Abstract:
OBJECTIVE:To evaluate the duration of protection of pentavaent rotavirus vaccine (RV5) against rotavirus hospitalizations in Nicaragua, a developing country in Central America. METHODS:We conducted a case-control study at 4 hospitals from 2007 through 2010, including 1016 children hospitalized with laboratory-confirmed rotavirus diarrhea, 4930 controls with nonrotavirus diarrhea (ie, "test-negative"), and 5627 controls without diarrhea. All cases and controls were aged ≥ 6 months and born after August 2006. Outcomes included odds of antecedent vaccination between case-patients and controls, and effectiveness of vaccination (1 - adjusted odds ratio [OR] × 100). Duration of protection was assessed by comparing effectiveness among children aged <1 year compared with ≥ 1 year. RESULTS:Indicators of socioeconomic conditions and nonrotavirus vaccination (oral polio vaccine and diphtheria/tetanus/pertussis/hepatitis A/hepatitis B) for test-negative controls were more comparable to the rotavirus case-patients than nondiarrhea controls. RV5 vaccination was associated with a significantly lower risk of rotavirus hospitalization by using test-negative controls (OR: 0.55; 95% confidence interval [CI]: 0.41-0.74) and nondiarrhea controls (OR: 0.30; 95% CI: 0.22-0.40). Risk of rotavirus hospitalization was twofold lower among RV5 vaccinated children aged <1 year (OR: 0.36; 95% CI: 0.22-0.57) compared with RV5 vaccinated children aged ≥ 1 year (OR: 0.70; 95% CI: 0.47-1.05). CONCLUSIONS:RV5 provided good protection against severe rotavirus disease in Nicaragua during the first year of life, when most severe and fatal rotavirus disease in developing countries occurs. However, the decline in protection with age warrants monitoring of disease among older children and consideration of a booster dose evaluation at the end of infancy.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Patel M,Pedreira C,De Oliveira LH,Umaña J,Tate J,Lopman B,Sanchez E,Reyes M,Mercado J,Gonzalez A,Perez MC,Balmaceda A,Andrus J,Parashar Udoi
10.1542/peds.2011-3478subject
Has Abstractpub_date
2012-08-01 00:00:00pages
e365-72issue
2eissn
0031-4005issn
1098-4275pii
peds.2011-3478journal_volume
130pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:BACKGROUND AND OBJECTIVES:In Rwanda, significant progress has been made in advancing access to antiretroviral therapy (ART) among youth. As availability of ART increases, adherence is critical for preventing poor clinical outcomes and transmission of HIV. The goals of the study are to (1) describe ART adherence and men...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-3235
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine whether risks of impaired cognitive function could be predicted for children or groups of children with adenotonsillar hypertrophy who were suspected of having obstructive sleep-disordered breathing, from historical and polysomnographic variables used separately or i...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0173
更新日期:2006-09-01 00:00:00
abstract::To determine whether mothers with complicated pregnancies are at increased risk of postpartum depression and whether their children are at increased risk of being perceived as vulnerable, the investigators conducted an interview survey of mothers of 1095 children aged 4 to 8 in a community-based sample of primary care...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) exhibits tight links with insulin resistance (IR) and the metabolic syndrome (MetS), a cluster of cardiovascular risk factors. Compared with non-Hispanic whites, non-Hispanic black adolescents have more IR but a lower prevalence of NAFLD and MetS. Our hypothesis was t...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-3584
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVES:Pulse oximetry (POX) has been confirmed as a specific screening modality for critical congenital heart disease (CCHD), with moderate sensitivity. However, POX is not able to detect most serious and critical cardiac lesions (major congenital heart disease [CHD]) without hypoxemia. In this study, we investigat...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2017-1154
更新日期:2017-10-01 00:00:00
abstract::In 2010, Care Considerations for Duchenne Muscular Dystrophy, sponsored by the Centers for Disease Control and Prevention, was published in Lancet Neurology, and in 2018, these guidelines were updated. Since the publication of the first set of guidelines, survival of individuals with Duchenne muscular dystrophy has in...
journal_title:Pediatrics
pub_type: 杂志文章,实务指引
doi:10.1542/peds.2018-0333H
更新日期:2018-10-01 00:00:00
abstract:INTRODUCTION:4-Aminopyridine (4-AP) is a potassium channel blocker used to increase muscle strength in the treatment of demyelinating diseases such as multiple sclerosis. We describe a case of ingestion by an 8-month-old child that resulted in severe but transient symptoms. CASE REPORT:An 8-month-old boy was found wit...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.111.1.e82
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To assess the apparent increase in the diagnosis of Lemierre syndrome (LS) and other Fusobacterium necrophorum infections at a large children's hospital. Infections with F necrophorum ranged from peritonsillar abscess to potentially fatal LS. LS is an oropharyngeal infection characterized by septic thrombophl...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.112.5.e380
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVES:Severe neonatal jaundice is a common clinical manifestation of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and the most difficult to manage; kernicterus is not an uncommon outcome. We assessed in healthy, direct Coombs test-negative Greek newborns of >/=38 weeks' gestational age 1) the current burd...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.1.25
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVES:To estimate the cost and health benefits of implementing a risk factor-based prevention strategy for early-onset neonatal group B streptococcal (GBS) disease, using baseline assumptions and costs from a health maintenance organization. With the risk factor-based strategy, intrapartum antibiotics (IPAs) would...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.103.4.703
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:Cardiac arrest is uncommon among pediatric patients. Prehospital data demonstrate differences in care processes between children and adults receiving cardiopulmonary resuscitation and advanced life support. We sought to evaluate whether children receiving in-hospital cardiopulmonary resuscitation would attain...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0453
更新日期:2006-09-01 00:00:00
abstract::Thirty-two 5- to 17-year-old children who had severe, acute asthma were randomly assigned to receive either high doses (0.15 mg/kg of body weight per dose) or low doses (0.05 mg/kg of body weight per dose) of nebulized albuterol every 20 minutes for six doses. Compared with the low-dose regimen, the high-dose regimen ...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1989-04-01 00:00:00
abstract::The clinical course, laboratory data, outcome, and autopsy findings in 61 pediatric patients with suspected brain death were reviewed. In 58% of patients, the initial EEG was isoelectric, and cerebral blood flow was absent. In six of nine children, the initial EEG, which showed activity, became isoelectric by 72 hours...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND:It remains unclear if fatal brain injuries in young children are characterized by immediate rapid deterioration or can present after an initial period of lucidity. This issue has legal implications in child abuse, for which understanding the clinical course affects perpetrator identification. OBJECTIVE:To d...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-2671
更新日期:2005-07-01 00:00:00
abstract::Patients with phagocyte defects frequently develop bacterial or fungal pneumonias, but they are not considered to be at increased risk for viral infections. We describe 3 patients with known phagocyte immunodeficiencies who developed lower respiratory tract infections (LRTI) caused by respiratory syncytial virus (RSV)...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.4.835
更新日期:2000-10-01 00:00:00
abstract::The pharmacokinetics and pharmacodynamics of dobutamine were studied in 13 critically ill neonates requiring inotropic support. Dobutamine was administered as a constant infusion in increasing doses of 2.5, 5, and 7.5 micrograms/kg per minute. During dobutamine infusions, there were significant increases in cardiac ou...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Sarcosinemia has been detected by routine screening of urine for metabolic and transport disorders in Massachusetts. Three infants who had sarcosinemia were detected through the neonatal urine specimen, an observed incidence of 1:350,000. A fourth child had sarcosinemia detected through family screening after his brot...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1984-10-01 00:00:00
abstract:OBJECTIVE:To examine the effect of experimental changes in children's sleep duration on self-reported food intake, food reinforcement, appetite-regulating hormones, and measured weight. METHODS:Using a within-subjects, counterbalanced, crossover design, 37 children, 8 to 11 years of age (27% overweight/obese) complete...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2013-1274
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVES:The current study is a 1-year follow-up analysis of data from a randomized controlled trial of Enhanced Milieu Teaching (EMT) for toddlers with language delays. Outcomes and predictors of child language and parent intervention implementation were examined 6 and 12 months after the end of the intervention. M...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2016-3646
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Approximately half of women with intellectual and developmental disabilities (IDDs) lose custody of their children at some point in their child's development, but their rates of and risk factors for newborn discharge to child protective services from the birth hospitalization are relatively unknown. METHODS...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-1416
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:Pyogenic granuloma is a common, acquired, vascular tumor of the skin in children, often ulcerates or bleeds, and is commonly localized to the face. The treatment of choice has been surgical removal, either by excision or shave, followed by electrocautery. The site, young age of the patient, and the inherent n...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.99.3.368
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Isolated cases of camphor-induced seizures have been reported in young children after gastrointestinal, dermal, and inhalation exposure. In 1982, after a series of unintentional ingestions of camphor products, the US Food and Drug Administration restricted the camphor content to <11% in some products intende...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-2097
更新日期:2009-05-01 00:00:00
abstract::Causal analysis is a core function of safety programs. Although established protocols exist for conducting root cause analysis for serious safety events, there is limited guidance for apparent cause analysis (ACA) in health care. At our institution, through a novel facilitated ACA approach, we aim to improve safety cu...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2019-1819
更新日期:2020-05-01 00:00:00
abstract::Roughly 1% of all weight loss surgery is performed in adolescents. There is strong evidence demonstrating significant postsurgical weight loss, improvement in quality of life, and reduction in comorbidities such as hypertension and diabetes. Reports of postoperative complications in adolescents are few because of the ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2016-1039
更新日期:2016-12-01 00:00:00
abstract::Multiple arterial punctures in the neonate can result in iatrogenic arteriovenous fistula formation. In one case, a 3-month-old infant who had been born prematurely was noted to have physical findings consistent with arteriovenous malformation following approximately 90 arterial blood gas determinations over a 13-week...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND:Childhood asthma prevalence doubled from 1980 to 1995 and then increased more slowly from 2001 to 2010. During this second period, racial disparities increased. More recent trends remain to be described. METHODS:We analyzed current asthma prevalence using 2001-2013 National Health Interview Survey data for ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-2354
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the clinical presentation and polysomnography of prepubertal children with repetitive sleep terrors and sleepwalking, to compare them with a control group, and to evaluate the treatment of associated sleep disorders. METHODS:Patients with complaint of sleep terrors with or without sleepwalking w...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.111.1.e17
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:School health programs are frequently attempted in low- and/or middle-income countries; however, programmatic scope and reach is limited by human resource constraints. We sought to determine if trained community members could implement a school health program that improved outcomes in rural pr...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2018-0975
更新日期:2019-04-01 00:00:00
abstract::An important adaptation of the gastrointestinal tract to the extrauterine environment is its development of a mucosal barrier against the penetration of proteins and protein fragments. To combat the potential danger of invasion across the mucosal barrier the newborn infant must develop within the lumen and on the lumi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:Several studies have found decreased cost and length of stay for patients who are cared for by pediatric hospitalists compared with traditional faculty models. The objective of this study was to compare cost and length of stay between a faculty group and 2 separate hospitalist groups in a community teaching h...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-3146
更新日期:2006-10-01 00:00:00