当前位置： SCI文献检索 > European Review for Medical and Pharmacological Sciences期刊下所有文献 > Long noncoding RNA DLX6-AS1 functions as a competing endogenous RNA for miR-577 to promote malignant development of colorectal cancer.

Long noncoding RNA DLX6-AS1 functions as a competing endogenous RNA for miR-577 to promote malignant development of colorectal cancer.

Abstract：

OBJECTIVE:Recent researches have proved that long noncoding RNAs (lncRNAs) play essential roles in tumorigenesis. The aim of this study was to investigate the exact role of lncRNA DLX6-AS1 in the development of colorectal cancer (CRC), and to explore the possible mechanism. PATIENTS AND METHODS:DLX6-AS1 expression in CRC tissues was detected by Real Time-quantitative Polymerase Chain Reaction (RT-qPCR). Function assays were conducted to detect the effect of DLX6-AS1 on the proliferation and metastasis of CRC in vitro. Furthermore, luciferase reporter gene assay and RNA immunoprecipitation assay (RIP) were used to explore the underlying mechanism of DLX6-AS1. RESULTS:DLX6-AS1 expression in CRC samples was significantly higher than that of adjacent tissues. Loss of DLX6-AS1 markedly inhibited the proliferation, migration, and invasion of CRC cells. Furthermore, luciferase reporter gene assay and RIP assay showed that DLX6-AS1 acted as a competing endogenous RNA via sponging miR-577 in CRC. CONCLUSIONS:DLX6-AS1 could promote the proliferation, migration, and invasion of CRC by sponging miR-577, which might offer a potential therapeutic target for CRC.

journal_name

Eur Rev Med Pharmacol Sci

journal_title

European review for medical and pharmacological sciences

authors

Zhou FR,Pan ZP,Shen F,Huang LQ,Cui JH,Cai K,Guo XL

doi

10.26355/eurrev_201905_17800

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

3742-3748

issue

9

eissn

1128-3602

issn

2284-0729

journal_volume

23

pub_type

杂志文章

相关文献

European Review for Medical and Pharmacological Sciences文献大全
  • SARS-CoV-2 infection: NLRP3 inflammasome as plausible target to prevent cardiopulmonary complications?

    abstract：:NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome has recently become an intriguing target of several chronic and viral diseases. Here, we argue that targeting NLRP3 inflammasome could be a strategy to prevent cardiovascular outcomes [fulminant myocarditis, heart failure, venous thromboembolism (VT...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202009_22867

    authors： Quagliariello V,Bonelli A,Caronna A,Lombari MC,Conforti G,Libutti M,Iaffaioli RV,Berretta M,Botti G,Maurea N

    更新日期：2020-09-01 00:00:00

  • 13C-octanoic acid breath test to study gastric emptying time.

    abstract：:Digestion is a complex process regulated by several factors. Among these, one of the most important is the time of gastric emptying. A delayed gastric emptying time can be caused by several factors and can generate considerable discomfort in humans. It ranges from mild to real debilitating disorders. Until now, differ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,评审

    doi：

    authors： Bruno G,Lopetuso LR,Ianiro G,Laterza L,Gerardi V,Petito V,Poscia A,Gasbarrini A,Ojetti V,Scaldaferri F

    更新日期：2013-01-01 00:00:00

  • MicroRNA-599 regulates the development of Parkinson's disease through mediating LRRK2 expression.

    abstract：OBJECTIVE:This study investigates whether microRNA-599 can inhibit the progression of Parkinson's disease (PD) by regulating the LRRK2 expression. We aim to search for a new therapeutic target for PD. MATERIALS AND METHODS:A mouse model of PD was first established. A relative amount of TH+ neurons in the mouse brain w...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201901_16886

    authors： Wu Q,Xi DZ,Wang YH

    更新日期：2019-01-01 00:00:00

  • The investigation of melatonin effect on liver antioxidant and oxidant levels in fructose-mediated metabolic syndrome model.

    abstract：OBJECTIVE:Metabolic syndrome (MetS) can be induced by the oxidative stress conditions caused by ingestion of large amounts of fructose. We investigated the possible protective effects of melatonin administration on liver tissues in fructose-fed rats. MATERIALS AND METHODS:Thirty-two rats were randomly divided into fou...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Demirtas CY,Pasaoglu OT,Bircan FS,Kantar S,Turkozkan N

    更新日期：2015-05-01 00:00:00

  • Protective effects of melatonin on ischemia-reperfusion induced myocardial damage and hemodynamic recovery in rats.

    abstract：AIM:To investigate the mechanism of melatonin (MT) protection of adult rate myocardial ischemia-reperfusion injury and its influence on rat's hemodynamic recovery. MATERIALS AND METHODS:48 rats were randomly divided into MT group (n=36) and the control group (n=12), MT group was divided into three sub-groups according...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Liu LF,Qin Q,Qian ZH,Shi M,Deng QC,Zhu WP,Zhang H,Tao XM,Liu Y

    更新日期：2014-01-01 00:00:00

  • Electroionotherapy in acute arthrorheumatic pain.

    abstract：:The authors evaluated the efficacy of an electronic treatment for pain, using an ion flow generator, BE-101 model by Bio-Ejt, on 19 patients suffering from acute pain of an arthrorheumatic nature. Each patient was treated for two weeks every other day (6 sittings), each sitting lasting 20 minutes at an intensity of ab...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 临床试验,杂志文章

    doi：

    authors： Maugeri D,Russo MS,Bonanno MR,Curasí MP,Speciale S,Santangelo A,Panebianco P,Malaguarnera M

    更新日期：1999-03-01 00:00:00

  • MiR-340-5p is a potential prognostic indicator of colorectal cancer and modulates ANXA3.

    abstract：OBJECTIVE:MicroRNAs (miRNAs) are increasingly recognized as oncogenes or tumor suppressors in colorectal cancer (CRC). The aim of this study was to explore the expression and functions of miR-340-5p in CRC. PATIENTS AND METHODS:The expression of miR-340-5p in CRC tissues and cell lines was detected by quantitative RT-...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201808_15619

    authors： Yang L,Men WL,Yan KM,Tie J,Nie YZ,Xiao HJ

    更新日期：2018-08-01 00:00:00

  • An update on clinical applications of hepatospecific contrast media in magnetic resonance imaging of liver parenchyma.

    abstract：:Hepatobiliary-specific contrast agents are now widely used in magnetic resonance imaging (MRI) of liver parenchyma. As extracellular fluid agents, they provide informations regarding lesion vascularity and their use in the hepatobiliary or delayed phase (DPI), and give additional data regarding hepatocyte presence and...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Giuga M,De Gaetano AM,Guerra A,Infante A,Iezzi R,Spinelli I,Siciliano M,Grieco A,Rapaccini GL,Gasbarrini A,Pompili M,Bonomo L

    更新日期：2016-06-01 00:00:00

  • TGF-β1 aggravates degenerative nucleus pulposus cells inflammation and fibrosis through the upregulation of angiopoietin-like protein 2 expression.

    abstract：OBJECTIVE:Inflammation and fibrosis progress of nucleus pulposus (NP) cells participate in the pathologic changes of intervertebral disc degeneration (IDD). ANGPTL2 is well known for its angiogenesis and proinflammatory properties and transforming growth factor β1 (TGF-β1) is also responsible for tissue fibrosis. Howev...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202012_23991

    authors： Cui L,Wei H,Li ZM,Dong XB,Wang PY

    更新日期：2020-12-01 00:00:00

  • Chest and breast MRI: the added value of a fast imaging for a new diagnostic approach in the planning of augmentation surgery in patients with thoracic asymmetries.

    abstract：OBJECTIVE:In breast augmentation surgery, breast symmetry depends on the breast tissue, implants and chest wall. Any asymmetry of the anterior thoracic wall can influence the breast shape. If breast asymmetry is detected in the preoperative evaluation, a chest wall deformity should be suspected. Until now, very few rep...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Rinaldi P,Parapatt GK,Giuliani M,Borelli C,Giardina GG,Fubelli R,Buccheri C,Tambasco D,Belli P,Salgarello M,Bonomo L

    更新日期：2015-07-01 00:00:00

  • Regulation of redox signalling and autophagy during cardiovascular diseases-role of resveratrol.

    abstract：:Cardiovascular diseases remain one of the major health problems worldwide. The worldwide research against cardio-vascular diseases as well as genome wide association studies were successful in indentifying the loci associated with these prominent life threatening diseases but still a substantial amount of casualty rem...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,评审

    doi：

    authors： Fu DG

    更新日期：2015-04-01 00:00:00

  • Elasticity/distensibility of the ascending aorta: basal conditions and simulated conditions from space flights.

    abstract：INTRODUCTION:The hysto-morfological composition of the ascending aorta wall gives to the vessel its characteristic elasticity/distensibility, which is deteriorated due to both physiological (age) and pathological events (hypertension, diabetes, dyslipidemia). This contributes to reduce the wall elasticity and to occurr...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Alessandri N,Tufano F,Petrassi M,Alessandri C,Lanzi L,Fusco L,Moscariello F,De Angelis C,Tomao E

    更新日期：2010-05-01 00:00:00

  • Effects of oleic acid on SP-B expression and release in A549 cells.

    abstract：OBJECTIVE:Pulmonary surfactant-associated protein B (SP-B), which is synthesized and secreted by alveolar epithelial type II cells, is crucial for normal functioning of pulmonary surfactant. Degeneration of pulmonary surfactant is the essential cause of acute lung injury (ALI). ALI is often studied in animal models usi...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Zhou DJ,Chen Y,Zhang XJ,Ma C,Qiu J,Zhou JH

    更新日期：2015-09-01 00:00:00

  • Does cervical ureaplasma/mycoplasma colonization increase the lower uterine segment bleeding risk during cesarean section among patients with placenta previa? A cross-sectional study.

    abstract：OBJECTIVE:The underlying inflammation of endometrium may impede normal implantation of placenta during pregnancy. Our objective is to show cervical colonization of ureaplasma and/or mycoplasma as a marker of endometritis in pregnancies complicated with placenta previa that can be a risk factor for placenta accreta and ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Aydogan P,Kahyaoglu S,Saygan S,Kaymak O,Mollamahmutoglu L,Danisman N

    更新日期：2014-08-01 00:00:00

  • Analysis of changes in joint function and peripheral blood mononuclear cells in patients with systemic lupus erythematosus and intervention effects of different drugs.

    abstract：OBJECTIVE:To investigate the therapeutic effect of drug therapy with cyclophosphamide and leflunomide on the joint function damage of patients with systemic lupus erythematosus (SLE) and its regulatory effects on expression levels of programmed death receptor 1, Notch signaling pathway genes and interferon-inducible pr...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,随机对照试验

    doi：

    authors： Zhou QS,Hu J,Hu H

    更新日期：2017-10-01 00:00:00

  • High expression of LncRNA CASC15 is a risk factor for gastric cancer prognosis and promote the proliferation of gastric cancer.

    abstract：OBJECTIVE:To investigate the expression of long non-coding RNA CASC15 in gastric cancer tissue and its effect on the proliferation of gastric cancer cell line MKN28. MATERIALS AND METHODS:We found that expression of lncRNA CASC15 in gastric cancer tissue was higher than normal gastric epithelium through the TCGA and G...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201712_14010

    authors： Yao XM,Tang JH,Zhu H,Jing Y

    更新日期：2017-12-01 00:00:00

  • The role of cefditoren in the treatment of lower community-acquired respiratory tract infections (LRTIs): from bacterial eradication to reduced lung inflammation and epithelial damage.

    abstract：OBJECTIVES:Lower respiratory tract infections (LRTIs), including pneumonia and acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD), are among the most common diagnoses in both outpatient and inpatient settings. Due to the burden of LRTIs healthcare providers must adopt practices focused on improving out...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,评审

    doi：

    authors： Di Marco F,Braido F,Santus P,Scichilone N,Blasi F

    更新日期：2014-01-01 00:00:00

  • Mirtogenol® supplementation in association with dorzolamide-timolol or latanoprost improves the retinal microcirculation in asymptomatic patients with increased ocular pressure.

    abstract：OBJECTIVE:Supplementation with Mirtogenol® improves the retinal microcirculation and reduces intraocular pressure (IOP) in ocular hypertension, when administrated either alone or in association with an ophthalmic solution (latanoprost). In this study, microcirculatory parameters (perfusion of the circle of Zinn-Haller ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Gizzi C,Torino-Rodriguez P,Belcaro G,Hu S,Hosoi M,Feragalli B

    更新日期：2017-10-01 00:00:00

  • An 11-lncRNA risk scoring model predicts prognosis of lung squamous cell carcinoma.

    abstract：OBJECTIVE:The study aims to construct a multi-gene risk scoring model that can be used to predict the prognosis of patients with lung squamous cell carcinoma (LUSC). PATIENTS AND METHODS:RNA-seq data from 494 LUSC tumor samples and 49 peripheral lung tissue samples were obtained from TCGA_LUSC database. Differential a...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202005_21330

    authors： Liu JH,Xu YM,Yan J

    更新日期：2020-05-01 00:00:00

  • ERBB2 gene expression silencing involved in ovarian cancer cell migration and invasion through mediating MAPK1/MAPK3 signaling pathway.

    abstract：OBJECTIVE:To explore possible mechanism of ERBB2 gene expression silencing mediating mitogen-activated protein kinase 1/mitogen-activated protein kinase 3 (MAPK1/MAPK3) signaling pathway on proliferation, migration, and invasion of ovarian cancer cells. PATIENTS AND METHODS:A total of 240 cancer specimens were collect...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202005_21309

    authors： Yu TT,Wang CY,Tong R

    更新日期：2020-05-01 00:00:00

  • Hepatotoxicity associated to synthetic cannabinoids use.

    abstract：:Synthetic cannabinoids (SCs) are psychotropic compounds, chemically created in laboratory to mimic cannabinergic brain activity of delta-9 tetrahydrocannabinol. The consumption of these compounds for recreational purposes can lead to a variety of adverse effects on health including overdose and deaths. Increasingly po...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Solimini R,Busardò FP,Rotolo MC,Ricci S,Mastrobattista L,Mortali C,Graziano S,Pellegrini M,di Luca NM,Palmi I

    更新日期：2017-03-01 00:00:00

  • Effect of an extra-virgin olive oil enriched with probiotics or antioxidants on functional dyspepsia: a pilot study.

    abstract：BACKGROUND:While antioxidants and probiotics have been proposed for the treatment of functional dyspepsia, current data are still heterogeneous and studies are poorly designed. Extra-virgin olive oil, a common ingredient of Mediterranean diet, has shown antioxidant properties. AIMS:To evaluate the effect of extra-virg...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,随机对照试验

    doi：

    authors： Ianiro G,Pizzoferrato M,Franceschi F,Tarullo A,Luisi T,Gasbarrini G

    更新日期：2013-01-01 00:00:00

  • Real-world effectiveness and safety of Guselkumab for the treatment of psoriasis: a 6-month prospective study in a series of psoriatic patients.

    abstract：OBJECTIVE:Guselkumab is a fully human monoclonal IgG1 antibody which, by selectively binding to the p19 subunit of IL-23, prevents it from binding to the IL-23 receptor on the cell surfaces. To date, no prospective data are available on the efficacy and safety of this drug in everyday clinical practice in patients with...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202101_24408

    authors： Malara G,Trifirò C,Bartolotta A,Giofré C,D'Arrigo G,Testa A,De Lorenzo A,Tripepi G

    更新日期：2021-01-01 00:00:00

  • LncRNA 00152 promotes the development of hepatocellular carcinoma by activating JAK2/STAT3 pathway.

    abstract：OBJECTIVE:The aim of this study was to explore the regulatory role of lncRNA 00152 and JAK2/STAT3 pathway in the pathogenesis of hepatocellular carcinoma (HCC), and to investigate the possible underlying mechanism. PATIENTS AND METHODS:Expression levels of lncRNA 00152 in HCC tissues, matched para-cancerous tissues an...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201902_16991

    authors： Li SJ,Sui MH,Sun ZX,Zhang WW

    更新日期：2019-02-01 00:00:00

  • Melatonin inhibits the inflammation and apoptosis in rats with diabetic retinopathy via MAPK pathway.

    abstract：:The article "Melatonin inhibits the inflammation and apoptosis in rats with diabetic retinopathy via MAPK pathway, by Y. Ma, Q. Zhao, Y. Shao, M.-Z. Cao, M. Zhao, D. Wang, published in Eur Rev Med Pharmacol Sci 2019; 23 (3 Suppl): 1-8-DOI: 10.26355/eurrev_201908_18620-PMID: 31389568" has been withdrawn from the author...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202007_22183

    authors： Ma Y,Zhao Q,Shao Y,Cao MZ,Zhao M,Wang D

    更新日期：2020-07-01 00:00:00

  • MiR-365 participates in coronary atherosclerosis through regulating IL-6.

    abstract：OBJECTIVE:This study aims to investigate the role and mechanism of miR-365 in the coronary atherosclerosis (AS). PATIENTS AND METHODS:Blood were collected from AS patients and healthy people, coronary plaque and adjacent arterial tissue were collected from AS patients. QRT-PCR method was used to detect expressions of ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Lin B,Feng DG,Wang F,Wang JX,Xu CG,Zhao H,Cheng ZY

    更新日期：2016-12-01 00:00:00

  • Effects of vitamin D levels on asthma control and severity in pre-school children.

    abstract：OBJECTIVE:Prevalence of asthma and vitamin D deficiency has been increasing and leading to significant morbidities. This study aimed to compare the vitamin D levels in the pre-school children with asthma and in healthy controls and to assess the relationship between vitamin D levels and asthma clinical parameters and c...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Turkeli A,Ayaz O,Uncu A,Ozhan B,Bas VN,Tufan AK,Yilmaz O,Yuksel H

    更新日期：2016-01-01 00:00:00

  • The relationship between anticancer effect of metformin and the transcriptional regulation of certain genes (CHOP, CAV-1, HO-1, SGK-1 and Par-4) on MCF-7 cell line.

    abstract：BACKGROUND:1,1-dimethylbiguanide hydrochloride (biguanide metformin) is a hypoglycemic agent that is widely used in the treatment of Type 2 diabetes. Use of metformin was found to be associated with the lower risk of cancer. It is suggested that metformin has an anticancer and antiproliferative effect and affects the a...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Salis O,Bedir A,Ozdemir T,Okuyucu A,Alacam H

    更新日期：2014-06-01 00:00:00

  • The approach of retroperitoneal laparoscopic partial dissection of adipose renal capsule plus ligation of renal pedicle lymphatic vessels to the treatment of chyluria.

    abstract：OBJECTIVE:To compare the clinical effect of two surgical methods of treating chyluria, namely, retroperitoneal laparoscopic partial dissection of adipose renal capsule plus ligation of renal pedicle lymphatic vessels and retroperitoneal laparoscopic complete dissection of adipose renal capsule plus ligation of renal pe...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Zhang YD,Cao RF,Jiang ZJ

    更新日期：2016-12-01 00:00:00

  • Effect of miR-7 on resistance of breast cancer cells to adriamycin via regulating EGFR/PI3K signaling pathway.

    abstract：OBJECTIVE:To explore whether micro ribonucleic acid (miR)-7 affects the resistance of breast cancer cells to adriamycin (ADR) through regulating the epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-hydroxy kinase (PI3K) signaling pathway. MATERIALS AND METHODS:MiR-7 expression was compared among MCF-10A,...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201906_18195

    authors： Huang Q,Wu YY,Xing SJ,Yu ZW

    更新日期：2019-06-01 00:00:00