Abstract:
BACKGROUND:The understanding of molecular alterations of tumors has severely changed the concept of classification in all fields of pathology. The availability of high-throughput technologies such as next-generation sequencing allows for a much more precise definition of tumor entities. Also in the field of brain tumors a dramatic increase of knowledge has occurred over the last years partially calling into question the purely morphologically based concepts that were used as exclusive defining criteria in the WHO 2007 classification. METHODS:Review of the WHO 2016 classification of brain tumors as well as a search and review of publications in the literature relevant for brain tumor classification from 2007 up to now. RESULTS:The idea of incorporating the molecular features in classifying tumors of the central nervous system led the authors of the new WHO 2016 classification to encounter inevitable conceptual problems, particularly with respect to linking morphology to molecular alterations. As a solution they introduced the concept of a "layered diagnosis" to the classification of brain tumors that still allows at a lower level a purely morphologically based diagnosis while partially forcing the incorporation of molecular characteristics for an "integrated diagnosis" at the highest diagnostic level. In this context the broad availability of molecular assays was debated. On the one hand molecular antibodies specifically targeting mutated proteins should be available in nearly all neuropathological laboratories. On the other hand, different high-throughput assays are accessible only in few first-world neuropathological institutions. As examples oligodendrogliomas are now primarily defined by molecular characteristics since the required assays are generally established, whereas molecular grouping of ependymomas, found to clearly outperform morphologically based tumor interpretation, was rejected from inclusion in the WHO 2016 classification because the required assays are currently only established in a small number of institutions. CONCLUSION:In summary, while neuropathologists have now encountered various challenges in the transitional phase from the previous WHO 2007 version to the new WHO 2016 classification of brain tumors, clinical neurooncologists now face many new diagnoses allowing a clearly improved understanding that could offer them more effective therapeutic opportunities in neurooncological treatment. The new WHO 2016 classification presumably presents the highest number of modifications since the initial WHO classification of 1979 and thereby forces all professionals in the field of neurooncology to intensively understand the new concepts. This review article aims to present the basic concepts of the new WHO 2016 brain tumor classification for neurosurgeons with a focus on neurooncology.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Banan R,Hartmann Cdoi
10.1007/s00701-016-3062-3subject
Has Abstractpub_date
2017-03-01 00:00:00pages
403-418issue
3eissn
0001-6268issn
0942-0940pii
10.1007/s00701-016-3062-3journal_volume
159pub_type
杂志文章,评审abstract:BACKGROUND:Hair-sparing techniques in cranial neurosurgery have gained traction in recent years and previous studies have shown no difference in infection rates, yet limited data exists evaluating the specific closure techniques utilized during hair-sparing craniotomies. Therefore, it was the intention of this study to...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04239-3
更新日期:2020-04-01 00:00:00
abstract::Experience from five cases operated on within one year (among 50 microsurgical operations at the base of the brain) persuades us to discuss the topical relations of the meningiomas of the tuberculum sellae and the modifications in operating techniques necessary. For the two contrasting types of tumour found, which are...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401930
更新日期:1977-01-01 00:00:00
abstract::General aspects of glioblastomas are considered such as preoperative diagnosis, stereotactic punctures for tissue samples, location and tumour size, interference with CSF circulation. The operative risk and different approaches to treatment are discussed, and the results are compared. The described combined treatment ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406638
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Catheter-assisted Guglielmi detachable coiling (CAGDC) is a technical option that was developed to allow the endovascular treatment of wide-necked aneurysms. We report upon our experiences of the CAGDC in treating aneurysms with an assessment of its efficacy and safety. METHODS:The effect of CAGDC of wide-n...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-006-0881-7
更新日期:2006-10-01 00:00:00
abstract::In 17 primary transnasal operations on Nelson tumours long-term results are assessed measuring ACTH plasma levels and performing regular neuroradiological controls. In small intrasellar adenomas only one recurrent ACTH elevation near to pretreatment levels without symptoms from tumour growth was observed after 10 year...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405437
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Surgical treatment of petroclival meningiomas remains challenging. In order to refine indications for the use of stereotactic radiosurgery in the treatment of these tumours, we retrospectively evaluated our experience in this field. METHODS:Thirty-two patients harboring a petroclival meningioma were treated...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-003-0123-1
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Nitric oxide is a key mediator of post-traumatic inflammation in the brain. We examined the expressions of iNOS, nNOS, and eNOS in inbred DA and PVGa rat strains where DA is susceptible to autoimmune neuroinflammation and PVGa-resistant. METHODS:Parietal contusions using a weight drop model were produced in...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1297-1
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Aneurysmal subarachnoid hemorrhage (SAH) causes long-term psychosocial impairments even in patients who regain functional independence. Little is known about predictors of these impairments. We studied how early clinical data and neuropsychological results predict work status and health-related quality of li...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1417-y
更新日期:2012-08-01 00:00:00
abstract::The authors report a series of 37 cases of unruptured aneurysms, admitted and operated upon over a 5 year period (1985-1990), which represents an incidence of 18% of the total number of aneurysm patients operated upon during this period. These unruptured aneurysms were discovered in 4 types of circumstances: 1) Associ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01541779
更新日期:1992-01-01 00:00:00
abstract::Quantitative isotope ventriculography (QIV) has been suggested as a method for diagnosing hydrocephalus and predicting the results of CSF shunt insertion. However, the physiological significance of this and other tracer clearance studies is questionable. Using a simplified mathematical model for tracer clearance follo...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01808440
更新日期:1981-01-01 00:00:00
abstract::Leptomeningeal spread and hydrocephalus are increasingly recognized as late disease complications of glioblastoma with almost a quarter of patients requiring early cerebrospinal fluid shunting. The neurosurgeon is challenged with maintaining shunt patency when tumor disease progression is rapid and adjuvant oncologic ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-018-3509-9
更新日期:2018-05-01 00:00:00
abstract::In theory, lymphokine-activated killer (LAK) cells offer a potential method to treat cerebral gliomas, especially low-grade gliomas. LAK cells would be administered by repeated injections straight into the cavity of a subtotally removed tumour. However, brain-tumour cyst fluid has been shown to be immunosuppressive in...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400532
更新日期:1988-01-01 00:00:00
abstract::27 cases of cranioplasty with autogenous bone grafts stored in a deep-freezer and autoclaved before use are reported. The results of follow-up for an average period of one year were satisfactory from the standpoint of brain protection and cosmetic reconstruction. A small area of absorption of grafted bone was observed...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01402184
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Most surgical teams currently consider that endoscopy has become the "gold standard" technique for the transsphenoidal approach to pituitary surgery. Pituitary adenomas are commonly benign tumours and should benefit from the least invasive approach. METHOD:In Foch Hospital, from 2006 to 2020, 2835 patients ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04542-z
更新日期:2020-08-29 00:00:00
abstract::A 34-year-old female patient suffering from right-sided facial palsy presented to our hospital. Her hearing range was within normal limits. She had undergone GKS after receiving a diagnosis of facial nerve schwannoma (FNS). On the fourth day after GKS, the patient experienced sudden onset hearing loss on the right sid...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1983-7
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Transposition of the vertebral artery (VA) for microvascular decompression for hemifacial spasm (HFS) is often challenging. Various procedures have been proposed to transpose the immobile tortuous VA that cannot be decompressed satisfactorily in the usual manner. METHODS:A Teflon piece that is cut into a we...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-018-03793-1
更新日期:2019-07-01 00:00:00
abstract:INTRODUCTION:An open collaborative international network has been established which aims to improve inter-centre standards for collection of high-resolution, neurointensive care data on patients with traumatic brain injury. The group is also working towards the creation of an open access, detailed and validated databas...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,多中心研究
doi:10.1007/s00701-003-0066-6
更新日期:2003-08-01 00:00:00
abstract::Arachnoid cysts are frequent anomalies of the CNS. They are benign lesions within the arachnoid membrane and have been reported to occur in virtually all locations where arachnoid is present. An intraventricular location, however, is rare and occurrence within the fourth ventricle is particularly uncommon. The first r...
journal_title:Acta neurochirurgica
pub_type: 杂志文章,评审
doi:10.1007/s00701-009-0309-2
更新日期:2010-01-01 00:00:00
abstract::Colloid cysts of the third ventricle have been investigated by chemical characterization of the cyst contents using ELISA with monoclonal antibodies for certain carbohydrate epitopes as well as a polyclonal antiserum against peptide domains, and immunohistochemistry on the cyst wall using the same antibodies. Furtherm...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050102
更新日期:1998-01-01 00:00:00
abstract::The authors report on the results obtained on a series of 325 patients operated on for single brain metastasis at the Institute of Neurosurgery of the University of Rome during the period 1951-1979. After analyzing the results vis-à-vis the site of the brain metastasis, the site of the primitive tumour and the surgica...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401183
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate gross and microscopic anatomical features of the vestibulocochlear nerve or eighth cranial nerve (CNVIII) from fresh cadavers, especially the nerve's central myelin portion (CMP) and transitional zone (TZ), and to consider any pathological implications. METHODS:Six fres...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1479-x
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The natural history of vertebrobasilar artery dissection (VAD) is not fully known. The purpose of this study was to review the clinical outcome of the patients with VAD, then to propose an appropriate management strategy for VAD. METHOD:From 1992 to 2004, 35 VAD patients admitted to our institutes were retr...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-006-0742-4
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Middle cerebral artery (MCA) aneurysms are among the more challenging aneurysms for endovascular treatment. We report a contemporary 5-year experience with endovascular therapy for MCA aneurysms at a high-volume neurovascular center. METHODS:Review of prospectively maintained intracranial aneurysm database....
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1594-8
更新日期:2013-04-01 00:00:00
abstract:OBJECT:The aim of this study was to document the possible role of Gamma Knife radiosurgery, suitable for the treatment of deep and well limited tumors, in the management of pineal parenchymal tumors (PPT). POPULATION AND METHODS:We reviewed retrospectively a series of 13 patients with PPT treated by Gamma Knife radios...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-005-0626-z
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess the reliability of fluorescein sodium in predicting conclusive tissue diagnosis in stereotactic brain biopsies and to characterize features of contrast-enhancing and non-enhancing MRI lesions associated with fluorescence. METHODS:A total of 19 patients were studied, 1...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04318-5
更新日期:2020-08-01 00:00:00
abstract::Forty-three patients were operated on for ruptured intracranial aneurysms during a 12-month-period. Intraoperative evaluation of cortical blood flow by means of a thermal diffusion probe was performed in 23 out of the 41 patients who were operated on for aneurysms of the anterior circulation. The autoregulation index ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401447
更新日期:1994-01-01 00:00:00
abstract::Firstly, 14 patients are described who developed either an acquired Chiari malformation (ACM) alone (7 cases) or ACM and syringomyelia (7 cases) after lumbar subarachnoid space (SAS) shunting or in one case, epidural anaesthesia with SAS penetration. Four groups are considered: 3 cases with craniofacial dysostosis and...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050119
更新日期:1998-01-01 00:00:00
abstract::The effects of the new spasmolytic agent HA1077, which belongs to the calciumantagonists but acts by mechanisms different from those of conventional calcium channel blockers, on the cerebral microcirculation were studied in rats using isolated and cannulated intracerebral (parenchymal) arterioles of 50 microns average...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01420194
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The authors applied a scaffold-free osteogenic three-dimensional (3D) graft made of adipose-derived mesenchymal stem cells (AMSCs) in patients undergoing minimally invasive transforaminal lumbar interbody fusion (MI-TLIF). METHODS:Three patients (two patients and one patient with 1 and 2 levels, respectivel...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-016-3051-6
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Convection-enhanced delivery (CED) is a technique allowing local infusion of therapeutic agents into the central nervous system, circumventing the blood-brain or spinal cord barrier. OBJECTIVE:To evaluate the utility of nimustine hydrochloride (ACNU) CED in controlling tumor progression in an experimental s...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3123-2
更新日期:2017-05-01 00:00:00