Universal fluorescence module for intraoperative fluorescein angiography-a technical report.


BACKGROUND:Even in specialized centers, suboptimal aneurysm clipping can be as high as 12%. Intraoperative fluorescence angiography with indocyanine green and, more recently, fluorescein sodium have been shown to be a good method for intraoperative flow assessment. However, the cost with the apparatus it entails limits its widespread use. We have developed a low-cost universal fluorescence module (FM) designed to visualize fluorescein and perform intraoperative angiography. The purpose of this paper is to describe this device as well as to present our early experience with its use in the treatment of cerebral aneurysms. METHOD:A FM was designed and built using a cyan-blue narrow bandpass (460 to 490 nm) excitation filter and a yellow-orange longpass (blocking wavelengths under 520 nm) barrier filter mounted on a 3D-printed holding tray in a specific disposition to perfectly match the light source and the objective lens of the surgical microscope. It allowed switching from white light to fluorescence mode in a simple and sterile fashion. Its perfect attachment to the microscope was possible by reusing the lens fittings extracted from used original drape sets that would otherwise be discarded. Four patients underwent aneurysm clipping using the FM at two institutions from April to September 2018. RESULTS:A bright green fluorescence against a dark background was observed after intravenous bolus of fluorescein. Blood vessels became obviously distinct from non-contrast-filled structures such as clipped aneurysms and the brain. Vascular anatomy could be appreciated without any distortion, including perforating arteries. CONCLUSIONS:Intraoperative fluorescence angiography was successfully performed with the use of this universal FM after intravenous injection of fluorescein sodium. This simple and low-cost device may be useful in resource-limited centers, where other sorts of intraoperative angiography are not available.


Acta Neurochir (Wien)


Acta neurochirurgica


Leal RTM,Fernandes RA,Escudeiro GP,Rodrigues RMC,Monteiro R,Landeiro JA




Has Abstract


2019-07-01 00:00:00














  • Brain oedema induced by ventricular puncture. A study by magnetic resonance on a series of forty-one normal-pressure hydrocephalic patients.

    abstract::After ventricular catheterization magnetic resonance (MR) imaging very often demonstrates a focal area of high signal along the drain track which corresponds to parenchymal oedema. This high signal seemed to be more pronounced when the frontal area was catheterized than when the junctional parieto-temporo-occipital pa...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Raftopoulos C,Bidaut L,Chaskis C,Cantraine F,Clarysse S,Balériaux D

    更新日期:1994-01-01 00:00:00

  • Surgical management of haemangioblastoma of the posterior fossa.

    abstract::Fifty-one cases of posterior fossa haemangioblastoma have been seen in our department over a period of 23 years. Seven cases were associated with spinal cord lesions and one with a supratentorial lesion. There were 22 cases of Lindau's disease (43%). The onset was earlier and recurrences commoner than in isolated case...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Symon L,Murota T,Pell M,Bordi L

    更新日期:1993-01-01 00:00:00

  • Intra-operative correction of brain-shift.

    abstract:BACKGROUND:Brain-shift is a major source of error in neuronavigation systems based on pre-operative images. In this paper, we present intra-operative correction of brain-shift using 3D ultrasound. METHODS:The method is based on image registration of vessels extracted from pre-operative MRA and intra-operative power Do...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Reinertsen I,Lindseth F,Askeland C,Iversen DH,Unsgård G

    更新日期:2014-07-01 00:00:00

  • Different clinical course of pallidal deep brain stimulation for phasic- and tonic-type cervical dystonia.

    abstract:BACKGROUND:Dystonia has been treated well using deep brain stimulation at the globus pallidus internus (GPi DBS). Dystonia can be categorized as two basic types of movement, phasic-type and tonic-type. Cervical dystonia is the most common type of focal dystonia, and sequential differences in clinical outcomes between p...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Chung M,Huh R

    更新日期:2016-01-01 00:00:00

  • Optic nerve gliomas. I. Clinical diagnosis and pathology.

    abstract::At the National Institute of Neurosurgery a team of ophthalmologists and neurosurgeons has for 20 years been collaborating in the research and treatment of optic nerve gliomas. Among 34 patients, 30 were under the age of 20 years, and 20 under the age of 10 years. Of the 20 patients younger than 10 years, 16 were girl...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Pásztor E,Remenár L

    更新日期:1978-01-01 00:00:00

  • Practical application of intraoperative ultrasound imaging.

    abstract::Intraoperative real-time ultrasound imaging (US) was used in over 500 patients to investigate which of the previously considered applications are of practical use in everyday neurosurgery. During all intraoperative applications for a wide variety of pathological conditions, small deep-seated as well as subcortically l...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: van Velthoven V,Auer LM

    更新日期:1990-01-01 00:00:00

  • Arterial aneurysms associated with arteriovenous malformations of the brain: classification, incidence, risk of hemorrhage, and treatment-a systematic review.

    abstract:BACKGROUND:Aneurysms associated with brain arteriovenous malformations (bAVMs) influence the natural history of these lesions and pose important therapeutic challenges. However, the epidemiology, natural history, and appropriate management of the aneurysms associated with bAVMs are not completely understood due to the ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章,meta分析


    authors: Cagnazzo F,Brinjikji W,Lanzino G

    更新日期:2016-11-01 00:00:00

  • Ruptured distal anterior choroidal artery aneurysm presenting with casting intraventricular haemorrhage.

    abstract::This report describes a rare case of a distal anterior choroidal artery aneurysm which developed intraventricular haemorrhage without subarachnoid haemorrhage as shown on computerized tomographic (CT) scan. A 69-year-old hypertensive man suddenly became unconscious. An emergency CT scan showed a severe intraventricula...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章,评审


    authors: Yoneoka Y,Ezuka I,Takai N,Oda T,Tamura T,Yamashita S

    更新日期:1998-01-01 00:00:00

  • Solitary plasmacytoma of the spine: relationship of IGM to tumour progression and recurrence.

    abstract::The authors report a retrospective study of 15 patients with solitary vertebral plasmacytoma. 15 patients were considered in this study on the basis of the following characteristics: 1) histologically confirmed plasmacytoma following surgical removal; 2) existence of a single vertebral lesion, documented by skeletal a...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Cervoni L,Celli P,Salvati M,Tarantino R,Fortuna A

    更新日期:1995-01-01 00:00:00

  • Leptomeningeal dissemination of malignant gliomas. Incidence, diagnosis and outcome.

    abstract::To understand the clinicopathology features of leptomeningeal dissemination of malignant gliomas, a total of 157 consecutive patients treated between 1978 and 1989 were analysed. Twenty-two patients (14%) were judged to have dissemination. In 20 patients, the dissemination was diagnosed antemortem. Eleven patients had...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Arita N,Taneda M,Hayakawa T

    更新日期:1994-01-01 00:00:00

  • Unilateral microsurgical approaches to extramedullary spinal tumours. Operative technique and results.

    abstract::The operative technique of limited approaches to extramedullary spinal tumours is described. The results after unilateral approaches are as satisfying as after standard laminectomies. The rationale of attempting an unilateral approach is to avoid damage to the dorsal static structures of the vertebral column. Access g...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Eggert HR,Scheremet R,Seeger W,Gaitzsch J

    更新日期:1983-01-01 00:00:00

  • Epidural pressure monitoring with the so-called Rotterdam transducer. Further in vivo results.

    abstract::Results of measurements in vivo of intracranial pressure obtained with a new telemetric epidural pressure transducer are described. The relations of epidural pressure to ventricular fluid pressure are studied in acute experiments and found to be linear, but variable. The functioning of 18 transducers was studied over ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: de Jong DA,Berfelo MW,de Lange SA,Maas AI

    更新日期:1979-01-01 00:00:00

  • Computerized tomography (CT) in patients with head injuries. Assessment of outcome based upon initial clinical findings and initial CT scans.

    abstract::In this study, which comprises 144 consecutive head injuries, the initial clinical assessment and the findings of the initial CT scan are related to the outcome. The mortality is related to the patient's level of consciousness and pupillary light reflex on admission. The disability rate (= number of disabled/number of...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Espersen JO,Petersen OF

    更新日期:1982-01-01 00:00:00

  • Linear accelerator and Greitz-Bergstrom's head fixation system in radiosurgery of single cerebral metastases. A report of 86 cases.

    abstract::Between 1984 and 1991 86 patients with single cerebral metastases underwent linear accelerator radiosurgery using the atraumatic and reproducible Greitz-Bergström head-fixation device. Routine one-month follow-up documented disappearance of the tumour in 16 patients, with resolution of the oedema and ventricular shift...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Valentino V,Mirri MA,Schinaia G,Dalle Ore G

    更新日期:1993-01-01 00:00:00

  • Image fusion of MR images and real-time ultrasonography: evaluation of fusion accuracy combining two commercial instruments, a neuronavigation system and a ultrasound system.

    abstract:OBJECTIVE:The aim of our study was to evaluate MRI/Ultrasonography fusion accuracy depending on three ultrasonographic parameters. METHOD:An ultrasonography and MRI compatible model was created, consisting of a plastic box, which contained 3 objects. MRI scans were performed with 128 sagittal slices. The objects were ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Schlaier JR,Warnat J,Dorenbeck U,Proescholdt M,Schebesch KM,Brawanski A

    更新日期:2004-03-01 00:00:00

  • Linear array ultrasound in low-grade glioma surgery: histology-based assessment of accuracy in comparison to conventional intraoperative ultrasound and intraoperative MRI.

    abstract:INTRODUCTION:In low-grade glioma (LGG) surgery, intraoperative differentiation between tumor and most likely tumor-free brain tissue can be challenging. Intraoperative ultrasound can facilitate tumor resection. The aim of this study is to evaluate the accuracy of linear array ultrasound in comparison to conventional in...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Coburger J,Scheuerle A,Thal DR,Engelke J,Hlavac M,Wirtz CR,König R

    更新日期:2015-02-01 00:00:00

  • A four lumen screwing device for multiparametric brain monitoring.

    abstract::We describe multiparametric monitoring in severe head trauma using a new screwing device. Our aim was to create a screw which would make the implantation of the probes and thus multiparametric monitoring easier. The new screw allows us to implant 3 probes (microdialysis, Paratrend and an intracranial pressure device) ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Feuerstein TH,Langemann H,Gratzl O,Mendelowitsch A

    更新日期:2000-01-01 00:00:00

  • Frameless stereotactic guided neurosurgery: clinical experience with an infrared based pointer device navigation system.

    abstract::An infrared based frameless stereotactic navigation device (Easy Guide Neuro) was investigated for its clinical applicability, registration/application accuracy and limitations in a standard operating room set-up. In a five-month period 40 frameless stereotactic procedures (23 female, 17 male, mean age 46.4, yrs range...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Roessler K,Ungersboeck K,Dietrich W,Aichholzer M,Hittmeir K,Matula C,Czech T,Koos WT

    更新日期:1997-01-01 00:00:00

  • Malignant glioma: its initial presentation as intracranial haemorrhage.

    abstract::Malignant glioma presenting as an intracerebral haematoma is very rare. Two patients having malignant gliomas, initially presenting as intraparenchymal haematomas, are discussed. One patient survived, but the other patient rapidly deteriorated and died. ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Richardson RR,Siqueira EB,Cerullo LJ

    更新日期:1979-01-01 00:00:00

  • Double balloon protection during carotid artery stenting for vulnerable carotid stenosis reduces the incidence of new brain lesions.

    abstract:BACKGROUND:The use of distal filter protection alone is associated with a high risk of ischemic complications when vulnerable carotid stenosis is treated by carotid artery stenting (CAS). Double balloon protection, a combination of distal balloon protection and proximal balloon occlusion, can be utilized. We assessed t...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Nakazaki M,Nonaka T,Takahashi A,Yonemasu Y,Nomura T,Onda T,Honda O,Hashimoto Y,Ohnishi H,Sasaki M,Daibo M,Honmou O

    更新日期:2016-07-01 00:00:00

  • Cranio-cerebral erosion (growing fracture of the skull in children). Part II. Clinical and radiological observations.

    abstract::This paper is based on a study of sixty cases of cranio-cerebral erosion treated in the Department of Neurosurgery. All India Institute of Medical Sciences, New Delhi during the last 20 years. This constitutes the largest series, so far reported from anywhere. It has provided a unique opportunity to get a comprehensiv...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章,评审


    authors: Tandon PN,Banerji AK,Bhatia R,Goulatia RK

    更新日期:1987-01-01 00:00:00

  • Cerebral primitive neuro-ectodermal tumour following treatment of a unilateral retinoblastoma.

    abstract::Cerebral primitive neuro-ectodermal tumour (PNET) occurring as a second primary malignancy in childhood is exceedingly rare. We present a 7-year-old boy who developed a proven supratentorial PNET five years after enucleation and radio-/chemotherapy for a sporadic, unilateral retinoblastoma with optic nerve invasion. T...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Dorfmüller G,Würtz FG,Kleinert R,Lanner G

    更新日期:1997-01-01 00:00:00

  • Early and late re-operations after anterior cervical decompression and fusion during an 11-year follow-up.

    abstract:BACKGROUND:Anterior cervical decompression and fusion (ACDF) may necessitate acute and late re-operations. Published long-term follow studies after ACDF are scarce. OBJECTIVE:Our goal was to give a detailed description of early and late re-operations after ACDF in an 11-year follow-up. METHODS:We retrospectively anal...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Saarinen T,Niemelä M,Kivisaari R,Pitkäniemi J,Pohjola J,Hernesniemi J

    更新日期:2013-02-01 00:00:00

  • Syringomyelia with Chiari malformation; 3 unusual cases with implications for pathogenesis.

    abstract::Syringomyelia is an important cause of neurological deficit. Most cases of non-traumatic syringomyelia occur in association with a Chiari malformation. We present three unusual examples of syringomyelia with such an association. The first case is that of syringomyelia in a young woman with Marfan's syndrome, a spontan...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Owler BK,Halmagyi GM,Brennan J,Besser M

    更新日期:2004-10-01 00:00:00

  • COXIBRAIN: results of the prospective, randomised, phase II/III study for the selective COX-2 inhibition in chronic subdural haematoma patients.

    abstract:BACKGROUND:Chronic subdural haematomas (cSDHs) have shown an increasing incidence in an ageing population over the last 20 years, while unacceptable recurrence rates of up to 30 % persist. The recurrence rate of cSDH seems to be related to the excessive neoangiogenesis in the parietal membrane, which is mediated via va...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章,随机对照试验


    authors: Schaumann A,Klene W,Rosenstengel C,Ringel F,Tüttenberg J,Vajkoczy P

    更新日期:2016-11-01 00:00:00

  • Carpal tunnel syndrome and acromegaly.

    abstract::50 patients with acromegaly and carpal tunnel syndrome have been examined electrophysiologically before and after transnasal operation of the pituitary adenoma. 32 of the 50 patients (64%) had symptoms of carpal tunnel syndrome. 13 of them had neurological deficits. 28 of the examined patients had pathological neurogr...

    journal_title:Acta neurochirurgica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Baum H,Lüdecke DK,Herrmann HD

    更新日期:1986-01-01 00:00:00

  • Clinical features of the haemorrhage type moyamoya disease based on 31 cases.

    abstract::We evaluated and analysed our own 31 cases of the haemorrhagic type of moyamoya disease to clarify the clinical features of this disease. The cases were divided into three groups. Group A consisted of 12 cases with aneurysms. Aneurysms on the circle of Willis were treated as ordinary saccular aneurysms. Group B consis...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Kawaguchi S,Sakaki T,Kakizaki T,Kamada K,Shimomura T,Iwanaga H

    更新日期:1996-01-01 00:00:00

  • The common consensus criteria have high predictive values for long-term postoperative acromegaly remission.

    abstract:OBJECTIVE:The aim of this work was to retrospectively study the long-term reliability of the common consensus endocrinological criteria for the assessment of postoperative remission of acromegaly. PATIENTS AND METHODS:In 96 consecutive patients, surgical remission of acromegaly following transsphenoidal surgery was co...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Kristof RA,Grote A,Redel L,Neuloh G,Klingmüller D,Schramm J

    更新日期:2011-01-01 00:00:00

  • Acute intracranial hypertension and shunt dependency following treatment of intracranial arachnoid cyst in a child: a case report and review of the literature.

    abstract::Arachnoid cysts are developmental anomalies that represent 1% of all intracranial space occupying lesions. Treatment of symptomatic cases may include shunting of the cyst or an open fenestration of it, among other less acceptable surgical procedures. Each procedure has its own pros and cons. We present a case of the d...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章,评审


    authors: Laviv Y,Michowitz S

    更新日期:2010-08-01 00:00:00

  • Clinical implications and radiographic characteristics of the relation between giant intracranial aneurysms of the posterior circulation and the brainstem.

    abstract:BACKGROUND:Giant intracranial aneurysms of the posterior circulation (GPCirA) are rare entities compressing the brainstem and adjacent structures. Previous evidence has shown that the amount of brainstem shift away from the cranial base is not associated with neurological deficits. This raises the question whether othe...

    journal_title:Acta neurochirurgica

    pub_type: 临床试验,杂志文章


    authors: Haemmerli J,Lenga P,Hong B,Kursumovic A,Maldaner N,Burkhardt JK,Bijlenga P,Rüfenacht DA,Schmidt NO,Vajkoczy P,Dengler J

    更新日期:2019-09-01 00:00:00