Abstract：
BACKGROUND:Vaccination against tumour-associated antigens is one approach to elicit anti-tumour responses. We investigated the effect of polynucleotide (DNA) vaccination using a model antigen (E. coli lacZ) in a syngeneic gliosarcoma model (9L). METHODS:Fisher 344 rats were vaccinated thrice by intramuscular injection of a lacZ-encoding or a control plasmid in weekly intervals. One week after the last vaccination, lacZ-expressing 9L cells were implanted into the striatum. RESULTS:After 3 weeks, in lacZ-vaccinated animals the tumours were significantly smaller than in control-vaccinated animals. In cytotoxic T cell assays lysis rates of >50 % could only be observed in a few of the lacZ-vaccinated animals. This response was directed against lacZ-expressing and parental 9L cells but not against syngeneic MADB 106 adenocarcinoma cells. In Elispot assays interferon-γ production was observed upon stimulation with 9LlacZ and 9L wild-type but not MADB 106 cells. This response was higher for lacZ-immunized animals. All animals revealed dense infiltrates with CD8+ lymphocytes and, to a lesser extent, with NK cells. CD25-staining indicated cells possibly associated with the maintenance of peripheral tolerance to self-antigens. All tumours were densely infiltrated by microglia consisting mostly of ramified cells. Only focal accumulation of macrophage-like cells expressing ED1, a marker for phagocytic activity, was observed. CONCLUSION:Prophylactic DNA vaccination resulted in effective but incomplete suppression of brain tumour formation. Mechanisms other than cytotoxic T cell responses as measured in the generally used in vitro assays appear to play a role in tumour suppression.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Ginzkey C,Eicker S,Marget M,Krause J,Brecht S,Westphal M,Hugo HH,Mehdorn M,Steinmann J,Hamel Wdoi
10.1007/s00701-012-1526-7subject
Has Abstractpub_date
2013-01-01 00:00:00pages
51-8; discussion 59issue
1eissn
0001-6268issn
0942-0940journal_volume
155pub_type
杂志文章abstract：:Nine cases of posttraumatic primary brain stem haematoma are described. All cases presented ocular and vegetative symptoms. Hyperextension was regarded as the most likely mechanism of injury. All patients were treated conservatively; half of them with a good outcome. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01428496
更新日期：1995-01-01 00:00:00
abstract：:The occurrence of abdominal aortic aneurysms (AAAs) and intracranial aneurysms (IAs) in the same patient and in the same family was studied among 89 patients with AAAs and 485 patients with IAs. Among the AAA-patients two had IAs themselves and five had IAs in the family, whereas three IA-patients had AAAs themselves ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF02076012
更新日期：1987-01-01 00:00:00
abstract：:27 cases of cranioplasty with autogenous bone grafts stored in a deep-freezer and autoclaved before use are reported. The results of follow-up for an average period of one year were satisfactory from the standpoint of brain protection and cosmetic reconstruction. A small area of absorption of grafted bone was observed...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01402184
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Adipose lesions of nerve primarily include intra- and extraneural lipomas and lipomatosis of nerve (LN). This paper will summarize the advances that have been made in the past decade, particularly related to LN and nerve territory overgrowth that have improved our understanding of the natural history, geneti...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/s00701-020-04620-2
更新日期：2020-10-22 00:00:00
abstract：:Intact aneurysms of the carotid siphon at the point of take-off of the posterior communicating artery may exhibit orbital pain, whether associated with oculomotor palsy or not as a warning symptom prior to rupture. In order to explain this symptom the hypothesis of a sensory pathway within the third cranial nerve, whi...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF02001462
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:Major artery aneurysms may be found incidentally while evaluating moyamoya disease (MMD). The purpose of this study was to delineate the prevalence and characteristics of these uncommon aneurysms with a brief mention of their management and outcomes. METHODS:We conducted a retrospective review of 249 adult ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-011-0948-y
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Schwannomas occur sporadically or in association with neurofibromatosis 2 (NF2), an autosomal dominant disorder, which predisposes to multiple schwannomas, meningiomas and spinal ependymomas, with bilateral vestibular schwannomas as the classic hallmark. As NF2 and sporadic schwannomas differ in some respect...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010070036
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Microsurgical circumferential stripping of intracerebral metastases is often insufficient in achieving local tumor control. Supramarginal resection may improve local tumor control. METHODS:A retrospective analysis was performed for patients who underwent supramarginal resection of a cerebral metastasis by a...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-015-2405-9
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVE:The aim of this work was to retrospectively study the long-term reliability of the common consensus endocrinological criteria for the assessment of postoperative remission of acromegaly. PATIENTS AND METHODS:In 96 consecutive patients, surgical remission of acromegaly following transsphenoidal surgery was co...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-010-0790-7
更新日期：2011-01-01 00:00:00
abstract：:To evaluate the interrelationships between anterior pituitary function and the antidiuretic system in patients harbouring hypothalamo-hypophyseal tumorous lesions, combined anterior pituitary stimulation tests were performed in the pre (n = 192 patients) and postoperative (n = 151 patients) state. Basal and stimulated...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01842828
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:In this study, we compared the dosimetric properties between Gamma Knife (GK) and Cyberknife (CK), and investigated the clinical implications in treating brain metastases (BMs). METHODS:Between 2011 and 2013, 77 patients treated with either single-fraction GK for small BMs (n = 40) or fractionated CK for la...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-015-2585-3
更新日期：2015-11-01 00:00:00
abstract：INTRODUCTION:Spontaneous posterior interosseous nerve palsy is a rare condition. Entrapment is mostly at level of the arcade of Frohse, and a few cases of distal entrapment have been described. METHODS:A case of entrapment distal to the arcade of Frohse is described here. Cases of distal entrapment have been reviewed ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/s00701-018-3615-8
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Microscopic transsphenoidal surgery (mTSS) is a well-established method to address adenomas of the pituitary gland. Endoscopic transsphenoidal surgery (eTSS) has become a viable alternative, however. Advocates suggest that the greater illumination, panoramic visualization, and angled endoscopic views afforde...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00701-017-3438-z
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Traumatic brain injury (TBI) is a critical public health and socio-economic problem throughout the world, making epidemiological monitoring of incidence, prevalence and outcome of TBI necessary. We aimed to describe the epidemiology of traumatic brain injury in Europe and to evaluate the methodology of incid...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00701-015-2512-7
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Computer-assisted design and manufacturing (CAD/CAM) techniques have been implemented in craniosynostosis surgery to facilitate cranial remodeling. However, until now, computed tomography (CT) scans with ionizing radiation were necessary to plan the procedure and create guiding templates. The purpose of this...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-020-04445-z
更新日期：2020-06-09 00:00:00
abstract：:Firstly, 14 patients are described who developed either an acquired Chiari malformation (ACM) alone (7 cases) or ACM and syringomyelia (7 cases) after lumbar subarachnoid space (SAS) shunting or in one case, epidural anaesthesia with SAS penetration. Four groups are considered: 3 cases with craniofacial dysostosis and...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010050119
更新日期：1998-01-01 00:00:00
abstract：:Malignant glioma presenting as an intracerebral haematoma is very rare. Two patients having malignant gliomas, initially presenting as intraparenchymal haematomas, are discussed. One patient survived, but the other patient rapidly deteriorated and died. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01407682
更新日期：1979-01-01 00:00:00
abstract：BACKGROUND:In terms of response to fractionated radiotherapy, metastatic brain tumors of certain origins are considered radioresistant. OBJECTIVE:To determine the influence of "radioresistant" histology on outcomes of brain metastases treated with radiosurgery. METHODS:Between 2001 and 2017, 121 patients with brain m...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-018-3726-2
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:To evaluate the significance of protein S-100b as a serum marker for the prediction of functional outcome in the event of symptomatic spinal cord compression due to epidural metastases. METHOD:34 patients with paresis due to metastatic spinal cord compression were included in this prospective study. Venous ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-004-0242-3
更新日期：2004-05-01 00:00:00
abstract：:The brain-type isoenzyme of creatine kinase was determined in serum (S) and cerebrospinal fluid (CSF) in 37 patients with severe head injury, and a correlation was made with the Glasgow coma score and Glasgow outcome score. All patients with normal S-CKBB and CSF-CKBB activities had a coma score of 15, i.e., no neurol...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01418476
更新日期：1985-01-01 00:00:00
abstract：:We evaluated and analysed our own 31 cases of the haemorrhagic type of moyamoya disease to clarify the clinical features of this disease. The cases were divided into three groups. Group A consisted of 12 cases with aneurysms. Aneurysms on the circle of Willis were treated as ordinary saccular aneurysms. Group B consis...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01809751
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:Microvascular decompression (MVD) has become a well-established surgical procedure for hemifacial spasm (HFS). Before surgery, it is essential to evaluate any possible deformity of the brainstem and establish the precise location of the offending vessels. In the present study of HFS patients we examined coro...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-013-1941-4
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:Induced endothelin-1 (ET-1) production and decreased nitric oxide synthase (NOS) bioavailability have been found in aneurysmal subarachnoid hemorrhage (SAH). Atorvastatin is recognized to have pleiotropic effects including increasing NOS bioavailability as well as reducing inflammation and oxidative damage ot...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-010-0652-3
更新日期：2010-08-01 00:00:00
abstract：:In spite of the recent advances in neuroradiology including the CT scan and the spin-echo-magnetic resonance (MR), accurate diagnosis of arteriovenous malformations (AVMs) involving the spinal cord is still based on selective angiography. This last procedure is invasive and needs to be repeated during the follow up. P...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01476287
更新日期：1993-01-01 00:00:00
abstract：:A case of anterior interosseous nerve palsy is demonstrated due to an anatomical variation not recorded before causing this syndrome. Main median-nerve trunk and anterior interosseous nerve passed differently in relation to the pronator teres muscle. Surgery led to a rapid recovery of nerve function. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01424572
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:To evaluate the clinical presentation, diagnostic and therapeutic management and outcome of 27 cases of post-traumatic thoracic outlet syndrome (PT TOS). METHODS:Retrospective chart analysis. RESULTS:Nineteen women and eight men were included in this study. Involvement in a traffic accident was the most co...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-011-1269-x
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Fenestrations of intracranial arteries are variants resulting from incomplete fusion of vessels during development with unknown clinical significance. They are best visualised with 3D rotational angiography (3DRA). OBJECTIVE:In a prospective consecutive series of patients with suspected aneurysms, 3DRA was ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-012-1587-7
更新日期：2013-02-01 00:00:00
abstract：STUDY DESIGN:Retrospective analysis of 357 cases of degenerative disc disease treated by interbody fusion with threaded titanium cages. OBJECTIVE:To determine the safety and efficiency of cervical and lumbar interbody fusions using threaded titanium cages and autogenous bone. SUMMARY OF BACKGROUND DATA:Stabilizing th...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010050453
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Cerebral cavernous malformations (CCM) are known to be highly epileptogenic lesions. A number of studies on CCM surgery deal with CCM-associated seizures and/or epilepsy. In order to counsel patients with CCM-associated epilepsy, clear results from such studies would be highly useful. This study reviews the ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/s00701-010-0915-z
更新日期：2011-02-01 00:00:00
abstract：:In this study, which comprises 144 consecutive head injuries, the initial clinical assessment and the findings of the initial CT scan are related to the outcome. The mortality is related to the patient's level of consciousness and pupillary light reflex on admission. The disability rate (= number of disabled/number of...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01405444
更新日期：1982-01-01 00:00:00
