Phase shift and correlation coefficient measurement of cerebral autoregulation during deep breathing in traumatic brain injury (TBI).


BACKGROUND:Impairment of cerebral autoregulation is known to adversely affect outcome following traumatic brain injury (TBI). The phase shift (PS) method of cerebral autoregulation (CA) assessment describes the time lag between fluctuations in arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV) in the middle cerebral artery. An alternative method (Mx-ABP) is based on the statistical correlation between ABP and CBFV waveforms over time. We compared these two indices in a cohort of severely head injured patients undergoing controlled, 6-breaths-per-minute ventilation. METHODS:PS and Mx-ABP were calculated from 33 recordings of CBFV and MAP in 22 patients with TBI. Spearman's correlation coefficient was used to assess the agreement between PS and Mx-ABP. The relationship between ICP slow wave amplitude, MAP slow wave amplitude and mean ICP was also examined. FINDINGS:Mean values for Mx-ABP and PS were 0.44 +/- 0.27, and 49 +/- 26 (degrees), respectively. PS correlated significantly with Mx-ABP (r = -0.648, p < 0.001). A Bland-Altman plot of normalised Mx-ABP and Phase Shift values showed no significant bias or relationship (mean difference = 0.0004, r = -0.037, p = 0.852). During the test procedure, ICP fluctuated in an approximately sinusoidal fashion, with a mean amplitude of 4.96 +/- 2.72 mmHg (peak to peak). The magnitude of ICP fluctuation during deep breathing correlated weakly but significantly with mean ICP (r = 0.391, p < 0.05) and with the amplitude of ABP fluctuations (r = 0.625, p < 0.0005). CONCLUSIONS:Phase shift and Mx-ABP in TBI are well correlated. Deep breathing presents as an effective tool with which to assess autoregulation using the phase shift method.


Acta Neurochir (Wien)


Acta neurochirurgica


Lewis PM,Rosenfeld JV,Diehl RR,Mehdorn HM,Lang EW




Has Abstract


2008-02-01 00:00:00


139-46; discussion 146-7










  • Pure pineal germinomas: analysis of gender incidence.

    abstract:OBJECTIVE:Pure pineal germinomas have been rarely reported in girls. Gender incidence and differences of pure pineal germinomas are not well known. The authors report a series of pure pineal germinoma and its gender characteristic is reviewed. METHODS AND RESULTS:Of a total of 50 germ cell tumors operated on between 1...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Cuccia V,Galarza M

    更新日期:2006-08-01 00:00:00

  • Childhood and adolescent meningiomas: a report of 38 cases and review of literature.

    abstract:BACKGROUND:The aim is to study the clinical, radiological and pathological features of childhood and adolescent meningiomas and analyse outcome prognosticators. METHOD:A retrospective analysis of the case records of patients less than 20 years of age operated for a meningioma in our institute since 1982 was performed....

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Menon G,Nair S,Sudhir J,Rao BR,Mathew A,Bahuleyan B

    更新日期:2009-03-01 00:00:00

  • Longitudinal smartphone-based self-assessment of objective functional impairment in patients undergoing surgery for lumbar degenerative disc disease: initial experience.

    abstract:BACKGROUND:The worldwide spread of smartphone usage enables new possibilities for longitudinal monitoring of objective functional impairment (OFI) in patients undergoing surgery for lumbar degenerative disc disease (DDD). METHODS:Three patients, undergoing elective surgery for lumbar DDD, self-assessed OFI using a rec...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Sosnova M,Zeitlberger AM,Ziga M,Gautschi OP,Weyerbrock A,Stienen MN,Maldaner N

    更新日期:2020-09-01 00:00:00

  • Meningiomas from a developmental perspective: exploring the crossroads between meningeal embryology and tumorigenesis.

    abstract::Meningiomas are tumors arising from the meninges and represent the most frequent central nervous system tumors in adults. Recent large-scale genetic studies and preclinical meningioma mouse modelling led to a better comprehension of meningioma development and suggested evidences of close relationships between meningea...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章,评审


    authors: Boetto J,Peyre M,Kalamarides M

    更新日期:2021-01-01 00:00:00

  • What is the cause of post-traumatic stress disorder following subarachnoid haemorrhage? Post-ictal events are key.

    abstract:BACKGROUND:Post-traumatic stress disorder (PTSD) is common after subarachnoid haemorrhage (SAH) and causes poor outcome. Knowing which SAH events cause the stress leading to PTSD development could allow for their severity, and so the chances of PTSD, to be reduced. The dramatic nature of SAH onset has meant ictal event...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Baisch SB,Schenk T,Noble AJ

    更新日期:2011-04-01 00:00:00

  • Staging, scoring and grading of medulloblastoma. A postoperative prognosis predicting system based on the cases of a single institute.

    abstract::Although recently survival of some medulloblastoma patients increased remarkably, it remains a serious diagnosis in others. In order to predict the postoperative prognosis in patients treated for medulloblastoma, a new staging, scoring and grading system was developed. Sixty-six patients operated on microsurgically be...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Sure U,Berghorn WJ,Bertalanffy H,Wakabayashi T,Yoshida J,Sugita K,Seeger W

    更新日期:1995-01-01 00:00:00

  • Image-guided percutaneous biopsy of peripheral nerve tumors of indeterminate nature: risks and benefits.

    abstract:BACKGROUND:Usual management of peripheral nerve tumors is to avoid biopsy in those that are likely benign; the risk of biopsy outweighs the benefit of definitive tissue diagnosis. Biopsy of presumed malignant lesions is performed widely. There is a subset of peripheral nerve tumors that are not easily categorized as be...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Pendleton C,Spinner RJ

    更新日期:2020-06-01 00:00:00

  • No apparent role for neutrophils and neutrophil-derived myeloperoxidase in experimental subarachnoid haemorrhage and vasospasm: a preliminary study.

    abstract:OBJECTIVE:The literature contains investigations and discussion of the role of neutrophils and neutrophil-derived myeloperoxidase (MPO) in inflammatory processes, local ischaemia, and ischaemia-reperfusion injury models. Our aim was to determine whether the same roles existed for neutrophils and the system involving ne...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Oruckaptan HH,Caner HH,Kilinc K,Ozgen T

    更新日期:2000-01-01 00:00:00

  • An assessment of patient-reported long-term outcomes following surgery for cauda equina syndrome.

    abstract:BACKGROUND:Data regarding long-term outcomes following surgery for cauda equina syndrome (CES) is scarce. In addition, these studies rely on patient descriptions of the presence or absence of symptoms, with no gradation of severity. This study aimed to assess long-term bladder, bowel, sexual and physical function using...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Hazelwood JE,Hoeritzauer I,Pronin S,Demetriades AK

    更新日期:2019-09-01 00:00:00

  • Facial nerve function and hearing after microsurgical removal of sporadic vestibular schwannomas in a population-based cohort.

    abstract:BACKGROUND:Vestibular schwannoma (VS) is a benign tumor originating from the vestibulocochlear nerve. The optimal treatment strategy is debated, since surgery may result in iatrogenic facial nerve injury. We report the results of VS surgery in a population-based unselected cohort in a center with access to Cyber Knife ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Taha I,Hyvärinen A,Ranta A,Kämäräinen OP,Huttunen J,Mervaala E,Löppönen H,Rauramaa T,Ronkainen A,Jääskeläinen JE,Immonen A,Danner N

    更新日期:2020-01-01 00:00:00

  • Supraorbital subfrontal trans-laminar endoscope-assisted approach for tumors of the posterior third ventricle.

    abstract:BACKGROUND:Different surgical approaches have been developed for dealing with third ventricle lesions, all aimed at obtaining a safe removal minimizing brain manipulation. The supraorbital subfrontal trans-lamina terminalis route, commonly employed only for the anterior third ventricle, could represent, in selected cas...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Iacoangeli M,Colasanti R,Esposito D,Di Rienzo A,di Somma L,Dobran M,Gladi M,Scerrati M

    更新日期:2017-04-01 00:00:00

  • Hyponatremia is predictable in patients with aneurysmal subarachnoid hemorrhage--clinical significance of serum atrial natriuretic peptide.

    abstract:PURPOSE:Serum atrial natriuretic peptide (ANP) that is elevated after aneurysmal subarachnoid hemorrhage (SAH) causes diuresis and natriuresis (cerebral salt wasting) and might exacerbate delayed ischemic neurological deficit (DIND). We investigated relationships among hyponatremia, serum ANP elevation, and the onset o...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Nakagawa I,Kurokawa S,Nakase H

    更新日期:2010-12-01 00:00:00

  • Primary extraosseous intradural spinal Ewing's sarcoma: report of two cases.

    abstract::Two cases of primary extraosseous intradural spinal Ewing's sarcoma are reported with a review of the current literature. This rare neoplasm shares features with cerebral primitive neuroectodermal tumors, complicating a correct diagnosis. Gross total resection seems to be the main treatment, although adjuvant therapie...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章,评审


    authors: Pancucci G,Simal-Julian JA,Plaza-Ramirez E,García-Marcos R,Mayordomo-Aranda E,Botella-Asunción C

    更新日期:2013-07-01 00:00:00

  • Surgical nuances of the expanded endoscopic anterior skull base craniectomy for hyperostotic meningioma resection.

    abstract:BACKGROUND:The rostral expanded endoscopic approach (EEA) to anterior cranial fossa (ACF) has several advantages over transcranial/craniofacial surgery, providing early access to the vascular supply of tumors and reducing morbidities of craniotomy especially that of brain retraction. This article presents endoscopic la...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Silveira-Bertazzo G,Manjila S,London NR Jr,Prevedello DM

    更新日期:2020-06-01 00:00:00

  • Neurosurgical intensive care improves outcome after severe head injury.

    abstract::The present study compares the clinical outcome, as expressed by the Glasgow outcome scale, of two groups of severely head injured patients treated before (49 patients) and after (72 patients) the establishment of a neurosurgical intensive care (NIC) unit at the department of neurosurgery. Uppsala University Hospital....

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Wärme PE,Bergström R,Persson L

    更新日期:1991-01-01 00:00:00

  • Trapped fourth ventricle-treatment options and the role of open posterior fenestration in the surgical management.

    abstract:BACKGROUND:Trapped fourth ventricle (TFV) is a rare and difficult to treat condition. Most patients have a past inciting event (infection, IVH, trauma) and history of prior CSF diversion. The symptoms are due to the mass effect on brainstem and cerebellum. Rarely, TFV can also be associated with syrinx formation due to...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Tyagi G,Singh P,Bhat DI,Shukla D,Pruthi N,Devi BI

    更新日期:2020-10-01 00:00:00

  • Treatment of vestibular schwannomas. Why, when and how?

    abstract::Sporadic vestibular schwannoma (VS) causes unilateral hearing loss, tinnitus, vertigo and unsteadiness. In many cases, the tumour size may remain unchanged for many years following diagnosis, which is typically made by MRI. In the majority of cases the tumour is small, leaving the clinician and patient with the option...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章,评审


    authors: Myrseth E,Pedersen PH,Møller P,Lund-Johansen M

    更新日期:2007-01-01 00:00:00

  • Evaluation of brain tumour laser surgery.

    abstract::A surgical carbon dioxide laser unit (laser) has been used since 1977 in twenty-five cases of various brain tumours, including ten meningiomas (four sphenoid ridge, two parasagittal, two falx, one olfactory, one posterior fossa), eleven gliomas (seven glioblastoma, four astrocytoma), two metastatic brain tumours, one ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Hara M,Takeuchi K,Okada J,Takizawa T,Matsumoto M

    更新日期:1980-01-01 00:00:00

  • Convection-enhanced delivery of a hydrophilic nitrosourea ameliorates deficits and suppresses tumor growth in experimental spinal cord glioma models.

    abstract:BACKGROUND:Convection-enhanced delivery (CED) is a technique allowing local infusion of therapeutic agents into the central nervous system, circumventing the blood-brain or spinal cord barrier. OBJECTIVE:To evaluate the utility of nimustine hydrochloride (ACNU) CED in controlling tumor progression in an experimental s...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Ogita S,Endo T,Sugiyama S,Saito R,Inoue T,Sumiyoshi A,Nonaka H,Kawashima R,Sonoda Y,Tominaga T

    更新日期:2017-05-01 00:00:00

  • Need for ensuring care for neuro-emergencies-lessons learned from the COVID-19 pandemic.

    abstract:BACKGROUND:To investigate whether patients with critical emergency conditions are seeking or receiving the medical care that they require, we characterized the reality of care for patients presenting with neuro-emergencies during the first phase of the COVID-19 pandemic. METHODS:In this observational, longitudinal coh...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Hecht N,Wessels L,Werft FO,Schneider UC,Czabanka M,Vajkoczy P

    更新日期:2020-08-01 00:00:00

  • Belgian doctors' attitudes on the management of patients in persistent vegetative state (PVS): ethical and regulatory aspects.

    abstract:BACKGROUND:The best care and management of patients in persistent vegetative state (PVS) has been the subject of sustained moral and legal debate for a number of years. However, the views of specialist doctors in Belgium involved in the care for patients in PVS are largely unknown. METHODS:A postal questionnaire was s...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Dierickx K,Schotsmans P,Grubb A,Walsh P,Lambe N

    更新日期:1998-01-01 00:00:00

  • Stereolithographic models in the interdisciplinary planning of treatment for complex intracranial aneurysms.

    abstract:BACKGROUND:Treatment of complex intracranial aneurysms requires strategic pre-interventional or preoperative planning. In addition to modern three-dimensional (3D) rotational angiography, computed tomography angiography (CTA) or magnetic resonance angiogram (MRA), a solid, tangible 3D model may improve anatomical compr...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Andereggen L,Gralla J,Andres RH,Weber S,Schroth G,Beck J,Widmer HR,Reinert M,Raabe A,Peterhans M

    更新日期:2016-09-01 00:00:00

  • Relation of cerebral vasospasm to operative findings of subarachnoid blood around ruptured aneurysms.

    abstract::An investigation was carried out in 28 patients in order to evaluate the relationship between angiographically documented vasospasm, amount of subarachnoid blood found at surgery around ruptured intracranial aneurysms, and delayed ischaemic deficits. Angiography was performed at time intervals ranging between 5 and 17...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Tomasello F,Albanese V,Picozzi P,Spadaro A,Conforti P

    更新日期:1982-01-01 00:00:00

  • Serpentine aneurysm of the posterior cerebral artery treated by internal maxillary artery bypass followed by parent artery occlusion: a case report and literature review.

    abstract::Serpentine aneurysms of the posterior cerebral artery (PCA) treated by the internal maxillary artery (IMA) bypass are rare. Here, the authors report the case of a 34-year-old male patient who presented with a half-year history of gradual severe headache and right-sided limb monoparesis and paresthesia lasting for 1 we...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章,评审


    authors: Zhang J,Shi X,Liu F,Sun Y,Qian H,Zhou Z

    更新日期:2019-06-01 00:00:00

  • Cerebral vasospasm diagnosis by means of angiography and blood velocity measurements.

    abstract::We investigated 76 patients with known subarachnoid haemorrhage (SAH) in order to compare the results of angiography and non-invasive Doppler recordings of cerebral artery blood velocity in the diagnosis of cerebral vasospasm. One radiologist and one neurovascular surgeon assessed angiographic spasm visually on a four...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Lindegaard KF,Nornes H,Bakke SJ,Sorteberg W,Nakstad P

    更新日期:1989-01-01 00:00:00

  • COXIBRAIN: results of the prospective, randomised, phase II/III study for the selective COX-2 inhibition in chronic subdural haematoma patients.

    abstract:BACKGROUND:Chronic subdural haematomas (cSDHs) have shown an increasing incidence in an ageing population over the last 20 years, while unacceptable recurrence rates of up to 30 % persist. The recurrence rate of cSDH seems to be related to the excessive neoangiogenesis in the parietal membrane, which is mediated via va...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章,随机对照试验


    authors: Schaumann A,Klene W,Rosenstengel C,Ringel F,Tüttenberg J,Vajkoczy P

    更新日期:2016-11-01 00:00:00

  • Extradural haematoma of the posterior fossa: a report of eight cases and a review of the literature.

    abstract::The authors review the literature and present 8 cases of extradural haematoma of the posterior fossa operated from 1979 to 1985 at the Neurosurgical Clinic of the University of Pavia. Emphasis is placed on the importance of an early diagnosis of the symptoms which are often ignored due to the absence of specific clini...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Brambilla G,Rainoldi F,Gipponi D,Paoletti P

    更新日期:1986-01-01 00:00:00

  • Superficial radial intraneural ganglion cysts at the wrist.

    abstract::Superficial radial intraneural ganglion cysts are rare. Only nine previous cases have been described. We provide two examples with a wrist joint connection and review the literature to provide further support for the unifying articular (synovial) theory for the pathogenesis and treatment of intraneural ganglia. ...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Spinner RJ,Mikami Y,Desy NM,Amrami KK,Berger RA

    更新日期:2018-12-01 00:00:00

  • Cervical cord compression and severe hydrocephalus in a child with Saudi variant of multiple sulfatase deficiency. Report of case.

    abstract::We report a 2.5-year-old boy with Saudi variant of multiple sulfatase deficiency (MSD or Austin's disease). He presented with the features of cervical cord compression and a severe form of hydrocephalus. The former was due to a thickened posterior arch of the atlas and the latter from a narrow foramen magnum and menin...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: al-Moutaery KR,Choudhury AR,Hassanen MO

    更新日期:1994-01-01 00:00:00

  • Serotonin in contused spinal cord.

    abstract::An intensive experimental spinal cord impact trauma in rabbits led, after 90 minutes, to a significant increase of serotonin content in the segments of spinal cord at the injury epicentres. Adjacent segments showed normal values. It is suggested that the existing contradictory published data concerning the serotonin c...

    journal_title:Acta neurochirurgica

    pub_type: 杂志文章


    authors: Nĕmecek S,Suba P,Cerman J

    更新日期:1977-01-01 00:00:00