,Ahbap E,Unsal A,Borlu F

    更新日期：2011-12-01 00:00:00

  • On a case of "Macrodystrophia lipomatosa".

    abstract：:Macrodistrophia Lipomatosa is a congenital malformation of rare finding and unknown pathogenic mechanism. The pathology is mainly characterized by the interest of lower extremities and peculiar macroscopic feature is the presence of hyperthrophic fibro-adipose tissue. In our experience the localization to the upper ex...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Di Ianni F,Di Ianni G,Isidoro C,Migliorato L,Piersante S

    更新日期：1997-09-01 00:00:00

  • The increase of miR-27a affects the role of cisplatin on proliferation and migration capacities of liver cancer cells.

    abstract：OBJECTIVE:To study the effects of chronic virus-mediated micro ribonucleic acid miR-27a on proliferation and migration capacities of liver cancer cells. PATIENTS AND METHODS:A total of 60 patients with primary liver cancer from January 2015 to December 2016 were selected as observation group, 60 patients with chronic ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201809_15809

    authors： Li W,Yu ZX,Ma BF

    更新日期：2018-09-01 00:00:00

  • Circular RNA circ-PRKCI promotes cell proliferation and invasion by binding to microRNA-545 in gastric cancer.

    abstract：OBJECTIVE:The carcinogenic effects of circular RNA circ-PRKCI have been recognized in a variety of malignancies. However, the exact biological function of circ-PRKCI in gastric cancer has not been fully elucidated. Therefore, the aim of this study was to explore the expression of circ-PRKCI in gastric cancer (GC) and t...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201911_19435

    authors： Wu L,Li Y,Xu XM,Zhu X

    更新日期：2019-11-01 00:00:00

  • The role of quacks in the practice of proctology.

    abstract：:Most human beings will do almost anything to prolong their existence or to relieve themselves from the suffering of a disease. Others will do anything to exploit these desires by selling what they claim to be magical remedies or panacea for all diseases-even for the incurable ones. Quack is one of the several names us...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Gupta PJ

    更新日期：2010-09-01 00:00:00

  • Adipose tissue-derived mesenchymal stem cells and hepatic differentiation: old concepts and future perspectives.

    abstract：:Mesenchymal stem cells (MSCs) are multipotent cells, able to differentiate into elements of the mesodermal lineage. Bone marrow and adipose tissue represent the main sources for MSC isolation. In the last decade, several studies have reported the plasticity of MSCs toward a hepatocyte-like phenotype. The use of MSCs t...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,评审

    doi：

    authors： Puglisi MA,Saulnier N,Piscaglia AC,Tondi P,Agnes S,Gasbarrini A

    更新日期：2011-04-01 00:00:00

  • Correlation of CT indicators of NSCLC and pathological features and the expression level of p53 and c-myc.

    abstract：OBJECTIVE:To investigate the correlations of the computed tomography (CT) signs of non-small cell lung cancer (NSCLC) with pathological features and the expression levels of phosphoprotein 53 (p53) and c-Myc in patients. PATIENTS AND METHODS:87 patients with NSCLC admitted to the Department of Oncology in our hospital...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201801_14110

    authors： Li HS,Lv RQ,Liu L

    更新日期：2018-01-01 00:00:00

  • Short Report - Medical nutrition therapy for critically ill patients with COVID-19.

    abstract：:No Abstract Available. ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202004_20874

    authors： Romano L,Bilotta F,Dauri M,Macheda S,Pujia A,De Santis GL,Tarsitano MG,Merra G,Di Renzo L,Esposito E,De Lorenzo A

    更新日期：2020-04-01 00:00:00

  • Combined treatment in advanced stages (IIIb-IV) of non-small cell lung cancer.

    abstract：:Chemotherapy regimens based on platinum represent the reference standards in Non-Small Cell Lung Cancer (NSCLC) and when it is associated with radiotherapy and/or surgery (combined treatment) it improves survival of patients. Aim of this study was to estimate the efficacy of chemotherapy, based on high-dose epirubicin...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 临床试验,杂志文章

    doi：

    authors： Mariotta S,Sposato B,Li Bianchi E,Fiorucci F,Ricci A,Carbone F,Crescenzi M,Schmid G

    更新日期：2002-03-01 00:00:00

  • Critical genes of hepatocellular carcinoma revealed by network and module analysis of RNA-seq data.

    abstract：OBJECTIVE:RNA-seq data of hepatocellular carcinoma (HCC) was analyzed to identify critical genes related to the pathogenesis and prognosis. MATERIALS AND METHODS:Three RNA-seq datasets of HCC (GSE69164, GSE63863 and GSE55758) were downloaded from Gene Expression Omnibus (GEO), while another dataset including 54 HCC ca...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Yang MR,Zhang Y,Wu XX,Chen W

    更新日期：2016-10-01 00:00:00

  • Paragangliomas of the carotid body and other rare localisation.

    abstract：:Cervical paragangliomas are uncommon benign or malignant neoplasms, originated by stem cells of neural crest. It is not easy nowadays to define properly their biological behaviour, the possible multiple location and the association with Multiple Endocrine Neoplasms. After a wide review about recent diagnostic, patholo...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 临床试验,杂志文章

    doi：

    authors： Marchesi M,Biffoni M,Jaus MO,Nobili Benedetti R,Tromba L,Berni A,Campana FP

    更新日期：1998-03-01 00:00:00

  • CircRNA_100395 protects breast carcinoma deterioration by targeting MAPK6.

    abstract：OBJECTIVE:This study aims to uncover the differential expression of circRNA_100395 in breast carcinoma specimens, and its regulatory effect on cancer cell phenotypes. The role of circRNA_100395 in affecting breast carcinoma progression and the molecular mechanism are explored as well. PATIENTS AND METHODS:CircRNA_1003...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202012_24012

    authors： Yu XP,Liu CG,Qiu F,Xu YQ,Xing F,Yin JQ,Han SJ,Yu H,Han Y,Jing X,He GJ

    更新日期：2020-12-01 00:00:00

  • Persistent eradication of Helicobacter pylori after systemic politherapy associated with periodontal pockets treatment with metronidazole and calcium sulphate.

    abstract：:The sensitivity of H. Pylori to antibiotic treatment is well known. Politherapy (omeprazole or pantoprazole or ranitidine, amoxicillin and/or azithromycin and/or clarithromycin, metronidazole and bismuth citrate) notably changed the percentage of H. pylori eradication but rarely resolutive. Periodontal pockets treatme...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 临床试验,杂志文章

    doi：

    authors： Tarullo A,Tattoli M,Cagiano R

    更新日期：2001-07-01 00:00:00

  • N-acetylcysteine as powerful molecule to destroy bacterial biofilms. A systematic review.

    abstract：OBJECTIVE:Biofilms are microbial communities consisting of bacteria, extremely capable to self-reproduce on biological surfaces, causing infections. Frequently, these biofilms are resistant to classical antibacterial treatments and host immune response. Thus, new adjuvant molecules are mandatory in clinical practice. N...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,评审

    doi：

    authors： Dinicola S,De Grazia S,Carlomagno G,Pintucci JP

    更新日期：2014-10-01 00:00:00

  • LncRNA CCAT2 enhances cell proliferation via GSK3β/β-catenin signaling pathway in human osteosarcoma.

    abstract：OBJECTIVE:Osteosarcoma (OS) is a kind of malignant bone tumor. The aim of the manuscript is to investigate the clinical significance and the functional effects of long non-coding (lncRNA) colon cancer-associated transcript 2 (CCAT2) in osteosarcoma. PATIENTS AND METHODS:Expression of CCAT2 was detected by quantitative...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201805_15053

    authors： Ruan R,Zhao XL

    更新日期：2018-05-01 00:00:00

  • Knockdown of long noncoding RNA AB073614 inhibits glioma cell proliferation and migration via affecting epithelial-mesenchymal transition.

    abstract：OBJECTIVE:This study was aimed to explore the role of long noncoding RNA (lncRNA) AB073614 and its potential mechanisms in the glioma development. MATERIALS AND METHODS:Expression levels of lncRNA AB073614 in glioma tissues and glioma cell lines were evaluated by quantitative real-time PCR (qRT-PCR). MTT assays were c...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Li J,Wang YM,Song YL

    更新日期：2016-10-01 00:00:00

  • Menopause: new frontiers in the treatment of urogenital atrophy.

    abstract：OBJECTIVE:Urogenital atrophy is a degenerative process that may occur during menopause causing debilitating disorders and painful symptomatology. Estrogen therapy slows the onset of atrophy, but it requires ongoing therapy to maintain its effectiveness. To mitigate the degenerative evolutions associated with menopause,...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201801_14211

    authors： Casarotti GA,Chiodera P,Tremolada C

    更新日期：2018-01-01 00:00:00

  • miR-98-TXLNG1 (FIAT)/Sp7 function loop mediates osteoblast mineralization.

    abstract：OBJECTIVE:To investigate the role of microRNAs (miRNAs) and its mechanism in osteoblast mineralization. MATERIALS AND METHODS:Real-time polymerase chain reaction (PCR), Northern Blot, and Western Blot were used to identify the expression mode of regulators. Overexpression and down-regulation experiments were carried o...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201806_15246

    authors： Yang L,Huang LY,Li LB,Tang Z,Chen K,Chen LP,Luo HY,Luo J,Zhao XL

    更新日期：2018-06-01 00:00:00

  • MiR-183 modulates multi-drug resistance in hepatocellular cancer (HCC) cells via miR-183-IDH2/SOCS6-HIF-1α feedback loop.

    abstract：OBJECTIVE:MiR-183 acts as an oncomiR and is usually upregulated in hepatocellular cancer (HCC). This study aims to study the association between miR-183 dysregulation and multi-drug resistance (MDR). Also, how it is dysregulated in HCC cells was investigated. MATERIALS AND METHODS:The association between miR-183 and H...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Wang XJ,Zhang DL,Fu C,Wei BZ,Li GJ

    更新日期：2016-05-01 00:00:00

  • Effects of vitamin D levels on asthma control and severity in pre-school children.

    abstract：OBJECTIVE:Prevalence of asthma and vitamin D deficiency has been increasing and leading to significant morbidities. This study aimed to compare the vitamin D levels in the pre-school children with asthma and in healthy controls and to assess the relationship between vitamin D levels and asthma clinical parameters and c...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Turkeli A,Ayaz O,Uncu A,Ozhan B,Bas VN,Tufan AK,Yilmaz O,Yuksel H

    更新日期：2016-01-01 00:00:00

  • Circ_0009910 promotes proliferation and metastasis of hepatocellular carcinoma cells through miR-335-5p/ROCK1 axis.

    abstract：OBJECTIVE:CircRNAs serve an essential role in regulating the development and progression of various tumors. The aim of this study was to examine the role and mechanism of circ_0009910 in hepatocellular carcinoma (HCC). MATERIALS AND METHODS:RT-qPCR was used to detect the expression of circ_0009910 and miR-335-5p in ti...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202002_20349

    authors： Li HW,Liu J

    更新日期：2020-02-01 00:00:00

  • Effect of pioglitazone combined with simvastatin on the CD40-CD40 ligand system in rabbits with atherosclerosis.

    abstract：OBJECTIVE:This paper aims to investigate the interaction mechanism between pioglitazone/simvastatin and the CD40-CD40 ligand (CD40-CD40L) system and to determine their interaction effects on atherosclerosis in rabbits. MATERIALS AND METHODS:Forty rabbits were randomly divided into five groups of eight: normal control,...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Xue L,Zhu XH,Yang XF,Bao XC,Gao XQ,Qiu YH,Wu Z,Ji XP,Li HW

    更新日期：2015-01-01 00:00:00

  • CHARGE syndrome: an overview on dental and maxillofacial features.

    abstract：OBJECTIVES:CHARGE is an acronym referring to the aspects of this rare syndromic condition. Patients with CHARGE association are today considered as subjects lacking in pathognomonic dental alterations. The present study is aimed at adding to the body of evidence of the cases reported in literature and the continuous cl...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Inchingolo F,Pacifici A,Gargari M,Acitores Garcia JI,Amantea M,Marrelli M,Dipalma G,Inchingolo AM,Rinaldi R,Inchingolo AD,Pacifici L,Tatullo M

    更新日期：2014-01-01 00:00:00

  • The accuracy of CBCT in measuring jaws bone density.

    abstract：BACKGROUND:The cone-beam computerized tomography (CBCT) has become widely used for oral and maxillofacial imaging, providing a good spatial resolution, gray density range, and contrast, as well as a good pixel/noise ratio. In the CBCT the dimensional accuracy is also comparable with Computer Tomography (CT), but in con...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Cassetta M,Stefanelli LV,Di Carlo S,Pompa G,Barbato E

    更新日期：2012-10-01 00:00:00

  • Exosomes derived from Taxol-resistant nasopharyngeal carcinoma (NPC) cells transferred DDX53 to NPC cells and promoted cancer resistance to Taxol.

    abstract：OBJECTIVE:Nasopharyngeal carcinoma (NPC) is a common cancer with high incidence in Southern China. Taxol is one of the first-line chemotherapeutic drugs for treating NPC; however, Taxol resistance has become the main difficulty for clinical treatment and the mechanisms remain not fully understood. In this study, we mai...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202101_24375

    authors： Yuan F,Zhou ZF

    更新日期：2021-01-01 00:00:00

  • Clinical diagnostic value of free body of reduced iron protoporphyrin in uterus epithelial cells on cervical carcinoma and precancerous lesion.

    abstract：OBJECTIVE:Cervical cancer is a common malignant tumor in women with increased incidence and younger onset age. As a curable tumor, timely diagnosis and early intervention are critical. Based on the golden standard of cervical tissues pathology examination, we investigated the value of free body of reduced iron protopor...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Zhou X,Zuo JH,Wu ZY,Ma Y,Ou SR

    更新日期：2017-05-01 00:00:00

  • Use of robotic colonoscopy in patients with previous incomplete colonoscopy.

    abstract：OBJECTIVE:Conventional colonoscopy (CC) is the gold standard to diagnostic and therapeutic approach to colon. However, in few cases, cecal intubation could fail due to colon anatomy, patient compliance and physician expertise. Endotics robotic colonoscopy is a novel, safe, mini-invasive modality to explore the entire c...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Tumino E,Parisi G,Bertoni M,Bertini M,Metrangolo S,Ierardi E,Cervelli R,Bresci G,Sacco R

    更新日期：2017-02-01 00:00:00

  • Effects of pioglitazone and glipizide on platelet function in patients with type 2 diabetes.

    abstract：OBJECTIVE:Platelet hyper-reactivity is one of the most important causes of accelerated atherosclerosis and increased risk of thrombotic vascular events associated with type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of different add-on anti-diabetic therapies on platelet function in T2DM pa...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,随机对照试验

    doi：

    authors： Xiao CC,Ren A,Yang J,Ye SD,Xing XN,Li SM,Chen C,Chen RP

    更新日期：2015-01-01 00:00:00