Abstract:
:The thalamus is believed to be a key node in human memory networks, however, very little is known about its real-time functional role. Here we examined the dynamics of thalamocortical communication during long-term episodic memory retrieval in two experiments. In experiment 1, intrathalamic and surface EEG was recorded in an epileptic patient implanted with depth electrodes for brain stimulation therapy. In a recognition memory test, early (300-500 ms) stimulus-linked oscillatory synchrony between mediodorsal thalamic and frontal surface electrodes at beta frequency (20 Hz) was enhanced for correctly remembered old compared to correctly rejected new items. Directionality measures (Granger causality) indicated that the thalamus was the sender, and the neocortex the receiver, of this beta signal, which also modulated the power of neocortical gamma (55-80 Hz) oscillations (cross-frequency coupling). Experiment 2 validated the cross-frequency coupling effects in a healthy participant sample. Confirming the findings from experiment 1, significantly increased cross-frequency coupling was found over frontal scalp electrodes during successful recognition. Extending anatomical knowledge on thalamic connectivity with frontal neocortex, these results suggest that the thalamus sends an early memory signal to frontal regions, triggering further memory search processes.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Staudigl T,Zaehle T,Voges J,Hanslmayr S,Esslinger C,Hinrichs H,Schmitt FC,Heinze HJ,Richardson-Klavehn Adoi
10.1016/j.neuropsychologia.2012.08.023subject
Has Abstractpub_date
2012-12-01 00:00:00pages
3519-27issue
14eissn
0028-3932issn
1873-3514pii
S0028-3932(12)00371-5journal_volume
50pub_type
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