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Up and down regulation of serine esterase release from mouse cytotoxic T lymphocytes by tumor-promoting phorbol ester.

Abstract：

:Activation of mouse cytotoxic T lymphocytes (CTL) with target cells expressing antigen resulted in the release of serine esterase (SE) into the culture supernatant. Short term treatment (3 hr) of CTL with phorbol-12-myristate-13-acetate (PMA) plus ionophore also caused stimulation of SE release from CTL, while neither PMA alone or ionophore alone could induce SE release. In contrast to this, long term treatment (24 hrs) of CTL with PMA resulted in the inability of CTL to release SE in respond to antigen or PMA plus ionophore. It was also demonstrated that protein kinase C activity of CTL disappeared during induction of desensitization of CTL by PMA.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nishimura T,Ito T

doi

10.1016/0006-291x(87)90784-4

subject

Has Abstract

pub_date

1987-08-14 00:00:00

pages

1262-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90784-4

journal_volume

146

pub_type

杂志文章

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