当前位置： SCI文献检索 > European Review for Medical and Pharmacological Sciences期刊下所有文献 > High expression of LncRNA CASC15 is a risk factor for gastric cancer prognosis and promote the proliferation of gastric cancer.

High expression of LncRNA CASC15 is a risk factor for gastric cancer prognosis and promote the proliferation of gastric cancer.

Abstract：

OBJECTIVE:To investigate the expression of long non-coding RNA CASC15 in gastric cancer tissue and its effect on the proliferation of gastric cancer cell line MKN28. MATERIALS AND METHODS:We found that expression of lncRNA CASC15 in gastric cancer tissue was higher than normal gastric epithelium through the TCGA and Gene Expression Omnibus (GEO) database. Then, we detect the RNA level of CASC15 from clinical samples of 42 normal gastric epithelial tissues and 60 gastric cancer tissues. In order to explore the function of CASC15 in gastric cancer, we perform gain-function and loss-function assay in gastric cancer cell lines. RESULTS:We found that expression of lncRNA CASC15 in gastric cancer tissue was higher than normal gastric epithelium through the TCGA database and the related microarray data set was searched from Gene Expression Omnibus (GEO) database.  Then, we extracted total RNA from clinical samples of 42 normal gastric epithelial tissues and 60 gastric cancer tissues. The results of quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) were consistent with those of TCGA analysis. Clinical data analysis showed that the expression of LncRNA CASC15 was correlated with the total survival, tumor size and TMN staging in clinical patients. Clinical data analysis showed that the expression level of CASC15 was correlated with tumor size and TNM stage in clinical patients. Compared with the negative control group, the proliferation and cell cloning ability of MKN28 cells overexpressing LncRNA CASC15 significantly increased (p<0.001), indicating that overexpression of LncRNA CASC15 promoted the proliferation of MKN28 cells. CONCLUSIONS:The expression of LncRNA CASC15 was significantly higher in gastric cancer tissues and its expression was negatively correlated with the overall survival of clinical patients. It was positively correlated with the tumor size and TMN stage. LncRNA CASC15 could promote the proliferation of gastric cancer cells and was expected to become the molecular marker for prediction and prognosis of gastric cancer, as well as a potential therapeutic target.

journal_name

Eur Rev Med Pharmacol Sci

journal_title

European review for medical and pharmacological sciences

authors

Yao XM,Tang JH,Zhu H,Jing Y

doi

10.26355/eurrev_201712_14010

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

5661-5667

issue

24

eissn

1128-3602

issn

2284-0729

journal_volume

21

pub_type

杂志文章

相关文献

European Review for Medical and Pharmacological Sciences文献大全
  • QT dispersion in carbon monoxide poisoning.

    abstract：BACKGROUND:Carbon monoxide (CO) poisoning are serious health problems, and effect of reducing the blood's oxygen carrying capacity. Deaths due to CO poisoning are mostly related to myocardial injury and central nervous system pathologies. AIM:The objective of this study was to determine the relationship between carbon...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 临床试验,杂志文章

    doi：

    authors： Atescelik M,Bozdemir MN,Yildiz M,Gurbuz S,Ayranci M,Goktekin MC,Kobat MA,Dagli MN,Eken C

    更新日期：2012-03-01 00:00:00

  • Role of TNF-alpha polymorphism in patients with nickel allergy: a marker of susceptibility to contact polysensitization.

    abstract：OBJECTIVE:Nickel allergy is the most frequent contact allergy in the industrialized country. In allergic contact dermatitis after the presentation of haptenated peptides by resident or newly recruited skin cells, activated CD8+ T cells release IFN-γ and TNF-α, these cytokines are potent activator of keratinocytes. The ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Colagiovanni A,Di Renzo L,Sarlo F,Schiavino D,De Lorenzo A

    更新日期：2016-06-01 00:00:00

  • Assessment of the analgesic, anti-inflammatory and sedative effects of the dichloromethanol extract of Schinus molle.

    abstract：OBJECTIVE:Determination of the active fraction and compounds of the dichloromethanol extract of Schinus molle seeds and evaluation of their biological effects. MATERIALS AND METHODS:Dried seeds of Schinus molle were sequentially extracted in hexane, acetyl acetate and dichloromethane. The dichloromethane extract was s...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Taylor A,Oyedeji OO,Aremu O,Oyemitan I,Gwebu ET,Oyedeji AO,Nkeh-Chungag BN

    更新日期：2016-01-01 00:00:00

  • Open study of a diclofenac sodium prolonged-release in patients suffering from coxarthrosis.

    abstract：:Fourty adult patients with coxarthrosis were treated for 30 days with oral diclofenac sodium at the daily dose of 150 mg: 20 of these were administered one 150 mg prolonged-release capsule per day, the other 20 received one 50 mg enteric-coated tablet every 8 hours. The presence and severity of several symptoms and si...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 临床试验,杂志文章

    doi：

    authors： Varese C,Palazzini A

    更新日期：1997-01-01 00:00:00

  • MiR-101 promotes nasopharyngeal carcinoma cell apoptosis through inhibiting Ras/Raf/MEK/ERK signaling pathway.

    abstract：:The article "MiR-101 promotes nasopharyngeal carcinoma cell apoptosis through inhibiting Ras/Raf/MEK/ERK signaling pathway, by R.-S. Wu, E.-H. Qiu, J.-J. Zhu, J.-R. Wang, H.-L. Lin, published in Eur Rev Med Pharmacol Sci 2018; 22(1): 150-157-DOI: 10.26355/eurrev_201801_14112-PMID: 29364482" has been withdrawn from the...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202008_22580

    authors： Wu RS,Qiu EH,Zhu JJ,Wang JR,Lin HL

    更新日期：2020-08-01 00:00:00

  • Computerized dynamic pupillometry indices mirrors the heart rate variability parameters.

    abstract：OBJECTIVE:Dynamic pupillometry (DP) is a simple, non-invasive computerized assessment of pupillary light response which provides data concerning both branches of the autonomous nervous system (ANS). Heart rate variability (HRV) analysis assess cardiac health and the ANS modulation on the heart. In this study, we aimed ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Okutucu S,Civelekler M,Aparci M,Sabanoglu C,Dikmetas O,Aksoy H,Yetis Sayin B,Oto A

    更新日期：2016-05-01 00:00:00

  • Biological therapies in autoimmune chronic inflammatory diseases (ACIDs).

    abstract：:Autoimmune chronic inflammatory diseases (ACIDs) represent a growing part of chronic diseases and their cellular and molecular pathways have been deeply investigated in recent years in order to disclose some clue aspects that could be optimal targets of specific therapies. Among the autoimmune rheumatic diseases a maj...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,评审

    doi：

    authors： Ferraccioli GF,Gremese E

    更新日期：2006-01-01 00:00:00

  • Evaluation of hand circulation with CardioWaves photoplethysmograph device during Allen test in healthy volunteers.

    abstract：OBJECTIVE:Radial artery occlusion is a potential complication of transradial procedures and its occurrence ranges from 0.8 to 30%. It is virtually always asymptomatic but the functional and sensorial consequences of a long acting hand hypoperfusion could go underestimated. CardioWaves is a novel photoplethysmograh devi...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Tanzilli G,Truscelli G,Barillà F,Cocco N,Pannitteri G,Tanzilli A,Al Kindy S,Mangieri E,Gaudio C

    更新日期：2015-08-01 00:00:00

  • Effect of different body position on anorectal manometry for chronic constipation patients.

    abstract：OBJECTIVE:To analyze the different influence of body position on wireless high-resolution anorectal manometry parameters and in classification for chronic constipation patients. PATIENTS AND METHODS:Fifty consecutive patients with chronic constipation and 20 healthy volunteers were included in this study, all of whom ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201910_19162

    authors： Su H,Peng LH,Sun G,Yang YS,Wu J,Jiang GJ,Ge H

    更新日期：2019-10-01 00:00:00

  • Persistent eradication of Helicobacter pylori after systemic politherapy associated with periodontal pockets treatment with metronidazole and calcium sulphate.

    abstract：:The sensitivity of H. Pylori to antibiotic treatment is well known. Politherapy (omeprazole or pantoprazole or ranitidine, amoxicillin and/or azithromycin and/or clarithromycin, metronidazole and bismuth citrate) notably changed the percentage of H. pylori eradication but rarely resolutive. Periodontal pockets treatme...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 临床试验,杂志文章

    doi：

    authors： Tarullo A,Tattoli M,Cagiano R

    更新日期：2001-07-01 00:00:00

  • Boswellia serrata and Salvia miltiorrhiza extracts reduce DMN-induced hepatic fibrosis in mice by TGF-beta1 downregulation.

    abstract：BACKGROUND:Hepatic fibrosis is characterised by a progressive accumulation of fibrillar extracellular matrix (ECM) proteins, including collagen that occurs in chronic liver diseases. Transforming growth factor-beta1 (TGF-beta)/Smad3 signalling plays a major role in tissue fibrogenesis acting as a potent stimulus of ECM...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Sferra R,Vetuschi A,Catitti V,Ammanniti S,Pompili S,Melideo D,Frieri G,Gaudio E,Latella G

    更新日期：2012-10-01 00:00:00

  • FeNO levels in children with asthma and other diseases of the lung.

    abstract：BACKGROUND:Prolonged cough in children is one of the major complaints seen in hospitals. It is difficult to make a proper diagnosis and start the appropriate treatment. Fraction of exhaled nitric oxide (FeNO) measurement is a valuable non-invasive diagnostic tool in determining the cause of prolonged cough in children....

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Kelekçi S,Sen V,Yolbas I,Uluca Ü,Tan I,Gürkan MF

    更新日期：2013-11-01 00:00:00

  • Ugly duckling or Nosferatu? Cardiac injury in endurance sport - screening recommendations.

    abstract：:In the beginning sporting activity may be exhausting, but over time, physical activity turns out to have beneficial effects to the body and even extended cycling or running is an emotional and healthy enrichment in life. On the other hand, spectacular sudden deaths during marathon, football and, just recently, in the ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,评审

    doi：

    authors： Leischik R,Dworrak B

    更新日期：2014-01-01 00:00:00

  • MiR-5195-3p inhibits the proliferation of glioma cells by targeting BIRC2.

    abstract：OBJECTIVE:The aim of this study was to investigate the effects of microRNA-5195-3p (miR-5195-3p) on the proliferation of glioma cells and to explore its related mechanisms. PATIENTS AND METHODS:The expression level of miR-5195-3p in glioma tissues and cell lines was detected by quantitative Real Time-Polymerase Chain ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202001_19921

    authors： Yang J,Yan DM,Xhu LX,Si DM,Liang QH

    更新日期：2020-01-01 00:00:00

  • MiR-198 affects the proliferation and apoptosis of colorectal cancer through regulation of ADAM28/JAK-STAT signaling pathway.

    abstract：OBJECTIVE:Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. microRNA-198 (miR-198) was reported to be a tumor suppressive miRNA but its role in CRC is largely unknown. Thus, we aimed to investigate the role of miR-198 and its downstream signaling pathway in CRC. PATIENTS AND METHODS:Quantit...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201902_17106

    authors： Li LX,Lam IH,Liang FF,Yi SP,Ye LF,Wang JT,Guo WW,Xu M

    更新日期：2019-02-01 00:00:00

  • The effect of low dosage of procaine on lung cancer cell proliferation.

    abstract：OBJECTIVE:Non-small cell lung cancer (NSCLC) is the most common type of human lung cancer leading cause of cancer death worldwide. However, first-line drugs such as gefitinib and erlotinib showed great drug resistance in the clinical. MATERIALS AND METHODS:The cell proliferation was evaluated by MTT assay; gene expres...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Ma XW,Li Y,Han XC,Xin QZ

    更新日期：2016-11-01 00:00:00

  • Treatment for acute asthma in the Emergency Department: practical aspects.

    abstract：:This article describes the management of acute asthma exacerbation in the Emergency Department (ED). An asthma exacerbation can be defined as clinical worsening of disease or an asymptomatic decrease in peak flows. Acute exacerbations of asthma may represent reactions to airway irritants or failures of chronic treatme...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,评审

    doi：

    authors： Urso DL

    更新日期：2010-03-01 00:00:00

  • Imaging assessment of portal venous system: pictorial essay of normal anatomy, anatomic variants and congenital anomalies.

    abstract：:The purpose of this pictorial essay is to describe anatomic variants and congenital anomalies of portal venous system and related liver parenchymal alterations. The imaging findings of some of these entities have been previously described in other articles, however this work encompasses all congenital anomalies of por...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Guerra A,De Gaetano AM,Infante A,Mele C,Marini MG,Rinninella E,Inchingolo R,Bonomo L

    更新日期：2017-10-01 00:00:00

  • Hepatotoxicity of paracetamol and related fatalities.

    abstract：:Paracetamol, also known as acetaminophen, is the most commonly used antipyretic and pain reliever and since 1955 it is available over-the-counter as a single formulation or in combination with other substances and, as indicated by the World Health Organization, it can be used in all the three steps of pain intensity. ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Tittarelli R,Pellegrini M,Scarpellini MG,Marinelli E,Bruti V,di Luca NM,Busardò FP,Zaami S

    更新日期：2017-03-01 00:00:00

  • Diagnostic value of microRNAs in breast cancer: a meta-analysis.

    abstract：OBJECTIVE:To explore the value of diagnosis accuracy of aberrant microRNAs in breast cancer. MATERIALS AND METHODS:We searched PubMed, Embase, EBSCO and the Cochrane Library, accessing to the case of articles about microRNA expression in breast carcinoma patients after literature screening and quality assessment, extr...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,meta分析

    doi：

    authors： Xin ZC,Yang HQ,Wang XW,Zhang Q

    更新日期：2017-01-01 00:00:00

  • Therapeutic challenge during the long-term follow-up of a patient with indolent systemic mastocytosis with extensive cutaneous involvement.

    abstract：:From a dermatological aspect, it posed a considerable challenge the skin-limited form of mastocytosis, urticaria pigmentosa and indolent systemic mastocytosis (ISM) with cutaneous lesions. Despite the favourable prognosis, lifelong dermatological control is needed, during which the average symptomatic therapy does not...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Marton I,Pósfai É,Borbényi Z,Bödör C,Papp G,Demeter J,Korom I,Varga E,Bata-Csörgő Z

    更新日期：2015-01-01 00:00:00

  • Antimicrobial activity of a 48-kDa protease (AMP48) from Artocarpus heterophyllus latex.

    abstract：BACKGROUND AND OBJECTIVE:Artocarpus heterophyllus (jackfruit) is a latex producing plant. Plant latex is produced from secretory cells and contains many intergradients. It also has been used in folk medicine. This study aimed to purify and characterize the biological activities of a protease from jackfruit latex. MATE...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Siritapetawee J,Thammasirirak S,Samosornsuk W

    更新日期：2012-01-01 00:00:00

  • A new walker with upper trunk suspension system for severely disabled patients.

    abstract：:We have recently designed a new type of walker for those severely disabled patients who cannot walk with commonly used medical walkers. A drawing and the description of this new walker is reported in order to permit the worldwide companies as well as artisans to develop and produce it for the people affected from seve...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Scoppetta C,Scoppetta M

    更新日期：2013-10-01 00:00:00

  • MicroRNA-138 inhibits proliferation and induces apoptosis of laryngeal carcinoma via targeting MAPK6.

    abstract：OBJECTIVE:To explore whether microRNA-138 could regulate the incidence and progression of laryngeal carcinoma through modulating proliferation and apoptosis of laryngeal carcinoma cells via MAPK6. PATIENTS AND METHODS:MicroRNA-138 expression in laryngeal carcinoma tissues and paracancerous tissues were detected by qRT...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201809_15820

    authors： Zhou YH,Huang YY,Ma M

    更新日期：2018-09-01 00:00:00

  • Mechanism of lncRNA FEZF1-AS1 in promoting the occurrence and development of oral squamous cell carcinoma through targeting miR-196a.

    abstract：OBJECTIVE:Previous studies have demonstrated that long non-coding ribonucleic acid (lncRNA) FEZF1-AS1 acts as a cancer-promoting gene. However, no reports have investigated the role of FEZF1-AS1 in oral squamous cell carcinoma (OSCC) yet. Therefore, the aim of this study was to explore whether FEZF1-AS1 promoted the ex...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201908_18534

    authors： Xu L,Hou TJ,Yang P

    更新日期：2019-08-01 00:00:00

  • The relationship between intracranial pressure and neurocognitive function before and after the repair of a skull injury.

    abstract：OBJECTIVE:This study examines the relationship between intracranial pressure (ICP) changes after skull injury repair and neurocognitive function before and after the repair. PATIENTS AND METHODS:Sixty patients undergoing skull injury repair participated in the study. A non-invasive detection analyzer was used to detec...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： He J,Chen LL,Sun DK,Wang HT,Wang JJ,Zhai X

    更新日期：2017-03-01 00:00:00

  • Prevention of surgical site infections in orthopaedic surgery: a synthesis of current recommendations.

    abstract：:Despite adopted precautions, surgical site infection (SSI) rate in orthopaedic surgery and its consequences still remain a major problem. Worldwide, infection prevention and control in perioperative settings are considered of primary importance for every healthcare system. The management of perioperative infections ca...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.26355/eurrev_201904_17497

    authors： Tucci G,Romanini E,Zanoli G,Pavan L,Fantoni M,Venditti M

    更新日期：2019-04-01 00:00:00

  • Bisphosphonate-related osteonecrosis of the jaw (BRONJ): 5 year experience in the treatment of 131 cases with ozone therapy.

    abstract：BACKGROUND:Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) are the result of the assumption of such drugs. The most widely used molecules are pamidronate and zoledronic acid, which are pyrophosphate analogues and are usually given to patient with bone remodelling diseases. International literature reports showe...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Agrillo A,Filiaci F,Ramieri V,Riccardi E,Quarato D,Rinna C,Gennaro P,Cascino F,Mitro V,Ungari C

    更新日期：2012-11-01 00:00:00

  • The effect of sequential transcatheter arterial chemoembolization (TACE) and portal venous embolizations (PVE) vs. TACE or PVE alone on rabbit VX2 liver carcinoma and on liver regeneration.

    abstract：OBJECTIVE:This study aimed to build VX2 liver tumor model in rabbits and to investigate the sequential transcatheter arterial chemoembolization (TACE) and portal vein embolizations (PVE) vs. TACE or PVE alone on rabbit VX2 liver carcinoma and liver regeneration. MATERIALS AND METHODS:VX2 liver tumor models were built ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Guo WC,He XF,Li YH,Li ZH,Mei QL,Chen Y

    更新日期：2016-07-01 00:00:00

  • First and second trimester biochemical markers in familial mediterranean fever.

    abstract：OBJECTIVES:Our aim was to investigate whether the maternal serum concentrations of first and second trimester serum analytes are altered in familial Mediterranean fever (FMF) pregnancies. MATERIALS AND METHODS:The screening tests were compared in a series of 16 serum samples from FMF pregnancies and in a cohort of 48 ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Turkcapar F,Engin-Üstün Y,Simsek OY,Deveer R,Danisman N,Dilmen U,Mollamahmutoglu L

    更新日期：2013-07-01 00:00:00