Abstract：
BACKGROUND:To evaluate the significance of protein S-100b as a serum marker for the prediction of functional outcome in the event of symptomatic spinal cord compression due to epidural metastases. METHOD:34 patients with paresis due to metastatic spinal cord compression were included in this prospective study. Venous blood samples for protein S-100b were taken after admission and regularly after operative decompression. The individual time course of protein S-100b levels was correlated with the clinical outcome by means of motor function. Outcome was considered to be favourable in case of neurological improvement and preservation or retrieval of walking ability whereas non-improvement or further neurological deterioration without restoration of function of ambulation was regarded to be unfavourable. FINDINGS:Patients with favourable outcome had serum levels of S-100b which were either normal all the time or which were initially increased but normalised within 2 to 3 days. Patients with unfavourable outcome, however, had increased levels throughout which showed either a further increase or only a slow decrease within approximately two weeks (p=0.0001). INTERPRETATION:These preliminary results suggest that, analogous to cerebral disorders, protein S-100b might be a promising serum marker to predict functional outcome in symptomatic spinal cord compression.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Marquardt G,Setzer M,Seifert Vdoi
10.1007/s00701-004-0242-3subject
Has Abstractpub_date
2004-05-01 00:00:00pages
449-52issue
5eissn
0001-6268issn
0942-0940journal_volume
146pub_type
杂志文章abstract：:A rare case of primary cerebral abscess due to Nocardia asteroides, and its surgical removal, are described. Postoperative meningitis caused by the same fungi was succesfully cured with sulphadiazine and cycloserine. The nocardial disease, its neurological complications, and therapy are reviewed. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401932
更新日期：1977-01-01 00:00:00
abstract：:Despite a body of evidence showing that various neurotrophic factors support the survival of nerve cells and stimulate axonal outgrowth, doubt remains about their optimal site of application as well as the more compelling question of what clinical benefit, if any, they would confer. Ciliary neurotrophic factor (CNTF) ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-005-0631-2
更新日期：2006-01-01 00:00:00
abstract：:Regression of meningioma after haemorrhage and the cessation of hormone treatment is well reported. However, spontaneous regression is very rarely observed. Here, we report the spontaneous regression of a parafalcine meningioma in a 56-year-old woman with multiple sclerosis, who was referred to our department after an...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-016-3019-6
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Usual management of peripheral nerve tumors is to avoid biopsy in those that are likely benign; the risk of biopsy outweighs the benefit of definitive tissue diagnosis. Biopsy of presumed malignant lesions is performed widely. There is a subset of peripheral nerve tumors that are not easily categorized as be...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-020-04257-1
更新日期：2020-06-01 00:00:00
abstract：:The authors describe a seventeen-years-old girl suffering from partial seizures with complex symptomatology. The neuroradiological studies demonstrated a slow-growing glial tumour seated deeply in the right temporo-occipital region. Scalp EEG demonstrated a bilateral asynchronous temporal focus without definite latera...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01774387
更新日期：1978-01-01 00:00:00
abstract：UNLABELLED:The paper presents clinical evaluation of the polypropylene-polyester knit used as a cranioplasty material. MATERIAL:Between year 1980 and 2002 275 cranioplastic procedures using the polypropylene-polyester plates Codubix were carried out in the Department of Neurosurgery of the Medical University of Łódź. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-005-0581-8
更新日期：2005-09-01 00:00:00
abstract：:Congenital craniovertebral junction deformities can be associated with an anomalous vertebral artery (VA). At times, the artery crosses the joint posteriorly (i.e., persistent first intersegmental artery) and is at risk during posterior approach. We report a new variant, wherein the bilateral VA coursed medially after...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-018-3601-1
更新日期：2018-08-01 00:00:00
abstract：:There is a potential risk of sacrificing the cortical vein during neurosurgical operations, particularly in the interhemispheric or subtemporal approach. An impaired cortical vein might cause cerebral venous circulatory disturbances (CVCDs) resulting in venous infarction. In this article, we have reviewed the manageme...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-005-0501-y
更新日期：2005-06-01 00:00:00
abstract：:A case of spontaneous temporal pneumatocoele secondarily infected by Haemophilus parainfluenzae is reported. Its relation to the lateral ventricle and to a defect in the tegmen tympani was confirmed by computerized tomography (CT). The possible aetiological mechanisms are discussed. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01808962
更新日期：1979-01-01 00:00:00
abstract：OBJECTIVE:To analyze prospectively the frequency and the risk of symptomatic and asymptomatic haemorrhage after image guided stereotactic biopsy of intra-axial brain tumours. METHODS:The study was conducted within a time frame of 24 months (April 1998-April 2000). 326 patients (150 males, 176 females; mean age 56.8 ye...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010170058
更新日期：2001-01-01 00:00:00
abstract：:The authors report a retrospective study of 15 patients with solitary vertebral plasmacytoma. 15 patients were considered in this study on the basis of the following characteristics: 1) histologically confirmed plasmacytoma following surgical removal; 2) existence of a single vertebral lesion, documented by skeletal a...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF02187754
更新日期：1995-01-01 00:00:00
abstract：:Although intracranial cavernomas are known to cause haemorrhage, data concerning the frequency, severity and delay of recurrent bleedings are controversial. We report a series of 6 patients with histologically proven cavernoma, presenting with early clinical signs and radiological proof of rebleeding, that is occurrin...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/BF01411299
更新日期：1997-01-01 00:00:00
abstract：:Due to the limited absorptive capacity of the pleural cavity, infants and young children are not generally ideal candidates for ventriculopleural shunts. We report using chest cavities as alternate for temporary diversion of CSF in a young child. Venous access to the cervical region could not be utilized because of sc...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01400595
更新日期：1992-01-01 00:00:00
abstract：:Considerable positive experience in functional radiosurgery has been reported since Leksell's first experience in 1951, but the development of frameless radiosurgery was been limited because of the difficulty of identifying invisible functional targets. In this paper we report on two cases of bilateral parkinsonian tr...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-011-0962-0
更新日期：2011-05-01 00:00:00
abstract：:A simple, reliable and cheap device for intra-operative monitoring of the facial nerve during surgery for cerebellopontine angle tumours is presented. It consists of a single use tracheostomy tube with a low pressure air inflatable cuff placed in the mouth of the patient on the side of the tumour, connected by a press...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01400638
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Surgical treatment of petroclival meningiomas remains challenging. In order to refine indications for the use of stereotactic radiosurgery in the treatment of these tumours, we retrospectively evaluated our experience in this field. METHODS:Thirty-two patients harboring a petroclival meningioma were treated...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-003-0123-1
更新日期：2003-10-01 00:00:00
abstract：:In patients with brain metastasis from lung cancer, we have been able to control local recurrence in approximately 80% of cases. But many of them tend to show brain atrophy with mental deterioration developing a few months after whole brain radiation. To prevent brain atrophy, we have attempted treating patients, whos...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401458
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND:Impairment of cerebral autoregulation is known to adversely affect outcome following traumatic brain injury (TBI). The phase shift (PS) method of cerebral autoregulation (CA) assessment describes the time lag between fluctuations in arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV) in the...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-007-1447-z
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:The benefits of surgery for symptomatic spinal metastases have been demonstrated, largely based on series of patients undergoing debulking and instrumentation operations. However, as cancer treatments improve and overall survival lengths increase, the incidence of recurrent spinal cord compression after debu...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,多中心研究
doi：10.1007/s00701-019-04197-5
更新日期：2020-04-01 00:00:00
abstract：:We describe a case of transsphenoidal deflation of a detachable balloon after embolization of a carotid-cavernous fistula (CCF). The patient developed complete third and sixth nerve palsies immediately after detachable balloon embolization of the CCF, which was considered to be caused by cavernous sinus (CS) compressi...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-006-1072-2
更新日期：2007-02-01 00:00:00
abstract：:Regional cerebral blood flow (rCBF) was measured in three patients after relief of elevated intracranial pressure and restoration of normal cerebral perfusion pressure. Two patients, studied within 4 hours after closed head injury were found to have marked impairment of cortical blood flow and elevation of cerebrovasc...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01406289
更新日期：1975-01-01 00:00:00
abstract：BACKGROUND:Compressive optic neuropathy (CON) with visual loss is, apart from corneal exposure and disfigurating proptosis, the most serious clinical sign encountered in Graves' ophthalmopathy. However, numerous different approaches and operative techniques have been proposed for orbital decompression, with varying res...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010200013
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:This study was conducted to investigate the usefulness of intracranial cerebrospinal fluid (CSF) volume measurement using MR-based methods in the management of patients with normal pressure hydrocephalus (NPH). METHODS:The study group comprised 19 patients with NPH who showed a favorable outcome after ventr...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010170079
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:An Afghani man presented to a U.S. military facility in Afghanistan with a 3-month history of clear fluid from his left naris and frequent sinusitis. Eleven years earlier, he had been struck in the forehead by an object falling from the sky. MATERIALS AND METHODS:Neurologic examination revealed decreased se...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-008-0148-6
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:The scientific activity of neurosurgeons and neurosurgery residents as measured by bibliometric parameters is of increased interest. While data about academic output for neurosurgeons in the USA, the UK, and Canada have been published, no similar results for German neurosurgical residents exist. Within this ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-019-04011-2
更新日期：2019-10-01 00:00:00
abstract：:Nine cases of posttraumatic primary brain stem haematoma are described. All cases presented ocular and vegetative symptoms. Hyperextension was regarded as the most likely mechanism of injury. All patients were treated conservatively; half of them with a good outcome. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01428496
更新日期：1995-01-01 00:00:00
abstract：:Therapy for vasogenic brain oedema (VBE) is still an unsolved problem. Experimental work with the aim of establishing an oncotherapeutic option is presented. VBE is performed by focal freeze injury in rats. Using a stereotactic head holder hypo- or hyperosmolar human serum albumin is administered via the intraventricu...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01412002
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:The arcade of Struthers has been described as possible cause of compression of the ulnar nerve but several authors and our own experience have doubt cast on its existence. We, therefore, performed an anatomical study to determine whether or not the arcade of Struthers exists. METHODS:Ten arms from fresh fro...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-003-0006-5
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:The understanding of molecular alterations of tumors has severely changed the concept of classification in all fields of pathology. The availability of high-throughput technologies such as next-generation sequencing allows for a much more precise definition of tumor entities. Also in the field of brain tumor...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/s00701-016-3062-3
更新日期：2017-03-01 00:00:00
abstract：:Traditional clinical outcome measures for the treatment of Parkinson's disease (PD) have focused on motor function and activities of daily living. However, in the past decade there has been a new emphasis on the use of health related quality of life (HRQOL) measures for translating how a patient's response to treatmen...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010070090
更新日期：2000-01-01 00:00:00
