Abstract：
:The ability to predict patient-specific soft tissue deformations is key for computer-integrated surgery systems and the core enabling technology for a new era of personalized medicine. Element-Free Galerkin (EFG) methods are better suited for solving soft tissue deformation problems than the finite element method (FEM) due to their capability of handling large deformation while also eliminating the necessity of creating a complex predefined mesh. Nevertheless, meshless methods based on EFG formulation, exhibit three major limitations: (i) meshless shape functions using higher order basis cannot always be computed for arbitrarily distributed nodes (irregular node placement is crucial for facilitating automated discretization of complex geometries); (ii) imposition of the Essential Boundary Conditions (EBC) is not straightforward; and, (iii) numerical (Gauss) integration in space is not exact as meshless shape functions are not polynomial. This paper presents a suite of Meshless Total Lagrangian Explicit Dynamics (MTLED) algorithms incorporating a Modified Moving Least Squares (MMLS) method for interpolating scattered data both for visualization and for numerical computations of soft tissue deformation, a novel way of imposing EBC for explicit time integration, and an adaptive numerical integration procedure within the Meshless Total Lagrangian Explicit Dynamics algorithm. The appropriateness and effectiveness of the proposed methods is demonstrated using comparisons with the established non-linear procedures from commercial finite element software ABAQUS and experiments with very large deformations. To demonstrate the translational benefits of MTLED we also present a realistic brain-shift computation.
journal_name
Med Image Analjournal_title
Medical image analysisauthors
Joldes G,Bourantas G,Zwick B,Chowdhury H,Wittek A,Agrawal S,Mountris K,Hyde D,Warfield SK,Miller Kdoi
10.1016/j.media.2019.06.004subject
Has Abstractpub_date
2019-08-01 00:00:00pages
152-171eissn
1361-8415issn
1361-8423pii
S1361-8415(18)30572-3journal_volume
56pub_type
杂志文章abstract：:Fundus camera imaging of the retina is widely used to diagnose and manage ophthalmologic disorders including diabetic retinopathy, glaucoma, and age-related macular degeneration. Retinal images typically have a limited field of view, and multiple images can be joined together using an image registration technique to f...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2010.04.001
更新日期：2010-08-01 00:00:00
abstract：:A new method is proposed to quantify the myocardial motion from both 2D C(ine)-MRI and T(agged)-MRI sequences. The tag pattern offers natural landmarks within the image that makes it possible to accurately quantify the motion within the myocardial wall. Therefore, several methods have been proposed for T-MRI. However,...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2019.06.016
更新日期：2019-10-01 00:00:00
abstract：:Both resting state fMRI (R-fMRI) and task-based fMRI (T-fMRI) have been widely used to study the functional activities of the human brain during task-free and task-performance periods, respectively. However, due to the difficulty in strictly controlling the participating subject's mental status and their cognitive beh...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2013.07.003
更新日期：2013-12-01 00:00:00
abstract：:Typically, a medical image offers spatial information on the anatomy (and pathology) modulated by imaging specific characteristics. Many imaging modalities including Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) can be interpreted in this way. We can venture further and consider that a medical image na...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2019.101535
更新日期：2019-12-01 00:00:00
abstract：:Many cardiac pathologies are reflected in abnormal myocardial deformation, accessible through magnetic resonance tagging (MRT). Interpretation of the MRT data is difficult, since the relation between pathology and deformation is not straightforward. Mathematical models of cardiac mechanics could be used to translate m...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2006.04.001
更新日期：2006-08-01 00:00:00
abstract：:The dynamics of the carotid artery wall has been recognized as a valuable indicator to evaluate the status of atherosclerotic disease in the preclinical stage. However, it is still a challenge to accurately measure this dynamics from ultrasound images. This paper aims at developing an elasticity-based state-space appr...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2017.01.004
更新日期：2017-04-01 00:00:00
abstract：:Three-dimensional freehand ultrasound imaging produces a set of irregularly spaced B-scans, which are typically reconstructed on a regular grid for visualization and data analysis. Most standard reconstruction algorithms are designed to minimize computational requirements and do not exploit the underlying shape of the...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/s1361-8415(99)80028-0
更新日期：1999-12-01 00:00:00
abstract：:Highly relevant for both clinical and legal medicine applications, the established radiological methods for estimating unknown age in children and adolescents are based on visual examination of bone ossification in X-ray images of the hand. Our group has initiated the development of fully automatic age estimation meth...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2019.101538
更新日期：2019-12-01 00:00:00
abstract：:An automated segmentation method is presented for multi-organ segmentation in abdominal CT images. Dictionary learning and sparse coding techniques are used in the proposed method to generate target specific priors for segmentation. The method simultaneously learns dictionaries which have reconstructive power and clas...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2015.04.015
更新日期：2015-07-01 00:00:00
abstract：:We have developed a new computer-aided diagnosis scheme for automated detection of lung nodules in digital chest radiographs based on a combination of morphological features and the wavelet snake. In our scheme, two processes were applied in parallel to reduce the false-positive detections after initial nodule candida...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/s1361-8415(02)00064-6
更新日期：2002-12-01 00:00:00
abstract：:Graph-based groupwise registration methods are widely used in atlas construction. Given a group of images, a graph is built whose nodes represent the images, and whose edges represent a geodesic path between two nodes. The distribution of images on an image manifold is explored through edge traversal in a graph. The f...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2020.101711
更新日期：2020-08-01 00:00:00
abstract：:We propose a novel Riemannian framework for statistical analysis of shapes that is able to account for the nonlinearity in shape variation. By adopting a physical perspective, we introduce a differential representation that puts the local geometric variability into focus. We model these differential coordinates as ele...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2017.09.004
更新日期：2018-01-01 00:00:00
abstract：:In this work, various wavelet based methods like the discrete wavelet transform, the dual-tree complex wavelet transform, the Gabor wavelet transform, curvelets, contourlets and shearlets are applied for the automated classification of colonic polyps. The methods are tested on 8 HD-endoscopic image databases, where ea...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2016.02.001
更新日期：2016-07-01 00:00:00
abstract：:Robust and fast detection of anatomical structures represents an important component of medical image analysis technologies. Current solutions for anatomy detection are based on machine learning, and are generally driven by suboptimal and exhaustive search strategies. In particular, these techniques do not effectively...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2018.06.007
更新日期：2018-08-01 00:00:00
abstract：:A multiple hypothesis tracking approach to the segmentation of small 3D vessel structures is presented. By simultaneously tracking multiple hypothetical vessel trajectories, low contrast passages can be traversed, leading to an improved tracking performance in areas of low contrast. This work also contributes a novel ...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2009.12.003
更新日期：2010-04-01 00:00:00
abstract：:In this study, we propose a novel anomaly detection model targeting subtle brain lesions in multiparametric MRI. To compensate for the lack of annotated data adequately sampling the heterogeneity of such pathologies, we cast this problem as an outlier detection problem and introduce a novel configuration of unsupervis...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2019.101618
更新日期：2020-02-01 00:00:00
abstract：:After two decades of increasing interest and research activity, computer-assisted diagnostic approaches are reaching the stage where more routine deployment in clinical practice is becoming a possibility [Kruppinski, E.A., 2004. Computer-aided detection in clinical environment: Benefits and challenges for radiologists...
journal_title：Medical image analysis
pub_type： 杂志文章,评审
doi：10.1016/j.media.2005.06.003
更新日期：2006-04-01 00:00:00
abstract：:In-silico continuum simulations of organ and tissue scale physiology often require a discretisation or mesh of the solution domain. Cubic Hermite meshes provide a smooth representation of anatomy that is well-suited for simulating large deformation mechanics. Models of organ mechanics and deformation have demonstrated...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2011.06.010
更新日期：2011-12-01 00:00:00
abstract：:We describe a new algorithm for non-rigid registration capable of estimating a constrained dense displacement field from multi-modal image data. We applied this algorithm to capture non-rigid deformation between digital images of histological slides and digital flat-bed scanned images of cryotomed sections of the lary...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2005.04.003
更新日期：2005-12-01 00:00:00
abstract：:During embryogenesis, a mammalian heart develops from a simple tubular shape into a complex 4-chamber organ, going through four distinct phases: early primitive tubular heart, emergence of trabeculations, trabecular remodeling and development of the compact myocardium. In this paper we propose a framework for standard...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2018.08.001
更新日期：2018-10-01 00:00:00
abstract：:In this note we summarize the history of computer aided surgery in orthopaedics and traumatology from the end of the nineteenth century to currently observable future trends. We concentrate on the two major components of such systems, pre-operative planning and intra-operative execution. The evolution of the necessary...
journal_title：Medical image analysis
pub_type： 社论
doi：10.1016/j.media.2016.06.033
更新日期：2016-10-01 00:00:00
abstract：:Real-time cardiac MRI appears as a promising technique to evaluate the mechanical function of the heart. However, ultra-fast MRI acquisitions come with an important signal-to-noise ratio (SNR) penalty, which drastically reduces the image quality. Hence, a real-time denoising approach would be desirable for SNR amelior...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2009.05.006
更新日期：2009-08-01 00:00:00
abstract：:In this paper, we present a generative Bayesian approach for estimating the low-dimensional latent space of diffeomorphic shape variability in a population of images. We develop a latent variable model for principal geodesic analysis (PGA) that provides a probabilistic framework for factor analysis in the space of dif...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2015.04.009
更新日期：2015-10-01 00:00:00
abstract：:Accurate cortical thickness estimation is important for the study of many neurodegenerative diseases. Many approaches have been previously proposed, which can be broadly categorised as mesh-based and voxel-based. While the mesh-based approaches can potentially achieve subvoxel resolution, they usually lack the computa...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2009.07.003
更新日期：2009-10-01 00:00:00
abstract：:Accurate automated segmentation and detection of ovarian cancer metastases may improve the diagnosis and prognosis of women with ovarian cancer. In this paper, we focus on an important subset of ovarian cancer metastases that spread to the surface of the liver and spleen. Automated ovarian cancer metastasis detection ...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2014.04.001
更新日期：2014-07-01 00:00:00
abstract：:Accurate digital representation of major white matter bundles in the brain is an important goal in neuroscience image computing since the representations can be used for surgical planning, intra-patient longitudinal analysis and inter-subject population connectivity studies. Reconstructing desired fiber bundles genera...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2018.02.008
更新日期：2018-05-01 00:00:00
abstract：:In this paper, we present a framework to estimate local ventricular myocardium contractility using clinical MRI, a heart model and data assimilation. First, we build a generic anatomical model of the ventricles including muscle fibre orientations and anatomical subdivisions. Then, this model is deformed to fit a clini...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2006.04.002
更新日期：2006-08-01 00:00:00
abstract：:Vascular pressure differences are established risk markers for a number of cardiovascular diseases. Relative pressures are, however, often driven by turbulence-induced flow fluctuations, where conventional non-invasive methods may yield inaccurate results. Recently, we proposed a novel method for non-turbulent flows, ...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2019.101627
更新日期：2020-02-01 00:00:00
abstract：:The Cartesian parallel magnetic imaging problem is formulated variationally using a high-order penalty for coil sensitivities and a total variation like penalty for the reconstructed image. Then the optimality system is derived and numerically discretized. The objective function used is non-convex, but it possesses a ...
journal_title：Medical image analysis
pub_type： 杂志文章
doi：10.1016/j.media.2011.07.002
更新日期：2012-01-01 00:00:00
abstract：:Statistical shape models (SSMs) have by now been firmly established as a robust tool for segmentation of medical images. While 2D models have been in use since the early 1990 s, wide-spread utilization of three-dimensional models appeared only in recent years, primarily made possible by breakthroughs in automatic dete...
journal_title：Medical image analysis
pub_type： 杂志文章,评审
doi：10.1016/j.media.2009.05.004
更新日期：2009-08-01 00:00:00
